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2.1
Bone Biopsy
Biopsy of Bone

Presentation

Abstract We present a rare case of delayed diagnosis of osteosarcoma of the medial clavicle in a young man. He presented following a pathological fracture with a falsely reassuring core and fine-needle aspiration biopsy. [ncbi.nlm.nih.gov]

At present, the only definitive way to determine the status of bone turnover in humans is via bone biopsy and histomorphometric evaluation. [clinicaltrials.gov]

Entire Body System

  • Anemia

    The results may detect the cause of anemia (too few red blood cells), abnormal white blood cells, or thrombocytopenia (too few platelets). [mountsinai.org]

    When these tests are negative, examining the marrow can reveal problems with the red blood cells that are uncommon causes of anemia (sideroblastic anemia, aplastic anemia). [medicinenet.com]

    A few examples include: Leukemia — cancer of the blood cells Anemia — low number of red blood cells and low hemoglobin Diseases such as aplastic anemia that can affect the marrow's ability to produce an adequate number of each of the different blood cell [labtestsonline.org]

  • Fatigue

    Call Your Doctor Call your doctor if any of the following occur: Fever or chills Redness, swelling, pain, bleeding, or pus from the biopsy site Nausea or vomiting Cough, breathing problems, or chest pain Joint pain, fatigue, stiffness, rash, or other [wkhs.com]

Respiratoric

  • Aspiration

    This video will demonstrate the procedure for bone marrow aspiration and bone marrow biopsy from the posterior iliac crest. [nejm.org]

    Bone marrow aspiration and biopsy are usually done together. A bone marrow aspiration removes a small amount of fluid and cells from the bone marrow. [cancer.ca]

    After 24 hours you can get the aspiration and biopsy area wet. [mayoclinic.org]

Skin

  • Ulcer

    We propose an algorithm for the management of spinal cord injury patients with grade IV pressure ulcers. [ncbi.nlm.nih.gov]

    20 mm from the periphery of the ulcer, in accordance with previously described procedures [ 14 ]. [academic.oup.com]

    Swab samples were obtained from the bottom of the ulcer by vigorous rotation of the swab. Ulcer cultures were only included in the analysis if they had been obtained within 3 days before bone biopsy. [cid.oxfordjournals.org]

    When the original source of an ulcer is not taken care of with shoe adaptations and offloading devices, ulcers usually occur on the same location; it does not signify a persistent bone infection. [woundsresearch.com]

  • Foot Ulcer

    Thirty two of 34 (94%), had a history of preceding foot ulceration, and in 25 of the cases a positive probe to bone test was recorded. [ncbi.nlm.nih.gov]

    2006, vol. 12 (pg. 186 - 9 ) 22 Diabetic foot ulcer and multidrug-resistant organisms: risk factors and impact, Diabet Med, 2004, vol. 21 (pg. 710 - 5 ) 23 A clinico-microbiological study of diabetic foot ulcers in an Indian tertiary care hospital, [academic.oup.com]

    The study’s team insists on early treatment of all DFUs, with a median length of 21 days between ulcer appearance and first visit to the foot clinic. [woundsresearch.com]

    The results for cultures of concomitant foot ulcer swab samples were available for 69 episodes of osteomyelitis. [cid.oxfordjournals.org]

Musculoskeletal

  • Bone Disorder

    Although bone specimens are usually decalcified for routine pathology to facilitate sample processing, when investigating metabolic bone disorders it is usually much more informative to analyse undecalcified samples. [ncbi.nlm.nih.gov]

Neurologic

  • Peripheral Neuropathy

    In the case of severe peripheral neuropathy resulting in superficial and deep anesthesia, no additional anesthesia was administered. [academic.oup.com]

    In case of severe peripheral neuropathy resulting in superficial and deep anesthesia, no additional anesthesia was performed. [cid.oxfordjournals.org]

    Diabetes-related peripheral neuropathy and, to a lesser extent, lower limb arteriopathy, are the main risk factors for DFUs. [woundsresearch.com]

Workup

All specimen sampled were sufficient for histopathological workup. Compared to the historical cohort the time needed for biopsy decreased significantly from 13 ± 6 to 6 ± 4 min (P = 0.0001). [ncbi.nlm.nih.gov]

Biopsy

  • Bone Biopsy Abnormal

    All 14 patients who developed complications because of deep abscess and sinus tract formation had intraoperative Jamshidi core needle bone biopsy abnormality consistent with osteomyelitis (positive Jamshidi core needle bone biopsy results). [ncbi.nlm.nih.gov]

Treatment

In most cases (82/99), bone biopsy led to consequences in medical treatment. Following histopathological diagnosis, 16 patients did not receive any anti-osteoporotic treatment. [ncbi.nlm.nih.gov]

Prognosis

The definite diagnosis was established by bone biopsy, which revealed two totally unrelated disorders that altered the management and prognosis for these two patients. [ncbi.nlm.nih.gov]

[…] cells, which fight infections cancers of the blood, such as leukemia whether cancers that started elsewhere have spread to the bone marrow (the assessment of how much a cancer has spread is called staging, and is important in determining treatment and prognosis [kidshealth.org]

Etiology

The severe fracture history of these patients emphasizes the gravity of their bone disease and stresses the need for further study on the etiology and treatment of this form of osteoporosis. [ncbi.nlm.nih.gov]

[…] diabetic foot ulcers in an Indian tertiary care hospital, Diabetes Care, 2006, vol. 29 (pg. 1727 - 32 ) 24 Effect of bone biopsy in guiding antimicrobial therapy for osteomyelitis complicating open wounds, Am J Med Sci, 2001, vol. 321 (pg. 367 - 71 ) 25 Etiologic [academic.oup.com]

Epidemiology

Researchers from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, used high resolution peripheral quantitative computed tomography (HRpQCT) to assess bone structure and strength at a microstructural level in living [sciencedaily.com]

Data bank registry can be a valuable tool to understand epidemiological aspects of MBD CKD. The Brazilian Registry of Bone Biopsy (REBRABO) will be a national registry, coordinating by the Brazilian Society of Nephrology - Committee of MBD-CKD. [ncbi.nlm.nih.gov]

Percutaneous bone biopsy is an undemanding and inexpensive way to induce better chances to cure the patient and to adequately manage the microbiological epidemiology. [woundsresearch.com]

Pathophysiology

This review will focus on recent insights into the pathophysiology of renal bone disease, as highlighted by bone biopsy, and discuss implications for treatment. [ncbi.nlm.nih.gov]

Prevention

Avoiding sun exposure while taking tetracycline prevents skin photosensitivity. The patient should adhere strictly to the medication dosing and schedule to prevent problems in interpretation of the dynamic histomorphometry. [emedicine.medscape.com]

Oral prednisolone was initiated, and subsequently, pamidronate infusions were commenced in an attempt to prevent progression of osteoporosis. [ncbi.nlm.nih.gov]

• A comfort cap to make the procedure more comfortable once the stylet is removed as well as to prevent premature dislodging. [rimos.com]

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