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Basaloid Squamous Cell Carcinoma


Presentation

  • We present here a case of BSCC in a 36 year female arising in the paranasal sinus with orbital and intracranial extension. Clinical and pathological findings including immunohistochemistry is presented along with brief discussion of literature.[alliedacademies.org]
  • presentation of the initial symptoms two months previously.[spandidos-publications.com]
  • On clinical observation, the tumor frequently presents as an exophytic mass that may have ulcerations, [ 5 ] in the case presented, however, the tumor was deep in the tonsil, and completely hidden on physical examination.[omicsonline.org]
  • The objective of this study is to present a case of BSCC in soft palate and to show the importance of the support in the immunohistochemistry for an early histopathological diagnosis. A review of the literature on this pathology is also presented.[scielo.sa.cr]
  • All subjects were diagnosed with laryngeal cancer at presentation except for the subject #2. This subject was presented with a neck mass of unknown primary and underwent neck dissection at first and had radiotherapy.[scielo.br]
Physician
  • Always seek the advice of your physician or other qualified health provider with any questions you may have regarding your medical condition.[practo.com]
  • The ASCP is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The ASCP designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit per article.[academic.oup.com]
Asymptomatic
  • […] metastasis, all patients diagnosed with BSCC of the UADT systematically should undergo a chest computed tomography scan to rule out the lung metastasis and a 2-deoxy-2-fluoro-D-glucose – positron emission tomography to detect the presence of extrapulmonary asymptomatic[ncbi.nlm.nih.gov]
Hunting
  • Hunt JL, Barnes L. Immunohistology of head and neck neoplasms. Basaloid squamous cell carcinoma. In: Dabbs DJ, editor. Diagnostic immunohistochemistry, 2nd ed. Philadelphia: Churchill Livingstone; 2006. p. 229–30. 31.[ncbi.nlm.nih.gov]
Keratosis
  • Also called epidermoid carcinoma, this non-melanoma skin cancer may develop from the skin condition actinic keratosis (pronounced ak-TIH-nik KAYR-uh-TOH-sis), which gives your skin thick, scaly patches.[sharecare.com]

Workup

  • Metastasis workup was negative and laboratory tests were within normal ranges. Pelvic magnetic resonance imaging (MRI) showed an enhancing heterogeneous mass measuring 24 18 mm located in the cervix.[intjcancermanag.com]
  • Because of the incidence of DM and the possibility of salvage and long‐term survival with metastases, we also recommend a more thorough diagnostic workup, including at least a chest computed tomography scan, at baseline and during follow‐up.[onlinelibrary.wiley.com]

Treatment

  • Patients had received treatment with surgery or radiation. Patients with metastatic disease were excluded.[ascopost.com]
  • Therefore, multimodal treatment is considered to be important for AEBSCC and some reports have stated that aggressive treatment of metastatic sites led to long-term survival [ 18, 19 ].[bmcgastroenterol.biomedcentral.com]
  • Results Across each cohort, patients with BSCC more often had high-grade tumors and treatment with lymph node dissection.[jamanetwork.com]
  • Two subjects (subjects #11 and #13) had previous treatment for laryngeal carcinoma. Subject #13 had concomitant chemo-radiotherapy and recurrence seven months after the initial treatment.[scielo.br]
  • Regarding treatment, in literature some authors perform surgery alone in 28.5% of patients with BSCC of larynx; combined modality treatment is administered in 67% of cases [ 27 ]. Total laryngectomy is the most common surgical treatment [ 16 ].[oncotarget.com]

Prognosis

  • On the other hand, BSCC is frequently considered a high-grade carcinoma of poorer prognosis than its SCC counterparts, mostly due to a higher rate of distant metastases.[jcp.bmj.com]
  • Our objective was to evaluate the prognosis of BSCC as compared to the usual SCC in the largest series of cases.[ascopubs.org]
  • We should further pay close attention to the future prognosis of BSCs.[peerj.com]
  • Prognosis does not differ for patients with BSCC of the oral cavity and those with conventional oral squamous cell carcinomas PSCC and W/MSCC.[jamanetwork.com]
  • […] in most cases ( World J Gastroenterol 1998;4:397, Cancer 1997;79:1871 ) Better prognosis that occurs with HPV associated basaloid squamous cell carcinoma of upper aerodigestive tract is different from basaloid squamous cell carcinoma of esophagus Treatment[pathologyoutlines.com]

Etiology

  • . • Etiology and pathogenesis of basaloid squamous cell carcinoma is similar to conventional squamous cell carcinoma. • Most patients have a long history of smoking and alcohol drinking. • In some cases there was a history of previous radiation to the[slideshare.net]
  • The role of viruses in the etiology of BSCC is still controversial, but many authors have reported a higher frequency of human papillomavirus and herpes simplex virus in basaloid tumors than in conventional SCC.[ 4 ] The origin for BSCC has been suggested[ncbi.nlm.nih.gov]
  • […] contrast to conventional squamous cell carcinoma.[ 8 ] Clinically, patients have similar presentation to conventional squamous cell carcinoma such as painless irregular mass (verrucous or smooth), firm, and may or may not be ulcerative.[ 2, 11, 12, 13 ] Etiology[ncbi.nlm.nih.gov]
  • 11 - 17 and have an unfavorable prognosis because of poor overall patient survival rates. 5, 11, 13, 16, 18 Clinically, patients with BSCC present features similar to those of patients with conventional squamous cell carcinoma (SCC) and have the same etiological[jamanetwork.com]
  • Trauma as a possible etiologic factor in basal cell carcinoma. J Dermatol Surg Oncol 1986; 12 :841–846. 49 Strickland PT, Creasia D, Kripke ML. Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation.[nature.com]

Epidemiology

  • Study Details The study involved retrospective review of the Surveillance, Epidemiology, and End Results database including individual case data for 34,196 patients treated between January 2004 and December 2009 who had head and neck primary squamous[ascopost.com]
  • Epidemiological characteristics and location of the tumors were similar for both groups (hypopharynx 31/oropharynx and oral cavity 19/larynx 8/rhinopharynx 1/cervical lymph nodes 3).[ascopubs.org]
  • Definition / general Variant of squamous cell carcinoma with distinct basaloid morphology Epidemiology Generally older males Reported incidence from 1 - 11% of squamous cell carcinomas; true incidence likely 2% Sites More common in mid to distal esophagus[pathologyoutlines.com]
  • Design and Setting Retrospective data review of a population-based registry from the Surveillance, Epidemiology, and End Results database.[jamanetwork.com]
  • Materials and Methods Ethic statement We obtained permission to use data files from the public database of the Surveillance, Epidemiology, and End Results (SEER) database.[peerj.com]
Sex distribution
Age distribution

Prevention

  • […] patients with BSCC or conventional SCC (PSCC or W/MSCC) of the tongue, floor of the mouth, inferior gingiva, or retromolar area matched by stage may undergo the same therapeutic protocols, ie, a combination of surgery and postoperative radiotherapy, to prevent[jamanetwork.com]
  • Prevention of stomal recurrence.[scielo.br]

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