General GI disturbances in 57 patients (35%) included frequent upper GI pain, chronic diarrhea, and constipation; gastroesophageal reflux was diagnosed, based on findings from either upper GI series or endoscopies, in 35 patients. [jamanetwork.com]

General GI disturbances in 57 patients (35%) included frequent upper GI pain, chronic diarrhea, and constipation; gastroesophageal reflux was diagnosed, based on findings from either upper GI series or endoscopies, in 35 patients. [jamanetwork.com]

Dental abnormalities in 33% of patients consisted of a pronounced gap between the upper front teeth, crowding, late eruption, and selective brown enamel discoloration. [jamanetwork.com]

Mild-to-profound bilateral sensorineural, predominantly high-frequency, hearing impairment evolved throughout childhood (89%; age range, 2-21 years; mean age at onset, 5 years). [jamanetwork.com]