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Bone Marrow Transplant

BMT Complications


Presentation

  • We report a 13-year-old girl who presented with typical LyP and pathological features of subtype A. Six months later, the patient presented with rapidly progressive peripheral and systemic lymphadenopathy.[ncbi.nlm.nih.gov]
Persistent Vomiting
  • Over time, he was non-ambulatory and his GI symptoms got progressively worse with severe dysphagia, abdominal pain episodes, persistent vomiting and diarrhea.[ncbi.nlm.nih.gov]
Foreign Body Sensation
  • Two years after the transplant the patient developed violaceous lichenoid papules coalescing into plaques over the face and upper extremities complaining of decrease visual acuity, foreign body sensation, and eye pain.[ncbi.nlm.nih.gov]
Photosensitivity
  • Abstract XLP is an erythroid porphyria that results in variable cutaneous photosensitivity due to accumulation of protoporphyrin.[ncbi.nlm.nih.gov]
Papule
  • Two years after the transplant the patient developed violaceous lichenoid papules coalescing into plaques over the face and upper extremities complaining of decrease visual acuity, foreign body sensation, and eye pain.[ncbi.nlm.nih.gov]
Cutaneous Manifestation
  • Tacrolimus, a macrolide immunosuppressant, is used topically for the treatment of cutaneous manifestations of graft-versus-host disease (GVHD) for rapid, symptomatic relief of pruritus and erythema.[ncbi.nlm.nih.gov]
Peripheral Neuropathy
  • The patient was receiving treatment with lidocaine patch 5% (two patches daily, which was started five months before another hospital admission for the treatment of vincristine-related peripheral neuropathy.[ncbi.nlm.nih.gov]

Workup

  • Transplant workup: On the first day, you will meet with your primary provider and team nurse to discuss your health history, have a physical exam and blood draw, tour the clinic, get consent forms to review and receive your transplant manual.[seattlecca.org]
  • When donors are requested, they undergo a workup that includes laboratory testing and viral screening, physical examination, and an informational session. When donor approval has been obtained, a date is set for the collection.[emedicine.medscape.com]
  • […] establishing the differential diagnosis. 7,11,13 Bronchoalveolar lavage (BAL) may prove necessary (revealing typical increments in tumor necrosis factor-alpha, TNF-alpha), together with transbronchial biopsy, with the purpose of completing the diagnostic workup[medintensiva.org]
  • Table 2 Transplant features ( n 30) Pretransplant workup was as appropriate to ensure adequate organ function and to establish disease status.[doi.org]
Total Bilirubin Increased
  • His total bilirubin increased to 2.8 mg/dL, and his body weight increased by 15%. An abdominal ultrasound noted ascites and hepatomegaly without reversal of blood flow.[ncbi.nlm.nih.gov]
Alternaria
  • Alternaria spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients, such as bone marrow transplant recipients.[ncbi.nlm.nih.gov]

Treatment

  • In a multivariate analysis on all 2479 patients, year of treatment, age and the interval between diagnosis and treatment were the three significant predictors of outcome.[dx.doi.org]
  • Surgical resection is often challenging but remains a well-established treatment option. Chemotherapy is often reserved for recurrent or refractory cases, but the goal of treatment is usually palliative.[ncbi.nlm.nih.gov]

Prognosis

  • CNS involvement is usually associated with a poor prognosis and increased mortality.[ncbi.nlm.nih.gov]
  • […] to be stored, but a limited amount of GVHD may have an anti-tumour effect) don’t take an entirely nihilistic approach to these patients if marrow recovery is imminent. however, prolonged ventilation and/or dialysis in these patients results in a poor prognosis[lifeinthefastlane.com]
  • TOPICS: Background About HLA Typing Types of donors Phases Relapse after allogeneic transplant Donor Lymphocyte Infusions Q&A Resources Research News In the News PubMed TOPIC SEARCH: Review Therapy Prognosis GVHD ...[lymphomation.org]
  • Forecast bone marrow transplant The prognosis varies widely depending on the type of disease, the stadium, the source of stem cells, HLA compatibility and conditioning regimen.[topdoctors.es]
  • Factors of importance for a more favorable prognosis are lower age, response to chemotherapy, only one course of primary chemotherapy, stage I or II disease, and low beta(2)-microglobulin at diagnosis.[unboundmedicine.com]

Etiology

  • The etiology of post-BMT TMA is thought to be multifactorial, including the effects of immunosuppressive agents, viral infections, TBI and GvHD.[ncbi.nlm.nih.gov]
  • There is no clear etiological treatment.[medintensiva.org]
  • Their positivity may suggest a fungal etiology, and in the case of galactomannan, indicate the specific cause.[bmtcare.com]

Epidemiology

  • Abstract To describe the epidemiology of BKV and to assess the presence of the African variant in bone marrow and kidney transplant patients who have suspected BKV reactivation.[ncbi.nlm.nih.gov]
  • Kyle Springer Science & Business Media , 31 lug 2012 - 1431 pagine Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology.[books.google.it]
  • He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education.[lifeinthefastlane.com]
  • Epidemiology of early post-transplant infections In the last two decades, the epidemiology of bacteremia in neutropenic patients has changed: the constant prevalence of Gram-positive microorganisms has replaced the re-emergence of Gram-negative bacilli[bmtcare.com]
Sex distribution
Age distribution

Pathophysiology

  • Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology.[doi.org]
  • This review focuses on diagnostic criteria, pathophysiology, treatment and renal outcomes of post-BMT TMA.[ncbi.nlm.nih.gov]
  • Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver[books.google.it]
  • Despite lack of clinical benefit in patients with progressive multiple sclerosis, magnetic resonance imaging evidence of inflammation was abrogated, while loss of brain volume continued for 2 years before subsiding. 41 In retrospect, the predominant pathophysiology[dx.doi.org]

Prevention

  • CONCLUSION: To prevent a similar case in the future, we will begin Gram staining all HCT products in transit more than 24 hours to alert physicians of the need for prophylactic antibiotic therapy. 2012 American Association of Blood Banks.[ncbi.nlm.nih.gov]
  • Careful monitoring, use of medicines to treat or prevent infections, and other forms of supportive care can help your child to feel as comfortable as possible.[curesearch.org]

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