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Bile Salt

Salts Bile


Presentation

  • Furthermore, biofilm dispersion assessment is presented to mimic the analysis of events triggering release of bacteria during the infection process.[ncbi.nlm.nih.gov]
  • Interestingly, the present Ns could be converted to solid dosage form using fluid-bed coating technology, maintaining a nanoscale size.[ncbi.nlm.nih.gov]
  • It has been shown in the present study that they can disrupt the components of gall stones/pigment stones.[ncbi.nlm.nih.gov]
  • A girl (at 2 mo) presented with pruritus, jaundice and elevated serum bile salts (BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919del and the nonsense mutation p.R1235X.[ncbi.nlm.nih.gov]
  • Abstract Knowledge about colloidal assemblies present in human intestinal fluids (HIFs), such as bile salt micelles and phospholipid vesicles, is regarded of importance for a better understanding of the in vivo dissolution and absorption behavior of poorly[ncbi.nlm.nih.gov]
Aspiration
  • In contrast, within the colloidal phase of the fasted state aspirate of a human volunteer, 4 different size fractions were separated from each other in a consistent and reproducible manner.[ncbi.nlm.nih.gov]
  • Bronchoalveolar lavage fluid (BALF) assessment for pepsin and bile salts is a common method to document reflux and aspiration.[ncbi.nlm.nih.gov]
Diarrhea
  • The cause of the recently described syndrome of chronic watery diarrhea associated with microscopic colitis is unknown. A patient appearing to have this disorder is described here.[ncbi.nlm.nih.gov]
  • (The symptom of chronic, watery, diarrhea is then often described as bile salt diarrhea.) In one study of sixty-two patients with chronic, watery diarrhea, it was considered to be the cause of diarrhea in twenty-eight (45.2%) patients.[healthcentral.com]
  • The diarrhea may be watery, and frequently occurs after meals. Testing of the diarrhea specimens will reveal excess amounts of bile salts (acids) present.[bilesalts.net]
  • Abstract Virulent Clostridium difficile strains produce toxin A and/or toxin B that are the etiological agents of diarrhea and pseudomembranous colitis.[ncbi.nlm.nih.gov]
  • Drugs & Medications Bile Salts-Caps-Casc-Phenolpth Tablet Bile Salts-Caps-Casc-Phenolpth Tablet Side Effects by Likelihood and Severity INFREQUENT side effects Burping Diarrhea Feel Like Throwing Up Stomach Cramps RARE side effects Abnormal Urine Color[webmd.com]

Treatment

  • Current CVD treatment methods include dietary intervention, statins, fibrates, niacin, cholesterol absorption inhibitors, and bile acid sequestrants. These formulations have limitations and, thus, additional treatment modalities are needed.[ncbi.nlm.nih.gov]
  • Response to treatment was defined as normalization of pruritus, disappearance of jaundice, and alanine aminotransferase (ALT) levels CONCLUSION: De novo or retargeted canalicular expression of BSEP occurs in treatment responders; children with late-onset[ncbi.nlm.nih.gov]
  • BSEP gene has been attached great importance in the susceptibility of PBC and the response rate of ursodeoxycholic acid (UDCA) treatment of PBC patients.[ncbi.nlm.nih.gov]
  • These findings open up a new avenue for the development of non-antibiotic therapeutics for CDI treatment.[ncbi.nlm.nih.gov]
  • However, in a predefined subgroup, small for gestational age infants, there was a significant effect on growth in favor of rhBSSL during treatment. The incidence of adverse events was higher in the rhBSSL group during treatment.[ncbi.nlm.nih.gov]

Prognosis

  • Confirming the correct diagnosis is of paramount importance because prognosis after transplantation differs with the genetic type of the disease.[ncbi.nlm.nih.gov]
  • What is the outcome (prognosis)? Most people with bile acid diarrhoea in which cause is unknown (idiopathic bile acid diarrhoea) respond very well to treatment with a bile acid binder medicine.[patient.info]

Etiology

  • Gut microbiota etiology of CVD, cholesterol metabolism, and the role of probiotic formulations as therapeutics for the treatment and prevention of CVD are described.[ncbi.nlm.nih.gov]
  • Abstract Virulent Clostridium difficile strains produce toxin A and/or toxin B that are the etiological agents of diarrhea and pseudomembranous colitis.[ncbi.nlm.nih.gov]
  • E2-mediated repression of BSEP expression represents an etiological contributing factor to ICP and therapies targeting the ERα/FXR interaction may be developed for prevention and treatment of ICP. 2014 by the American Association for the Study of Liver[ncbi.nlm.nih.gov]
  • Regardless of the etiology, chronic inflammation is the common pathological process for HCC development.[ncbi.nlm.nih.gov]
  • We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-α and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERα is an etiological contributing[ncbi.nlm.nih.gov]

Epidemiology

  • Author information 1 Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. 2 Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China. 3 Department[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • A major pathophysiologic role for bile-salt malabsorption in her, and perhaps other such patients, was suggested by her clinicopathologic response to cholestyramine.[ncbi.nlm.nih.gov]
  • In some pathophysiological states, inhibition of BSEP function is associated with its reduced expression on the canalicular membrane caused by impaired trafficking and sorting of BSEP.[ncbi.nlm.nih.gov]
  • Taking what is known about its pathophysiology, we designed a treatment consisting of rituximab, a chimeric monoclonal anti-CD20 antibody, in combination with intravenous immunoglobulin and plasmapheresis.[ncbi.nlm.nih.gov]
  • The tissue microenvironment is an integral player in cellular pathophysiology, but it is not routinely incorporated into laboratory studies.[ncbi.nlm.nih.gov]
  • In summary, we succeeded in establishing a PFIC2 model, which may be useful for its pathophysiological analysis and drug development. Publication type, MeSH terms, Substances Publication type Research Support, Non-U.S.[ncbi.nlm.nih.gov]

Prevention

  • Furthermore, sAC inhibition also prevented BSIA in primary mouse cholangiocytes.[ncbi.nlm.nih.gov]
  • , Chinese Center for Disease Control and Prevention, Beijing, China.[ncbi.nlm.nih.gov]
  • Gut microbiota etiology of CVD, cholesterol metabolism, and the role of probiotic formulations as therapeutics for the treatment and prevention of CVD are described.[ncbi.nlm.nih.gov]
  • E2-mediated repression of BSEP expression represents an etiological contributing factor to ICP and therapies targeting the ERα/FXR interaction may be developed for prevention and treatment of ICP. 2014 by the American Association for the Study of Liver[ncbi.nlm.nih.gov]
  • The increase in glutaraldehyde concentration prevents leakage of enzyme but showed a steep decrease in enzyme activity in the immobilized matrix.[ncbi.nlm.nih.gov]

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