Serum amylase was elevated in 33 patients; liver dysfunction was present in 50; hepatomegaly was found in 32; and biopsy-confirmed cirrhosis was present in 22 cases. Hyperuricemia was found in 22 patients, some of whom had received steroids. [ncbi.nlm.nih.gov]

The purpose of this article is to report a prototypical case with complete radiographic and histologic workup and to provide facts regarding Kummel disease that are salient to the primary care provider. [doi.org]

Besides confirming the diagnosis, another major role for the radiologist in the workup of osteonecrosis is staging the current state of the disease. The usual plain film and MR stages are listed below. [rad.washington.edu]

See Workup. Early diagnosis and appropriate intervention can delay the need for joint replacement. However, most patients present late in the disease course. [emedicine.com]

Most people with osteonecrosis need treatment. The goals of treatments are to: Improve use of the joint. Stop further damage. Protect bones and joints. Your treatment options may include surgery or nonsurgical treatments, such as medicines. [niams.nih.gov]

Although a treatment for bisphosphonate-induced bone lesions has not yet been established, we suggest careful evaluation of the patients' oral health before prescribing bisphosphonate treatment. [ncbi.nlm.nih.gov]

Clinical data as well as treatment and prognosis information were obtained from all 14 patients. RESULTS: Twelve patients (86%) were submitted to biphosphonate therapy. [ncbi.nlm.nih.gov]

In addition, lesion size and location can be more easily assessed on magnetic resonance images, and this has been shown to relate to prognosis and need for treatment. [doi.org]

They have been used most often in treating osteonecrosis of the hip where the prognosis without treatment is worse than that for other regions. [merck.com]

Editions Published Year of Publication subjects Accessible book, Necrosis, Bones, Abnormalities, Bones--Necrosis, Etiology, Tibia, Adverse effects, Blood supply, Blood-vessels, Decompression sickness, Diphosphonates, Diseases, Drug Therapy, Jaw Diseases [openlibrary.org]

The etiology and management of herpes zoster infection associated with destructive oral sequelae are discussed. [ncbi.nlm.nih.gov]

Because this disease can masquerade as many other pathologies, physicians should be aware of the etiology, presentation, and treatment options for osteonecrosis in the foot. [doi.org]

Introduction Clinical definition reduced vascular sup ply to the bone resulting in progressive and painful degeneration of the bone also termed osteonecrosis Epidemiology incidence typically occurs in the anterolateral femoral head demographics dependent [medbullets.com]

Epidemiology Frequency United States The frequency of AVN depends on the site involved. The most common site is the hip; other locations include the carpals, talus, femur, metatarsal, mandible, and humerus. [emedicine.com]

Epidemiology For oral bisphosphonates used to treat osteoporosis, the number of spontaneous reports of ONJ submitted to their manufacturers indicates a reporting rate of less than 1 per 100,000 patient treatment years. [iofbonehealth.org]

We will review the pathophysiologic mechanisms of AVN and the current use of MRI in the diagnosis of this condition. [doi.org]

Pathogenesis The underlying pathophysiological mechanisms behind ONJ have yet to be elucidated. [iofbonehealth.org]

Pathophysiology Although the pathophysiology of AVN is not fully understood, the final common pathway is interruption of blood flow to the bone. [emedicine.com]

Therefore, early treatment to slow or prevent progression and save the joint is desirable. No completely effective treatment is yet available. [merck.com]

Recognition of the quite characteristic imaging findings can prevent misdiagnosis and may have implications for the prediction of the natural course of the disease. [ncbi.nlm.nih.gov]