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Bone Biopsy

Biopsy of Bone


Presentation

  • Abstract We present a rare case of delayed diagnosis of osteosarcoma of the medial clavicle in a young man. He presented following a pathological fracture with a falsely reassuring core and fine-needle aspiration biopsy.[ncbi.nlm.nih.gov]
Foot Ulcer
  • Thirty two of 34 (94%), had a history of preceding foot ulceration, and in 25 of the cases a positive probe to bone test was recorded.[ncbi.nlm.nih.gov]
  • ulcers , Clin Microbiol Infect , 2006 , vol. 12 (pg. 186 - 9 ) 22 Diabetic foot ulcer and multidrug-resistant organisms: risk factors and impact , Diabet Med , 2004 , vol. 21 (pg. 710 - 5 ) 23 A clinico-microbiological study of diabetic foot ulcers in[academic.oup.com]
  • Chronic osteitis is a frequent complication of foot ulcerations in patients with diabetes, due to the pathogens spreading infections contiguously to the bone.[woundsresearch.com]
  • The results for cultures of concomitant foot ulcer swab samples were available for 69 episodes of osteomyelitis.[cid.oxfordjournals.org]
Severe Osteoporosis
  • On histomorphometric analysis, 3 specimens showed severe osteoporosis. In conclusion, iliac crest bone biopsy may need to be considered as an adjunct in screening for both unsuspected hematological disease and metabolic bone disease.[ncbi.nlm.nih.gov]
Anger
  • Author information 1 Department of Bone Diseases, University Hospital, Angers Cedex, France.[ncbi.nlm.nih.gov]
Waddling Gait
  • Radiographs of the long bones of a 9-year-old boy presenting with waddling gait, muscular weakness, underweight, and severe skeletal pain showed symmetric diaphyseal cortical thickening pathognomonic for CED.[ncbi.nlm.nih.gov]

Workup

  • All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 6 to 6 4 min (P 0.0001).[ncbi.nlm.nih.gov]
Nephrolithiasis
  • Primary hyperoxaluria is a rare congenital disorder characterized by large quantities of urinary oxalate with resultant nephrocalcinosis and nephrolithiasis and by deposits of calcium oxalate in other organs. Renal failure occurs early in life.[ncbi.nlm.nih.gov]
Parathyroid Hormone Increased
  • In chronic kidney disease the excessive production of parathyroid hormone increases the bone resorption rate and leads to histologic bone signs of secondary hyperparathyroidism.[ncbi.nlm.nih.gov]
Staphylococcus Aureus
  • Staphylococcus aureus was the commonest organism grown in both cultures. The bone pathogen was identified in the corresponding swab culture in only 55 cases (38.2%).[ncbi.nlm.nih.gov]
Bone Biopsy Abnormal
  • All 14 patients who developed complications because of deep abscess and sinus tract formation had intraoperative Jamshidi core needle bone biopsy abnormality consistent with osteomyelitis (positive Jamshidi core needle bone biopsy results).[ncbi.nlm.nih.gov]
Bone Biopsy Abnormal
  • All 14 patients who developed complications because of deep abscess and sinus tract formation had intraoperative Jamshidi core needle bone biopsy abnormality consistent with osteomyelitis (positive Jamshidi core needle bone biopsy results).[ncbi.nlm.nih.gov]

Treatment

  • In most cases (82/99), bone biopsy led to consequences in medical treatment. Following histopathological diagnosis, 16 patients did not receive any anti-osteoporotic treatment.[ncbi.nlm.nih.gov]

Prognosis

  • The definite diagnosis was established by bone biopsy, which revealed two totally unrelated disorders that altered the management and prognosis for these two patients.[ncbi.nlm.nih.gov]
  • […] cells, which fight infections cancers of the blood, such as leukemia whether cancers that started elsewhere have spread to the bone marrow (the assessment of how much a cancer has spread is called staging, and is important in determining treatment and prognosis[kidshealth.org]

Etiology

  • The severe fracture history of these patients emphasizes the gravity of their bone disease and stresses the need for further study on the etiology and treatment of this form of osteoporosis.[ncbi.nlm.nih.gov]
  • […] foot ulcers in an Indian tertiary care hospital , Diabetes Care , 2006 , vol. 29 (pg. 1727 - 32 ) 24 Effect of bone biopsy in guiding antimicrobial therapy for osteomyelitis complicating open wounds , Am J Med Sci , 2001 , vol. 321 (pg. 367 - 71 ) 25 Etiologic[academic.oup.com]

Epidemiology

  • Data bank registry can be a valuable tool to understand epidemiological aspects of MBD CKD. The Brazilian Registry of Bone Biopsy (REBRABO) will be a national registry, coordinating by the Brazilian Society of Nephrology - Committee of MBD-CKD.[ncbi.nlm.nih.gov]
  • Researchers from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, used high resolution peripheral quantitative computed tomography (HRpQCT) to assess bone structure and strength at a microstructural level in living[sciencedaily.com]
  • Percutaneous bone biopsy is an undemanding and inexpensive way to induce better chances to cure the patient and to adequately manage the microbiological epidemiology.[woundsresearch.com]
Sex distribution
Age distribution

Pathophysiology

  • This review will focus on recent insights into the pathophysiology of renal bone disease, as highlighted by bone biopsy, and discuss implications for treatment.[ncbi.nlm.nih.gov]

Prevention

  • Oral prednisolone was initiated, and subsequently, pamidronate infusions were commenced in an attempt to prevent progression of osteoporosis.[ncbi.nlm.nih.gov]
  • Avoiding sun exposure while taking tetracycline prevents skin photosensitivity. The patient should adhere strictly to the medication dosing and schedule to prevent problems in interpretation of the dynamic histomorphometry.[emedicine.medscape.com]

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