Hepatic necrosis with the presence of acidophilic hyaline bodies, necrotizing enteritis, epithelial necrosis and adrenal cortical necrosis were present in all monkeys. [ncbi.nlm.nih.gov]

Collection includes both citations and many full-text, downloadable documents from mid-1900s to present. AULIMP - Air University Library Index to Military Periodicals. [dtic.mil]

(1995), pp.. " Chemical and Biological Weapons: Possession and Programs Past and Present ", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008. [thefullwiki.org]

The secondary structure is stabilized by four disulfide bonds which are present around the plane of the lens (Fig. 3C ). [doi.org]

• Fever

  To the Editor: Bolivian hemorrhagic fever (BHF) was first described in 1959 during outbreaks affecting isolated human communities in eastern Bolivia. [dx.doi.org]

  Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever, is a hemorrhagic fever and zoonotic infectious disease originating in Bolivia after infection by Machupo mammarenavirus.BHF was first identified in 1963 as an ambisense RNA virus [en.wikipedia.org]

  fever. ( 5301560 ) Johnson K.M....Valverde L. 1967 24 Bolivian hemorrhagic fever. [malacards.org]

• Fatigue

  The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary [amp.pharm.mssm.edu]

  Symptoms: Preliminary symptoms of Bolivian hemorrhagic fever caused by the Machupo virus include fever, headache, fatigue, myalgia, and arthralgia. [stanford.edu]

  Following an incubation period of 1-2 weeks, patients infected with Machupo virus may develop an influenza-like illness with fever, malaise, and fatigue followed by the onset of headache, dizziness, myalgias, and severe lower back pain. [cdc.gov]

  Early clinical manifestations in humans are characterized by nonspecific signs and symptoms including fever, headache, fatigue, myalgia, and arthralgia. [wwwnc.cdc.gov]

• High Fever

  Bolivians referred to the mysterious disease as “Black Typhus” alluding to the hemorrhaging, high fever, pain, and rapid death caused by the illness. [stanford.edu]

  The illness was characterized by high fever, headache, and bleeding from the nose, ears, and mouth, accompanied by jaundice, severe abdominal and thoracic pain as well as acute neurological manifestations. [johnhawks.net]

• Fever of Unknown Origin

  […] of unknown origin [FUO] Fever with chills Fever with rigors Hyperpyrexia NOS Persistent fever Pyrexia NOS hemorrhagic (arthropod-borne) A94 ICD-10-CM Diagnosis Code A94 Unspecified arthropod-borne viral fever 2016 2017 2018 2019 Billable/Specific Code [icd10data.com]

• Generalized Lymphadenopathy

  Kyasanur Forest disease – Sudden onset of fever, chills, headache, severe prostration, arthralgia, generalized lymphadenopathy, myalgia, and facial flushing, followed in 72 hours by nausea, vomiting, diarrhea, and hemorrhage. [visualdx.com]

• Hypotension

  Hypotension may also have been due to decreased plasma protein synthesis. Copyright 1978 by The American Society of Tropical Medicine and Hygiene Article metrics loading... [ajtmh.org]

  As the disease progresses, hypotension, dehydration, bradycardia, pulmonary edema, and internal hemorrhage may occur. The mortality rate may reach 30%; pulmonary edema is the most common cause of death. There is no specific therapy. [medical-dictionary.thefreedictionary.com]

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

  Early signs of infection include fever, hypotension, relative bradycardia, tachypnea, conjunctivitis, and pharyngitis. Some patients may have an accompanying rash. [visualdx.com]

• Bleeding Gums

  Some initial symptoms caused by infection of the virus include fever, mild hypertension, headache, bleeding gums, and fatigue. [microbewiki.kenyon.edu]

  Initial symptoms may include conjunctival injection, mild hypertension, flushing, bleeding gums and cavities, headache, arthralgia, and petechial haemorrhages. [phac-aspc.gc.ca]

  Hemorrhagic and neurologic symptoms, including petechiae and bleeding gums, tremors, and lethargy are common. [journals.plos.org]

• Petechiae

  When first seen by the attending physicians, he had fever, thrombocytopenia, leukopenia, petechias, tremors, gingivorrhagia, and dehydration, consistent with symptoms of BHF. [dx.doi.org]

  Petechiae (blood spots) on the upper body and bleeding from the nose and gums are observed when the disease progresses to the hemorrhagic phase, usually within seven days of onset. [en.wikipedia.org]

• Flushing

  Flaviviridae Yellow fever – Facial flushing, conjunctival redness, and prominent low back pain in conjunction with the sudden onset of a flu-like illness. [visualdx.com]

  The disease has typical ongoing set of symptoms, involving:fever, malaise, headache and body pain, blood spots, bleeding from the nose and gums( very similar to Ebola and Marburg too) and overall weakness,loss of appetite and vomiting, flushed face and [sarahmaxresearch.wordpress.com]

  Initial symptoms may include conjunctival injection, mild hypertension, flushing, bleeding gums and cavities, headache, arthralgia, and petechial haemorrhages. [phac-aspc.gc.ca]

• Skin Rash

  Gross lesions included skin rash, lymphadenopathy, splenomegaly, meningeal edema, hydropericardium and enlarged friable livers. [ncbi.nlm.nih.gov]

  Red eyes are common, and patients may develop a petechial skin rash. Hiccups or difficulty breathing may occur. Internal and external bleeding may also be seen. [visualdx.com]

  The virus produces a fever as high as 107 degrees; mouth ulcers; a skin rash with tiny hemorrhages; pneumonia; infection of the heart leading to cardiac failure; kidney damage, and severe muscle aches. [faculty.humanities.uci.edu]

• Skin Lesion

  Pruritic skin lesions suggestive of S. scabiei mite infestation developed in 4 humans who had direct contact with affected farm animals but not foxes. [doi.org]

• Epistaxis

  In the later stages of this illness, patients may develop hemorrhagic manifestations including subconjunctival hemorrhage, epistaxis, hematemesis, melena, and hematuria, as well as neurological signs including tremor, seizures, and coma. [ncbi.nlm.nih.gov]

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

  Advanced symptoms include mucous membrane haemorrhage, epistaxis, melena, and neurological damage such as tremors, seizures, loss of muscle control, and coma. Symptoms usually arise after a one week incubation period and generally last for one week. [microbewiki.kenyon.edu]

  Symptoms can further develop into shock and generalized mucous membrane haemorrhage, epistaxis, haematemesis, melena, haematuria, accompanied by neurological damage such as tremor, seizures, and coma ( 4 ). [phac-aspc.gc.ca]

• Headache

  Initial symptoms include headache, fever, arthralgia, and myalgia. [ncbi.nlm.nih.gov]

  The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary [amp.pharm.mssm.edu]

  After an incubation period of 1 to 2 weeks, the patient experiences chills, fever, headache, muscle ache, anorexia, nausea, and vomiting. [medical-dictionary.thefreedictionary.com]

  The infection has a slow onset with fever, malaise, headache and myalgia, very similar to Malaria symptoms. [en.wikipedia.org]

  The infection has a slow onset with fever, malaise, headache and muscular pains. [wikidoc.org]

• Tremor

  When first seen by the attending physicians, he had fever, thrombocytopenia, leukopenia, petechias, tremors, gingivorrhagia, and dehydration, consistent with symptoms of BHF. [dx.doi.org]

  In the later stages of this illness, patients may develop hemorrhagic manifestations including subconjunctival hemorrhage, epistaxis, hematemesis, melena, and hematuria, as well as neurological signs including tremor, seizures, and coma. [ncbi.nlm.nih.gov]

• Dysarthria

  From July 4 through August 12, 1994, seven family members (aged 10 months-50 years) developed an illness characterized by fever, hypotension, subconjunctival and gingival bleeding, epistaxis, petechiae, tremor, and dysarthria. [cdc.gov]

• Meningism

  Gross lesions included skin rash, lymphadenopathy, splenomegaly, meningeal edema, hydropericardium and enlarged friable livers. [ncbi.nlm.nih.gov]

• Complement Fixing Antibody

  A report of four cases. ( 4159195 ) Stinebaugh B.J....de Alba E. 1966 25 Detection of complement-fixing antibody after Bolivian hemorrhagic fever, employing Machupo, JunA-n and Tacaribe virus antigens. ( 5840640 ) Mackenzie R.B....Johnson K.M. 1965 [malacards.org]

Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. Lancet. 1979 ; 2 : 1216 – 7. DOI PubMed Enria DA, Briggiler AM, Sanchez Z. [dx.doi.org]

Maiztegui JI, Fernandez NJ, de Damilano AJ Efficacy of immune plasma in treatment of Argentine haemorrhagic fever and association between treatment and a late neurological syndrome. [ncbi.nlm.nih.gov]

The current treatment for Argentine and Bolivian hemorrhagic fever is a serum administered to a patient after the disease has been diagnosed, and this treatment is quite effective. [diki.pl]

The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) is reported to have a mortality rate of 25-35%. [ncbi.nlm.nih.gov]

The etiological agent is Machupo virus (MACV, Arenaviridae). Related posts Arenavirus ; Lassa Fever ; Viral hemorrhagic fevers The virus is similar to that which causes Argentine hemorrhagic fever, and its reservoir is also wild rodents. [histopathology-india.net]

[…] hemorrhagic fever virus infections in suckling hamsters. ( 4745242 ) Terrell T.G....Kuehne R.W. 1973 16 Pathology of Bolivian hemorrhagic fever in the rhesus monkey. ( 4202335 ) Terrell T.G....Kastello M.D. 1973 17 Multiplication of Machupo virus, the etiological [malacards.org]

However, it was not until 1963 that the etiologic agent, Machupo virus, was isolated from the spleen of a patient who died from this disease ( 1 ). [dx.doi.org]

One patient with laboratory-confirmed Machupo virus infection who received ribavirin recovered without sequelae, as did a second patient with suspected BHF whose epidemiological and clinical features were similar to those of the first patient. [ncbi.nlm.nih.gov]

Cite this Apa Standard Harvard Vancouver BIBTEX RIS @article{375d1947b08f46fa90013a38cc06fa3f, title "Epidemiology and pathogenesis of Bolivian hemorrhagic fever", abstract "The etiologic agent of Bolivian hemorrhagic fever (BHF), Machupo virus (MACV) [utmb.influuent.utsystem.edu]

[…] zoonotic viral diseases 1D61 Arenavirus disease H01542 Bolivian hemorrhagic fever Pathogen Machupo mammarenavirus [GN: T40006 ] Other DBs ICD-11: 1D61.1 ICD-10: A96.1 MeSH: D006478 Reference PMID: 24636947 Authors Patterson M, Grant A, Paessler S Title Epidemiology [genome.jp]

Epidemic hemorrhagic fever in Bolivia: a preliminary report of the epidemiologic and clinical findings in a new epidemic area in South America. J Trop Med Hyg. 1964 ; 13 : 620 – 5. Johnson KM, MacKenzie RB, Webb PA, Kuns ML. [wwwnc.cdc.gov]

1 Pathogenesis of Bolivian Hemorrhagic Fever in Guinea Pigs. ( 26139838 ) 2015 2 Epidemiology and pathogenesis of Bolivian hemorrhagic fever. ( 24636947 ) Patterson M....Paessler S. 2014 3 Reemergence of Bolivian hemorrhagic fever, 2007-2008. ( 19788833 [malacards.org]

A reemergence of reported BHF cases has been reported in recent years, which necessitates the further study and development of a vaccine to prevent future outbreaks. [ncbi.nlm.nih.gov]

During the BHF epidemics in the 1960s, rodent control was recognized as the primary method for the prevention of Machupo virus transmission (9). [wwwnc.cdc.gov]

Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. [dx.doi.org]