Symptoma

Biotinidase Deficiency

MCD

It usually presents with ataxia and seizures, though atypical presentations have also been described. [ncbi.nlm.nih.gov]

  • Sighing

    We describe a 7-year old boy with subacute progressive quadriplegia and "sighing" respirations. Severe biotinidase deficiency was established, and the patient demonstrated complete recovery with biotin supplementation. [ncbi.nlm.nih.gov]

  • Perianal Rash

    On examination, he had failure to thrive, perioral and perianal rash, alopecia with hypopigmented hair, seborrhoeic dermatitis, bilateral blepharitis, respiratory distress and stridor. [ncbi.nlm.nih.gov]

  • Alopecia

    Biotinidase deficiency may be seen early in the neonatal period without the characteristic findings such as alopecia and seborrheic dermatitis. This diagnosis should be considered in patients with infantile spasms. [ncbi.nlm.nih.gov]

  • Eczema

    In addition, sparse scalp hair and chronic intractable eczema has been described in this syndrome. We report a 26-month-old girl with the disease and partial biotinidase deficiency. [ncbi.nlm.nih.gov]

    Individuals with untreated biotinidase deficiency may develop problems such as hypotonia (low muscle tone), eczema (skin rash), alopecia (hair loss), seizures, developmental delay, breathing problems, ataxia (balance, coordination and movement problem [thinkgenetic.com]

    Some other common features of BTD include eye infections, like pink eye (conjunctivitis), hair loss (alopecia), and a certain type of skin rash called eczema. [rarediseases.org]

    Rashes may be mistaken for eczema, seborrheic dermatitis, or the dermatoses observed in zinc deficiency. [emedicine.medscape.com]

  • Hearing Impairment

    Some symptomatic children showed residual impairments: hearing impairment (n 2), optic atrophy (n 2), both hearing impairment and optic atrophy (n 2). In addition, symptomatic children had a higher risk of delayed motor and speech development. [ncbi.nlm.nih.gov]

    All 11 symptomatic children had residual enzyme activity of n 2), optic atrophy ( n 2), both hearing impairment and optic atrophy ( n 2). In addition, symptomatic children had a higher risk of delayed motor and speech development. [doi.org]

  • Large Fontanel

    Less frequent defects seen with VACTERL association are prenatal and postnatal growth deficiency, laryngeal stenosis, ear anomaly, large fontanels, defect of lower limb, rib anomaly, tethered cord, and defects of external genitalia. [ncbi.nlm.nih.gov]

  • Abnormal Gait

    Two of whom became symptomatic with abnormal gait, alopecia, skin rashes and developmental delay. A need for more congruency in diagnostic, treatment and educational practices was highlighted across the province. [ncbi.nlm.nih.gov]

  • Quadriplegia

    We describe a 7-year old boy with subacute progressive quadriplegia and "sighing" respirations. Severe biotinidase deficiency was established, and the patient demonstrated complete recovery with biotin supplementation. [ncbi.nlm.nih.gov]

In present case, a negative sepsis workup, paucity of clinico-radiological signs despite marked breathlessness, skin changes, severe metabolic acidosis and ketonuria led us to suspect biotinidase deficiency, which was confirmed on enzyme analysis. [indianpediatrics.net]

With biotin treatment, these values rose to normal limits for both control groups. [ncbi.nlm.nih.gov]

The seizures are difficult to differentiate from other causes of epileptic encephalopathy, which generally have a poor prognosis. [ncbi.nlm.nih.gov]

Prognosis The prognosis for individuals diagnosed with BTD deficiency is very good, provided they are treated before symptoms occur and are compliant with biotin therapy. [orpha.net]

[…] sub-cortical cyst formation T2: the same changes as above signal abnormalities of the spinal cord may also be seen DWI: areas of restricted diffusion within the signal abnormalities MR spectroscopy: sometimes elevated lactate reduced NAA Treatment and prognosis [radiopaedia.org]

Ohtahara syndrome is a rare epileptic encephalopathy in infants; the underlying etiology is generally thought to be structural brain malformations. [ncbi.nlm.nih.gov]

Etiology BTD deficiency is caused by mutations in the BTD gene (3p25) resulting in reduced or absent BTD activity. This enzyme recycles free, non-protein bound, biotin which is required for multiple biotin-dependent metabolic processes. [orpha.net]

Etiology Mutations in the genes for holocarboxylase synthetase and biotinidase produce deficient or defective enzymes inhibiting the activation of the four carboxylases and limiting the recovery of protein bound biotin for reactivation of the carboxylases [clinicaladvisor.com]

Summary Epidemiology Prevalence of clinical biotinidase (BTD) deficiency is estimated to be 1/61,000. Carrier frequency in the general population is approximately 1/120. [orpha.net]

It does seem that biotin deficiency is usually caused by things that lead to biotinidase deficiency, so let’s look at the data on frequency ( Epidemiology) Biotin Deficiency – Epidemiology Based on the results of worldwide screening of biotinidase deficiency [epiphanyasd.blogspot.com]

Epidemiology Incidence is less than 1 in 60,000 babies - no more than 12 cases per year. [ 3 ] The carrier frequency in the general population is 1 in 120. [ 4 ] Presentation [ 1, 2 ] Usually presents aged 1 week to 2 years (earlier-onset carboxylase [patient.info]

Molecular and Systemic Pathophysiology Biotin is a water-soluble vitamin that as a coenzyme is covalently attached to four carboxylases in humans (Fig. 1 ) [ 1 ]. References 1. Wolf B (2001) Disorders of biotin metabolism. [link.springer.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Biotinidase deficiency is an inherited metabolic disease caused by reduced levels of biotinidase, an enzyme that recycles biotin [mayomedicallaboratories.com]

[…] the neurologic findings remained for a longer period of time. 11 There are even reports of adults with profound biotinidase deficiency who have never had symptoms but were diagnosed because their children had positive results of newborn screening. 2 Pathophysiology [wvdhhr.org]

Biotin therapy appears to prevent the development of neurological and cutaneous problems in our population. [ncbi.nlm.nih.gov]