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Bladder Adenocarcinoma

Adenocarcinoma of Bladder


Presentation

  • In the present case report Sweet's syndrome was the presenting feature of gall bladder adenocarcinoma; an association that has been rarely reported before.[ncbi.nlm.nih.gov]
  • Jean Bauer Affiliation not present Patrice Jichlinski Affiliation not present Abstract Primary adenocarcinoma of the bladder is a rare tumor.[pagepress.org]
  • The case we have presented is similar to the aforementioned cases, but the bladder metastasis presented as a large, irregular, pedunculated mass invasive to the bladder.[appliedradiology.com]
Noncompliance
  • Bladder augmentation with segments of small bowel (ileocystoplasty), large intestine (colocystoplasty) or stomach (gastrocystoplasty) has been used to treat patients with small or noncompliant bladders by increasing the capacity or compliance.[ncbi.nlm.nih.gov]
Overeating
  • Palpation revealed 8 x 7 cm midline mass extending from the umbilicus to the suprapubic region with induration over the ulcerative area. There was no hepatomegaly or splenomegaly. Digital rectal, chest and heart examinations were unremarkable.[pubs.sciepub.com]
  • Sixty-four Gy in 32 fractions external beam radiation over six and half week was delivered to PTV bladder and 45 Gy in 25 fractions over 5 weeks was delivered to PTV stomach.[ccij-online.org]
  • The lesions may spread over the nose, throat or esophagus. Presumably AN is induced by factors stimulating proliferation of epidermal keratinocytes and skin fibroblasts. In benign forms of AN, the main role is played by epidermal growth factors.[termedia.pl]
  • Save over 20% compared to the individual article price.[karger.com]
  • Over 72,000 people will be diagnosed with bladder cancer in 2013 and over 15,000 people will die of the disease.[compurocare.com]
Lacrimation
  • The immunohistochemical marker, GCDFP15, is reported in breast cystic fluid as well as in apocrine, lacrimal, ceruminous, Moll's, and eccrine glands.[cancerjournal.net]
Papule
  • Sweet's syndrome is a neutrophilic inflammatory dermatosis presenting with sudden onset tender red to purple papules and nodules, fever and neutrophilia.[ncbi.nlm.nih.gov]
  • Upon dermatological evaluation, numerous grey and brown skin papillary papules with axillary and inguinal areas were revealed. Additionally, hypertrophic lesions coexisting with fissures and numerous cracks were observed at the vermilion and tongue.[termedia.pl]
Meningism
  • Meningeal carcinomatosis from urinary bladder adenocarcinoma is extremely rare and up-regulation of the adhesion molecules in the meningeal adenocarcinoma was confirmed.[ncbi.nlm.nih.gov]
Hyperactivity
  • He was presented with prominent hyperactive delirium during the course of the disease. Meningeal carcinomatosis was detected 5 days before his death, but the primary site of the malignant tumor could not be determined.[ncbi.nlm.nih.gov]
Hematuria
  • A 54-year-old man, with the chief complaints of hematuria, pollakisuria, and pneumaturia, was referred to our hospital, with a diagnosis of giant urinary bladder adenocarcinoma with massive invasion to the rectum.[ncbi.nlm.nih.gov]
  • Metastasis to the bladder from pancreatic adenocarcinoma presenting with hematuria. Urol Radiol. 1992;13: 187-189. Kiefer ED. Carcinoma of the pancreas. Arch Internal Medicine. 1927;40:1-29. Back To Top[appliedradiology.com]
  • General Very rare [1] - approximately 0.5-2.0% of bladder cancers. [2] Clinical: Like urothelial carcinoma - usually hematuria. [1] Microscopic Features: Nuclear pleomorphism - may be mild. Usually glandular differentiation (most common).[librepathology.org]
  • Hematuria , dysuria and suprapubic pain are general symptoms of patients. Radical surgery is regarded the most frequent treatment option, but it is not satisfactory in 5-year survival rates [ 1 ].[omicsgroup.org]
Macroscopic Hematuria
  • hematuria, urodynia, abdomen pain or fever.[omicsgroup.org]
  • CASE REPORT A 57-year-old male patient presented with a six-month history of painless intermittent macroscopic hematuria without coagula. The patient was a smoker and an alcoholic (Child B alcoholic liver cirrhosis).[scielo.br]
  • Visible blood in the urine is referred to as gross, or macroscopic, hematuria. Bladder cancer often causes no symptoms until it reaches an advanced stage that is difficult to cure.[emedicinehealth.com]
Burning Micturition
Prostatic Nodule
  • On initial evaluation for his penile discharge, he was found to have a right prostatic nodule on physical examination with a normal prostate specific antigen level of 1.5 ng/mL.[jmedicalcasereports.com]

Workup

  • Finally, a thorough clinical workup is required to rule out another primary adenocarcinoma that may have metastasized. Urachal adenocarcinoma can show immunoreactivity for both CK20 and CK7, in addition to CDX2.[path.upmc.edu]
  • Further workup included colonoscopy showing multiple adenomatous polyps were identified without invasive malignancy and cystoscopic evaluations. Cystoscopy revealed a massive amount of mucoid material within the bladder associated with a mass.[jmedicalcasereports.com]
  • Cystoscopy, cytology, and biopsy when necessary are the principal diagnostic tests (see Workup ).[emedicine.medscape.com]
Liver Biopsy
  • Because of the rarity of primary bladder tumors with these histological features, rigid rectosigmoidoscopy, colonoscopy, upper digestive endoscopy, pelvis resonance and laparoscopy together with liver biopsy were sequentially performed with the aim of[scielo.br]
Squamous Metaplasia of the Bladder
  • There is only one previously reported case of urothelial carcinoma with associated squamous metaplasia of the bladder occurring in a spina bifida patient.[ncbi.nlm.nih.gov]
  • Keratinizing squamous metaplasia of the bladder: a review. Urol Int . 2008. 81(3):247-51. [Medline] . Khan MS, Thornhill JA, Gaffney E, Loftus B, Butler MR.[emedicine.medscape.com]

Treatment

  • Complete response was achieved at the end of this treatment. Today the patient is free of local or systemic disease. FOLFOX4 regimen may be a treatment option for primary adenocarcinoma of the bladder.[ncbi.nlm.nih.gov]
  • Treatment and prognosis Due to their extravesical location, urachal carcinomas present very late and thus carry a poor prognosis. Radical cystectomy is considered the treatment of choice.[radiopaedia.org]

Prognosis

  • Although the prognosis of T4 bladder adenocarcinomas has been reported to be quite poor in comparison with that of transitional cell carcinomas, the postoperative prognosis of T4 rectal adenocarcinomas has been reported to be more favorable and such tumors[ncbi.nlm.nih.gov]
  • Studies of AC of the bladder have reported a poor prognosis, with 5-year survival rates ranging from 0% to 31%.[am.asco.org]
  • Treatment and prognosis Due to their extravesical location, urachal carcinomas present very late and thus carry a poor prognosis. Radical cystectomy is considered the treatment of choice.[radiopaedia.org]
  • Prognosis is poor with 5-year survival rate of 18-47%, and high proportion presents with higher stage including up to 40% with metastasis at the time of diagnosis. advertisement advertisement[auanet.org]

Etiology

  • Etiology persistent urachal remnant (most common) cystitis glandularis (itself secondary to bladder outlet obstruction , chronic infection and/or bladder calculi ) schistosomiasis (bilharziasis), especially where endemic associated with bladder exstrophy[radiopaedia.org]
  • Immunohistochemical analysis using a panel of specific markers is an important alternative for etiological differentiation of these tumors.[scielo.br]
  • […] urothelial carcinoma component Epicenter is mucosa, not muscularis propria (which is found in urachal adenocarcinoma) Epidemiology Less than 2% of all bladder malignancies 2/3 in men; mean age 68 years Sites Usually lateral wall or trigone of bladder Etiology[pathologyoutlines.com]

Epidemiology

  • METHODS: We retrospectively analyzed cases of BAC with known tumor location from the Surveillance, Epidemiology, and End Results database from 1973 to 2012.[ncbi.nlm.nih.gov]
  • Epidemiology Primary adenocarcinoma of the bladder constitutes only 0.5-2% of all primary bladder malignancies, while spread from a colorectal primary is the most common (20%-33%) of all secondary tumours involving the bladder.[e-immunohistochemistry.info]
  • An analysis of Surveillance, Epidemiology, and End Results data of 1,525 patients with AC reported that, compared to nonurachal ACs of the bladder, urachal ACs had lower all-cause mortality (hazard ratio [HR] 0.56, 95% CI [0.38, 0.83]) and disease-specific[am.asco.org]
  • American Journal of Epidemiology. 2001;153(1):38-41. Pelucchi C, La Vecchia C. Alcohol, coffee, and bladder cancer risk: a review of epidemiological studies. European Journal of Cancer Prevention. 2009;18(1):62-68.[md-medicaldata.com]
  • An estimated 81,190 people will be diagnosed with bladder cancer and some 17,240 people are expected to die from the disease in 2018, according to the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program.[aacrfoundation.org]
Sex distribution
Age distribution

Pathophysiology

  • Nonurothelial primary bladder tumors are extremely rare and may include small cell carcinoma, carcinosarcoma, primary lymphoma, and sarcoma (see Pathophysiology ).[emedicine.medscape.com]

Prevention

  • Causes, Risk Factors, and Prevention Learn about the risk factors for bladder cancer and what you might be able to do to help lower your risk. Early Detection, Diagnosis, and Staging Know the signs and symptoms of bladder cancer.[cancer.org]
  • Prevention Bladder cancer is caused by random molecular events that cannot be prevented.[innerbody.com]
  • Supportive Care: Supportive care refers to treatments designed to prevent and control the side effects of cancer and its treatment.[texasoncology.com]
  • Bladder Cancer You cannot prevent bladder cancer.[cancertutor.com]
  • Preventing bladder cancer While it is not possible to prevent bladder cancer, it is possible to reduce your risks such as not smoking or quitting smoking, and avoiding exposure to chemicals listed above.[cancer.org.au]

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