Presentation
We report a 13-year-old girl who presented with typical LyP and pathological features of subtype A. Six months later, the patient presented with rapidly progressive peripheral and systemic lymphadenopathy. [ncbi.nlm.nih.gov]
Yi-Bin Chen, Director of the MGH BMT Program, gave two oral presentations on recent clinical trials. [massgeneral.org]
Entire Body System
- Hodgkin Lymphoma
The review highlights the most relevant studies on autologous stem cell transplantation for non-Hodgkin lymphoma at diagnosis published over the past year. [journals.lww.com]
[…] in the first line treatment of aggressive non-Hodgkin Lymphoma (NHL) in adults (2008) Cochrane Database Syst Rev, 23 (1), pp. [repositorio.unicamp.br]
Zinzani PL, Martelli M, Poletti V et al (2008) Practice guidelines for the management of extranodal non-Hodgkin’s lymphomas of adult non-immunodeficient patients. Part I: primary lung and mediastinal lymphomas. [link.springer.com]
Santini G, Salvagno L, Leoni T, et al: VACOP-B versus VACOP-B plus autologous bone marrow transplantation for advanced diffuse non-Hodgkin’s lymphoma: results of a prospective trial by the Non-Hodgkin’s Lymphoma Cooperative study group. [karger.com]
- Surgical Procedure
The risk of side effects of anesthesia during bone marrow donation is similar to that during other surgical procedures. Serious side effects of anesthesia are rare. [bloodcell.transplant.hrsa.gov]
Bone Marrow Cleveland Clinic has performed these procedures since 1976. A bone marrow harvest is done as an outpatient surgical procedure, with the patient (donor) under general anesthesia. [my.clevelandclinic.org]
It is not a surgical procedure to place the marrow into the bone, but is similar to receiving a blood transfusion. The stem cells find their way into the bone marrow and begin reproducing and growing new, healthy blood cells. [urmc.rochester.edu]
The cells may be 'harvested" from the donor's bone marrow through a surgical procedure, or acquired from the donor's peripheral blood.* * The latter method of obtain stem cells has become more common. peripheral blood stem cell transplant, PBSCT The goal [lymphomation.org]
Jaw & Teeth
- Oral Ulcers
In patients treated with radiochemotherapy for head and neck cancer, the prevalence of oral HSV infection increases up to 43.2% (CI, 0–100%). Prevalence of HSV infection was higher when oral ulcers existed. [springerlink.com]
Eyes
- Visual Impairment
We describe a 5 1/2 year old boy who was diagnosed with mild autosomal recessive osteopetrosis based on the presence of bony sclerosis, extramedullary haematopoeisis, leukoerythroblastosis and visual impairment who had an allogeneic bone marrow transplant [ncbi.nlm.nih.gov]
Published: 15/06/2016 Edited by: Patricia Pujante Crespo Transplantation of hematopoietic precursors or marrow transplantation is not without some risks or complications for the Visually Impaired or hematologic diseases, but there are hardly any risks [topdoctors.es]
Workup
Transplant workup: On the first day, you will meet with your primary provider and team nurse to discuss your health history, have a physical exam and blood draw, tour the clinic, get consent forms to review and receive your transplant manual. [seattlecca.org]
When donors are requested, they undergo a workup that includes laboratory testing and viral screening, physical examination, and an informational session. When donor approval has been obtained, a date is set for the collection. [emedicine.medscape.com]
[…] establishing the differential diagnosis. 7,11,13 Bronchoalveolar lavage (BAL) may prove necessary (revealing typical increments in tumor necrosis factor-alpha, TNF-alpha), together with transbronchial biopsy, with the purpose of completing the diagnostic workup [medintensiva.org]
Table 2 Transplant features ( n =30) Pretransplant workup was as appropriate to ensure adequate organ function and to establish disease status. [doi.org]
Treatment
The bottom line for our patients is that our research fuels innovative treatment options. [cancer.uams.edu]
Why are BMT and PBSCT used in cancer treatment? One reason BMT and PBSCT are used in cancer treatment is to make it possible for patients to receive very high doses of chemotherapy and/or radiation therapy. [cancer.gov]
The stem cells are then put back (reinfused) into the patient’s blood after treatment. [cancer.org]
As active members of the international cancer research community, our oncologists also collaborate with other research centers to offer patients the most promising treatments available. [weillcornell.org]
City of Hope has pioneered several outstanding advances for the prevention and treatment of this potentially fatal complication. [cityofhope.org]
Prognosis
CNS involvement is usually associated with a poor prognosis and increased mortality. [ncbi.nlm.nih.gov]
[…] to be stored, but a limited amount of GVHD may have an anti-tumour effect) don’t take an entirely nihilistic approach to these patients if marrow recovery is imminent. however, prolonged ventilation and/or dialysis in these patients results in a poor prognosis [lifeinthefastlane.com]
Factors of importance for a more favorable prognosis are lower age, response to chemotherapy, only one course of primary chemotherapy, stage I or II disease, and low beta(2)-microglobulin at diagnosis. [unboundmedicine.com]
Two months later, the toddler was diagnosed with sepsis and faced a grim prognosis. "We truly didn’t know if Finnley was ever going to wake up," Whitmore said. [abcnews.go.com]
[…] with aggressive lymphoma: Updated results of the randomized LNH-93-3 study (1997) Blood, 90, p. 594., Supply 1pt_BR dc.description.referenceGisselbrecht, C., Lepage, E., Molina, T., Shortened first-line high-dose chemotherapy for patients with poor-prognosis [repositorio.unicamp.br]
Etiology
The etiology of post-BMT TMA is thought to be multifactorial, including the effects of immunosuppressive agents, viral infections, TBI and GvHD. [ncbi.nlm.nih.gov]
There is no clear etiological treatment. [medintensiva.org]
Their positivity may suggest a fungal etiology, and in the case of galactomannan, indicate the specific cause. [bmtcare.com]
Epidemiology
Abstract To describe the epidemiology of BKV and to assess the presence of the African variant in bone marrow and kidney transplant patients who have suspected BKV reactivation. [ncbi.nlm.nih.gov]
Epidemiology of early post-transplant infections In the last two decades, the epidemiology of bacteremia in neutropenic patients has changed: the constant prevalence of Gram-positive microorganisms has replaced the re-emergence of Gram-negative bacilli [bmtcare.com]
Kyle Springer Science & Business Media, 31 lug 2012 - 1431 pagine Neoplastic Diseases of the Blood integrates the history, epidemiology, pathology, pathophysiology, and therapeutics of modern neoplastic hematopathology. [books.google.it]
An exceptional outcome Keener was so thankful and invigorated by her recovery that she soon returned to Dana-Farber/Boston Children’s as a part-time researcher in Epidemiology. [blog.dana-farber.org]
Pathophysiology
Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which immune mechanisms appear to be an important component of the pathophysiology. [doi.org]
This review focuses on diagnostic criteria, pathophysiology, treatment and renal outcomes of post-BMT TMA. [ncbi.nlm.nih.gov]
Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver [books.google.it]
Despite lack of clinical benefit in patients with progressive multiple sclerosis, magnetic resonance imaging evidence of inflammation was abrogated, while loss of brain volume continued for 2 years before subsiding. 41 In retrospect, the predominant pathophysiology [oadoi.org]
Prevention
Doctors may give the patient antibiotics to prevent or treat infection. They may also give the patient transfusions of platelets to prevent bleeding and red blood cells to treat anemia. [cancer.gov]
Careful monitoring, use of medicines to treat or prevent infections, and other forms of supportive care can help your child to feel as comfortable as possible. [curesearch.org]
In order to prevent rejection, the donors for CGD patients should be a close a match as possible. [livingwithcgd.org]
City of Hope has pioneered several outstanding advances for the prevention and treatment of this potentially fatal complication. [cityofhope.org]