A 30-year-old male was admitted to our hospital with a complaint of abdominal distension, fatigue, and anorexia for 2 months. [ncbi.nlm.nih.gov]

Cancer Related Fatigue When it comes to cancer-related fatigue, this affects up to 80% to 90% of persons with cancer. It is more severe than what we refer to as general fatigue when people sort of say, “I’m tired,” but it’s not the same. [melioguide.com]

Signs of hypercalcemia include fatigue, rash, weakness and weight loss. How Are Metastatic Bone Lesions Found? They may be discovered as a result of an investigation into a new onset of pain, paralysis or other symptoms. [cancerliving.today]

Patients during/after RT often suffer from the RT‐related toxicities including radiation sickness, fatigue, nausea, vomiting, mucous membrane disorder, etc. [intechopen.com]

Bone pain that is worse at night Discomfort when you walk or sit, or trouble finding a comfortable position Fatigue or weakness Bone fractures Numb area, trouble moving a body part, or trouble urinating Weight loss without trying, or loss of appetite [drugs.com]

We report the case of an 11-year-old boy who came to our observation with localized pain in the left arm for nearly 5 months. No previous history of trauma was referred in an otherwise healthy patient. [ncbi.nlm.nih.gov]

Radiation therapy can help to relieve localized pain due to bone metastasis. It is delivered via various means. [cancerliving.today]

Local pain usually precedes radicular pain and may predate the appearance of other neurologic signs by weeks or months. Most patients with spinal cord compression will have weakness or paralysis. [doi.org]

The plethora of ongoing clinical trials will hopefully translate into improved treatments options for patients suffering from bone metastatic cancers. [ncbi.nlm.nih.gov]

Osteoblasts synthesize a plethora of biologically active factors, which comprise the unique bone microenvironment. [kluedo.ub.uni-kl.de]

He had a history of myelodysplastic syndrome and refractory anemia with ringed sideroblasts diagnosed 5 years earlier. [ncbi.nlm.nih.gov]

Oxycodone was also administered but discontinued due to nausea. [ncbi.nlm.nih.gov]

When it does occur, signs and symptoms of bone metastasis include: Bone pain Broken bones Urinary incontinence Bowel incontinence Weakness in the legs or arms High levels of calcium in the blood (hypercalcemia), which can cause nausea, vomiting, constipation [mayoclinic.org]

High blood levels of calcium can lead to other problems such as loss of appetite, excessive thirst, nausea and constipation. As the cancer dissolves the bone, it breaks easily. [novartisoncology.com]

Case 2: Clinical history A 48 year-old white woman presented with a four-week history of left lower quadrant abdominal pain. [bmcclinpathol.biomedcentral.com]

High calcium can cause constipation, which can result in abdominal pain, and with very high calcium levels, confusion and mental status changes can occur. [oncolink.org]

Metastatic disease to the liver causes jaundice, elevated liver enzymes, abdominal pain, loss of appetite, nausea, and vomiting. Metastatic breast cancer to the lung or pleura causes chronic cough, dyspnea, abnormal chest x-ray, and chest pain. [breast-cancer.ca]

Non-steroidal anti-inflammatory drugs and zoledronic acid were administered for back pain. Oxycodone was also administered but discontinued due to nausea. [ncbi.nlm.nih.gov]

CHATZIIOANNOU, Pancreatic cancer's initial presentation: back pain due to osteoblastic bone metastasis, European Journal of Cancer Care, 19, 1, (137), (2010). M. Beheshti, C. Pirich and W. [doi.org]

The patient developed low back pain due to unknown etiology, 3 months after surgery. A follow-up 18F-FDG PET/CT scan demonstrated multifocal bone destruction. Unfortunately, the patient died 12 months after surgery. [ncbi.nlm.nih.gov]

Evaluation and Treatment of Acute Low Back Pain. Am Fam Physician 2007; 75: 1181-8. How to Cite 1. Komadina R, Špiler M, Grabljevec K, Snoj M. BONE METASTATIC DISEASE AND SKELETAL RELATED EVENTS – national recommendations. [vestnik.szd.si]

Randomized Trial Comparing Interferential Therapy With Motorized Lumbar Traction and Massage in the Management of Low Back Pain in a Primary Care Setting. [psychfysio.nl]

MRI T2W sagittal image showing (a) metastasis with cord compression (prostate) [4] Differential Diagnosis Multiple Myeloma Infection Primary sarcoma Arthritis Low Back Pain Traumatic Fracture Aetiology Metastatic bone cancer starts with a tumor within [physio-pedia.com]

Discussion N-BPs are highly effective therapeutic agents routinely used for the treatment of bone disorders, particularly tumor-induced bone disease. [ncbi.nlm.nih.gov]

A 73-year-old man complained of sternoclavicular joint pain; blood tests revealed elevated C-reactive protein. The patient developed delirium; magnetic resonance imaging showed metastatic bone tumors. He died two weeks after admission. [ncbi.nlm.nih.gov]

The authors report a unique case of occult prostate cancer that presented with an anterior midline neck mass diagnosed as a thyroglossal duct cyst. [ncbi.nlm.nih.gov]

The EORTC QLQ-C30 scale at 1 month demonstrated significant improvement (P 0.05) in the physical (P 0.03) and emotion function (P 0.003), global health status (P 0.002), pain (P 0.001) and insomnia (P 0.002). [ncbi.nlm.nih.gov]

For histologic tissue sections, bone is stained green, whereas bone marrow and tumor cells (asterisk) are stained red. (E) Fluorescence analyses of B02-GFP/βGal tumor cells residing in bone. Arrows indicate fluorescent tumor cells. [ncbi.nlm.nih.gov]

The pathological findings of resected rib bones exhibited hypercellular bone marrow without excess of blasts. [ncbi.nlm.nih.gov]