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Bismuth Subsalicylate
2 Hydroxy BENZO[1 3 2]DIOXABISMIN 4 One

Images

WIKIDATA, Public Domain
WIKIDATA, Public Domain
WIKIDATA, CC0 1.0
WIKIDATA, Public Domain
WIKIDATA, Public Domain

Presentation

OBJECTIVE: To determine whether the observed decrease in tetracycline bioavailability is due to the active drug bismuth subsalicylate via complexation, or to magnesium aluminum silicate (Veegum), an inactive excipient present only in the liquid formulation [ncbi.nlm.nih.gov]

The following example further describes and demonstrates an embodiment within the scope of the present invention. [google.com]

In the present study, the water sorption of the sealers with 20 wt% of bismuth subsalicylate presented water sorption in accordance to the requirement. The other concentrations did not fulfill the standard. [scielo.br]

Microconidia, macroconidia, and chlamydospores were all present (Fig. 1A and B ). [aem.asm.org]

Entire Body System

  • Inflammation

    We also examined the effects of medical treatment on altering the severity of associated antral inflammation. [ncbi.nlm.nih.gov]

    It is also used to reduce inflammation within the intestine. It is further used in growth media for selective isolation of microorganisms. Bemerkungen Incompatible with strong oxidizing agents. Literaturverweise Johnson, A. L.; Blaine, E. [alfa.com]

    It also helps to decrease inflammation in the intestine and kills organisms that cause diarrhea. Bismuth subsalicylate is available as a liquid, tablet or chewable tablet. [sharecare.com]

  • Hunting

    […] pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur A01N 55/02 A HUMAN NECESSITIES 01 AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING [patentscope.wipo.int]

  • Military Personnel

    J Infect Dis 180 : 2053–2055 7 Scott DA et al. (1990) Norfloxacin for the prophylaxis of travelers' diarrhea in U.S. military personnel. [doi.org]

Gastrointestinal

  • Constipation

    Effectiveness Moderate (for diarrhea) Effectiveness Slight (for gastric ulcer) Effectiveness Moderate (for irritable bowel syndrome) Effectiveness Moderate (for nausea) Effectiveness Slight (for gastric ulcer pain) Side effects Moderate (black stool, constipation [patientslikeme.com]

    Eight of the loperamide-treated subjects experienced constipation compared with one in the bismuth subsalicylate-treated group; otherwise, there was no difference in minor side effects experienced between both treatment groups. [ncbi.nlm.nih.gov]

    Bismuth-containing antacids (unless chelates) are not recommended because absorbed bismuth can be neurotoxic, causing encephalopathy; they tend to be constipating. [services2.ascribe.com]

    Loperamide side effects may include: abdominal pain constipation dizziness nausea or vomiting Bismuth subsalicylate side effects may include: constipation blackened stools and/or tongue ringing sound in the ear (called tinnitus) Who shouldn’t take OTC [familydoctor.org]

  • Black Stools

    Moderate (for irritable bowel syndrome) Effectiveness Moderate (for nausea) Effectiveness Slight (for gastric ulcer pain) Side effects Moderate (black stool, constipation) Burden Somewhat hard to take Cost: < $25 monthly Mar 12, 2015 (Started Feb 25, [patientslikeme.com]

    Adverse effects Black tongue, black stool, salicylism (i.e., contraindicated in children, given the risk of Reye syndrome). [medical-dictionary.thefreedictionary.com]

    You have an ulcer, bleeding problem, or bloody or black stool. Stop use and ask a doctor if: Your symptoms get worse. You experience ringing in the ears or loss of hearing. Your diarrhea lasts for more than two days. You take too much. [knowyourotcs.org]

    Bleeding problems: Bismuth subsalicylate should not be used without a doctor's recommendation if you have ulcers, bleeding disorders, or bloody or black stools. Diabetes: Salicylate medications can cause decreased blood glucose control. [uniprix.com]

  • Lactose Intolerance

    Many things can cause it, including: viruses bacteria and parasites medicines such as antibiotics lactose intolerance fructose or artificial sweeteners digestive disorders such as celiac disease or irritable bowel syndrome It is a common condition that [familydoctor.org]

Skin

  • Dermatitis

    01-17 Cholesterol-lowering combination compositions of niacin and magnesium salt Parry et al. 1986 Pseudomembranous colitis caused by topical clindamycin phosphate EP0625906A1 ( de ) 1994-11-30 Zusammensetzungen zur behandlung heliobacter pylori und dermatitis [google.dj]

Neurologic

  • Irritability

    HAZARDS IDENTIFICATION Classification of the substance or mixture in accordance with 29 CFR 1910 (OSHA HCS) GHS07 Skin Irrit. 2 H315 Causes skin irritation. Eye Irrit. 2A H319 Causes serious eye irritation. [americanelements.com]

    Oct 15, 2015 (Started Feb 25, 2015) Effectiveness Moderate (for abdominal cramps) Effectiveness Moderate (for diarrhea) Effectiveness Slight (for gastric ulcer) Effectiveness Moderate (for irritable bowel syndrome) Effectiveness Moderate (for nausea) [patientslikeme.com]

    —The recent review article by Lindsley 1 suggests the use of various antacids, including bismuth subsalicylate (Pepto-Bismol and others), to minimize salicylate-induced gastric irritation. [jamanetwork.com]

    Irritable Bowel Syndrome (IBS) Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating,... [medicinenet.com]

  • Agitation

    Then, 500 parts of carbon black, 6.700 parts Extender ASP 200, 37,300 parts of titanium dioxide (TI-PURE® 900, DuPont) and 2.500 parts of bismuth subsalicylate are pre-mixed and fed to an agitator mill of type ZKW. [patents.google.com]

Workup

Extensive toxic, metabolic, and infectious workup demonstrated bismuth toxicity. Spinal tap and brain magnetic resonance scan were normal. Electroencephalography showed bihemispheric slowing. [ncbi.nlm.nih.gov]

Microbiology

  • Helicobacter Pylori

    Peiris, A sweeter way to combat Helicobacter pylori? Bismuth(III) complexes and oxido-clusters derived from non-nutritive sweeteners and their activity against H. pylori, Journal of Organometallic Chemistry, 724, (88), (2013). [doi.org]

    Abstract We evaluated clindamycin and bismuth subsalicylate (Pepto-Bismol) for treatment of Helicobacter pylori infection. [ncbi.nlm.nih.gov]

    H. pylori ( Helicobacter Pylori ) Infection Symptoms, Test, Treatment Helicobacter pylori (H. pylori) is a bacteria that causes chronic inflammation (gastritis) of the inner lining of the stomach,... [medicinenet.com]

    Bismuth subsalicylate in the treatment of H2 blocker resistant duodenal ulcers: role of Helicobacter pylori. [gut.bmj.com]

Treatment

CONCLUSIONS: Bismuth subsalicylate treatment for 8 weeks is safe and well tolerated. This regimen appears to be efficacious for the treatment of microscopic colitis and is worthy of further study in a controlled trial. [ncbi.nlm.nih.gov]

Etiology

Abstract The goals of this study were threefold: to compare the etiology of travelers' diarrhea in West Africa and Mexico, to evaluate two fecal transport systems for the recovery of enteropathogens, and to verify the efficacy of liquid bismuth subsalicylate [ncbi.nlm.nih.gov]

JAMA 267 : 1932–1935 10 Mattila L (1994) Clinical features and duration of traveler's diarrhea in relation to its etiology. [doi.org]

An etiologic agent was identified in 166 of the 249 patients (67 percent) evaluated. Duration of Diarrhea Figure 1. Figure 1. Percentage of Patients Who Continued to Have Diarrhea over a Given Period (Eight Hours), According to Study Group. [nejm.org]

Epidemiology

Recent epidemiological studies suggest that microscopic colitis may affect as many patients as Crohn's disease or ulcerative colitis. [doi.org]

Children should not take medication with bismuth subsalicylate because epidemiologic evidence points to an association between the use of salicylate-containing medications during viral infections and the onset of Reye’s Syndrome. [reyessyndrome.wordpress.com]

may lead to accumulation and toxicity. [5] Some of the risks of salicylism can apply to the use of bismuth subsalicylate. [6] [7] [8] Children should not take medication with bismuth subsalicylate while recovering from influenza or chicken pox, as epidemiologic [en.wikipedia.org]

Prevention

A liquid preparation, in a dose of 60 ml qid (4.2 g/d), was 62 percent effective in preventing traveler's diarrhea during a three-week period of risk and a tablet formulation (BSS 600 mg qid) was 76 percent effective in preventing experimentally induced [ncbi.nlm.nih.gov]

Decker, Inc 18 DuPont HL and Ericsson CD (1993) Prevention and treatment of traveler's diarrhea. N Engl J Med 328 : 1821–1827. 19 DuPont HL et al. (1987) Prevention of travelers' diarrhea by the tablet formulation of bismuth subsalicylate. [doi.org]

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02047162 Layout table for location information HOPE Karachi, Pakistan Centers for Disease Control and Prevention Procter and Gamble Health Oriented Preventive Education Layout [clinicaltrials.gov]

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