Presentation
The varied clinical picture of Bartonella infection and a review of clinical aspects of endocarditis caused by Bartonella are presented. [ncbi.nlm.nih.gov]
Entire Body System
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Fatigue
The blood samples Breitschwerdt and Maggi tested came from previously healthy women who were suffering from symptoms including muscle fatigue and weakness. [sciencedaily.com]
Predominant symptoms included fatigue (79.2%), sleeplessness (64.1%), joint pain (64.1%), and muscle pain (63.0%). [ncbi.nlm.nih.gov]
[…] little, fractionated, early awakening Ears/Hearing: buzzing, ringing, ear pain, sound sensitivity Exaggerated symptoms or worse hangover from alcohol Eyes/Vision: double, blurry, increased floaters, light sensitivity Facial paralysis (Bell's palsy) Fatigue [anapsid.org]
Our first patient was a previously healthy 14-year-old male adolescent who developed gradually worsening frontal headaches, fatigue, and knee arthralgia. [doi.org]
It can be a difficult drug to tolerate due to fatigue and effects on the liver, but with the proper liver detoxification support it can be very useful. [pannaturopathic.com]
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Camping
KEYWORDS: AMPylation; bacterial effector; filamentation induced by cAMP; parallel evolution [ncbi.nlm.nih.gov]
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Pseudotumor
Pseudotumoral lesions involving the mammary glands, the liver, or the spleen and, recently, glomerulonephritis and cases of monoclonal and biclonal gammopathy have also been associated with B. henselae antibodies. [doi.org]
Respiratoric
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Rhinitis
B. v. berkhoffii is now associated with cardiac arrhythmias, endocarditis and myocarditis, granulomatous lymphadenitis, granulomatous rhinitis, and epistaxis ( 6, 32 ). [doi.org]
Subsequently, the organism has been found in another dog with endocarditis ( 57 ) and it has been implicated in granulomatous lymphadenitis, granulomatous rhinitis, peliosis hepatis, myocardial inflammation, cardiac arrhythmias, syncope, and sudden death [web.archive.org]
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Nasal Discharge
discharge/epistaxis ( 37 ). [doi.org]
Cardiovascular
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Cyanosis
Abstract After a short-term fever, complex regional pain syndrome, characterized by hyperalgesia, intermittent swelling, erythema and cyanosis of both feet, was diagnosed in a female veterinarian. [ncbi.nlm.nih.gov]
Face, Head & Neck
Urogenital
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Renal Insufficiency
The gentamicin levels in patients with renal insufficiency, obesity, or increased fluid volume should be monitored closely; and a reduced total daily dose of gentamicin should be administered as a twice-daily dosing schedule to avoid the nephrotoxicity [doi.org]
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Hematuria
Kidney manifestations, including hematuria, parenchymal infarction, and glomerulonephritis, may affect as many as 40%-50% of patients with infective endocarditis. [ncbi.nlm.nih.gov]
Neurologic
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Hyperalgesia
Abstract After a short-term fever, complex regional pain syndrome, characterized by hyperalgesia, intermittent swelling, erythema and cyanosis of both feet, was diagnosed in a female veterinarian. [ncbi.nlm.nih.gov]
Workup
Microbiology
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Blood Culture Positive
The prevalence of blood culture-positive cats is high worldwide and is up to 41% in California ( 50 ). [doi.org]
In that study, homeless people with blood cultures positive for B. quintana were randomized to receive either no treatment (untreated controls) or a combination of gentamicin (3 mg/kg of body weight/day i.v. for 14 days) and doxycycline (200 mg/day p.o [dx.doi.org]
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Tropheryma Whipplei
DNAs from 10 bacterial strains and isolates were used as a negative control: Rickettsia helvetica, Escherichia coli, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Tropheryma whipplei, Afipia felis, Coxiella burnetii, Bosea massiliensis, Staphylococcus [jcm.asm.org]
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Mycobacterium Avium Complex
Of note, AIDS patients receiving prophylaxis with a macrolide or rifamycin antibiotic for Mycobacterium avium complex infection appear to be protected from developing infections with Bartonella species ( 57 ). [doi.org]
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Trypanosoma Cruzi
They are well known in Central and South America where they transmit Trypanosoma cruzi to mammals, including humans, through their feces. [ncbi.nlm.nih.gov]
Other Pathologies
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Retinal Phlebitis
On the basis of serologic testing or polymerase chain reaction (PCR), several recent publications have associated B. henselae with uveitis, focal retinal phlebitis, neuroretinitis, retinal and optical nerve neovascularization, and retinal artery and vein [doi.org]
Treatment
Because there are only two reports of randomized clinical trials for the treatment of Bartonella infections, an unequivocal treatment for all Bartonella infections does not exist, and thus, antibiotic treatment recommendations differ for each clinical [doi.org]
Following antibiotic treatment, B. koehlerae antibodies and DNA were not detected and all symptoms resolved. [ncbi.nlm.nih.gov]
Tier One Rifamycin-based Treatments In these treatments Rifampin or Rifabutin is the main effective ingredient. [treatlyme.net]
Prognosis
Better initial visual acuity confers a better final visual acuity prognosis. [eyewiki.aao.org]
Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX Abstract Inflammatory breast cancer (IBC) is a very aggressive type of advanced breast cancer with a poor prognosis. [cancerres.aacrjournals.org]
Prognosis Usually self-limiting. Trench fever re-infection may occur within 3-6 months because antibodies do not give full protection. [patient.info]
Second, genetic predisposition might play a role in chronicity, pathogenesis, antimicrobial resistance, and prognosis for patients with Lyme disease. There have been no previously reported cases of concurrent Lyme disease and B henselae infection. [doi.org]
Etiology
Rodent-associated Bartonella elizabethae and Rickettsia akari were the primary etiologic agents of interest. [ncbi.nlm.nih.gov]
See Infective Endocarditis: Diagnostic Testing for Identification of Microbiological Etiology in Special Instructions. [mayocliniclabs.com]
Moreover, we used PCR and sequencing of the 16S–23S intergenic spacer (ITS) region to identify the etiological agent as Bartonella henselae. [cancerres.aacrjournals.org]
Epidemiology
We review current knowledge on the etiologic agents, clinical features, and epidemiologic characteristics of these emerging zoonoses. [ncbi.nlm.nih.gov]
Epidemiologic arguments must carefully control for confounding, and none to date argues convincingly for tick transmission of Bartonella spp. [doi.org]
Pathophysiology
We demonstrated the apparently firm vitreoretinal interface adhesions at the level of the optic nerve in light of a recent editorial offered by Parsa and Hoyt offering that the pathophysiology of NAION is related to sudden release of vitreopapillary traction [eyewiki.aao.org]
Clinicians continue to be challenged to explain the pathophysiology behind chronic Lyme disease. Persistent symptoms following even aggressive therapy for Lyme disease continue to frustrate both patients and their physicians. [doi.org]
The pathophysiology of the acute phase of human bartonellosis resembles AIDS. Med. Hypotheses 74, 45–49 (2010). 8. Chamberlin, J. et al. [nature.com]
Prevention
Researchers at North Carolina State University and the Centers for Disease Control and Prevention have produced the first link between a species of bacteria most commonly found in sheep and human illness. Dr. [sciencedaily.com]
[…] de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, C.P. 04510, Ciudad de México, México. 2 Division of Vector-Borne Diseases, Centers for Disease Control and Prevention [ncbi.nlm.nih.gov]
Characterization of a gene regulatory system that controls bacterial virulence factors may prove to be a valuable target for antimicrobial therapy to prevent infections caused by B. henselae. [grantome.com]
NIH-funded research has greatly increased knowledge of asthma and led to better treatment and prevention options. Director, Dr. Anthony S. Fauci NIAID Offices, Divisions & Centers [niaid.nih.gov]