Presentation
We report a 13-year-old girl who presented with typical LyP and pathological features of subtype A. Six months later, the patient presented with rapidly progressive peripheral and systemic lymphadenopathy. [ncbi.nlm.nih.gov]
Gastrointestinal
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Persistent Vomiting
Over time, he was non-ambulatory and his GI symptoms got progressively worse with severe dysphagia, abdominal pain episodes, persistent vomiting and diarrhea. [ncbi.nlm.nih.gov]
Skin
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Papule
Two years after the transplant the patient developed violaceous lichenoid papules coalescing into plaques over the face and upper extremities complaining of decrease visual acuity, foreign body sensation, and eye pain. [ncbi.nlm.nih.gov]
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Photosensitivity
Abstract XLP is an erythroid porphyria that results in variable cutaneous photosensitivity due to accumulation of protoporphyrin. [ncbi.nlm.nih.gov]
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Cutaneous Manifestation
Tacrolimus, a macrolide immunosuppressant, is used topically for the treatment of cutaneous manifestations of graft-versus-host disease (GVHD) for rapid, symptomatic relief of pruritus and erythema. [ncbi.nlm.nih.gov]
Eyes
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Foreign Body Sensation
Two years after the transplant the patient developed violaceous lichenoid papules coalescing into plaques over the face and upper extremities complaining of decrease visual acuity, foreign body sensation, and eye pain. [ncbi.nlm.nih.gov]
Neurologic
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Peripheral Neuropathy
The patient was receiving treatment with lidocaine patch 5% (two patches daily, which was started five months before another hospital admission for the treatment of vincristine-related peripheral neuropathy. [ncbi.nlm.nih.gov]
Workup
Transplant workup: On the first day, you will meet with your primary provider and team nurse to discuss your health history, have a physical exam and blood draw, tour the clinic, get consent forms to review and receive your transplant manual. [seattlecca.org]
When donors are requested, they undergo a workup that includes laboratory testing and viral screening, physical examination, and an informational session. When donor approval has been obtained, a date is set for the collection. [emedicine.medscape.com]
[…] establishing the differential diagnosis. 7,11,13 Bronchoalveolar lavage (BAL) may prove necessary (revealing typical increments in tumor necrosis factor-alpha, TNF-alpha), together with transbronchial biopsy, with the purpose of completing the diagnostic workup [medintensiva.org]
Table 2 Transplant features ( n 30) Pretransplant workup was as appropriate to ensure adequate organ function and to establish disease status. [doi.org]
Serum
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Total Bilirubin Increased
His total bilirubin increased to 2.8 mg/dL, and his body weight increased by 15%. An abdominal ultrasound noted ascites and hepatomegaly without reversal of blood flow. [ncbi.nlm.nih.gov]
Microbiology
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Alternaria
Alternaria spp. have emerged as opportunistic pathogens particularly in immunosuppressed patients, such as bone marrow transplant recipients. [ncbi.nlm.nih.gov]
Treatment
In a multivariate analysis on all 2479 patients, year of treatment, age and the interval between diagnosis and treatment were the three significant predictors of outcome. [haematologica.org]
The patient was receiving treatment with lidocaine patch 5% (two patches daily, which was started five months before another hospital admission for the treatment of vincristine-related peripheral neuropathy. [ncbi.nlm.nih.gov]
Prognosis
CNS involvement is usually associated with a poor prognosis and increased mortality. [ncbi.nlm.nih.gov]
[…] to be stored, but a limited amount of GVHD may have an anti-tumour effect) don’t take an entirely nihilistic approach to these patients if marrow recovery is imminent. however, prolonged ventilation and/or dialysis in these patients results in a poor prognosis [lifeinthefastlane.com]
TOPICS: Background About HLA Typing Types of donors Phases Relapse after allogeneic transplant Donor Lymphocyte Infusions Q&A Resources Research News In the News PubMed TOPIC SEARCH: Review Therapy Prognosis GVHD ... [lymphomation.org]
Two months later, the toddler was diagnosed with sepsis and faced a grim prognosis. "We truly didn’t know if Finnley was ever going to wake up," Whitmore said. [abcnews.go.com]
Forecast bone marrow transplant The prognosis varies widely depending on the type of disease, the stadium, the source of stem cells, HLA compatibility and conditioning regimen. [topdoctors.es]
Etiology
The etiology of post-BMT TMA is thought to be multifactorial, including the effects of immunosuppressive agents, viral infections, TBI and GvHD. [ncbi.nlm.nih.gov]
There is no clear etiological treatment. [medintensiva.org]
Their positivity may suggest a fungal etiology, and in the case of galactomannan, indicate the specific cause. [bmtcare.com]
Epidemiology
Abstract To describe the epidemiology of BKV and to assess the presence of the African variant in bone marrow and kidney transplant patients who have suspected BKV reactivation. [ncbi.nlm.nih.gov]
An exceptional outcome Keener was so thankful and invigorated by her recovery that she soon returned to Dana-Farber/Boston Children’s as a part-time researcher in Epidemiology. [blog.dana-farber.org]
He has since completed further training in emergency medicine, clinical toxicology, clinical epidemiology and health professional education. [lifeinthefastlane.com]
Kyle Springer Science & Business Media, 31 lug 2012 - 1431 pagine Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. [books.google.it]
Pathophysiology
Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology. [doi.org]
This review focuses on diagnostic criteria, pathophysiology, treatment and renal outcomes of post-BMT TMA. [ncbi.nlm.nih.gov]
Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver [books.google.it]
Despite lack of clinical benefit in patients with progressive multiple sclerosis, magnetic resonance imaging evidence of inflammation was abrogated, while loss of brain volume continued for 2 years before subsiding. 41 In retrospect, the predominant pathophysiology [dx.doi.org]
Prevention
It might be possible to prevent or slow the onset of corneal clouding by treating the cornea with drugs known to prevent myofibroblast conversion. Copyright 2016 Elsevier Ltd. All rights reserved. [ncbi.nlm.nih.gov]
One of the most effective ways to prevent this reaction is to remove the lymphocytes from the transplanted marrow. [clinicaltrials.gov]
During these procedures, patients first undergo chemotherapy and/or radiation to destroy their diseased bone marrow and to prevent rejection of donor cells. [ptcommunity.com]