Presentation
BACKGROUND: The clinical presentation of Bordetella pertussis can overlap with that of respiratory syncytial virus (RSV), and coinfection does occur, but management differs. [ncbi.nlm.nih.gov]
Entire Body System
- Fever
Fever abated within 24 hours of instituting levofloxacin, and he was weaned off oxygen within 72 hours. [journals.lww.com]
A38.0 Scarlet fever with otitis media A38.1 Scarlet fever with myocarditis A38.8 Scarlet fever with other complications Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes. [icd10data.com]
All whole cell vaccines are reactogenic, causing fever and local reactions in many vaccinees. In the past, these vaccines were thought to cause infant deaths and brain damage. [doi.org]
- Pediatric Disease
EPIDEMIOLOGY• Predominately a pediatric disease• Highest in the 1st year of life• Maternal antibodies are not protective.• Females suffers more than males.• World wide in distribution• Epidemics occurs periodically.• In early stage of infection droplets [de.slideshare.net]
- Fatigue
His symptoms had been slowly progressing over the preceding 6 months, with the additional development of fatigue and nonproductive cough 2–3 months before presentation, both of which had worsened in the past 2 weeks. [journals.lww.com]
Respiratoric
- Pertussis
/parapertussis) and IS10001 (specific only for B. parapertussis) Analytical Specificity B. pertussis, 100 % B. parapertussis, 100 % Analytical Sensitivity (LoD with 95% probability) 0.212 cp/µl (on Amplirun® Bordetella pertussis DNA control, Vircell) [geneproof.com]
Revised Abstract Objectives Pertussis (whooping cough) is caused by Bordetella pertussis and Bordetella parapertussis, with several states in the USA reporting an increased incidence. [copanusa.com]
Result Code Result Name LOINC Code Component Name 26405 B. parapertussis DNA 29723-4 Bordetella parapertussis DNA 3919 B. pertussis DNA 23826-1 Bordetella pertussis DNA FOCUS100 SOURCE 31208-2 Specimen source [questdiagnostics.com]
Additional Info: Reference Range: NEGATIVE: B. pertussis target nucleic acid is NOT DETECTED. NEGATIVE: B. parapertussis target nuc. acid is NOT DETECTED. Synonyms: Bordetella pertussis and Bordetella parapertussis by PCR [akronchildrens.org]
- Cough
Frequencies of typical symptoms of whooping cough, such as paroxysmal coughing, whooping and vomiting, were almost identical in the two groups. Nocturnal coughing and contact anamnesis were noted more often in the Bordetella pertussis group. [ncbi.nlm.nih.gov]
The guidance and protocol are intended for real-time PCR on DNA extracted from clinical specimens obtained from patients with suspected whooping cough (i.e. Bordetella pertussis or B. parapertussis). [ecdc.europa.eu]
Alternative Name(s) Whooping Cough LOINC®' Code(s) The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. [questdiagnostics.com]
- Persistent Cough
Pertussis, also known as whooping cough, is a respiratory infection that causes a persistent cough in all age groups from the newborn to the elderly. [ibl-international.com]
Pertussis can also present as a non-specific persistent cough Vomiting often follows a coughing spasm. Infants may develop apnoea and/or cyanosis with coughing spasms. Close contact with a case of Pertussis may raise suspicion. [rch.org.au]
[…] with Tdap vaccine (CDC, 2015) Diagnosis Indications for Testing Patients with persistent cough, especially in the absence of fever, sore throat, hoarseness, tachypnea, or wheeze Posttussive emesis in setting of acute viral illness symptoms Laboratory [arupconsult.com]
Gastrointestinal
- Nausea
Medscape Medical News, November 2, 2022 Terminal Patients and Therapy; Organ Donors; and Nausea Pathway The top 3 things you should know to start your day. 3 Things to Know Today, November 2, 2022 ECNP 2022 Major Depression Treatments Boost Brain Connectivity [medscape.com]
- Diarrhea
Fever, cough and watery diarrhea persisted, but the absolute neutrophil count became normal and then elevated by day 5 of his illness. [journals.lww.com]
- Gagging
Gly ACC GCC 2 CCC 1 TCC 1 4 Pro AGG GGG 1 CGG 1 TGG 1 3 Thr AGT GGT 1 CGT 1 TGT 1 3 Val AAC GAC 1 CAC 1 TAC 1 3 Six Box tRNA Sets Isotype tRNA Count by Anticodon Total Ser AGA GGA 1 CGA 1 TGA ACT GCT 1 3 Arg ACG 2 GCG CCG 1 TCG CCT 1 TCT 1 5 Leu AAG GAG [gtrnadb2009.ucsc.edu]
Workup
Microbiology
- Bordetella Pertussis
Technology Packaging GeneProof Bordetella pertussis/parapertussis PCR Kit BP/ISEX/025 real-time PCR 25 reactions GeneProof Bordetella pertussis/parapertussis PCR Kit BP/ISEX/100 real-time PCR 100 reactions Product Leaflet EQA Panels Technical specification [geneproof.com]
Bordetella pertussis was isolated in six patients, and 17 culture-positive cases with Bordetella parapertussis were identified. Patients with Bordetella pertussis or Bordetella parapertussis were found simultaneously in the same classrooms. [ncbi.nlm.nih.gov]
Result Code Result Name LOINC Code Component Name 26405 B. parapertussis DNA 29723-4 Bordetella parapertussis DNA 3919 B. pertussis DNA 23826-1 Bordetella pertussis DNA FOCUS100 SOURCE 31208-2 Specimen source [questdiagnostics.com]
[…] of bordetella infections. [ecdc.europa.eu]
- Gram-Positive Bacteria
A BLASTP search homologous loci of other gram-negative and Staphylococuus epidermis (gram positive) bacteria with the NCBI A. junii SH205 nonredundant protein database sequences enabled us to identify pgaC that shares a high degree of similarly with pgaC [scirp.org]
- Burkholderia Mallei
[…] graminis Burkholderia mallei Burkholderia multivorans Burkholderia oklahomensis Burkholderia phymatum Burkholderia phytofirmans Burkholderia pickettii synonym for Ralstonia pickettii Burkholderia pseudomallei Burkholderia pseudomallei-like synonym for [ded.uni-stuttgart.de]
Treatment
Prompt treatment might shorten illness duration, and prompt HHM prophylaxis might prevent secondary illnesses. [ncbi.nlm.nih.gov]
Etiology
The results of this prospective study suggest that Bordetella parapertussis is a more common etiologic agent of mild respiratory tract infection among vaccinated school-aged children than is generally recognised. [ncbi.nlm.nih.gov]
Lien vers Pubmed [PMID] – 30976607 Lien DOI – 10.1093/ofid/ofz122 Open Forum Infect Dis 2019 Apr; 6(4): ofz122 Whooping cough’s primary etiological agent is Bordetella pertussis. [research.pasteur.fr]
[…] diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Bordetella pertussis is the highly contagious etiological [mayocliniclabs.com]
[…] medium, or Regan Lowe media; ESwab; swabs with solid plastic shaft; dry swab Useful For Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Bordetella pertussis is the highly contagious etiological [bassett.testcatalog.org]
Epidemiology
Specific diagnostic tools were applied for the first time in a Tunisian prospective study in order to get a first estimation of the prevalence of Bordetella pertussis/parapertussis infections and to evaluate their use to determine the epidemiologic characteristics [ncbi.nlm.nih.gov]
Epidemiology and Pathogenesis Epidemiology Before the introduction of the vaccine (and currently in nonimmunized populations), pertussis (whooping cough) periodically became an epidemic disease that cycled approximately every 2 to 5 years. [clinicalgate.com]
Epidemiology of pertussis. Pediatr Infect Dis J 2006;25:361–2. [3]. Mattoo S, Cherry J. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. [journals.lww.com]
Pathophysiology
Useful For Suggests clinical disorders or settings where the test may be helpful Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical [mayocliniclabs.com]
Prevention
Prompt treatment might shorten illness duration, and prompt HHM prophylaxis might prevent secondary illnesses. [ncbi.nlm.nih.gov]
(specific only for B. parapertussis) No false-positive results for Bordetella holmesii EASY-TO-USE CONCEPT Single tube Ready-to-Use Master Mix contains all components for PCR amplification No additional PCR reagents pipetting necessary CONTAMINATION PREVENTION [geneproof.com]