Presentation
The present study excluded patients presenting with progressive aphasia. [es.slideshare.net]
Method: A 33-year-old man presented with 1.5 years of progressive behavioral and cognitive changes. [academic.oup.com]
[…] project present a novel way to define criteria regarding cognition profile through language analysis in all: AD and FTDL all variants. [theses.fr]
Early apathy or inertia [one of the following symptoms (B.1–B.2) must be present]: B.1. Apathy B.2. Inertia C. Early loss of sympathy or empathy [one of the following symptoms (C.1–C.2) must be present]: C.1. [radiopaedia.org]
Entire Body System
- Weakness
For many years, individuals with frontotemporal dementia show muscle weakness and coordination problems, leaving them needing a wheelchair — or bedbound. [alz.org]
Increased difficulty producing speech due to weakness or incoordination – speech sounds weak, imprecise and uncoordinated Reading and writing abilities may be preserved longer than speech, but these eventually decline, as well Mutism eventually develops [psp.org]
Read More ▶ 2018-08-02 10:56 UTC European Edition Narrow ranges have prevailed for the most part, though themes of Yen weakness and Aussie Dollar firmness have been evident, while EUR-USD managed to edge out a fresh two-week low at 1.1581. [xe.com]
Physical therapists know how to assess muscle strength or weakness and use exercises or suggest adaptive equipment to make getting around easier. [aftdkidsandteens.org]
Some individuals with bvFTD also experience movement difficulties similar to Parkinson’s disease, including decreased facial expressions, muscle stiffness, weakness and rigidity. [verywell.com]
- Epilepsy
) cerebral lipidosis ( E75.4 ) Creutzfeldt-Jakob disease ( A81.0- ) dementia with Lewy bodies ( G31.83 ) dementia with Parkinsonism ( G31.83 ) epilepsy and recurrent seizures ( G40.- ) frontotemporal dementia ( G31.09 ) hepatolenticular degeneration [icd10data.com]
Neurologic
- Irritability
[…] on the skin: No irritant effect. on the eye: No relevant irritating effects. [italmarth.com]
[…] most common symptoms of bvFTD are behavioral or emotional challenges, including compulsively overeating, having an emotionally-detached demeanor, making socially inappropriate responses, and displaying hypersexual conversation and actions, along with irritability [verywell.com]
There are medications that can reduce agitation, irritability and/or depression. These treatments should be used to help improve quality of life. [alz.org]
Some individuals with bvFTD may benefit from taking a selective serotonin reuptake inhibitor (SSRI) to address symptoms such as apathy, irritability and disinhibited behavior. [theaftd.org]
- Mild Cognitive Impairment
cognitive impairment, so stated G31.85 Corticobasal degeneration G31.89 Other specified degenerative diseases of nervous system G31.9 Degenerative disease of nervous system, unspecified Reimbursement claims with a date of service on or after October [icd10data.com]
Neural correlates of Alzheimer’s disease and mild cognitive impairment: a systematic and quantitative meta-analysis involving 1351 patients. [frontiersin.org]
- Seizure
) cerebral lipidosis ( E75.4 ) Creutzfeldt-Jakob disease ( A81.0- ) dementia with Lewy bodies ( G31.83 ) dementia with Parkinsonism ( G31.83 ) epilepsy and recurrent seizures ( G40.- ) frontotemporal dementia ( G31.09 ) hepatolenticular degeneration [icd10data.com]
Treatment
Treatment is aimed at managing and alleviating symptoms. Common treatments include: Medications Some antidepressants can help reduce the behavioral problems caused by changes to the brain. [healthline.com]
Treatment and outcomes There are no specific treatments for any of the frontotemporal subtypes. There are medications that can reduce agitation, irritability and/or depression. These treatments should be used to help improve quality of life. [alz.org]
Treatment There is no specific cure for FTD; treatment is focused on symptom management and support for patients, families, and caregivers. [aafp.org]
Psychological treatments such as cognitive stimulation and behavioural therapy can help maintain memory function address anxiety. [psychologized.org]
As symptoms progress, however, families usually seek a clinician's assistance for diagnosis and treatment. [verywell.com]
Prognosis
What is the prognosis of bvFTD? The rate of progression is very variable and can range from two to twenty years. As the disease progresses, people will need help with most aspects of daily life. [ftdtalk.org]
Prognosis and Life Expectancy (Long-Term Outlook) Average life expectancy from onset of symptoms is approximately eight to nine years, though some people may live 20 years or so with the disease. [verywell.com]
These phenotypes could also support understanding of prognosis and clinical management. [neurology.org]
Management and Prognosis The progression of behavioral variant FTD can range from 3 to 17 years, with a mean course of 8 years from the time of diagnosis to death. [bvftd.blogspot.com]
Prognosis [ edit ] Symptoms of frontotemporal dementia progress at a rapid, steady rate. Patients suffering from the disease can survive between 2–15 years. [en.wikipedia.org]
Etiology
Keywords Adult — Aged — Feeding and Eating Disorders/etiology/physiopathology — Female — Frontotemporal Dementia/complications/genetics/pathology/physiopathology — Humans — Hypothalamus/pathology — Magnetic Resonance Imaging — Male — Middle Aged Identifiers [archive-ouverte.unige.ch]
Neuroimaging (magnetic resonance imaging) usually demonstrates focal atrophy in addition to excluding other etiologies. [aafp.org]
The diagnosis and understanding of apraxia of speech: Why including neurodegenerative etiologies may be important. Journal of Speech, Language, and Hearing Research, 55(5), S1518-S1522. doi: 10.1044/1092-4388(2012/11-0309). Duffy, J. R., Strand, E. [infad.eu]
Patients with dementia of any presumed etiology would have to be recruited and followed to death and autopsy confirmation of diagnosis. [es.slideshare.net]
Epidemiology
Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management. CNS Drugs 2012 ; 26 : 841 -70. ↵ Vercelletto M, Boutoleau-Bretonnière C, Volteau C, Puel M, Auriacombe S, Sarazin M, et al. [bmj.com]
Epidemiology, Diagnosis, Management and Outcomes. Drugs & Aging, 1999; 15: 81-89. [ Links ] 36. Seo SW, Thibodeau M-P, Perry DC, Hua A, Sidhu M, Sible I, et al. [scielo.org.pe]
Bernardi L, Frangipani F, Smirne N et al (2012) Epidemiology and genetics of frontotemporal dementia: a door-to-door survey in Southern Italy. Neurobiol Aging 33(12):2948 e1–2948 e10 CrossRef Google Scholar 5. [link.springer.com]
Although epidemiologic studies are limited, approximately 20 to 50 percent of persons younger than 65 years with dementia have FTD, a prevalence similar to that of Alzheimer disease in persons 45 to 64 years of age (15 per 100,000). 1 – 3 FTD is underdiagnosed [aafp.org]
Pathophysiology
Our findings suggest different pathophysiological mechanisms in these 2 separate neurodegenerative disorders. Copyright © 2016 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]
Abstract BACKGROUND AND PURPOSE: Brain iron deposition has been implicated as a major culprit in the pathophysiology of neurodegeneration. [ajnr.org]
[…] capture pathophysiological changes become available. [bmj.com]
B 30 Pathophysiology Common pathologic findings in FTD are atrophy and neuronal loss affecting the frontal and temporal lobes of the brain. 10 There is histologic heterogeneity in patients with FTD, but about 55 percent of patients have FTD with ubiquitin-positive [aafp.org]
Prevention
[…] and adaptive feedback. a loop for dementia clinicians to provide objective observations regarding the health progression of the person with dementia and medication effectiveness, warn about trends closely related to dementia (e.g. apathy), and support preventive [demcare.eu]
Researchers don’t know why these proteins develop or how to prevent them. Frontotemporal dementia has one known risk factor: genetics. Scientists have found several genes related to the disease. [healthline.com]
Most of the patients at Patton were transferred there from prisons after their mental illness prevented them from following institutional rules, Sfera said. [clbb.mgh.harvard.edu]
Further potential for in vivo distinction of patients with differing pathologic processes could, in turn, help prevent the dilution of positive effects in therapies that occurs when patients are grouped under the single umbrella of one overarching clinical [neurology.org]
SRTM data were captured in February 2000, when the snow-laden pine forests that dominate the area would have prevented the penetration of the SRTM radar to ground level. [viewfinderpanoramas.org]