Frequent mutation of histone modifying genes in non-Hodgkin lymphoma. Nature 2011 ;476: 298 - 303 29. Lohr JG, Stjanov P, Lawrence MS, et al. [nejm.org]

Others ocular symptoms were decreased visual acuity or blurred vision. [haematologica.org]

One patient who received intrathecal MTX developed treatment related “chemical meningitis”, and was subsequently treated with HD-MTX to which she had a CSF response. The median overall survival was not reached. [bloodjournal.org]

Response of meningeal Waldenström’s macroglobulinemia to 2-chlorodeoxyadenosine. J Clin Oncol. 1995; 13 ( 9 ):2476. [ PubMed ] [ Google Scholar ] 8. Vos JM, Kersten M-J, Kraan W, et al. [ncbi.nlm.nih.gov]

The diagnosis was assessed by the histopathology of a meningeal or a brain biopsy in eight cases. No data are available in this series regarding electrophoresis of CSF as this was not performed in routine practice. [haematologica.org]

Bing-Neel syndrome the central nervous system manifestations of Waldenstrцm macroglobulinemia; symptoms may include encephalopathy, hemorrhage, stroke, convulsions, delirium, and coma. Medical dictionary. 2011. [medicine.academic.ru]

Four patients with a tumoral form presented with convulsions, hemiparesis or aphasia. No intraocular involvement was documented in this series. Biological results CSF analysis was performed for all patients. [haematologica.org]

[…] dementia (12/44, 27%), sensory deficit with hypoesthesia, dysesthesia or paresthesia (11/44, 25%), headache (8/44, 18%), pain (mainly localized in the back, neck or limbs) (8/44, 18%), cauda equina syndrome (6/44, 14%), motor deficit (6/44, 14%) and dysarthria [haematologica.org]

Other signs were poor performance status ( 2) (12/44, 27%), cognitive impairment with frontal syndrome, memory loss or dementia (12/44, 27%), sensory deficit with hypoesthesia, dysesthesia or paresthesia (11/44, 25%), headache (8/44, 18%), pain (mainly [haematologica.org]

The symptoms or signs that led to the diagnosis of BNS were extremely heterogeneous, the most common being a balance disorder or disturbed gait [21 patients (48%), with ataxia described in 15 patients and dizziness in 6 patients] and cranial nerve involvement [haematologica.org]