Presentation
We present a rare case of endocarditis in a 33-year-old woman with a splenectomy. The patient presented with meningeal symptoms and was diagnosed with endocarditis on the medical admissions unit using a portable echocardiography machine. [ncbi.nlm.nih.gov]
Entire Body System
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Camping
Comparison of the potencies of WT toxin and those of mutants that only increase cAMP or only create transmembrane pores establishes that at least two mechanisms are contributory and that simply the production of cAMP is not enough to account for the cytotoxicity [ncbi.nlm.nih.gov]
Compared with intact CyaA, a CyaA-AC – toxoid unable to generate cAMP promoted a faster, albeit transient, elevation of [Ca 2 ] i. [doi.org]
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Anemia
OBJECTIVES: To analyze a Bordetella holmesii isolate from a patient with sickle cell anemia and to compare it with other B. holmesii strains and isolates and with strains of B. pertussis and B. bronchiseptica, two well-characterized species of the Bordetella [ncbi.nlm.nih.gov]
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Hypoxemia
Pertussis pneumonia, hypoxemia, hyperleukocytosis, and pulmonary hypertension: improvement in oxygenation after a double volume exchange transfusion. Pediatrics 114 : e264-e266. [ PubMed ] [ Google Scholar ] 670. Romanus, V., R. Jonsell, and S. O. [ncbi.nlm.nih.gov]
Workup
Microbiology
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Vibrio Vulnificus
Choy and Joon Haeng Rhee, Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells, Cellular Microbiology, 10, 4, (848-862), (2007). Erik L. Hewlett, Gina M. Donato and Mary C. [doi.org]
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Clostridium Perfringens
Popoff and Richard Titball, Structural relationships between small β-pore-forming toxins from Clostridium perfringens, The Comprehensive Sourcebook of Bacterial Protein Toxins, 10.1016/B978-0-12-800188-2.00027-6, (794-814), (2015). [doi.org]
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Legionella Pneumophila
Swanson, Regulation of the Legionella pneumophila Life Cycle, Legionella pneumophila, 10.1007/978-0-387-70896-6_6, (95-111), (2007). Trevor H. Stenson and Mark S. [doi.org]
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Borrelia Burgdorferi
Analysis of the Borrelia burgdorferi GeHo fla gene and antigenic characterization of its gene product. [ncbi.nlm.nih.gov]
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Helicobacter Pylori
Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J Bacteriol. 1991 Feb; 173 (3):937–946. [ PMC free article ] [ PubMed ] [ Google Scholar ] Kutsukake K, Ohya Y, Iino T. [ncbi.nlm.nih.gov]
Treatment
There are no current standards for susceptibility testing or treatment recommendations. [ncbi.nlm.nih.gov]
Treatment 2 Antibacterial treatment is effective during the earlier stages of pertussis and can reduce spread to others. Several types of antibiotics are active against B. pertussis, but macrolides are preferred for both treatment and prophylaxis. [quidel.com]
Etiology
It is the etiologic agent of whooping cough. [uniprot.org]
[…] diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Bordetella pertussis is the highly contagious etiological [mayomedicallaboratories.com]
Pertussis is the term used for the disease specifically caused by B. pertussis, whereas pertussis-like illness or syndrome is more appropriately used when referring to the other etiologic agents. [wwwnc.cdc.gov]
Evidence for an etiological role of adenoviral infection in pertussis syndrome. N. Engl. J. Med. 283 : 390-394. [ PubMed ] [ Google Scholar ] 167. Conner, J. S., and J. F. Speers. 1963. [ncbi.nlm.nih.gov]
Epidemiology
The rare occurrence and challenges in identifying this pathogen led us to perform a comprehensive review of the epidemiology, clinical presentations, and treatment options for this potentially invasive pathogen. [ncbi.nlm.nih.gov]
Her research interests are the epidemiology and molecular characterization of Bordetella pertussis and other related species. Top Acknowledgment We are grateful to Pere Simon for providing part of the epidemiologic information. [wwwnc.cdc.gov]
[…] antigens such as pertussis toxin (PT) and filamentous haemagglutinin (FHA) are sensitive, easy to perform and can be used for monitoring of humoral immunostatus following vaccination, differential diagnosis of acute and recent infections as well as epidemiological [ibl-international.com]
Pathophysiology
Useful For Suggests clinical disorders or settings where the test may be helpful Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]
Prevention
Regarding prevention, there is no consensus on prophylactic treatment following index cases and no vaccine is available. Epidemiological data are also sparse, with few prevalence studies available. [ncbi.nlm.nih.gov]
A point mutation in the transmitter (H729Q) prevented autophosphorylation of 'BvgS. In contrast to other characterized sensor proteins, autophosphorylation also required sequences in the 'BvgS receiver and C-terminal domains. [doi.org]
Whoping cough is vaccine-preventable disease that presents a great mortality rate in some countries. For over 40 years wholecell pertussis vaccines have been very effective, preventing about 760,000 deaths annually worldwide. [en.vircell.com]