Presentation
Overall, beta-carotene nanoparticles presented significant bioactivity in aqueous medium surpassing their high hydrophobicity constraint. [ncbi.nlm.nih.gov]
Entire Body System
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Vietnamese
Vietnamese gac and crude palm oil have the highest content of β-carotene of any known plant sources, 10 times higher than carrots, for example. [en.wikipedia.org]
The Vietnamese fruit known as the gac, and crude palm oil, have the highest content of beta-carotene per ounce. [drweil.com]
Eyes
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Blurred Vision
Two patients had been diagnosed with AH and intervened by surgical vitrectomy due to blurred vision. [ncbi.nlm.nih.gov]
Skin
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Photosensitivity
Erythropoietic protoporphyria (EPP) is an inborn error of heme biosynthesis with high levels of protoporphyrin in red cells and is characterized by mild to moderate photosensitivity. [ncbi.nlm.nih.gov]
Photosensitivity disorders Many studies have been performed in patients with abnormal skin reactions to sunlight, called photosensitivity disorders (i.e. erythropoietic protoporphyria). [web.archive.org]
Learn more Food Interactions Not Available General References Mathews-Roth MM, Pathak MA, Fitzpatrick TB, Harber LH, Kass EH: Beta carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases. [drugbank.ca]
[…] and photoaging remain sparse, Bayerl has noted that beta-carotene has been shown to protect against the phototoxic effects of porphyrins in the photohemolysis model, and that the provitamin A substance is indicated for erythropoietic protoporphyria, photosensitive [mdedge.com]
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Yellow Discoloration of the Skin
Carotenodermia : High doses of β-carotene supplements ( 30 mg/day) and the consumption of large amounts of carotene-rich food have resulted in a yellow discoloration of the skin (xanthoderma) known as carotenodermia. [lpi.oregonstate.edu]
Neurologic
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Meningism
Microscopic examination of the liver of the other patient, who had Rothmund-Rhomson syndrome and died of acute bacterial meningitis, revealed no abnormalities. [ncbi.nlm.nih.gov]
Workup
Serum
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Dyslipidemia
Abstract The purpose of this study was to investigate the status of retinol, beta-carotene, and alpha-tocopherol serum concentrations in adolescents with dyslipidemia. [ncbi.nlm.nih.gov]
Biopsy
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Hepatocellular Carcinoma
carcinoma, Scientific Reports, 10.1038/s41598-017-00233-5, 7, 1, (2017). [doi.org]
Treatment
We, therefore, wonder whether dietary supplementation of carotenoids and vitamin A should be considered in research protocols regarding prevention and/or treatment of (pre)malignant conditions. [ncbi.nlm.nih.gov]
Prognosis
Because of limited vision and poor prognosis, she was treated with an experimental rescue therapy of high-dose 9-cis beta-carotene Dunaliella bardawil powder for 3 months, starting 10 days postingestion. [ncbi.nlm.nih.gov]
[…] may be markedly elevated in patients with chronic glomerulonephritis and nephrotic syndrome Inborn errors of metabolism - Carotenemia may result from a failure to convert carotene into vitamin A due to an inborn error of metabolism Familial conditions Prognosis [emedicine.medscape.com]
Lung cancer was deemed a particularly appropriate target for this trial because of its high incidence, its generally poor prognosis, and the existence of a well-defined high-risk population (i.e., smokers) 3. [nejm.org]
Etiology
Despite decades of concerted epidemiological research, relatively little is known about the etiology of prostate cancer. [ncbi.nlm.nih.gov]
The pathogenesis of AMD is only partly understood, and its etiology remains obscure. [clinicaltrials.gov]
MEDLINE, EMBASE, and Dissertations and Theses were systematically searched to identify original epidemiological studies with a comparison group that investigated vitamin or mineral supplementation as an etiological factor for thyroid cancer. [doi.org]
Epidemiology
Epidemiological studies have reported on the importance of vitamin D in cancer prevention and treatment. [ncbi.nlm.nih.gov]
A large body of observational epidemiologic study has demonstrated that individuals who eat more fruits and vegetables rich in carotenoids and/or who have higher levels of serum beta-carotene have a lower risk of cancer, particularly lung cancer. [citeseerx.ist.psu.edu]
Thus, this panel recommended that one of the NEI's program development priorities should be to "initiate epidemiologic studies of macular diseases to identify possible causative, protective, or aggravating factors." [clinicaltrials.gov]
Pathophysiology
Our results indicate a genotoxic potential of both CP and apo8' already at the concentrations 100 nM and 1 microM, i.e. at pathophysiologically relevant levels of beta-carotene and beta-carotene breakdown products. [ncbi.nlm.nih.gov]
Adam Csordas, Interfering with Smoking‐Induced Pathophysiology, Cigarette Smoke Toxicity, (329-353), (2011). Gerard E. Mullin, Vitamin A and Immunity, Nutrition in Clinical Practice, 26, 4, (495-496), (2011). [doi.org]
Carotinemia was originally noted as xanthosis diabetica in 1904 by von Noorden, who observed it to be prominent in the nasolabial folds and on the palms and soles. [2] Pathophysiology Carotenoids are pigments of plant origin and are responsible for the [emedicine.medscape.com]
Prevention
Beta-carotene taken by mouth may prevent osteoarthritis from getting worse, but it does not seem to prevent osteoarthritis. Ovarian cancer. [webmd.com]
We, therefore, wonder whether dietary supplementation of carotenoids and vitamin A should be considered in research protocols regarding prevention and/or treatment of (pre)malignant conditions. [ncbi.nlm.nih.gov]
White, Opportunities for Cancer Prevention During Midlife, American Journal of Preventive Medicine, 46, 3, (S73), (2014). Vicky Tai, Andrew Grey, Mark J. [doi.org]