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Bone Lymphoma

Primary Bone Lymphoma


Presentation

  • Pain was the most commonly presented symptom (67.5%), and the pelvis was the most frequently presented site (21.3%). Grade 2 and diffuse large B cell lymphoma comprised the majority of histologies (78.7% and 70.3%, respectively).[ncbi.nlm.nih.gov]
  • Long extremity bones were the most common presenting sites. Multifocal disease was present in three cases. Treatment modalities included surgery, chemotherapy, and radiotherapy.[ncbi.nlm.nih.gov]
  • The patient presented subacute low-back pain, initially with good response to corticosteroid treatment.Primary bone lymphoma is a very unusual disease, commonly affecting only 1 vertebra.[ncbi.nlm.nih.gov]
  • Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented.[ncbi.nlm.nih.gov]
  • Patients can present with pain, swelling or pathologic fracture. Definitive diagnosis is made after biopsy examination. Treatment consists of chemotherapy, radiotherapy and surgery. We report 3 male patients who presented with pain and swelling.[ncbi.nlm.nih.gov]
Generalized Lymphadenopathy
  • The patient had progressive generalized lymphadenopathy for the previous 3 years. Whole body bone scan for evaluation of bone pain showed multiple abnormal hot uptakes at the low sternal body and T8 and T10 vertebra.[ncbi.nlm.nih.gov]
Fishing
  • The diagnosis was confirmed with pathologic analysis, genetic karyotyping, positron emission and computed tomography scans, and fluorescence in situ hybridization (FISH).[ncbi.nlm.nih.gov]
  • Marrow samples can also be used for fluorescence in situ hybridization (FISH), flow cytometry, immunophenotyping, karyotype tests and polymerase chain reaction.[lls.org]
  • […] alone is treatment of choice - gives better response Radiotherapy may cause bone sarcoma Clinical images Femur Images hosted on other servers: Imaging of sacral lymphoma Gross description Usually small biopsy to avoid pathologic fracture disabilities Fish[pathologyoutlines.com]
Forearm Pain
  • The patient was a 14-year-old girl with left forearm pain and swelling after trauma. Six months later after the last chemotherapy and radiotherapy, pain and swelling of left knee was presented.[ncbi.nlm.nih.gov]
  • In this case report, we describe a male who presented with left-sided distal forearm pain, swelling of 2 months duration, and progressive limited wrist motion for about 1 month. The patient had no significant medical history except diabetes.[dovepress.com]
Swelling of the Finger
  • Abstract A 66-year-old woman presents with progressive bilateral swelling of her fingers, elbows, and toes.[ncbi.nlm.nih.gov]
Resistant Hypertension
  • hypertension without medication April 26, 2019 News Emory holds flag raising ceremony for National Donate Life Month April 24, 2019 News Emory Saint Joseph's Hospital achieves sixth consecutive Magnet designation for nursing excellence April 19, 2019[emoryhealthcare.org]
Low Back Pain
  • The patient presented subacute low-back pain, initially with good response to corticosteroid treatment.Primary bone lymphoma is a very unusual disease, commonly affecting only 1 vertebra.[ncbi.nlm.nih.gov]
Delayed Wound Healing
  • Another patient with involvement of the fibular head experienced foot drop and delayed wound healing. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography revealed complete response to the treatment.[ncbi.nlm.nih.gov]
Suggestibility
  • These findings suggest that pediatric and adult PBL-DLBCLs are distinct entities.[ncbi.nlm.nih.gov]
  • Paratrabecular nodules are characteristic and virtually diagnostic of involvement Diagnostic of involvement if there is a prior diagnosis of follicular lymphoma If no prior diagnosis we consider this to be highly suggestive Node biopsy, immunologic study[surgpathcriteria.stanford.edu]
  • Despite this variability, the presence of a solitary, permeative, metadiaphyseal lesion with a layered periosteal reaction on plain radiographs and a soft-tissue mass on MR images, especially in a patient older than 30 years, is highly suggestive of lymphoma[ncbi.nlm.nih.gov]
  • The natural history of the disease suggests that OL may be a distinct entity, different to nodal lymphomas, so the results of clinical trials in nodal lymphoma may not be relevant to OL.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: Relatively high rates of survival were achieved but the number of local failures suggests that the dose of radiotherapy should remain higher than it is for other types of lymphoma.[ncbi.nlm.nih.gov]
Urinary Retention
  • Abstract A 20-year-old student presented with 2 months history of fever and night sweats, 15 days history of low backache, progressive weakness of both limbs of 7 days duration, and urinary retention for last 24 h.[ncbi.nlm.nih.gov]
Foot Drop
  • Another patient with involvement of the fibular head experienced foot drop and delayed wound healing. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography revealed complete response to the treatment.[ncbi.nlm.nih.gov]

Workup

  • A positron emission tomography CT (PET-CT) performed as part of the staging workup revealed fluorodeoxyglucose avid lesions in the spine and left femur.[ncbi.nlm.nih.gov]

Treatment

  • Bone lymphoma may show osteosclerotic and osteolytic CT patterns at diagnosis, during treatment, and after treatment.[ncbi.nlm.nih.gov]
  • Three patients had fractures at presentation that persisted after treatment, one with recurrent lymphoma.[ncbi.nlm.nih.gov]
  • Treatment modalities included surgery, chemotherapy, and radiotherapy. Median follow-up was 8 years (range 0.5-18.5 years), and overall survival was 100%.[ncbi.nlm.nih.gov]
  • Medical records of 7 patients with PBL were reviewed and information on age at diagnosis, sex, NHL clinical staging (CS), treatment and response to treatment were retrieved.[ncbi.nlm.nih.gov]
  • Because it is not common, the optimal treatment strategy has not been established. Here, we present a patient with PBL of the left radius and review the related literature. We focus on the standard treatment for PBL.[ncbi.nlm.nih.gov]

Prognosis

  • Pediatric PBL-DLBCL has a favorable prognosis but remains poorly characterized. Herein, 10 such cases are detailed. They involved 11- to 20-year-old males with bone lesions that were often painful.[ncbi.nlm.nih.gov]
  • BACKGROUND: To the authors' knowledge, there is limited information on the preferred treatment and long-term prognosis of primary bone lymphomas (PBLs).[ncbi.nlm.nih.gov]
  • Clinical features, management and prognosis of 37 MB-DLBCL patients and 63 'controls' (stage-IV DLBCL and skeletal involvement) were analysed. Presentation and treatment of MB-DLBCL and controls were identical.[ncbi.nlm.nih.gov]
  • High baseline ECOG scores ( 2) and unachieved CR in initial therapy were factors for poor PB-DLBCL prognosis. The role of radiotherapy and rituximab in PLB therapy remains to be confirmed in further investigation.[ncbi.nlm.nih.gov]
  • The prognosis of primary bone lymphoma is generally good. Here, the current evidence for the optimal treatment of primary bone lymphoma is reviewed and questions for future investigation are addressed.[ncbi.nlm.nih.gov]

Epidemiology

  • […] lymphoma Primary bone lymphoma (PBL): defined as lymphoma presenting in an osseous site with no evidence of disease elsewhere for at least 6 months Presence of regional lymph nodes does not exclude the diagnosis of PBL ( Joint Bone Spine 2000;67:446 ) Epidemiology[pathologyoutlines.com]
  • The epidemiology of non-Hodgkin's lymphoma: comparison of nodal and extra-nodal sites. Int J Cancer 1997; 17: 923–30. 2. Conlan MG, Bast M, Armitage JO, Weisenburger DD.[caribbean.scielo.org]
  • (solitary site) most primary lymphomas of bone are Non-Hodgkin's B-cell lymphomas rather than T-cell variants diagnosed when there is only a single node of disease for six months multiple bony sites (no visceral sites) bone and soft tissue lymphoma Epidemiology[orthobullets.com]
Sex distribution
Age distribution

Pathophysiology

  • […] by lymphoma is more common than primary, considered to be stage IV Sites Any bone can be involved Usually sites of bone marrow, axial skeleton (spine), femur Common in metaphysis; presence in diaphysis or epiphysis probably means progressive disease Pathophysiology[pathologyoutlines.com]

Prevention

  • Although small numbers prevent firm conclusions, the inclusion of the whole bone or regional nodes in the irradiated volume did not appear to improve results.[ncbi.nlm.nih.gov]
  • […] for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Ram Prasad Peer reviewer comments 2 Editor who approved publication: Dr William Cho Chen Tian, Yong Yu, Hongliang Yang, Lei Zhu, Yafei Wang, Yizhuo Zhang Key Laboratory of Cancer Prevention[dovepress.com]
  • Platelets help to clot the blood to prevent bleeding. These stem cells develop into red blood cells, white blood cells and platelets. How transplants work You have a stem cell transplant after very high doses of chemotherapy.[cancerresearchuk.org]
  • Your doctor will use metal rods or plates and screws to fix a fracture or prevent bone breakage before it occurs.[orthoinfo.aaos.org]
  • Next you receive strong chemotherapy (and possibly radiation therapy) to attack your cancer cells, destroy or suppress your immune system and prevent your body from forming new blood cells.[seattlecca.org]

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