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Basal Cell Carcinoma of the Vulva

Basal Cell Carcinoma of Vulva


Presentation

  • Four patients presented in the eighth and ninth decades of life (70, 78, 87 and 89 years). Seventy-five percent of patients had a unifocal lesion. Cases 3 or 4 presented with recurrent lesions at 5 and 10 years, respectively.[ncbi.nlm.nih.gov]
  • CASES: Four patients presented in the eighth and ninth decades of life (70, 78, 87 and 89 years). Seventy-five percent of the patients had a unifocal lesion. Cases 3 and 4 presented with recurrent lesions at 5 and 10 years, respectively.[reproductivemedicine.com]
Chronic Infection
  • Syphilis, chronic irritation, chronic infection, trauma, arsenic, age, immune deficiency, certain genetic diseases such as Gorlin syndrome, xeroderma pigmentosum, human papilloma virus (the most relevant in the squamous cells of the genital etiology),[medcraveonline.com]
  • Syphilis, chronic irritation, chronic infection, trauma, arsenicals, and radiotherapy have been implicated as possible precipitating factors. 5 , 6 Clinically, vulvar BCC is an indolent and destructive tumor that rarely metastases, but the local recurrence[ncbi.nlm.nih.gov]
Pallor
  • In 7 cases, a distinctive noninvasive squamous epithelial proliferation, exhibiting a triad of marked acanthosis with variable verruciform architecture, loss of the granular cell layer with superficial epithelial cell pallor, and multilayered parakeratosis[thedoctorsdoctor.com]
Ulcer
  • The lesions were described grossly as ulcerations or masses located on the anterior labium majus. Etiologies were indeterminate although 2 patients had previously received vulvar irradiation.[ncbi.nlm.nih.gov]
Hyperkeratosis
  • Histology Epidermal atrophy, localized hyperkeratosis, degeneration of the basement membrane Loss of collagenous and elastic connective tissue Presence of an inflammatory infiltrate Therapy Vaginal cancer Localization : The upper third of the posterior[amboss.com]
  • Differentiated VIN are often misdiagnosed as a benign lesion (squamous-cell hyperplasia with hyperkeratosis). These are, however, high-grade lesions that must be treated with surgery to prevent progression into squamous-cell carcinoma.[oncolex.org]
  • White lesions are caused by hyperkeratosis, whereas red ones represent hypervascularity. Gray or brown lesions are produced by melanocytic overactivity and pigment incontinence.[glowm.com]
Papule
  • […] or nodule, usually 1-2 cm; some nodules may grow to a size of up to 10 cm The surface of the papule may be red, if intact.[dovemed.com]
  • Superficial types may present with an ulcer, a macule, or papule. Clinically, it is not possible to separate the precursor lesion of VIN from superficial invasion.[thedoctorsdoctor.com]
  • On physical examination visible genital lumps or ulcers, may be associated with the surrounding skin hypopigmentation, hyperpigmentation plaques, macules or papules.[hoajonline.com]
Angiokeratoma
  • It may mimic other dermatological pathologies such as eczema, psoriasis, seborrheic keratosis or angiokeratoma. 2 Therefore, it is recommended that all suspicious vulvar lesions should be biopsied for early diagnosis.[ncbi.nlm.nih.gov]
Neglect
  • They may be invasive and destructive if neglected or improperly treated. Nevertheless, they have a very low propensity for metastatic spread, but frequently recur after simple excision.[ncbi.nlm.nih.gov]
Vaginal Bleeding
  • We report a 78 year-old woman presenting with the complaint of painful vulvar ulceration and vaginal bleeding.[ncbi.nlm.nih.gov]
  • bleeding Leukoplakia, vaginal ulceration with contact bleeding Malodorous discharge Possibly urinary frequency Diagnosis : Therapy Senile vaginitis should also be considered in patients presenting with vaginal pruritus, burning, and pain.[amboss.com]
  • But over time, you might notice a change in the color of your vulva, unusual growths, itching that doesn’t go away, or abnormal vaginal bleeding or tenderness. If you have these symptoms, it doesn’t mean you have vulvar cancer.[webmd.com]
  • Signs and symptoms of vaginal cancer include pain or abnormal vaginal bleeding. Vaginal cancer often does not cause early signs or symptoms. It may be found during a routine pelvic exam and Pap test.[northshore.org]
Pruritus Vulvae
  • Presenting symptomatology consisted primarily of pruritus vulvae and/or the presence of a vulvar mass (79%) of long duration (average, 6 years, 7 months).[ncbi.nlm.nih.gov]

Treatment

  • Primary treatment should consist of wide local excision and continued follow-up.[ncbi.nlm.nih.gov]
  • Recurring tumors have a poorer prognosis compared to tumors that do not recur Response to treatment: Tumors that respond to treatment have better prognosis compared to tumors that do not respond so well to treatment Without treatment (or with delayed[dovemed.com]

Prognosis

  • What is the Prognosis of Basal Cell Carcinoma of Vulva? (Outcomes/Resolutions) With early detection and prompt treatment, the prognosis of Basal Cell Carcinoma of Vulva is excellent.[dovemed.com]
  • Their characteristic presentation, histology, and prognosis warrant their differentiation.[ncbi.nlm.nih.gov]
  • The behaviour of vulval melanomas is unpredictable, and overall the prognosis is poor with 32% 5-year survival. Prognosis is related to tumour thickness and disease spread.[slhd.nsw.gov.au]
  • Vulvar cancer is usually associated with a poor prognosis.[amboss.com]
  • Diagnosis Prognosis and Treatment VULVAR CANCER Pathology Symptoms, Signs, and Diagnosis Prognosis Treatment VAGINAL CANCER Symptoms and Signs Prognosis and Treatment FALLOPIAN TUBE CANCER Symptoms, Signs, and Diagnosis GESTATIONAL TROPHOBLASTIC DISEASE[health.am]

Etiology

  • Etiologies were indeterminate although 2 patients had previously received vulvar irradiation.[ncbi.nlm.nih.gov]
  • Vulvar BCC is a rare tumor, accounting for less than 1% of all BCCs, with an unclear etiology, often delayed diagnosis and typically asymptomatic.[medcraveonline.com]
  • Vaginal cancer is closely related to vulvar cancer in terms of etiology and histology, but it occurs inside the vagina (typically the posterior third of the vaginal wall), rather than the vulva.[amboss.com]

Epidemiology

  • ., genital lichen planus ( hypertrophied skin with purple lesions) Etiology : unclear (hormonal, immunological, and/or infectious factors are believed to play a role) Epidemiology : postmenopausal women and, less commonly, prepubescent girls Clinical[amboss.com]
  • Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992;79:448–54. 4. Creasman WT, Phillips JL, Menck HR. The National Cancer Data Base report on early stage invasive vulvar carcinoma.[aafp.org]
  • Epidemiology [ 1 ] Vulval cancer is rare and accounts for less than 1% of all cancer cases in the UK.[patient.info]
  • Epidemiology Vulvar cancer causes less than 1% of all cancer cases and deaths but around 6% of all gynecologic cancers diagnosed in the UK.[ipfs.io]
  • Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518–527. 2. Andersson S, Rylander E, Larson B, et al.[slideshare.net]
Sex distribution
Age distribution

Prevention

  • How can Basal Cell Carcinoma of Vulva be Prevented? Currently, there are no preventive measures against Basal Cell Carcinoma of Vulva.[dovemed.com]
  • Preventive Services Task Force. Available online at . Accessed 6/16/15. Moyer, VA on behalf of the U.S. Preventive Services Task Force. (2012 June 19). Screening for Cervical Cancer: U.S. Preventive Services Task Force Recommendation Statement.[labtestsonline.it]
  • The HPV vaccine can prevent the strains of HPV responsible for most cervical, vaginal and vulvar cancers.[hopkinsmedicine.org]
  • The vaccine is approved to prevent cervical cancer and genital warts. It may help prevent other cancers linked to HPV, such as vulvar cancer.[ufhealth.org]
  • Can It Be Prevented? Vulva cancer prevention : As the cause has not been clearly identified preventative care must focus on reducing exposure to possible risk factors. This includes: 1.[womens-health-advice.com]

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