Edit concept Question Editor Create issue ticket

Bordetella


Presentation

  • We present a rare case of endocarditis in a 33-year-old woman with a splenectomy. The patient presented with meningeal symptoms and was diagnosed with endocarditis on the medical admissions unit using a portable echocardiography machine.[ncbi.nlm.nih.gov]
  • Herein, we present a case of fatal B. trematum bacteremia with septic shock. The presumed primary site of the infection was a rapidly developing left leg deep soft tissue infection without necrotizing fasciitis.[ncbi.nlm.nih.gov]
  • The rare occurrence and challenges in identifying this pathogen led us to perform a comprehensive review of the epidemiology, clinical presentations, and treatment options for this potentially invasive pathogen.[ncbi.nlm.nih.gov]
  • In the present case, there was no evidence for a causative role of the organism in the diabetic foot infection, which is in agreement with previously published data.[ncbi.nlm.nih.gov]
  • Clinical presentations have included endocarditis, pneumonia, cellulitis, suppurative arthritis, pyelonephritis and septicaemia but no previous reports have documented meningitis secondary to this organism.[ncbi.nlm.nih.gov]
Camping
  • Comparison of the potencies of WT toxin and those of mutants that only increase cAMP or only create transmembrane pores establishes that at least two mechanisms are contributory and that simply the production of cAMP is not enough to account for the cytotoxicity[ncbi.nlm.nih.gov]
  • Compared with intact CyaA, a CyaA-AC- toxoid unable to generate cAMP promoted a faster, albeit transient, elevation of [Ca2 ]i.[ncbi.nlm.nih.gov]
  • Compared with intact CyaA, a CyaA-AC – toxoid unable to generate cAMP promoted a faster, albeit transient, elevation of [Ca 2 ] i .[doi.org]
  • Compared with intact CyaA, a CyaA-AC – toxoid unable to generate cAMP promoted a faster, albeit transient, elevation of [Ca 2 ] i.[doi.org]
Wound Infection
  • B. trematum has previously been identified in wound infections, but rarely known to be a source of bacteremia. Currently, 16S rRNA sequencing represents the reference standard method by which identification is made.[ncbi.nlm.nih.gov]
Bronchorrhea
  • After this first episode, the patient was hospitalized an additional 4 times with bronchorrhea symptoms. The isolates collected were analyzed by using biochemical, genotypic, and proteomic tools.[ncbi.nlm.nih.gov]
Purulent Sputum
  • The patient was first hospitalized due to dyspnea, which developed into severe cough with purulent sputum that yielded B. petrii on culture. After this first episode, the patient was hospitalized an additional 4 times with bronchorrhea symptoms.[ncbi.nlm.nih.gov]
Productive Cough
  • The patient had a moderate fever and productive cough, and her condition was initially diagnosed as mycoplasmal bronchitis on the basis of her clinical symptoms and rapid serodiagnosis of mycoplasmal infection.[ncbi.nlm.nih.gov]
Arthritis
  • Publication type, MeSH terms, Substances, Secondary source ID Publication type Case Reports MeSH terms Adolescent Anemia, Hemolytic/complications* Arthritis, Infectious/complications* Arthritis, Infectious/immunology Arthritis, Infectious/microbiology[ncbi.nlm.nih.gov]
  • Here we report the first two published cases of septic arthritis caused by B. holmesii documented in apparently immunocompetent patients and unaccompanied by bacteremia.[ncbi.nlm.nih.gov]
  • Clinical presentations have included endocarditis, pneumonia, cellulitis, suppurative arthritis, pyelonephritis and septicaemia but no previous reports have documented meningitis secondary to this organism.[ncbi.nlm.nih.gov]
  • Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and other clinical entities, such as meningitis, arthritis, or[ncbi.nlm.nih.gov]
Ulcer
  • However, B. trematum has to be considered when otherwise unclassified Gram-negative rods are isolated from infected diabetic ulcers.[ncbi.nlm.nih.gov]
  • Bordetella trematum spp. nov. has been isolated from wounds, ear infections and diabetic ulcers. We report a case of a 7-month-old infant with fever, vomiting and abnormal body movements with bacteremia caused by this novel species.[ncbi.nlm.nih.gov]
  • We report on two new cases Bordetella trematum in chronic ulcers. Literature shows that this species is infrequently isolated from clinical samples. Only a few cases have been reported so far.[ncbi.nlm.nih.gov]
Meningism
  • B. holmesii meningitis has not been previously reported.[ncbi.nlm.nih.gov]
  • Here we report what we believe to be the first clinical description of an adult with B. holmesii meningitis and bacteraemia with a brief review of published cases.[ncbi.nlm.nih.gov]
  • The patient presented with meningeal symptoms and was diagnosed with endocarditis on the medical admissions unit using a portable echocardiography machine.[ncbi.nlm.nih.gov]
  • Although first reported to induce bacteremia mainly in immunocompromised patients, it has also been isolated in healthy persons and has shown the capacity to induce pertussis-like symptoms and other clinical entities, such as meningitis, arthritis, or[ncbi.nlm.nih.gov]
  • Posttraumatic purulent meningitis due to Bordetella bronchiseptica. J. Pediatr. 86 : 639-640. (Letter). [ PubMed ] [ Google Scholar ] 126. Chang, S. M. 1950. Pertussis due to Brucella bronchoseptica. Case report.[ncbi.nlm.nih.gov]

Workup

Vibrio Vulnificus
  • Choy and Joon Haeng Rhee, Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells, Cellular Microbiology, 10, 4, (848-862), (2007). Erik L. Hewlett, Gina M. Donato and Mary C.[dx.doi.org]
  • Choy and Joon Haeng Rhee , Vibrio vulnificus RTX toxin kills host cells only after contact of the bacteria with host cells , Cellular Microbiology , 10 , 4 , (848-862) , (2007) . Erik L. Hewlett, Gina M. Donato and Mary C.[doi.org]
Clostridium Perfringens
  • Popoff and Richard Titball, Structural relationships between small β-pore-forming toxins from Clostridium perfringens, The Comprehensive Sourcebook of Bacterial Protein Toxins, 10.1016/B978-0-12-800188-2.00027-6, (794-814), (2015).[dx.doi.org]
  • Popoff and Richard Titball , Structural relationships between small β-pore-forming toxins from Clostridium perfringens , The Comprehensive Sourcebook of Bacterial Protein Toxins , 10.1016/B978-0-12-800188-2.00027-6 , (794-814) , (2015) .[doi.org]
Borrelia Burgdorferi
  • Analysis of the Borrelia burgdorferi GeHo fla gene and antigenic characterization of its gene product.[ncbi.nlm.nih.gov]
Helicobacter Pylori
  • Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J Bacteriol. 1991 Feb; 173 (3):937–946. [ PMC free article ] [ PubMed ] [ Google Scholar ] Kutsukake K, Ohya Y, Iino T.[ncbi.nlm.nih.gov]

Treatment

  • There are no current standards for susceptibility testing or treatment recommendations.[ncbi.nlm.nih.gov]
  • Treatment is delicate, as its susceptibility to macrolides (prescribed in respiratory infections) and ceftriaxone (used in invasive disease) is challenged.[ncbi.nlm.nih.gov]
  • We report a case of fulminant endocarditis on a prosthetic homograft aortic valve caused by Bordetella holmesii, which was successfully managed by surgical valve replacement and antibiotic treatment.[ncbi.nlm.nih.gov]
  • We review all 9 other reported cases of endocarditis and summarize treatment and outcome. Five were immunocompromised and 6 had predisposing cardiac conditions.[ncbi.nlm.nih.gov]
  • Treatment with erythromycin, which is usually considered the antibiotic of choice, will eliminate viable B. pertussis organisms from the respiratory tract.[en.vircell.com]

Etiology

  • It is the etiologic agent of whooping cough.[uniprot.org]
  • […] diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Bordetella pertussis is the highly contagious etiological[mayomedicallaboratories.com]
  • Pertussis is the term used for the disease specifically caused by B. pertussis , whereas pertussis-like illness or syndrome is more appropriately used when referring to the other etiologic agents.[wwwnc.cdc.gov]
  • Evidence for an etiological role of adenoviral infection in pertussis syndrome. N. Engl. J. Med. 283 : 390-394. [ PubMed ] [ Google Scholar ] 167. Conner, J. S., and J. F. Speers. 1963.[ncbi.nlm.nih.gov]

Epidemiology

  • The rare occurrence and challenges in identifying this pathogen led us to perform a comprehensive review of the epidemiology, clinical presentations, and treatment options for this potentially invasive pathogen.[ncbi.nlm.nih.gov]
  • Epidemiological data are also sparse, with few prevalence studies available. In this chapter, we provide an overview of the current state of knowledge on B. holmesii.[ncbi.nlm.nih.gov]
  • Her research interests are the epidemiology and molecular characterization of Bordetella pertussis and other related species. Top Acknowledgment We are grateful to Pere Simon for providing part of the epidemiologic information.[wwwnc.cdc.gov]
  • […] antigens such as pertussis toxin (PT) and filamentous haemagglutinin (FHA) are sensitive, easy to perform and can be used for monitoring of humoral immunostatus following vaccination, differential diagnosis of acute and recent infections as well as epidemiological[ibl-international.com]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical[mayomedicallaboratories.com]

Prevention

  • Regarding prevention, there is no consensus on prophylactic treatment following index cases and no vaccine is available. Epidemiological data are also sparse, with few prevalence studies available.[ncbi.nlm.nih.gov]
  • Whoping cough is vaccine-preventable disease that presents a great mortality rate in some countries. For over 40 years wholecell pertussis vaccines have been very effective, preventing about 760,000 deaths annually worldwide.[en.vircell.com]
  • A point mutation in the transmitter (H729Q) prevented autophosphorylation of 'BvgS. In contrast to other characterized sensor proteins, autophosphorylation also required sequences in the 'BvgS receiver and C-terminal domains.[doi.org]

Ask Question

5000 Characters left Format the text using: # Heading, **bold**, _italic_. HTML code is not allowed.
By publishing this question you agree to the TOS and Privacy policy.
• Use a precise title for your question.
• Ask a specific question and provide age, sex, symptoms, type and duration of treatment.
• Respect your own and other people's privacy, never post full names or contact information.
• Inappropriate questions will be deleted.
• In urgent cases contact a physician, visit a hospital or call an emergency service!