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Bordetella Bronchiseptica


Presentation

  • The first case comprised a 43-year-old patient who was admitted presenting chronic leg pain and coughing, with suspected pneumonia.[ncbi.nlm.nih.gov]
  • IS1001 is present in a subset of B. bronchiseptica strains that were derived mainly from pigs and rabbits, suggesting that these strains had a common ancestry.[ncbi.nlm.nih.gov]
  • We present a case of B. bronchiseptica chronic pulmonary infection and documentation of some phenotypic attributes of the clinical isolates allowing the microorganism to induce progressive respiratory degradation and chronic sputum colonization.[ncbi.nlm.nih.gov]
  • We present 2 immunocompromised patients diagnosed with B. bronchiseptica pneumonia. To our knowledge, these are the first reports of this disease in patients with B-cell lymphoma and an orthotopic cardiac transplant.[ncbi.nlm.nih.gov]
  • We present a case of a 61-year-old man with a renal transplant who developed B. bronchiseptica bacteremia likely as a result of close contact between dogs and his skin cancer biopsy sites.[ncbi.nlm.nih.gov]
Malnutrition
  • Most patients with B. bronchiseptica infections are compromised clinically such as in patients with a malignancy, AIDS, malnutrition, or chronic renal failure.[ncbi.nlm.nih.gov]
Sputum
  • BB was isolated from sputum culture and was successfully treated with trimethoprim/sulfamethoxazole in association with levofloxacin.[ncbi.nlm.nih.gov]
  • The organism was recovered on one occasion from a protected catheter brush specimen obtained at bronchoscopy and on two occasions from expectorated sputum specimens. The infection was eradicated with antimicrobial therapy.[ncbi.nlm.nih.gov]
  • We present a case of B. bronchiseptica chronic pulmonary infection and documentation of some phenotypic attributes of the clinical isolates allowing the microorganism to induce progressive respiratory degradation and chronic sputum colonization.[ncbi.nlm.nih.gov]
  • Gram stain of her sputum revealed moderate levels of gram-negative coccobacilli, which was later identified as B. bronchiseptica by mass spectrometry.[ncbi.nlm.nih.gov]
  • Here, we report isolation of B. bronchiseptica from a sputum sample of a cystic fibrosis patient recently exposed to a kitten with an acute respiratory illness.[ncbi.nlm.nih.gov]
Productive Cough
  • A persistent productive cough and a deterioration in his clinical condition led to his hospitalization for evaluation. Bronchoscopy was performed and a diagnosis of B. bronchiseptica pneumonia was made.[ncbi.nlm.nih.gov]
  • On the 16th day after admission, she complained of a productive cough with right pleuritic pain and had low-grade fever. After chest CT scans, we diagnosed pneumonia.[ncbi.nlm.nih.gov]
Aspiration
  • The diagnosis was obtained through a cytobacteriological test of sputum, bronchial aspiration, or bronchial fibroscopy with a bronchoalveolar lavage.[ncbi.nlm.nih.gov]
Pharyngitis
  • Abundant colonies of B. bronchiseptica were isolated from the pharyngeal exudate and respiratory secretions, suggesting prior oropharyngeal colonization by B. bronchiseptica, as a result of repeated contact with his dog, with subsequent infection of the[ncbi.nlm.nih.gov]
Pleuritic Pain
  • On the 16th day after admission, she complained of a productive cough with right pleuritic pain and had low-grade fever. After chest CT scans, we diagnosed pneumonia.[ncbi.nlm.nih.gov]
Leg Pain
  • The first case comprised a 43-year-old patient who was admitted presenting chronic leg pain and coughing, with suspected pneumonia.[ncbi.nlm.nih.gov]

Workup

Pulmonary Infiltrate
  • Unlike previous work reporting the involvement of B. bronchiseptica in cases of pneumonia, antibiotic treatment selected on the basis of in vitro antibacterial activity resulted in clearance of the infection and resolution of the pulmonary infiltrate.[ncbi.nlm.nih.gov]
Salmonella Typhi
  • The genes involved in biosynthesis of the Bordetella capsule encode products that are homologous to the Salmonella typhi Vi antigen biosynthesis enzymes, suggesting that the product of the Bordetella locus may be similar to the N-acetyl galactosaminuronic[doi.org]

Treatment

  • A 52-year-old white male with non small cell lung cancer developed fever during treatment with nivolumab. A persistent productive cough and a deterioration in his clinical condition led to his hospitalization for evaluation.[ncbi.nlm.nih.gov]
  • The patient died despite treatment with antibiotics. This case illustrates the potential virulence of B. bronchiseptica in susceptible patients and to our knowledge it is the first case of primary peritonitis due to this organism.[ncbi.nlm.nih.gov]
  • We recommend implementing adequate treatment aiming eradication from the first isolation of this bacterium. We advise for practices that minimize opportunities for zoonotic transmission of B. bronchiseptica from family pets.[ncbi.nlm.nih.gov]
  • We also address issues related to treatment and prognosis.[ncbi.nlm.nih.gov]
  • There are, however, some reports that B. bronchiseptica causes human respiratory infections in immunocompromised patients or those with underlying respiratory diseases, although there is a lack of treatment guidelines.[ncbi.nlm.nih.gov]

Prognosis

  • We also address issues related to treatment and prognosis.[ncbi.nlm.nih.gov]
  • We also address issues related to treatment and prognosis. * University of Missouri, Kansas City School of Medicine ‡ Department of Radiology, University of Missouri Departments of †Radiology § Pathology-Laboratory Medicine, Saint Luke's Hospital of Kansas[journals.lww.com]

Etiology

  • Bordetella bronchiseptica was identified as an unusual etiologic agent of pulmonary recurrent exacerbations and pneumonia in a cystic fibrosis (CF) patient by utilizing a 16S rRNA molecular kit in our hospital's clinical laboratory.[ncbi.nlm.nih.gov]
  • BB should be included in the etiology of pneumonia in immunodeficient HIV patients. As far as we know, these two were the first cases of pneumonia due to BB to occur in this university hospital.[ncbi.nlm.nih.gov]
  • The most prominent member of the genus comprising nine species so far is Bordetella pertussis, the etiological agent of whooping cough.[opus.bibliothek.uni-wuerzburg.de]
  • Studies on the etiology of infectious atrophic rhinitis of swine. II. Agglutination test on Bordetella bronchiseptica infection. Nihon Juigaku Zasshi. 1970 Dec; 32 (6):295–306. [ PubMed ] [ Google Scholar ] Koransky JR, Scales RW, Kraus SJ.[ncbi.nlm.nih.gov]
  • B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough.[doi.org]

Epidemiology

  • In this report, we briefly discuss the epidemiology, microbiology, and challenges in the laboratory identification of B. bronchiseptica and describe the protean imaging manifestations of this rare pulmonary infection.[ncbi.nlm.nih.gov]
  • A clinical and molecular epidemiologic study determined that this cluster represented a pseudo-outbreak due to bacterial contamination of rabbit blood used as a broth culture supplement.[ncbi.nlm.nih.gov]
  • The technique which we used may be useful for epidemiologic studies in which the transmission of B. bronchiseptica, both within and between species, is investigated.[ncbi.nlm.nih.gov]
  • Based on the results presented herein, the combination of REA and ribotyping should provide valuable information in understanding the molecular epidemiology of B. bronchiseptica infections.[ncbi.nlm.nih.gov]
  • We summarize here the pathogenesis, epidemiology, clinical symptoms and microbiological identification of B. bronchiseptica infection in humans. a The Institute of Graduate Studies, Liaoning Medical University, Jinzhou b Clinical Laboratory, General Hospital[journals.lww.com]
Sex distribution
Age distribution

Prevention

  • Intranasal Vaination is an important part of such preventative schemes.[nobivacbb.com]
  • An efficient vaccine for livestock animals would allow reducing the application of antibiotics, thereby preventing the massive release of pharmaceuticals into the environment.[ncbi.nlm.nih.gov]
  • Bordetella Bronchiseptica Intranasal Vaccine Indications For use as an aid in the prevention of respiratory disease associated with virulent Bordetella bronchiseptica in swine. Dosage and Administration Shake well before and occasionally during use.[drugs.com]
  • Guzmán 3 , Jens Schreiber 5 , Sabine Stegemann-Koniszewski 1,2,5,‡ and Dunja Bruder 1,2,*,‡ 1 Infection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke[mdpi.com]
  • […] inactivated vaccine to prevent progressive and non-progressive atrophic rhinitis in pigs This is a summary of the European public assessment report (EPAR).[ema.europa.eu]

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