We report a 13-year-old girl who presented with typical LyP and pathological features of subtype A. Six months later, the patient presented with rapidly progressive peripheral and systemic lymphadenopathy. [ncbi.nlm.nih.gov]

Yi-Bin Chen, Director of the MGH BMT Program, gave two oral presentations on recent clinical trials. [massgeneral.org]

• Fatigue

  The patient may also become easily fatigued and develop muscle aches. Sometimes GVHD can become disabling, and if it's severe enough, it can be life-threatening. Drugs that affect the immune system may be given to try to control it. [cancer.org]

  More than 70% of donors reported some degree of myalgia, headache, or fatigue, with smaller percentages reporting insomnia, nausea, fever, emesis, or other symptoms ( Figure 2 A). [doi.org]

  Patients who undergo BMT and PBSCT may experience short-term side effects such as nausea, vomiting, fatigue, loss of appetite, mouth sores, hair loss, and skin reactions. [cancer.gov]

• Collapse

  Due to small numbers, patients with scores of 4 or more were collapsed into one group. [doi.org]

• Asymptomatic

  He remained asymptomatic at the time of publication. Fig. 5 Evaluation of clinical responses after infusion of CART19 cells. ( A ) UPN 02 was treated with two cycles of rituximab and bendamustine with minimal response (R/B, arrows). [stm.sciencemag.org]

  Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial. Lancet 2003; 362 : 516–522. 50. [nature.com]

• Malaise

  Corticosteroid treatment was started on day 18 after infusion because of malaise and noninfectious febrile syndrome. [stm.sciencemag.org]

• Aspiration

  These cells can be ”collected” either by performing repeated bone marrow aspirations or by “mobilizing” HSCs into the circulation using special medications called cytokines (like GCSF, also called neupogen), and filtering them out of your blood using [cumc.columbia.edu]

  41.0 Bone marrow or hematopoietic stem cell transplant Note: To report donor source - see codes 00.91-00.93 Excludes: aspiration of bone marrow from donor (41.91) [icd9cm.chrisendres.com]

  In this procedure, the donor is placed under anesthesia, and bone marrow aspiration is performed, typically taking marrow from the iliac crest of the hip or from the breastbone. [britannica.com]

  Donors have commented that their buttocks felt sore for several days after aspiration. Contrary to organ donations, marrow is completely replenished by the body within a couple of weeks. There are no increased risks to the donor during this period. [cityofhope.org]

• Headache

  After bone pain and myalgia, headache was the most commonly reported symptom with 26% of donors experiencing headache of grade II or higher at some point during mobilization and collection ( Figure 2 A). [doi.org]

  Potential side effects: Lowers blood counts Nausea, vomiting Irritation and sores in the mouth and intestinal tract Hair loss Rash, itchy skin Irritation and damage to the bladder (rare) Headache, dizziness Bronzing and peeling of the skin. [ucsfbenioffchildrens.org]

• Dizziness

  Others risk factors include infection, allergic reactions, headaches, dizziness and nausea. Some may also have difficulty breathing and eating, as well as develop fertility issues. Donor A donor is needed for allogenic transplants. [docdoc.com.sg]

  Declared anemic after an annual physical, she ignored the dizzy spells, shortness of breath, and bruises on her legs. [blog.dana-farber.org]

  Potential side effects: Lowers blood counts Nausea, vomiting Irritation and sores in the mouth and intestinal tract Hair loss Rash, itchy skin Irritation and damage to the bladder (rare) Headache, dizziness Bronzing and peeling of the skin. [ucsfbenioffchildrens.org]

• Ataxia

  […] aspergillosis (main cause), CMV, HSV, Toxoplasma, Candida, Cryptococcus, bacterial meningitis prognosis is extremely poor Metabolic Encephalopathy > in allogenic transplantation altered mental status, seizures, Wernicke encephalopathy (altered mental status, ataxia [lifeinthefastlane.com]

  A 37-year-old woman with paresthesias and ataxia. N Engl J Med 2010; 362:1129-38. [dfhcc.harvard.edu]

Transplant workup: On the first day, you will meet with your primary provider and team nurse to discuss your health history, have a physical exam and blood draw, tour the clinic, get consent forms to review and receive your transplant manual. [seattlecca.org]

When donors are requested, they undergo a workup that includes laboratory testing and viral screening, physical examination, and an informational session. When donor approval has been obtained, a date is set for the collection. [emedicine.medscape.com]

[…] establishing the differential diagnosis. 7,11,13 Bronchoalveolar lavage (BAL) may prove necessary (revealing typical increments in tumor necrosis factor-alpha, TNF-alpha), together with transbronchial biopsy, with the purpose of completing the diagnostic workup [medintensiva.org]

Table 2 Transplant features ( n =30) Pretransplant workup was as appropriate to ensure adequate organ function and to establish disease status. [doi.org]

The bottom line for our patients is that our research fuels innovative treatment options. [cancer.uams.edu]

Why are BMT and PBSCT used in cancer treatment? One reason BMT and PBSCT are used in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy. [cancer.gov]

The stem cells are then put back (reinfused) into the patient’s blood after treatment. [cancer.org]

As active members of the international cancer research community, our oncologists also collaborate with other research centers to offer patients the most promising treatments available. [weillcornell.org]

City of Hope has pioneered several outstanding advances for the prevention and treatment of this potentially fatal complication. [cityofhope.org]

CNS involvement is usually associated with a poor prognosis and increased mortality. [ncbi.nlm.nih.gov]

[…] to be stored, but a limited amount of GVHD may have an anti-tumour effect) don’t take an entirely nihilistic approach to these patients if marrow recovery is imminent. however, prolonged ventilation and/or dialysis in these patients results in a poor prognosis [lifeinthefastlane.com]

Factors of importance for a more favorable prognosis are lower age, response to chemotherapy, only one course of primary chemotherapy, stage I or II disease, and low beta(2)-microglobulin at diagnosis. [unboundmedicine.com]

Two months later, the toddler was diagnosed with sepsis and faced a grim prognosis. "We truly didn’t know if Finnley was ever going to wake up," Whitmore said. [abcnews.go.com]

[…] with aggressive lymphoma: Updated results of the randomized LNH-93-3 study (1997) Blood, 90, p. 594., Supply 1pt_BR dc.description.referenceGisselbrecht, C., Lepage, E., Molina, T., Shortened first-line high-dose chemotherapy for patients with poor-prognosis [repositorio.unicamp.br]

The etiology of post-BMT TMA is thought to be multifactorial, including the effects of immunosuppressive agents, viral infections, TBI and GvHD. [ncbi.nlm.nih.gov]

There is no clear etiological treatment. [medintensiva.org]

Their positivity may suggest a fungal etiology, and in the case of galactomannan, indicate the specific cause. [bmtcare.com]

Abstract To describe the epidemiology of BKV and to assess the presence of the African variant in bone marrow and kidney transplant patients who have suspected BKV reactivation. [ncbi.nlm.nih.gov]

Epidemiology of early post-transplant infections In the last two decades, the epidemiology of bacteremia in neutropenic patients has changed: the constant prevalence of Gram-positive microorganisms has replaced the re-emergence of Gram-negative bacilli [bmtcare.com]

Kyle Springer Science & Business Media, 31 lug 2012 - 1431 pagine Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. [books.google.it]

An exceptional outcome Keener was so thankful and invigorated by her recovery that she soon returned to Dana-Farber/Boston Children’s as a part-time researcher in Epidemiology. [blog.dana-farber.org]

Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology. [doi.org]

This review focuses on diagnostic criteria, pathophysiology, treatment and renal outcomes of post-BMT TMA. [ncbi.nlm.nih.gov]

Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver [books.google.it]

Despite lack of clinical benefit in patients with progressive multiple sclerosis, magnetic resonance imaging evidence of inflammation was abrogated, while loss of brain volume continued for 2 years before subsiding. 41 In retrospect, the predominant pathophysiology [oadoi.org]

Doctors may give the patient antibiotics to prevent or treat infection. They may also give the patient transfusions of platelets to prevent bleeding and red blood cells to treat anemia. [cancer.gov]

Careful monitoring, use of medicines to treat or prevent infections, and other forms of supportive care can help your child to feel as comfortable as possible. [curesearch.org]

In order to prevent rejection, the donors for CGD patients should be a close a match as possible. [livingwithcgd.org]

City of Hope has pioneered several outstanding advances for the prevention and treatment of this potentially fatal complication. [cityofhope.org]