Hepatic necrosis with the presence of acidophilic hyaline bodies, necrotizing enteritis, epithelial necrosis and adrenal cortical necrosis were present in all monkeys. [ncbi.nlm.nih.gov]

Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

^ " Chemical and Biological Weapons: Possession and Programs Past and Present ", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008. [thefullwiki.org]

The secondary structure is stabilized by four disulfide bonds which are present around the plane of the lens (Fig. 3C ). [jvi.asm.org]

• Generalized Lymphadenopathy

  Kyasanur Forest disease – Sudden onset of fever, chills, headache, severe prostration, arthralgia, generalized lymphadenopathy, myalgia, and facial flushing, followed in 72 hours by nausea, vomiting, diarrhea, and hemorrhage. [visualdx.com]

• Fever

  fever. ( 5301560 ) Johnson K.M....Valverde L. 1967 24 Bolivian hemorrhagic fever. [malacards.org]

  fever A95.0 Sylvatic yellow fever A95.1 Urban yellow fever A95.9 Yellow fever, unspecified A96 Arenaviral hemorrhagic fever A96.0 Junin hemorrhagic fever A96.1 Machupo hemorrhagic fever A96.8 Other arenaviral hemorrhagic fevers A96.9 Arenaviral hemorrhagic [icd10data.com]

  To the Editor: Bolivian hemorrhagic fever (BHF) was first described in 1959 during outbreaks affecting isolated human communities in eastern Bolivia. [dx.doi.org]

• Fatigue

  The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary [amp.pharm.mssm.edu]

  Symptoms: Preliminary symptoms of Bolivian hemorrhagic fever caused by the Machupo virus include fever, headache, fatigue, myalgia, and arthralgia. [stanford.edu]

  Some initial symptoms caused by infection of the virus include fever, mild hypertension, headache, bleeding gums, and fatigue. [microbewiki.kenyon.edu]

  Recovery may be complicated by fatigue, anorexia, cachexia, alopecia, and arthralgia. Sequelae include hearing or vision loss, impaired motor coordination, transverse myelitis, uveitis, pericarditis, orchitis, parotitis, and pancreatitis. [visualdx.com]

• High Fever

  Bolivians referred to the mysterious disease as “Black Typhus” alluding to the hemorrhaging, high fever, pain, and rapid death caused by the illness. [stanford.edu]

  The illness was characterized by high fever, headache, and bleeding from the nose, ears, and mouth, accompanied by jaundice, severe abdominal and thoracic pain as well as acute neurological manifestations. [johnhawks.net]

• Fever of Unknown Origin

  (inanition) (of unknown origin) (persistent) (with chills) (with rigor) R50.9 ICD-10-CM Diagnosis Code R50.9 Fever, unspecified 2016 2017 2018 2019 Billable/Specific Code Applicable To Fever NOS Fever of unknown origin [FUO] Fever with chills Fever with [icd10data.com]

• Bleeding Gums

  Some initial symptoms caused by infection of the virus include fever, mild hypertension, headache, bleeding gums, and fatigue. [microbewiki.kenyon.edu]

  Hemorrhagic and neurologic symptoms, including petechiae and bleeding gums, tremors, and lethargy are common. [journals.plos.org]

• Hypotension

  Hypotension may also have been due to decreased plasma protein synthesis. Copyright © 1978 by The American Society of Tropical Medicine and Hygiene Article metrics loading... [ajtmh.org]

  As the disease progresses, hypotension, dehydration, bradycardia, pulmonary edema, and internal hemorrhage may occur. The mortality rate may reach 30%; pulmonary edema is the most common cause of death. There is no specific therapy. [medical-dictionary.thefreedictionary.com]

  Early signs of infection include fever, hypotension, relative bradycardia, tachypnea, conjunctivitis, and pharyngitis. Some patients may have an accompanying rash. [visualdx.com]

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

• Petechiae

  When first seen by the attending physicians, he had fever, thrombocytopenia, leukopenia, petechias, tremors, gingivorrhagia, and dehydration, consistent with symptoms of BHF. [dx.doi.org]

  Skin petechiae may be noted. [visualdx.com]

• Skin Rash

  Gross lesions included skin rash, lymphadenopathy, splenomegaly, meningeal edema, hydropericardium and enlarged friable livers. [ncbi.nlm.nih.gov]

  Red eyes are common, and patients may develop a petechial skin rash. Hiccups or difficulty breathing may occur. Internal and external bleeding may also be seen. [visualdx.com]

  The virus produces a fever as high as 107 degrees; mouth ulcers; a skin rash with tiny hemorrhages; pneumonia; infection of the heart leading to cardiac failure; kidney damage, and severe muscle aches. [faculty.humanities.uci.edu]

• Flushing

  Flaviviridae Yellow fever – Facial flushing, conjunctival redness, and prominent low back pain in conjunction with the sudden onset of a flu-like illness. [visualdx.com]

  The disease has typical ongoing set of symptoms, involving:fever, malaise, headache and body pain, blood spots, bleeding from the nose and gums( very similar to Ebola and Marburg too) and overall weakness,loss of appetite and vomiting, flushed face and [sarahmaxresearch.wordpress.com]

• Suggestibility

  This report describes the first use of intravenous ribavirin therapy for BHF in humans, and the results suggest the need for more extensive clinical studies to assess the usefulness of ribavirin for treating BHF. [ncbi.nlm.nih.gov]

  The absence of communitywide epidemics of BHF suggests that focused rodent control in towns of the disease-endemic region prevented large urban outbreaks. [wwwnc.cdc.gov]

  Structural database comparison ( 27, 45 ) suggests that MACV GP1 is composed of a fold that has not been previously observed. [jvi.asm.org]

  That all 5 patients were farmers suggests their infections were probably acquired through occupational exposure. Although all the patients received plasma transfusion from patients who had survived BHF infection, 3 patients still died. [dx.doi.org]

• Epistaxis

  In the later stages of this illness, patients may develop hemorrhagic manifestations including subconjunctival hemorrhage, epistaxis, hematemesis, melena, and hematuria, as well as neurological signs including tremor, seizures, and coma. [ncbi.nlm.nih.gov]

  Advanced symptoms include mucous membrane haemorrhage, epistaxis, melena, and neurological damage such as tremors, seizures, loss of muscle control, and coma. Symptoms usually arise after a one week incubation period and generally last for one week. [microbewiki.kenyon.edu]

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

• Headache

  Initial symptoms include headache, fever, arthralgia, and myalgia. [ncbi.nlm.nih.gov]

  Marburg – Fever, chills, cough, sore throat, headache, weakness, myalgias, chest pain, prostration, conjunctivitis, petechiae, purpura, and hemorrhage. [visualdx.com]

  The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary [amp.pharm.mssm.edu]

  After an incubation period of 1 to 2 weeks, the patient experiences chills, fever, headache, muscle ache, anorexia, nausea, and vomiting. [medical-dictionary.thefreedictionary.com]

  The infection has a slow onset with fever, malaise, headache and muscular pains. [wikidoc.org]

• Tremor

  When first seen by the attending physicians, he had fever, thrombocytopenia, leukopenia, petechias, tremors, gingivorrhagia, and dehydration, consistent with symptoms of BHF. [dx.doi.org]

• Dysarthria

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

• Complement Fixing Antibody

  A report of four cases. ( 4159195 ) Stinebaugh B.J....de Alba E. 1966 25 Detection of complement-fixing antibody after Bolivian hemorrhagic fever, employing Machupo, JunA-n and Tacaribe virus antigens. ( 5840640 ) Mackenzie R.B....Johnson K.M. 1965 [malacards.org]

Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet. 1979 ; 2 : 1216 – 7. DOI PubMed Enria DA, Briggiler AM, Sanchez Z. [dx.doi.org]

Maiztegui JI, Fernandez NJ, de Damilano AJ Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. [ncbi.nlm.nih.gov]

The current treatment for Argentine and Bolivian hemorrhagic fever is a serum administered to a patient after the disease has been diagnosed, and this treatment is quite effective. [diki.pl]

The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25-35%. [utmb.influuent.utsystem.edu]

The etiological agent is Machupo virus (MACV, Arenaviridae). Related posts Arenavirus ; Lassa Fever ; Viral hemorrhagic fevers The virus is similar to that which causes Argentine hemorrhagic fever, and its reservoir is also wild rodents. [histopathology-india.net]

[…] hemorrhagic fever virus infections in suckling hamsters. ( 4745242 ) Terrell T.G....Kuehne R.W. 1973 16 Pathology of Bolivian hemorrhagic fever in the rhesus monkey. ( 4202335 ) Terrell T.G....Kastello M.D. 1973 17 Multiplication of Machupo virus, the etiological [malacards.org]

The hemorrhagic fevers remained in the area for three centuries and the etiologic agent is still unknown. [johnhawks.net]

One patient with laboratory-confirmed Machupo virus infection who received ribavirin recovered without sequelae, as did a second patient with suspected BHF whose epidemiological and clinical features were similar to those of the first patient. [ncbi.nlm.nih.gov]

Cite this Apa Standard Harvard Vancouver BIBTEX RIS @article{375d1947b08f46fa90013a38cc06fa3f, title = "Epidemiology and pathogenesis of Bolivian hemorrhagic fever", abstract = "The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV [utmb.influuent.utsystem.edu]

Pathology and Pathogenesis of Human Viral Disease is a comprehensive reference that examines virus-induced clinical disease of humans in the context of the responsible virus and its epidemiology. [books.google.com]

1 Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs. ( 26139838 ) 2015 2 Epidemiology and pathogenesis of Bolivian hemorrhagic fever. ( 24636947 ) Patterson M....Paessler S. 2014 3 Reemergence of Bolivian hemorrhagic fever, 2007-2008. ( 19788833 [malacards.org]

[…] zoonotic viral diseases 1D61 Arenavirus disease H01542 Bolivian hemorrhagic fever Pathogen Machupo mammarenavirus [GN: T40006 ] Other DBs ICD-11: 1D61.1 ICD-10: A96.1 MeSH: D006478 Reference PMID: 24636947 Authors Patterson M, Grant A, Paessler S Title Epidemiology [genome.jp]

A reemergence of reported BHF cases has been reported in recent years, which necessitates the further study and development of a vaccine to prevent future outbreaks. [utmb.influuent.utsystem.edu]

During the BHF epidemics in the 1960s, rodent control was recognized as the primary method for the prevention of Machupo virus transmission (9). [wwwnc.cdc.gov]

Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. [dx.doi.org]