Presentation
The following examples are given for the purpose of illustrating the present invention. [google.mk]
Accordingly, it is an object of the present invention to provide a process for obtaining pure bicyclomycin in a relatively good yield. [patents.com]
CONCLUSIONS: The action of bicyclomycin illustrates the potential present in a largely abandoned antibacterial agent; it exhibits lethal synergy when coadministered with known, bacteriostatic inhibitors of gene expression. [ncbi.nlm.nih.gov]
In the present work the molecular mechanism by which bicyclomycin blocks the activity of Rho has been further investigated. [aac.asm.org]
Abstract Methods have been developed for formation of the eight-membered oxygen-containing ring system ( 2 ) present in the antibiotic bicyclomycin. [xlink.rsc.org]
Entire Body System
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Hodgkin Lymphoma
Bleomycin a2 (CAS: 11116-31-7) One of two components found in the glycopeptide antibiotic bleomycin sulfate; a chemotherapeutic agent used for the treatment of hodgkins lymphoma Germicidin A (CAS: 151271-57-7) A pyranone isolated from streptomyces sp. [bocsci.com]
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Inflammation
Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D. [bertin-bioreagent.com]
Cardiovascular
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Hypertension
Res Ca2 cardiac cells cephalosporins Chem cimetidine Clin clinical coexistence compounds decreased demonstrated dopamine doses Endocrinol enhancement enzyme function GABA gastric Gastroenterol gastrointestinal Gram-negative hemoglobin hormone human Hypertension [books.google.de]
Workup
Microbiology
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Legionella Pneumophila
At the time I couldn't remember why this was a reasonable question, but a commenter pointed me to this paper, which describes the induction of competence by bicyclomycin in Legionella pneumophila. [rrresearch.fieldofscience.com]
Legionella pneumophila Legionella pneumophila is a thin, aerobic, pleomorphic, flagellated, nonspore-forming, Gram-negative bacterium of the genus Legionella. [howlingpixel.com]
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Neisseria Gonorrhoeae
Keywords Free Form Neisseria Gonorrhoeae Micrococcus Luteus Peptide Antibiotic Peptide Unit These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves. [link.springer.com]
Treatment
Finally this compound is hydrolyzed by a careful treatment with 0.2N H2SO4 at low temperature. [chemdrug.com]
Compound 21, on hydrolysis and oxidation, gives the corresponding 2-oxo compound, which on treatment with magnesium isopropylcyclohexylamide followed by acetylation yields 32. [nrcresearchpress.com]
Treatment of wild-type and mutant rho proteins with purified bicyclomycin (25 mM) led to approximately 80% loss of ATPase activity after dialysis with no apparent loss of protein. [uniprot.org]
[…] or sodium iodide, a carboxyl group which is esterified by 4-nitrobenzyl: by treatment with an alkali metal dithionite, for example sotium dithionite, a carboxyl group which is esterified by a 2-lower alkyl-sulphonyl-lower alkyl group: by treatment with [google.mk]
Epidemiology
Resistance Database gratefully acknowledges recent funding from the Genome Canada & Canadian Institutes of Health Research's Bioinformatics & Computational Biology program, allowing integration of the Antibiotic Resistance Ontology (ARO) with the Genomic Epidemiology [card.mcmaster.ca]
Prevention
Rho transcription factor: symmetry and binding of bicyclomycin Biochemistry (American Chemical Society) 39(31): 77-83 2000 The antibiotic bicyclomycin inhibits rho-dependent termination processes by interfering with RNA translocation by preventing RNA [eurekamag.com]
Possibly, as a consequence of this interference, the antibiotic also prevents ATP-dependent stabilization of Rho hexamers. [aac.asm.org]
The larger increments would have prevented us from detecting small differences. Thus, strain and methodological differences are likely to account for differences in MIC between the present and previous studies. [academic.oup.com]
References Efficacy of bicozamycin in preventing traveler's diarrhea. Ericsson, C.D., DuPont, H.L., Galindo, E., Mathewson, J.J., Morgan, D.R., Wood, L.V., Mendiola, J. [wikigenes.org]