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Bacillus Cereus


Presentation

  • Three patients presenting with recurrent bacteremia were identified. The patients only recovered once the infected device had been removed. CONCLUSION: B. cereus infections may have various clinical presentations.[ncbi.nlm.nih.gov]
  • Bacillus cereus typically presents as a gastrointestinal infection, but rarely manifests as systemic disease. This report describes a case of B. cereus-related endocarditis that presented as a sickle cell crisis and bacteremia.[ncbi.nlm.nih.gov]
  • This case presented an aggressive evolution with multiple necrotic and hemorrhagic foci in the brain.[ncbi.nlm.nih.gov]
  • Although not specific to B. cereus bacteremia, patients who died of B. cereus tended to present with CNS symptoms and/or liver dysfunction.[ncbi.nlm.nih.gov]
  • The present work demonstrates for the first time the effect of L. delbrueckii subsp. lactis CIDCA 133, a potentially probiotic strain, in an in vitro model of B. cereus infection.[ncbi.nlm.nih.gov]
Anemia
  • We present a case of a rapidly progressive pseudomembranous tracheobronchitis and pneumonia in a 52-year-old woman with severe aplastic anemia.[ncbi.nlm.nih.gov]
  • A 5-year-old boy with standard-risk B-cell acute lymphoblastic anemia developed fever during induction chemotherapy. The patient had no neurological symptoms.[ncbi.nlm.nih.gov]
  • The initial course was characterized by severe cardiovascular shock, anemia, thrombocytopenia and disseminated intravascular coagulation, leading to periventricular leukomalacia, alopecia capitis and toxic epidermal necrolysis.[ncbi.nlm.nih.gov]
  • Died 19 3 63 Leukemia Died 18 4 29 Leukemia Recovered 17 5 60 Alcohol abuse Recovered 16 6 18 Alcohol abuse Recovered 15 7 54 Leukemia Recovered 14 8 21 Bronchiectasis Recovered 13 9 46 None (welder) Died 2 10 41 None (welder) Died 2 11 52 Aplastic anemia[jaclinicalreports.springeropen.com]
Sore Throat
  • We report on a 15-year-old girl with B-cell acute lymphoblastic leukemia, who fell into a somnolent state after presenting with a 12-hour history of fever, muscle soreness, myalgia in both calves, sore throat, and vomiting.[ncbi.nlm.nih.gov]
Acute Abdomen
  • Over a 2-day period, her clinical condition deteriorated rapidly, with the appearance of acute abdomen. Computed tomography investigation of the abdomen showed a liver abscess (diameter approximately 3 cm).[ncbi.nlm.nih.gov]
Heart Disease
  • Bacillus cereus is a rare cause of endocarditis, typically associated with intravenous drug abuse, rheumatic heart disease, prosthetic heart valves, pacemakers, or immunodeficiency.[ncbi.nlm.nih.gov]
  • Infection in patients with valvular heart disease is associated with significant mortality and morbidity. We describe a case of B. cereus endocarditis involving a mechanical mitral prosthesis that resolved after replacement of the prosthetic valve.[ncbi.nlm.nih.gov]
  • In November 2010, an afebrile infant with congenital heart disease was admitted to TCH for respiratory distress and developed fever and became clinically septic 4 days after an internal jugular line was placed.[cdc.gov]
Chest Pain
  • The presentation was severe, essentially marked by respiratory distress and pleuritic chest pain. Classic empirical treatment initiated for febrile neutropenia did not cover this rare pathogen and appropriate therapy was therefore delayed.[ncbi.nlm.nih.gov]
  • A healthy 60-year-old man developed community-acquired B. cereus pneumonia and alveolar hemorrhage unveiled by abrupt chest pain and hemoptysis with no other advance symptoms.[ncbi.nlm.nih.gov]
Myopathy
  • We report a pediatric case of critical illness polyneuropathy and myopathy caused by Bacillus cereus sepsis during acute lymphoblastic leukemia therapy.[ncbi.nlm.nih.gov]
Fracture
  • We report a case of B. cereus surgical site infection after fasciotomy in a healthy 31 year-old man admitted to the orthopedic ward with a comminuted fracture of the tibia. No source was identified.[ncbi.nlm.nih.gov]
Myalgia
  • We report on a 15-year-old girl with B-cell acute lymphoblastic leukemia, who fell into a somnolent state after presenting with a 12-hour history of fever, muscle soreness, myalgia in both calves, sore throat, and vomiting.[ncbi.nlm.nih.gov]
Dermatitis
  • Abstract The aim of the study was to identify Bacillus species from the Demodex folliculorum of patients with topical steroidinduced facial rosaceiform dermatitis.[ncbi.nlm.nih.gov]
Alopecia
  • The initial course was characterized by severe cardiovascular shock, anemia, thrombocytopenia and disseminated intravascular coagulation, leading to periventricular leukomalacia, alopecia capitis and toxic epidermal necrolysis.[ncbi.nlm.nih.gov]
Purpura
  • On examination, diffuse purpura was noted on the left upper limb, and, as it rapidly extended to the left upper trunk, emergency surgery was performed.[ncbi.nlm.nih.gov]
Flaccid Paralysis
  • He was weaned from a respirator on day 23 after the onset of sepsis, but complete flaccid paralysis of the 4 extremities occurred. His compound muscle action potential and F-wave occurrence were reduced on a nerve conduction test.[ncbi.nlm.nih.gov]
Convulsions
  • He developed convulsions and severe consciousness disturbance following gastroenteritis after the ingestion of some fried rice.[ncbi.nlm.nih.gov]

Workup

Demodex Folliculorum
  • Abstract The aim of the study was to identify Bacillus species from the Demodex folliculorum of patients with topical steroidinduced facial rosaceiform dermatitis.[ncbi.nlm.nih.gov]

Treatment

  • The treatment consisted of appropriate antibiotics, G-CSF and removal of the central venous line. Infection control and nearly full neurological recovery was achieved.[ncbi.nlm.nih.gov]
  • After treatment with vancomycin, also shown to be effective in vitro, no clinical improvement was noted and the patient died.[ncbi.nlm.nih.gov]
  • This case suggests that CIP can recover even while continuing ALL treatment, but omitting VCR.[ncbi.nlm.nih.gov]
  • Our findings suggest that delayed treatment of B. cereus in patients with haematologic malignancies undergoing chemotherapy may result in extremely poor outcomes; thus, immediate empirical treatment with vancomycin should be considered.[ncbi.nlm.nih.gov]
  • A 15-year-old boy developed B. cereus sepsis and multiple organ failure on the 19th day after initiation of chemotherapy, and multidisciplinary treatment was started. Treatment was effective and septic shock with multiple organ failure remitted.[ncbi.nlm.nih.gov]

Prognosis

  • However, preventing a fatal prognosis in patients with B. cereus infection has not yet been achieved due to insufficient clinical investigations.[ncbi.nlm.nih.gov]
  • These results suggested that the vrrA gene may play a significant role in the pathogenesis of endophthalmitis, and genotyping of B. cereus has the potential for predicting clinical manifestation and prognosis of endophthalmitis.[ncbi.nlm.nih.gov]
  • Fulminant sepsis caused by Bacillus cereus in patients with hematologic malignancies: analysis of its prognosis and risk factors. Leuk Lymphoma. 2010;51(5):860–9. View Article PubMed Google Scholar Kassar R, Hachem R, Jiang Y, Chaftari A, Raad I.[ann-clinmicrob.biomedcentral.com]

Etiology

  • The panC sequence based phylogenetic affiliation of the B. cereus strains, together with findings of the retrospective cohort analyses, helped determining their etiological role.[ncbi.nlm.nih.gov]
  • B. anthracis, the etiological agent for anthrax, was used by Robert Koch in the 19th century as a model to develop the germ theory of disease, and B. cereus, a common soil organism, is also an occasional opportunistic pathogen of humans.[ncbi.nlm.nih.gov]
  • The main etiology was venous catheter-related (69 %). All-cause mortality at 4 weeks was not significantly different between the appropriate empirical therapy group (9 cases) and the inappropriate group (20 cases) in this study.[ncbi.nlm.nih.gov]
  • Abstract The Bacillus cereus group, which includes entomopathogens and etiologic agents of foodborne illness or anthrax, persists in various environments. The basis of their ecological diversification remains largely undescribed.[ncbi.nlm.nih.gov]
  • B. cereus should be considered a possible etiologic agent of contact lens-associated keratitis. Heat and many types of contact lens disinfecting solutions may be ineffective in eradicating B. cereus from contaminated contact lens cases.[ncbi.nlm.nih.gov]

Epidemiology

  • We report on the epidemiological and microbiological investigation of three outbreaks of food poisoning (A, B, and C) in Austria in 2013.[ncbi.nlm.nih.gov]
  • Two cases with nosocomial diarrhoea were apparently epidemiologically related (same time and ward), a third case was unrelated with respect to time and location.[ncbi.nlm.nih.gov]
  • An epidemiologic investigation was performed. Molecular comparison of patient and environmental isolates was performed by using pulsed-field gel electrophoresis. After an extensive investigation, no common hospital source could be found.[ncbi.nlm.nih.gov]
  • Epidemiology of Infectious Diseases: Bacillus cereus Causal agent Bacillus cereus food poisoning is a gastrointestinal intoxication caused by toxins produced by the Bacillus cereus bacterium.[healthknowledge.org.uk]
  • In addition to these 44 isolates of B. cereus, 12 epidemiologically unrelated B. cereus isolates, one Bacillus sphaericus isolate from a blood specimen from a patient seen in May 1990, and two B. sphaericus isolates from 95% alcohol in the liquor factory[jcm.asm.org]
Sex distribution
Age distribution

Prevention

  • Center for Disease Control and Prevention , Wenzhou, China . 4 4 College of Medicine, Hangzhou Normal University , Hangzhou, China .[ncbi.nlm.nih.gov]
  • We are taking this action to regulate this agent that is similar to B. anthracis to prevent its misuse, which could cause a biological threat to public health and/or national security.[ncbi.nlm.nih.gov]
  • Author information 1 Disease Control and Prevention Center, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, Japan.[ncbi.nlm.nih.gov]
  • Suspecting B. cereus as the aetiological agent may prevent unnecessary liver transplantation.[ncbi.nlm.nih.gov]
  • The aim of this work is the introduction of B. cereus as a differential diagnosis of sepsis in patients with acute leukemia in induction chemotherapy, to prevent delayed treatment.[ncbi.nlm.nih.gov]

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