Edit concept Question Editor Create issue ticket

Bone Marrow Infiltration of Lymphoma

Lymphoma Involves Bone Marrow


Presentation

  • Peripheral lymphodenopathy associated with B symptoms is the commonest presentation. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease.[ncbi.nlm.nih.gov]
  • Peripheral lymphodenopathy associated with B symptoms is the commonest presentation. Bone marrow involvement is more common in our setup as patients usually presented at an advanced stage of disease. Statistics Article View: 278 PDF Download: 171[journal.waocp.org]
  • Conclusion: Bone marrow involvement in Non-Hod-gkin's Lymphoma is more common in our setup as patients presents at a later stage.[annalskemu.org]
  • Primary bone marrow lymphoma: An uncommon extranodal presentation of aggressive non-hodgkin lymphomas . American Journal of Surgical Pathology , 36 (2), 296-304.[moh-it.pure.elsevier.com]
  • Case report Case presentation A 76-year-old male with a past history of traumatic epilepsy presented to Shiga University of Medical Science Hospital (Otsu, Japan) with fever and fatigue.[spandidos-publications.com]
Suggestibility
  • Our findings suggest that bone marrow staging should not be restricted to the high risk cases alone.[ncbi.nlm.nih.gov]
  • Our data suggest that female patients benefit from rituximab containing regimens more than men, possibly due to higher serum levels throughout induction and maintenance.[haematologica.org]
  • Raghavachar A, Bartram CR, Ganser A, Heil G, Kleihauer E, Kubanek B (1986) Acute undifferentiated leukemia: implications for cellular origin and clonality suggested by analysis of surface markers and immunoglobulin gene rearrangement.[link.springer.com]
  • A diagnosis suggesting the possibility of HL was offered. The FNAC of lymph node offered a diagnosis suspicious of HD. BMB confirmed the involvement by HL.[cancerjournal.net]
  • The IGHV1-2 rearrangements in SMZL are characterized by minimal somatic mutations and longer complementarities determining region 3 sequence with common motifs, suggesting possible selection by superantigens. 31 Taken together, the above findings suggest[dovepress.com]

Workup

  • […] their relative rarity in the prevalent nonneoplastic polyclonal background cells, polymerase chain reaction (PCR) studies for immunoglobulin heavy chain (IGH) gene rearrangement are almost always negative and are not generally used in the diagnostic workup[clinicaladvisor.com]
  • Therefore, bone marrow biopsy is an important part of diagnostic workup before the treatment is instituted.[jpma.org.pk]

Treatment

  • Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection.[books.google.com]
  • We also observed an association between rituximab C trough levels and response to treatment.[haematologica.org]
  • Staging of Non-Hodgkin's Lymphoma is important for the management and treatment of the patient. Bone marrow biopsy is one of the initial inves-tigations carried out for staging of the disease along with other investigations.[annalskemu.org]
  • High-dose chemotherapy treatment with stem cell support. Radiotherapy. Temsirolimus is a possible treatment for relapsed or refractory mantle cell lymphoma but evidence is weak currently.[patient.info]
  • The most common type is external beam radiation therapy, which is a series of daily outpatient treatments to accurately deliver radiation to the cancer cells. Treatment sessions usually last less than 30 minutes.[physio-pedia.com]

Prognosis

  • Salles, “Biomarkers and Prognosis in Malignant Lymphomas,” Clinical Lymphoma Myeloma and Leukemia, Vol. 9, No. 2, 2009, pp. 160-166. [ 29 ] A. Nussenzweig and M. C.[scirp.org]
  • […] and likely to occur in atypical cases) deletion 13q14 (up to 50% of cases, better prognosis, involving a nontranscribed gene and two micro-RNA genes) deletion 11q22-q23 (20% of cases, poor prognosis, involving the ATM gene) deletion 17p13 (5-10% of cases[pleiad.umdnj.edu]
  • Prognosis Low-grade NHL types have a relatively good prognosis, with median survival as long as 10 years; however, they are usually not curable when advanced.[patient.info]
  • Although this finding has been associated with superior disease-free survival in young, immunocompetent CHL patients, it is associated with a worse prognosis in elderly patients.[clinicaladvisor.com]
  • Staging investigations performed at the time of diagnosis for patients with Hodgkin lymphoma are vital for determining the appropriate treatment and prognosis.[cancerjournal.net]

Etiology

  • More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up.[books.google.com]
  • However, the location and distribution of marrow abnormality can often provide a clue to both etiology and, if related to trauma, the mechanism of injury.[jaocr.org]
  • An elevated number of AIDS patients have B symptoms and pancytopenia, and BM biopsy should be performed when other etiologies are excluded.[cancerbiomed.org]
  • High-risk groups includes those who have received an organ transplant or who have a suppressed immune system." [3] "Several possible etiologic mechanisms are hypothesized for NHL.[physio-pedia.com]
  • Epidemiology and etiology SMZL is a rare hematological malignancy, often with a chronic clinical course, affecting mainly elderly people with a median age of 65 years at diagnosis and no incidence differences between sexes. 2 Chronic antigenic stimulus[dovepress.com]

Epidemiology

  • More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up.[books.google.com]
  • […] lymphoma Primary bone lymphoma (PBL): defined as lymphoma presenting in an osseous site with no evidence of disease elsewhere for at least 6 months Presence of regional lymph nodes does not exclude the diagnosis of PBL ( Joint Bone Spine 2000;67:446 ) Epidemiology[pathologyoutlines.com]
  • Genetics [ edit ] Clonal rearrangements of the immunoglobulin genes (heavy and light chains) are frequently seen. [11] The deletion 7q21-32 is seen in 40% of SMZL patients, and translocations of the CDK6 gene located at 7q21 have also been reported. [12] Epidemiology[en.wikipedia.org]
  • Leuk Lymph. 48:1139–1149. 2007. 5 Váróczy L, Gergely L, Zeher M, Szegedi G and Illés A: Malignant lymphoma-associated autoimmune diseases-a descriptive epidemiological study.[spandidos-publications.com]
  • Epidemiology NHL is more than five times as common as Hodgkin's disease.[patient.info]
Sex distribution
Age distribution

Pathophysiology

  • […] by lymphoma is more common than primary, considered to be stage IV Sites Any bone can be involved Usually sites of bone marrow, axial skeleton (spine), femur Common in metaphysis; presence in diaphysis or epiphysis probably means progressive disease Pathophysiology[pathologyoutlines.com]
  • In: The human bone marrow: anatomy, physiology, and pathophysiology. Boca Raton, Fla: CRC 1982:43-75. De Bruyn PPH, Breen PC, Thomas TB. The microcirculation of the bone marrow. Anat Rec 1970;168:55-68. Kuntz A, Richins CA.[jaocr.org]

Prevention

  • There usually is a fine reticulin fibrosis seen (with reticulin stain, not shown), which usually prevents these cells from being detected by flow cytometry or be seen on the aspirate smears. Download Image Views: 776 Downloads: 23 Size: 0.14 MB[imagebank.hematology.org]
  • Nucleosides: These inhibit DNA and RNA replication and thereby prevent cancer cells from growing [10] .[physio-pedia.com]
  • Louis). 30 After lysis, the purged samples were washed in medium containing 2.5 mg of deoxyribonuclease per milliliter (Sigma) to prevent cell clumping.[nejm.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!