Presentation
The present report includes, for the first time, bezafibrate among definite causes of acute pancreatitis. [ncbi.nlm.nih.gov]
Kaplan-Meier curves of MI incidence (in accordance with the time of diagnosis) for the 2 study groups are presented in Figure 2A. [jamanetwork.com]
Kaplan-Meier curves of MI incidence (in accordance with the time of diagnosis) for the 2 study groups are presented in Figure 2 A. [doi.org]
Workup
Extensive workup excluded other possible causes for recurrent pancreatitis in this patient, further supporting bezafibrate as the cause of the patient's acute illness. [ncbi.nlm.nih.gov]
Treatment
Condition or disease Intervention/treatment Phase PBC Drug: Bezafibrate Drug: placebo Phase 3 Detailed Description: This is a multi-center, randomized (treatment will be assigned by chance), placebo-controlled (an inactive substance will be compared with [clinicaltrials.gov]
Anti-inflammatory actions of bezafibrate may contribute to the clinical effectiveness of fibrates in the prevention and treatment of isolated hypertriglyceridaemia. © 2011 The Authors. [ncbi.nlm.nih.gov]
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). [jamanetwork.com]
Prognosis
[…] risk score (mean difference [MD], 0.60; 95% confidence interval [CI], 0.25-0.95; P=0.0008) and liver biochemistry: alkaline phosphatase (MD, -238.21 IU/L; 95% CI, -280.83 to -195.60; P CONCLUSION: Combination therapy improved liver biochemistry and the prognosis [ncbi.nlm.nih.gov]
Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008; 48 :871–877. 17. Kuiper EM, Hansen BE, de Vries RA et al. [nature.com]
Conclusion: Combination therapy improved liver biochemistry and the prognosis of PBC, but did not improve clinical symptoms or incidence of death. Attention should be paid to adverse events when using bezafibrate. [dovepress.com]
Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008;48:871-877. 8. Kumagi T, Guindi M, Fischer SE, et al. [nejm.org]
Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008 ;48: 871 - 877. 8. Kumagi T, Guindi M, Fischer SE, et al. [doi.org]
Epidemiology
BACKGROUND: Epidemiologic studies have suggested that hypertriglyceridemia and insulin resistance are related to the development of colon cancer. [ncbi.nlm.nih.gov]
Bezafibrate in men with lower extremity arterial disease: randomised controlled trial Papers BMJ 2002 ; 325 doi: https://doi.org/10.1136/bmj.325.7373.1139 (Published 16 November 2002) Cite this as: BMJ 2002;325:1139 Tom Meade, emeritus professor of epidemiology [bmj.com]
Plasma triglyceride as a risk factor for coronary heart disease: the epidemiologic evidence and beyond. Am J Epidemiol. 1989 ; 129 :249–259. Crossref Medline Google Scholar 9 Hokanson JE, Austin MA. [doi.org]
J.H.F. also is grateful for the support of the Center for Clinical Epidemiology and Biostatistics and the University of Pennsylvania CERT (Center for Education and Research on Therapeutics). [care.diabetesjournals.org]
Pathophysiology
The differentiating activity of fibrates could have significant implications both for the pharmacotoxicological profile of this class of compounds and for the pathophysiology of neoplastic disease. [nature.com]
Discussion The pathophysiology of X-ALD is not well understood, although it seems likely that accumulation of VLCFA is toxic and related to neurodegeneration [9]. [journals.plos.org]
Hyperlipidemia associated with HIV protease inhibitor use: pathophysiology, prevalence, risk factors and treatment. Scand J Infect Dis 2000 ;32:111-23. [ Links ] 44. Brewer H.B. [scielo.br]
Prevention
Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000;10221- 27PubMedGoogle ScholarCrossref 26. [jamanetwork.com]
We report the successful prevention of hypertriglyceridaemia-associated relapsing pancreatitis in a child with WAGR syndrome with Bezafibrate. [ncbi.nlm.nih.gov]
Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infarction Prevention (BIP) study. Circulation 2000;10221- 27 PubMed Google Scholar Crossref 26. [doi.org]