A case report of recreational overdose of benztropine in a 19 year old schizophrenic patient is presented. Delirium and anti-cholinergic manifestations persisted for five days necessitating prolonged hospitalization. [ncbi.nlm.nih.gov]

Portions of this work were presented as follows: Hiranita T, Soto PL, Tand G, and Katz JL (2013) Specificity of cocaine-induced dopamine-independent sigma agonist self-administration. [doi.org]

• Intravenous Administration

  ADMINISTRATION NOTE: Doses may be divided or given as a single daily dose at bedtime. Oral Administration May be administered without regard to meals. Injectable Administration Administer intramuscularly or intravenously. [m.pdr.net]

• Camping

  5 PubChem Compound ID PubChem Substance ID SuperDrug ATC ID N04AC01 SuperDrug CAS ID cas=000086135 Target and Pathway Target(s) Muscarinic acetylcholine receptor M1 Target Info Antagonist [ 536453 ], [ 536690 ] KEGG Pathway Calcium signaling pathway cAMP [db.idrblab.org]

• Nausea

  Slight reduction in dosage may control nausea and still give sufficient relief of symptoms. Vomiting may be controlled by temporary discontinuation, followed by resumption at a lower dosage. [rxlist.com]

  […] weakness, memory impairment, nervousness, delusions, euphoria, paresthesia, sensation of heaviness in limbs, toxic psychosis CV: hypotension, palpitations, tachycardia, arrhythmias EENT: blurred vision, diplopia, mydriasis, angle-closure glaucoma GI: nausea [medical-dictionary.thefreedictionary.com]

  Benztropine ( Symptoms or Effects ) Common: Dry mouth, blurred vision, constipation, sensitivity to light, nausea/vomiting, drowsiness or decreased sweating. [psyweb.com]

  Side Effects of Benztropine Common side effects of benztropine include, but are not limited to: Constipation Nausea Dry mouth Confusion or memory problems Blurred vision (often caused by dry eyes) Difficulty passing urine. [nervous-system.emedtv.com]

• Decreased Sweating

  Benztropine ( Symptoms or Effects ) Common: Dry mouth, blurred vision, constipation, sensitivity to light, nausea/vomiting, drowsiness or decreased sweating. [psyweb.com]

  May give IV or IM at same dose Blurred vision, constipation, decreased sweating, dry mouth, urinary retention Alcohol, Anticholinergics, TCAs Pre administration assessment Assess motor symptoms that interfere with ADLs & in pts with psychiatric disorders [quizlet.com]

  sweating, dermatoses Interactions Drug-drug. [medical-dictionary.thefreedictionary.com]

  This drug can cause decreased sweating, which could cause a severe rise in your body temperature ( hyperthermia ). The risk of this serious side effect is greater in hot weather, during vigorous exercise, and/or if you drink alcohol. [webmd.com]

At 6 weeks after withdrawal of treatment, all animals were tested for catalepsy after receiving 2.5 mg/kg H. During the chronic treatment phase, H inhibited and B enhanced spontaneous oral activity. [ncbi.nlm.nih.gov]

● AAN Practice Guidelines Practice parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. [medmk.com]

Indications: The symptomatic treatment of all etiologic groups of parkinsonism and drug-induced extrapyramidal reactions. [rxmed.com]

Other therapy, such as parathyroid hormone and/or vitamin D, may be indicated according to the etiology of the tetany. It is also important to institute oral calcium therapy as soon as practicable. Yes! [indiamart.com]

Epidemiology 3: 434–440. View Article Google Scholar 56. Lanevskij K, Japertas P, Didziapetris R, Petrauskas A (2009) Ionization-specific prediction of blood-brain permeability. J Pharm Sci 98: 122–134. View Article Google Scholar 57. [doi.org]

Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study - Wayne Hening et al. [medmk.com]

Gulbins E, Li PL (2006) Physiological and pathophysiological aspects of ceramide. Am J Physiol Regul Integr Comp Physiol 290: R11–R26. View Article Google Scholar 34. [doi.org]

Abstract The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine among 86 patients who received benztropine for the prevention of EPS (9.3%) was similar to that of the 568 patients who received chlorpromazine alone (10.6%). [ncbi.nlm.nih.gov]

If patient is alert, induce emesis (or use gastric lavage) and follow with a saline solution cathartic and activated charcoal to prevent further absorption. [glowm.com]

Benztropine may also be prescribed to prevent these side effects before they actually occur. This is called as prophylactic (preventative) therapy. Precautions Benztropine should never be used in children under age three. [minddisorders.com]

Benztropine is also used to treat and prevent these symptoms when they are caused by drugs such as chlorpromazine ( Thorazine ), fluphenazine ( Prolixin ), perphenazine ( Trilafon ), and others. [drugs.com]

Benztropine may also be prescribed to prevent these side effects before they actually occur. This is called a prophylactic (preventative) therapy. Precautions Benztropine should never be used in children under age three. [encyclopedia.com]