We present a case report of an unusual CSD presentation, persistent hepatic granulomatous disease due to Bartonella henselae infection despite combination therapy with doxycycline and rifampicin. Furthermore, a review of literature was conducted. [ncbi.nlm.nih.gov]

• Cat Scratch

  B henselae, a gram-negative bacteria, is the cause of cat scratch disease. [ncbi.nlm.nih.gov]

• Fever

  Osteomyelitis due to B. henselae should be considered in cases of prolonged fever of unknown origin. [ncbi.nlm.nih.gov]

• Lymphadenopathy

  Therefore it should always be included in the differential diagnosis of lymphadenopathy for adults. [ncbi.nlm.nih.gov]

• Pain

  He sought for clinical help because of unknown fever and persistent back pain for at least a month after an accidental needle puncture. [ncbi.nlm.nih.gov]

  This disease has two distinct phases: Oroya fever: During this phase, fever, headache, muscle aches, abdominal pain, and severe anemia may occur. [cdc.gov]

  Fever, muscular pain, local lymphadenopathy and, rarely, also neurological symptoms can occur, which usually disappear again after a few days. [laboklin.com]

• Fever of Unknown Origin

  Osteomyelitis due to B. henselae should be considered in cases of prolonged fever of unknown origin. [ncbi.nlm.nih.gov]

  Bartonella cat scratch disease lymphadenopathy fever of unknown origin hepatosplenic disease Accepted October 8, 2007. [pediatrics.aappublications.org]

• Nausea

  In June 2017, following the abrupt withdrawal of clozapine and tramadol (for migratory pain), he experienced severe anorexia, nausea, and vomiting, which resulted in hospitalization and a 20.5-kg weight loss over 40 days. [doi.org]

• Vomiting

  In June 2017, following the abrupt withdrawal of clozapine and tramadol (for migratory pain), he experienced severe anorexia, nausea, and vomiting, which resulted in hospitalization and a 20.5-kg weight loss over 40 days. [doi.org]

• Jaundice

  A putative vertical Bartonella henselae infection was defined on the basis of ultrastructural and molecular analyses in a three-year-old child with anemia, jaundice and hepatosplenomegaly since birth. [ncbi.nlm.nih.gov]

• Heart Failure

  Accordingly, infective endocarditis and heart failure were diagnosed. Although a blood culture was negative on day 7 after admission, a prolonged blood culture with subculture was performed according to the patient's history of contact with cats. [ncbi.nlm.nih.gov]

• Angiomatosis

  Treatment with clarithromycin resulted in resolution of the bacillary angiomatosis, fever, anemia, panserosites, and hepatitis. [ncbi.nlm.nih.gov]

  A species of gram-negative bacteria that is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY). This organism can also be a cause of CAT-SCRATCH DISEASE in immunocompetent patients. [connects.catalyst.harvard.edu]

• Myalgia

  […] lymphadenopathy Atypical symptoms: tiredness (nearly 100%), headache (80%), amyostasia, muscle twitches, tremors, seizures, fever in the mornings (30%, in phases up to six weeks, otherwise 1-3 weeks), chills, skin pain, swollen lymphnodes, arthralgia (often), myalgia [arminlabs.com]

  Patient 1 was a 38-year-old woman in whom fever, chills, headache, myalgias, nausea, and vomiting developed five years after cardiac transplantation while she was following a maintenance regimen of immunosuppressive drugs. 8 Three months earlier she had [doi.org]

• Seizure

  Focal presentations concerning for stroke or partial seizure activity may have underlying infectious etiology. [ncbi.nlm.nih.gov]

  Typical symptoms: Papulae/rash and regional lymphadenopathy Atypical symptoms: tiredness (nearly 100%), headache (80%), amyostasia, muscle twitches, tremors, seizures, fever in the mornings (30%, in phases up to six weeks, otherwise 1-3 weeks), chills [arminlabs.com]

• Irritability

  The older son developed intermittent disorientation and irritability, and the mother experienced fatigue, headaches, joint pain and memory loss. [ncbi.nlm.nih.gov]

  […] neuropsychiatric symptoms. 4 - 6 A clinical syndrome in youth, defined by the sudden onset of neuropsychiatric symptoms including obsessions/compulsions or food restriction, has been designated pediatric acute-onset neuropsychiatric syndrome (PANS). 7 Depression, irritability [doi.org]

  There’s a relationship between ME/cfs and IBS, Irritable Bowel Syndrome. A lot of people suffer from it, yet there are also many people who don’t have ME but do have IBS. [markhouse-projects.com]

• Neurologic Manifestation

  Neurological manifestations of bartonellosis in immunocompetent patients: a composite of reports from 2005-2012. J Neuroparasitol. 2012 ;3: 1 – 15. Google Scholar 29. Swedo, SE, Frankovich, J, Murphy, TK. [doi.org]

• Bartonella Henselae

  We also describe a novel method of identifying Bartonella henselae by real-time quantitative polymerase chain reaction and sequencing of amplified products. [ncbi.nlm.nih.gov]

• Bartonella Quintana

  […] of Bartonella quintana IgG antibody detected. [ltd.aruplab.com]

  Nº TEST CLASS BARTONELLA HENSELAE & QUINTANA IFA IgG Agents Bartonella henselae, Bartonella quintana PBAHQG 100 BARTONELLA HENSELAE & QUINTANA IFA IgM Agents Bartonella henselae, Bartonella quintana PBAHQM 100 BARTONELLA HENSELAE & QUINTANA IFA SLIDE [en.vircell.com]

  Antibody specificity/ reagent/ analyte Ig class Substrate Species Format FI 219b-1005-1 G FI 219b-1010-1 G FK 219b-1005-1 G FK 219b-1010-1 G FI 219b-1005-1 M FI 219b-1010-1 M FK 219b-1005-1 M FK 219b-1010-1 M Bartonella henselae Bartonella quintana IgG [euroimmun.com]

  In view of the strong suspicion of infective endocarditis, acute and convalescent sera from 30 patients with culture negative endocarditis were tested for antibodies to Brucella melitensis, Mycoplasma pneumoniae, Bartonella quintana, B. henselae, Coxiella [ncbi.nlm.nih.gov]

  Componentsi Component name Genome Accession(s) Component representation Proteins Chromosome BX897699 1466 Publications "The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." [uniprot.org]

The duration of treatment in patients with bartonella endocarditis is not clearly defined, and we decided to treat our patient with a prolonged course of antibiotic. Surgical treatment is usually necessary and was also successful in our patient. [ncbi.nlm.nih.gov]

These mechanisms suggest a novel link between communicable and non-communicable human diseases, and put forward the possibility that Bartonella henselae could enhance the susceptibility and worsen the prognosis in cardiovascular disease. [ncbi.nlm.nih.gov]

Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX Abstract Inflammatory breast cancer (IBC) is a very aggressive type of advanced breast cancer with a poor prognosis. [cancerres.aacrjournals.org]

Serologic studies and polymerase chain reaction testing of resected homograft valvular tissue provided evidence of Bartonella henselae as the etiology. [ncbi.nlm.nih.gov]

A species of gram-negative bacteria that is the etiologic agent of bacillary angiomatosis (ANGIOMATOSIS, BACILLARY). This organism can also be a cause of CAT-SCRATCH DISEASE in immunocompetent patients. [connects.catalyst.harvard.edu]

The epidemiologic association with cats was first made in 1931 and further substantiated throughout the years, refining the interaction predominantly to kittens. [ncbi.nlm.nih.gov]

Consideration is also given to epidemiological aspects in human and animal infections, with special emphasis on the application of new molecular methods for the characterization of isolates. [amazon.fr]

Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, People's Republic of China. [ncbi.nlm.nih.gov]