Presentation
CSF pleocytosis was present in 28% (27/96; p 0.000001 vs. MS) and elevated CSF total protein levels in 41% (31/76) of samples. [ncbi.nlm.nih.gov]
Case Presentation A 25-year-old left-handed Caucasian female presented to the emergency department of our hospital with acute onset of dysarthria and slight right-arm weakness which she noticed upon waking up in the morning. [doi.org]
Methods: A 10-year-old-boy presented a complex-focal seizure and secondary generalization. He vomited and his mimic was asymmetric. Blood and CSF examinations yielded normal results including negative oligoclonal bands. [thieme-connect.com]
The presentation can be similar to other forms of multiple sclerosis, although it is usually monophasic, most closely resembling acute Marburg type multiple sclerosis, with rapid progression and sometimes fulminant course 4,8,9. [radiopaedia.org]
Entire Body System
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Intermittent Fever
He had low-grade intermittent fever 20 days prior for 3 days. The patient was treated in the local hospital. [ruralneuropractice.com]
Gastrointestinal
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Progressive Dysphagia
Abstract We report a 50 years old woman admitted to the hospital due to progressive dysphagia and disarthria of there weeks duration. On admission a right hemiparesis was noted. CSF examination showed a protein of 9 mg/dl and no cells. [unboundmedicine.com]
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Gagging
He had left supranuclear facial palsy, and his gag reflex was exaggerated. Vision, pupils, and fundus examination was normal. Motor examination revealed left spastic hemiparesis of Grade 3 on Medical Research Council (MRC) scale with hyperreflexia. [ruralneuropractice.com]
Neurologic
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Expressive Aphasia
Her symptoms were tentatively explained by a suspected tumor of the superior and middle frontal gyri anterior to the Rolandic fissure and adjacent vasogenic edema, which was producing an expressive aphasia, typical of a Broca aphasia. [ajnr.org]
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Mild Cognitive Impairment
It may present as clinically similar to multiple sclerosis, affecting young adults with mild cognitive impairment without frank dementia, or be associated with altered behavior and focal CNS deficits. [ajnr.org]
Workup
Equally important, the workup of these patients has not been performed in a uniform manner. This includes the clinical and imaging examinations, the collection of paraclinical data and their follow-up. [slideheaven.com]
All CSF parameters evaluated in this study are routinely tested in Germany as part of the diagnostic workup of patients with suspected MS in Germany and are recommended by the guidelines of the German Society of Neurology and by the guidelines of the [doi.org]
Microbiology
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Human Herpesvirus 6
Baló’s concentric sclerosis associated with primary human herpesvirus 6 infection. J Neurol Neurosurg Psychiatry. 2005 ;76: 1723 – 1725. Google Scholar Crossref Medline 6. Dreha-Kulaczewski, SF, Helms, G, Dechent, P. [doi.org]
Pohl D et al. (2005) Baló's concentric sclerosis associated with human herpesvirus 6 infection. J Neurol Neurosurg Psychiatry 76 : 1723–1725 14. Singh S et al. (1999) Baló's concentric sclerosis: value of magnetic resonance imaging in diagnosis. [nature.com]
Baló's concentric sclerosis associated with primary human herpesvirus 6 infection. J Neurol Neurosurg Psychiatry. 2005; 76 :1723–1725. [ PMC free article ] [ PubMed ] [ Google Scholar ] 16. [ncbi.nlm.nih.gov]
Balóüs concentric sclerosis associated with primary human herpesvirus 6 infection. J Neurol Neurosurg Psychiatry 2005; 76: 1723-5. Kavanagh EC, Heran MK, Fenton DM, Lapointe JS, Nugent RA, Graeb DA. [new.medigraphic.com]
Treatment
We started treatment with a bolus of 1 g methylprednisolone daily. The patient was responding favourably to treatment by the third day and was discharged after 5 days of treatment due to symptom resolution. [elsevier.es]
Treatment to relieve symptoms, such as spasticity, weakness, pain, or ataxia, includes pharmacologic and rehabilitative modalities. What About Disease Modifying Treatments? Click To Enlarge Balos’ concentric sclerosis is quite rare. [msunites.com]
In addition to providing up-to-date information on pharmacological therapies for MS, the book also describes an array of non-pharmacological treatment options. [books.google.de]
However, data from randomized, controlled treatment trials are lacking, and so far it is unclear which approach is the most promising. [doi.org]
Prognosis
Scientists used to believe that the prognosis was similar to Marburg multiple sclerosis, but now they know that patients can survive, or even have spontaneous remission and asymptomatic cases. [1] It is also common that the clinic course is primary progressive [wikidoc.org]
Recognizing the characteristic MRI pattern of BCS can aid in early diagnosis and treatment, ultimately improving prognosis. The views expressed in this material are those of the author, and do not reflect the official policy or position of the U.S. [jaocr.org]
[…] signal T2: irregular concentric areas alternating iso/hypointense and hyperintense signal 4,9 T1 C (Gd): typically a peripheral ring of enhancement in the area of active demyelination 9 DWI: some restricted diffusion in the outer ring 7 Treatment and prognosis [radiopaedia.org]
Scientists used to believe that the prognosis was similar to Marburg multiple sclerosis, but now they know that patients can survive, or even have spontaneous remission and asymptomatic cases. [dbpedia.org]
Etiology
"Acute Cerebral White Matter Disease of Unknown Etiology in the Philippines" Clinical and Pathological Findings(in preparation), 1984 11. Spatz, H, Alig, Z. "Liber Leukoencephalitis Concentrica" Psychiat 96, 367, 1932 12. Tabira, T, Tateishi, J. [herdin.ph]
The heredofamilial or endogenous diseases of the central nervous system are characterized by germ layer selectivity, system selectivity and segment selectivity (Schaffer). 1 The exogenous diseases of the brain and spinal cord, the etiology of which is [archneurpsyc.ama-assn.org]
Their etiology is unknown. There is no satisfactory classification, and occasionally a new, equally obscure condition is added to this heterogeneous group. [jamanetwork.com]
Epidemiology
"An Epidemiological Study of Neurological Diseases, especially Incurable Diseases in the Philippines" Neurological Institute Kyushu University Fukuoka, 1984 7. Liu, DS, Lin, SH, Rao, ML. [herdin.ph]
Epidemiology The disease is more common in Chinese and Filipino populations (both Asiatic ) than in caucasoids. [7] See also Multiple sclerosis The Lesion Project References Karaarslan E, Altintas A, Senol U, et al. (August 2001). [cognopedia.com]
Differentiating Balo Concentric Sclerosis from other Diseases Epidemiology and Demographics The disease is more common in Chinese and Filipino populations (both Asiatic ) than in caucasoids [7]. [wikidoc.org]
The epidemiology of multiple sclerosis: Insights to disease pathogenesis. Handb Clin Neurol 2014 ; 122: 231 – 266. Google Scholar Medline 9. Kastrup, O, Stude, P, Limmroth, V. [doi.org]
Pathophysiology
The hypothesis concerning the pathophysiology of the lesions' typical and peculiar morphological appearance and its relationship to multiple sclerosis are briefly discussed. [link.springer.com]
Pathophysiology The lesions of the Balo sclerosis belong to the MS lesion pattern III (distal oligodendrogliopathy). [4] According with Dr. [cognopedia.com]
Historical Perspective Classification Pathophysiology The lesions of the Balo sclerosis belong to the MS lesion pattern III (distal oligodendrogliopathy). [4] According with Dr. [wikidoc.org]
At present, this entity is easier to diagnose and treat in its early stages thanks to MRI. 2 However, the pathophysiology of BCS is still to be determined and there is no consensus on the most suitable treatment in acute stages or in the long term. [elsevier.es]
Pathophysiology The lesions of the Balo sclerosis belong to the MS lesion pattern III (distal oligodendrogliopathy). [6] Balo concentric sclerosis is now believed to be a variant of pattern III multiple sclerosis. [7] According with Dr. [ipfs.io]
Prevention
“We’d be able to develop therapies and treatments to prevent MS… [and] come up with a vaccine against epsilon toxin to prevent that damage from happening,” Linden said. [foxnews.com]
Tissue preconditioning is a natural process by which the brain mounts protective measures to prevent further damage. [news-medical.net]
Dr Susan Kohlhaas, Head of Biomedical Research at the MS Society, said: "Discovering potential causes or triggers for MS could enable us to develop better treatments or even, one day, prevent the condition. [bbc.co.uk]
Risk Factors Natural History, Complications and Prognosis Diagnosis Diagnostic Criteria Symptoms Physical Examination Laboratory Findings Imaging Findings Other Diagnostic Studies Treatment Medical Therapy Surgery Prevention Multiple sclerosis The Lesion [wikidoc.org]
However, interpreting MRI findings is not easy, which may lead to misdiagnosis followed by administration of unnecessary secondary prevention treatments. [elsevier.es]