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Bezafibrate


Presentation

  • The present report includes, for the first time, bezafibrate among definite causes of acute pancreatitis.[ncbi.nlm.nih.gov]
  • Kaplan-Meier curves of MI incidence (in accordance with the time of diagnosis) for the 2 study groups are presented in Figure 2 A.[oadoi.org]
Abdominal Obesity
  • obesity, atherogenic dyslipidemia (elevated triglyceride levels, small low-density lipoprotein cholesterol [LDL-C] particles, low levels of high-density lipoprotein cholesterol [HDL-C]), elevated blood pressure, insulin resistance (with or without glucose[oadoi.org]
High Fever
  • Influenza-associated encephalopathy (IAE) is characterized by persistently high fever, febrile convulsions, severe brain edema and high mortality.[ncbi.nlm.nih.gov]
Arthritis
  • Abstract A patient with rheumatoid arthritis developed rhabdomyolysis while undergoing treatment with mizoribine concomitantly with bezafibrate.[ncbi.nlm.nih.gov]
Anger
  • Fédératives de Recherche 4208, Bretagne Loire University, Angers (J.B.), the Hepatology and Gastroenterology Department, Haut-Lévêque University Hospital, Pessac (V.L.), the Hepatology and Gastroenterology Department, Robert Debré University Hospital[ncbi.nlm.nih.gov]
Encephalopathy
  • Hyperpyrexia occasionally triggers acute life-threatening encephalopathy-like illnesses, including influenza-associated encephalopathy (IAE) in childhood, and can be responsible for impaired fatty acid beta-oxidation (FAO).[ncbi.nlm.nih.gov]
  • […] following criteria: ascites, esophageal or gastric varices, ultrasonographic signs of portal hypertension, platelet count 20 kPa), and survival without liver transplantation or liver complications (which were defined as ascites, variceal bleeding, hepatic encephalopathy[nejm.org]
Febrile Convulsions
  • Influenza-associated encephalopathy (IAE) is characterized by persistently high fever, febrile convulsions, severe brain edema and high mortality.[ncbi.nlm.nih.gov]
Convulsions
  • Influenza-associated encephalopathy (IAE) is characterized by persistently high fever, febrile convulsions, severe brain edema and high mortality.[ncbi.nlm.nih.gov]

Workup

  • Extensive workup excluded other possible causes for recurrent pancreatitis in this patient, further supporting bezafibrate as the cause of the patient's acute illness.[ncbi.nlm.nih.gov]
Albuminuria
  • Notably, end points that concerned microangiographic manifestations of diabetes were significantly improved by fenofibrate treatment; these included a reduction in the need for laser treatment for retinopathy and reduction in the progression of albuminuria[ncbi.nlm.nih.gov]
Insulin Decreased
  • On the metabolic study day after bezafibrate treatment, postprandial insulin decreased by 26% (p 0.01), and glucose concentrations were lower 2 to 5 h postprandially.[ncbi.nlm.nih.gov]
Brain Edema
  • Influenza-associated encephalopathy (IAE) is characterized by persistently high fever, febrile convulsions, severe brain edema and high mortality.[ncbi.nlm.nih.gov]

Treatment

  • RESULTS: Two patients discontinued the treatment after few days, three at 6 and one at 9 months. Bezafibrate treatment resulted in a significant decrease in AP as early as 3 months.[ncbi.nlm.nih.gov]

Prognosis

  • […] risk score (mean difference [MD], 0.60; 95% confidence interval [CI], 0.25-0.95; P 0.0008) and liver biochemistry: alkaline phosphatase (MD, -238.21 IU/L; 95% CI, -280.83 to -195.60; P CONCLUSION: Combination therapy improved liver biochemistry and the prognosis[ncbi.nlm.nih.gov]
  • Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008; 48 :871–877. 17. Kuiper EM, Hansen BE, de Vries RA et al.[nature.com]
  • Conclusion: Combination therapy improved liver biochemistry and the prognosis of PBC, but did not improve clinical symptoms or incidence of death. Attention should be paid to adverse events when using bezafibrate.[dovepress.com]
  • Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008 ;48: 871 - 877. 8. Kumagi T, Guindi M, Fischer SE, et al.[doi.org]

Epidemiology

  • BACKGROUND: Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer.[ncbi.nlm.nih.gov]
  • Bezafibrate in men with lower extremity arterial disease: randomised controlled trial Papers BMJ 2002 ; 325 doi: (Published 16 November 2002) Cite this as: BMJ 2002;325:1139 Tom Meade, emeritus professor of epidemiology ( Tom.meade{at}lshtm.ac.uk ) a,[bmj.com]
  • J.H.F. also is grateful for the support of the Center for Clinical Epidemiology and Biostatistics and the University of Pennsylvania CERT (Center for Education and Research on Therapeutics).[care.diabetesjournals.org]
  • Plasma triglyceride as a risk factor for coronary heart disease: the epidemiologic evidence and beyond. Am J Epidemiol. 1989 ; 129 :249–259. Crossref Medline Google Scholar 9 Hokanson JE, Austin MA.[doi.org]
Sex distribution
Age distribution

Pathophysiology

  • The differentiating activity of fibrates could have significant implications both for the pharmacotoxicological profile of this class of compounds and for the pathophysiology of neoplastic disease.[nature.com]
  • Discussion The pathophysiology of X-ALD is not well understood, although it seems likely that accumulation of VLCFA is toxic and related to neurodegeneration [9].[journals.plos.org]
  • Hyperlipidemia associated with HIV protease inhibitor use: pathophysiology, prevalence, risk factors and treatment. Scand J Infect Dis 2000 ;32:111-23. [ Links ] 44. Brewer H.B.[scielo.br]
  • […] of Cardiovascular Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan (4) University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki, Japan References Chan JC, Malik V, Jia W, et al: Diabetes in Asia: epidemiology, risk factors, and pathophysiology[cardiab.com]

Prevention

  • We report the successful prevention of hypertriglyceridaemia-associated relapsing pancreatitis in a child with WAGR syndrome with Bezafibrate.[ncbi.nlm.nih.gov]
  • Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000;10221- 27 PubMed Google Scholar Crossref 26.[oadoi.org]

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