Presentation
The aim of the present study was to determine whether pathogenic mutations were present in families with mitochondrial cardiomyopathy that presented during adolescence. [ncbi.nlm.nih.gov]
Biventricular hypertrophy and heart failure as initial presentation of Cushing's disease Thomas Morris Hey 1, Jordi Sanchez Dahl 1, Thomas Heiberg Brix 2, Eva Vad Søndergaard 1 1 Department of Cardiology, University Hospital of Odense, Odense, Denmark [casereports.bmj.com]
Cardiovascular
- Heart Disease
ICD-10-CM Codes › I00-I99 Diseases of the circulatory system › I30-I52 Other forms of heart disease › I51- Complications and ill-defined descriptions of heart disease › Cardiomegaly 2016 2017 2018 2019 Billable/Specific Code I51.7 is a billable/specific [icd10data.com]
In families in which parental mutations are known, preimplantation (where ethically and legally feasible) or prenatal genetic screening should be adopted because: (1) neonatal HCM in genetic heterozygosity is potentially lethal and (2) heart disease is [ncbi.nlm.nih.gov]
Atrial Enlargement : Atrial enlargement/hypertrophy occurs in conditions like chronic obstructive pulmonary disease, rheumatic heart disease or congenital heart disease with pulmonary hypertension etc. [yourarticlelibrary.com]
The diphasic QRS type of electrocardiogram in congenital heart disease. Am Heart J; 1937, 13: 202-206. Elliott LP, Anderson RC, Tuna N, Adams P, Neufeld HN. Complete Transposition of the Great Vessels : II. An Electrocardiographic Analysis. [lifeinthefastlane.com]
This case illustrates a highly atypical presentation of FAP, with advanced heart disease and mild neurologic impairment, relatively late onset and no family history. [elsevier.pt]
Workup
Axis
- Right Axis Deviation
In the presence of LVH – Additional signs indicating RVH : Right atrial enlargement. Right axis deviation. Tall biphasic QRS complexes in multiple leads. Deep S waves in V5-6. [lifeinthefastlane.com]
Encyclopedia An electrocardiographic finding suggestive of enlargement or thickening of both ventricles, with a combination of findings which are related to LVH and RVH, such as voltage criteria for LVH in the presence of marked right axis deviation. [tititudorancea.com]
Biventricular hypertrophy ECG In case the ECG or other examinations suggest left ventricular hypertrophy (LVH), one should suspect concomitant right ventricular hypertrophy (RVH) if the following ECG criteria are presented: Right axis deviation (>90°) [ecgwaves.com]
Voltage Criteria; e.g., R in aVL >11 mm; note wide QRS/T angle) Example 2: (ESTES Criteria: 3 points for voltage in V5, 3 points for ST-T changes) Right Ventricular Hypertrophy General ECG features include: Right axis deviation (> 90 degrees) Tall R-waves [ecg.utah.edu]
Right Ventricular Hypertrophy 3. Right Atrial Enlagement Note the R:S ratio > 1 in lead V1 as well as right axis deviation. EMAIL PRINT SAVE EMAIL SAVE Previous Next [healio.com]
P Wave
- P Pulmonale
Deep S-wave in V5 or V6 (>6 mm) Large RS complexes in multiple leads P pulmonale Figure 1. ECG changes seen in left ventricular hypertrophy (LVH) and right ventricular hypertrophy (RVH). [ecgwaves.com]
P pulmonale: It is reflected by the presence of tall- and peaked P waves in leads II, III and aVF. The amplitude is more than 2.5 mm. It is called P pulmonale because it occurs frequently due to pulmonary hypertension (Fig. 5.1a, b). 2. [yourarticlelibrary.com]
Right atrial abnormality increases the amplitude of the initial P-wave forces, contrasting with increase in the later P-wave forces that can result from left atrial abnormality (pseudo-P pulmonale). [ahajournals.org]
Other ECG Findings
- Electrocardiogram Change
There was no relationship between electrocardiogram changes and Doppler tricuspid regurgitation gradient. CONCLUSION. [pediatrics.aappublications.org]
The principal electrocardiogram (ECG) changes associated with ventricular hypertrophy are increases in QRS amplitude and duration, changes in instantaneous and mean QRS vectors, abnormalities in the ST segment and T waves, and abnormalities in the P wave [ahajournals.org]
Treatment
Results showed that after an average treatment time of 4.8 years, treatment that was based on losartan was better than treatment based on atenolol for reducing stroke risk. [guidelines.hypertension.ca]
We are here to help and encourage you in reaching your treatment goals. [heart.org]
Current treatment of AL amyloidosis. Haematologica. 2009; 94:1044-1048. 13. Palladini G, Perfetti V, Perlini S, et al. [geriatricsandgerontology.it]
It combines specialized centers for the treatment of cancers, cardiovascular diseases, neurological and orthopedic disorders, as well as an Ophthalmology Centre and a Fertility Center. [humanitas.net]
Treatment for dilated cardiomyopathy is directed at the underlying disease. [aafp.org]
Prognosis
The majority of patients with mild hypertrophy are at low risk and can be reassured regarding their prognosis. [nejm.org]
Moreover, both are independent estimators of worse prognosis.[ 6 ]. [en.ecgpedia.org]
Conclusions: Ours results enabled to develop tools which might help to better differentiate pathological and physiological left ventricular hypertrophy (LVH); but also to better characterize LVH and the prognosis in HCM patients. [theses.fr]
An independent predictor of prognosis in essential hypertension. Hypertension 1994; 24:793. 8. Devereux, RB, Pickering, TG, Harshfield, GA, et al. [ispub.com]
Heart failure with preserved left ventricular systolic function: epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol. 2004; 43:317–327. 2. Lam C, Donal E, Kraigher-Krainer E, et al. Epidemiology and preserved ejection fraction. [geriatricsandgerontology.it]
Etiology
Etiology The causes of cardiomyopathies are varied ( Table 2 ). 1 Dilated cardiomyopathy in adults is most commonly caused by CAD (ischemic cardiomyopathy) and hypertension, although viral myocarditis, valvular disease, and genetic predisposition may [aafp.org]
Recent advances in the etiology, diagnosis, and treatment of myocarditis and cardiomyopathies in children. Curr Opinion Pediatrics 1995;7:587-594. Spirito et al. [mottchildren.org]
Hypertrophic cardiomyopathy is characterized by left ventricular hypertrophy (wall thickness >12-15 mm; normal wall thickness is 12 mm or less, measured during diastole) without obvious etiology. [radiopaedia.org]
[…] general adult population Prevalence of HCM in children is unknown, but population based studies report an annual incidence of 0.3 to 0.5 per 100,000 Occurs in all ethnic groups and equally in both sexes Most affected individuals remain unidentified Etiology [pathologyoutlines.com]
Epidemiology
Antiplatelet Drugs Pleiotropic effects LDL receptor Re-Entry Diastole Normal coronary flow Supply / Demand Imbalance Preload, afterload & contractility Coronary Perfusion Pressure Left ventricular hypertrophy Ejection Fraction & Endsystolic Volume Clinical Epidemiology [profmontage.com.au]
Heart failure with preserved left ventricular systolic function: epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol. 2004; 43:317–327. 2. Lam C, Donal E, Kraigher-Krainer E, et al. Epidemiology and preserved ejection fraction. [geriatricsandgerontology.it]
Conclusion LV mass estimation and LVH diagnosis role in cardiovascular disease management is based on epidemiological research and also on clinical grounds. [cardiovascularultrasound.biomedcentral.com]
Epidemiology and causes-specific outcome of hypertrophic cardiomyopathy in children. Circulation. 2007;115:773-81. Medline 1885-5857/© 2011 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved [revespcardiol.org]
The epidemiology of heart failure: The Framingham study. J Am Coll Cardiol 1993; 22 (Supplement A): 6A - 13A.) [ispub.com]
Pathophysiology
Gender Differences in LV mass due to gender, independent of questions related to body size, may have pathophysiological implications. [cardiovascularultrasound.biomedcentral.com]
[…] disease expression Sporadic HCM can reflect an inaccurate family history, incomplete penetrance or a de novo mutation which may be heritable Patients who are genotype positive may be phenotypically negative without overt hypertrophy (subclinical HCM) Pathophysiology [pathologyoutlines.com]
Inotropic agents like dopamine and dobutamine are contraindicated as they are prone to decrease ventricular size and further obstruct cardiac outflow. [10] The pathophysiology of cardiac hypertrophy in infant of diabetic mother is explained by Pederson [mjdrdypu.org]
Genetic mutations can be identified in approximately 60% of patients; these are most common in genes that encode proteins of the cardiac sarcomere. [ 5 ] Management The pathophysiology of HCM is complex, leading to significant variability in clinical [patient.info]
First, this study provides clinical data to support a recently proposed paradigm that identifies distinct pathophysiologies for HFrEF and HFpEF (24). [heartfailure.onlinejacc.org]
Prevention
Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children. Can J Cardiol. Background 1. [guidelines.hypertension.ca]
Patients with multiple risk factors for sudden death benefit from implantable cardioverter defibrillator (ICD) implantation for primary prevention. [patient.info]
However, before this happens, there are several things you can do the help lower your risk factors and prevent further cardiac muscle structure changes. [belmarrahealth.com]
SBE can usually be prevented by taking an antibiotic before these procedures. Exercise guidelines: An individual exercise program is best planned with the doctor so that all factors can be included. [mottchildren.org]
Young patients with extreme hypertrophy, even those with few or no symptoms, appear to be at substantial long-term risk and deserve consideration for interventions to prevent sudden death. [nejm.org]