This product is presented as at least 95% of the intact 220 kDa form, with 5% in the reported breakdown products of 140 kDa and 90 kDa. [thenativeantigencompany.com]

We present a very rare case of a patient with non-small-cell lung cancer and unilateral pleural effusion who presented BP infection. References [1] S. Mattoo, J.D. [archbronconeumol.org]

Be advised that the target sequence IS481 used in this procedure for Bordetella pertussis may also be present in certain strains of B. holmseii and B. bronchiseptica. [health.mo.gov]

A major difference in this Bordetella endotoxin lies in the absence of an O polysaccharide or O antigen chain which, when present, forms the outermost domain of LPS. [listlabs.com]

Pertussis IgG antibodies will be present in anyone who has been vaccinated. Pertussis IgM and IgA antibodies will usually only be present a short time after vaccination or infection. [labtestsonline.org.au]

• Fever

  Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders [en.wikipedia.org]

  It is caused by Bordetella pertussis ... pneumophila (Legionellosis)- Pontiac Fever and Legionnaires’ Disease Mycoplasma pneumoniae Infection Pertussis ... to diagnose pertussis. [arupconsult.com]

• Malaise

  The first stage, colonization, is an upper respiratory disease with fever, malaise and coughing, which increases in intensity over about a 10-day period. [textbookofbacteriology.net]

  The first stage causes upper respiratory ailments with fever, malaise, and coughing. The second stage begins gradually with a prolonged and paroxysmal cough that ends with the characteristic gasp, or whoop. [web.mst.edu]

  The first stage is the catarrhal phase with symptoms of mild respiratory infection including malaise, conjunctivitis, nasal discharge, sore throat, dry cough and mild fever. This progresses after one or two weeks to the paroxysmal coughing stage. [patient.info]

• Low Fever

  Symptomology is very similar to a traditional upper respiratory infection and includes mild coughing, low fever, and coryza. Individuals are most infectious during this stage. [pathwaymedicine.org]

  The first stage, known as the catarrhal stage, mimics the common cold, and is classified by a runny nose, low fever, sneezing, and mild cough (4). [austincc.edu]

• Pediatric Disease

  EPIDEMIOLOGY• Predominately a pediatric disease• Highest in the 1st year of life• Maternal antibodies are not protective.• Females suffers more than males.• World wide in distribution• Epidemics occurs periodically.• In early stage of infection droplets [slideshare.net]

• Pertussis

  Description Technical documentation Shipping method Bordetella pertussis FHA Bordetella pertussis Filamentous haemagglutinin (FHA) is extracted from Bordetella pertussis and purified to a very high degree (>98%). [thenativeantigencompany.com]

  CDC-recommended first-line tests for pertussis are Bordetella pertussis/parapertussis by PCR ( 0065080 ) and/or Bordetella pertussis Culture ( 0060117 ). [ltd.aruplab.com]

  […] aspects, as they relate to a laboratory test Bordetella pertussis is the highly contagious etiological agent of pertussis or whooping cough. [mayomedicallaboratories.com]

  Other Bordetella pertussis virulence factors derived from native organisms and offered by List Labs, include Pertussis Toxin, Pertussis Toxin Subunits, Pertussis Toxin Mutant, native Adenylate Cyclase Antigen, Filamentous Hemagglutinin (FHA), Fimbriae [listlabs.com]

  This shift in the proportion of different B. pertussis strains may explain the persistence of pertussis (whooping cough). [microbewiki.kenyon.edu]

• Cough

  cough"), we also see this word in "antitussive drugs" which prevent coughing. [medicaletymology.wikia.com]

  Incubation period is five to ten days - Infected person usually first shows cold symptoms (i.e. runny nose, sneezing, fever, and mild cough) - The cough worsens and comes in bursts - At the end of the cough, the infected person takes in air with a [bioweb.uwlax.edu]

  […] atypical pneumonia Detection of Bordetella parapertussis mediated infections (ca. 15% of all cases of whooping cough) Results of IgA and IgG antibody activity are expressed in IU/ml referenced to the first international standard of the WHO [virion-serion.de]

  Consider pertussis in patients with cough longer than 14 days. [web.archive.org]

• Pneumonia

  Pneumonia Legionella pneumophila (Legionellosis)- Pontiac Fever and Legionnaires’ Disease Septic Arthritis ... Streptococcus pneumoniae bacteria cause a wide variety of infections, including pneumonia, bacteremia, otitis media (OM), ... [arupconsult.com]

  […] with M. pneumoniae. [ncbi.nlm.nih.gov]

  Sensitive demonstration of IgM antibodies for diagnosis of acute primary infections, particularly in children Detection of IgA and IgG antibodies for laboratory confirmation of whooping cough as well as for differential diagnosis in case of atypical pneumonia [virion-serion.de]

• Paroxysmal Cough

  After 7-10 day incubation, a prolonged course ensues,consisting of 3 overlapping stages Catarrhal Paroxysmal coughing Convalescent Partially immune persons and infants older than 6 months may not show all typical features Paroxysmal coughing may be absent [web.archive.org]

  A baboon model for pertussis was recently developed that closely matches the clinical illness, including development of paroxysmal cough and demonstration of host-to-host transmission by aerosolized respiratory droplets. [doi.org]

  Since paroxysmal cough is considered one of the main symptoms of pertussis, we retrospectively assessed the frequency of paroxysmal cough in ARI. Paroxysmal cough was reported by the parents or observed by the clinician. [bmcinfectdis.biomedcentral.com]

• Common Cold

  Initially, symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough. This is then followed by several weeks of severe coughing fits. [osmosis.org]

  Initially, symptoms resemble those of a common cold, including sneezing, runny nose, low-grade fever and a mild cough. Read more [ecdc.europa.eu]

  While common cold and flu viruses can cause ordinary coughs (which can often be relieved with humidifiers and cough syrups), B. pertussis bacteria causes “whooping cough,” a serious cough that can go on for over 6 weeks. [giantmicrobes.com]

  The signs and symptoms are similar to a common cold: runny nose, sneezing, mild cough, and low-grade fever. [diagenodediagnostics.com]

• Choking

  $69.95 $21.90 $19.95 $79.00 $69.00 $69.00 $29.95 $15.95 $18.95 $11.95 Special offers and product promotions WARNING: CHOKING HAZARD -- Small parts. Not for children under 3 yrs. [amazon.com]

  The child chokes, gasps and flails the extremities, with eyes bulging and watering and face reddened. There is frequently post-cough vomiting. The paroxysms may be severe enough to bring on cyanosis. This is called the paroxysmal stage. [patient.info]

  […] include symptoms such as: Frequent severe bouts of coughing sometimes followed by vomiting Several rapid coughs followed by a whooping sound as the person inhales; affected adults may cough but not whoop, and infants may have trouble breathing and may choke [labtestsonline.org.au]

  You may have choking spells or may cough so hard that you vomit.DR.T.V.RAO MD 4 5. [slideshare.net]

• Gagging

  They often have trouble breathing and coughing is frequently followed by vomiting or gagging. The name whooping cough comes from the noise of the cough that ends with a ‘whoop’ sound when the air is drawn back into the chest. [childrens.health.qld.gov.au]

• Hypertension

  Pulmonary hypertension is an early sign of potentially fatal disease and can cause failure of conventional respiratory therapy in severe acute respiratory distress syndrome (ARDS). [ncbi.nlm.nih.gov]

  […] patógenos causantes de infecciones crónicas en pacientes con fibrosis quística VINCI Optimizing provider-initiated HIV testing, linkage, and retention in care in the district of Manhiça, Mozambique INTE-AFRICA Integrating and decentralizing diabetes and hypertension [isglobal.org]

  Serious complications associated with the pertussis are cyanosis, pneumonia, bradycardia, seizures, encephalopathy, refractory pulmonary hypertension, and even death Footnote 2. [canada.ca]

  […] this age group.17 Several studies have analysed different variables and have found a higher risk of death or more severe disease in infants aged less than 4 months with low birth weight, hyperleukocytosis (≥100000 leukocytes/μL), who develop pulmonary hypertension [analesdepediatria.org]

  Refractory pulmonary hypertension can be a late sequela in infants with pertussis. 1, 7 View/Print Figure Figure 2. Reported pertussis complications by age group in the United States from 1997 to 2000 (n = 28,187). [aafp.org]

• Febrile Seizures

  Moderate or severe systemic reactions (such as fever [105°F or higher], febrile seizures, persistent crying lasting 3 hours or longer, and hypotonic-hyporesponsive episodes) have been reported after administration of DTaP but occur less frequently than [cdc.gov]

However, whereas a genetic workup for complement regulator mutations was performed, no mutation was found in our patient. [ncbi.nlm.nih.gov]

Tamra Carlson - 2019-06-10 09:52 Disease Topic Infectious Encephalitis workup CSF analysis – critical for diagnosis unless contraindicated (Zunt, Infectious Diseases Society of ... [arupconsult.com]

(See Prognosis, DDx, Presentation, and Workup.) [4] Complications of pertussis can include the following (see Prognosis, Treatment, and Medication): Hypoxic encephalopathy Tuberculosis activation Hernia Reinduction of paroxysmal coughing with upper respiratory [emedicine.medscape.com]

• Atelectasis

  This exudate compromises the small airways (especially those of infants) and predisposes the affected individual to atelectasis, cough, cyanosis, and pneumonia. [emedicine.medscape.com]

  Autopsy studies of pertussis victims performed in the early 20th century revealed a diffuse bronchopneumonia with increased secretion of mucus, associated with airway plugging and atelectasis ( 1 ). [pnas.org]

• Lymphocytosis

  Lymphocytosis is likely due to systemic spread of one or several pertussis exotoxins, possibly Pertussis Toxin itself. [pathwaymedicine.org]

  However, occasional apneic episodes with cyanosis and peripheral lymphocytosis suggested neonatal pertussis and prompted us to examine the presence of Bordetella pertussis using loop-mediated isothermal amplification (LAMP) based on the insertion sequence [ncbi.nlm.nih.gov]

  Morphologic examination of the peripheral blood smear revealed numerous mature lymphocytes with scant cytoplasm, condensed chromatin, and clefted nuclei—characteristic of Bordetella pertussis lymphocytosis. [bloodjournal.org]

  The toxin has previously been known by a number of names, many referring to the biological consequences of its actions in vivo: e.g. histamine-sensitizing factor, lymphocytosis-promoting factor, islet-activating protein and pertussigen. [creative-diagnostics.com]

• Leukocytosis

  To assess safety, mouse weight gain test and leukocytosis promotion test were performed using 4-week-old ddY female mice. [ncbi.nlm.nih.gov]

  We observed that both leukocytosis and lymphocytosis were present in four cases with B. pertussis. [bmcresnotes.biomedcentral.com]

  […] nonproductive cough Insidious onset Gradually worsening symptoms Paroxysmal One to six Paroxysms (bursts of coughing during a single exhalation) followed by an inspiratory “whooping” sound, post-tussive cyanosis, and emesis Peaks after two weeks Weight loss, leukocytosis [aafp.org]

  Leukocytosis, particularly with white blood cell (WBC) counts of more than 100,000, has been associated with fatalities from pertussis. [emedicine.medscape.com]

Treatment reduces contagious phase in 5 days and may negate PCR results. B. parapertussis is a related species that may also cause pertussis syndrome; illness usually milder. [web.archive.org]

Here, we describe the disease course, diagnostic difficulties and treatment procedure. After 20 days of treatment based on the doctors’ experience (without an established diagnosis), the child was deemed healthy and discharged. [ncbi.nlm.nih.gov]

With early treatment (before coughing fits begin) pertussis is likely to be less severe. Early treatment is also likely to prevent the transmission of B. pertussis to close contacts. [dentalcare.com]

[…] vaccine against diphtheria, tetanus, and pertussis acellular pertussis vaccine 5 doses before school-age, completed by 4-6 years of age Tdap vaccine booster vaccine at 11-12 years of age should also be given to pregnant mothers and those around them Prognosis [medbullets.com]

Prognosis Prognosis for full recovery from pertussis is excellent in children over 3 months of age. In those less than 3 months the mortality is 1-3%. [emedicine.medscape.com]

Prognosis : Pertussis usually causes prolonged symptoms: often one to two weeks of cold-like symptoms, followed by several weeks to months of severe coughing. It may take a few more weeks of recovery with gradual clearing of symptoms. [thevaccinemom.com]

Prognosis [ 5 ] The most severe infections are usually in infants, with morbidity and mortality greatest in those aged less than 6 months. [patient.info]

M. pneumoniae etiology was diagnosed by culture and RT-PCR. The evolution was fatal for all of the subjects. [ncbi.nlm.nih.gov]

Bordetella pertussis is the etiological agent of whooping cough, a severe infection of the respiratory tract which is particularly dangerous for young infants. [biozentrum.uni-wuerzburg.de]

Microbiology Department, University Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, 08950, Spain. 3 CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. 4 CIBER of Epidemiology and Public [ncbi.nlm.nih.gov]

Epidemiological, clinical, and laboratory aspects of pertussis in adults. Clinical Infectious Disease, 28, S112-117. - Farizo, K. M., Cochi, S. L., Zell, E. R. et al. (1992). Epidemiological features of pertussis in the United States. [bioweb.uwlax.edu]

Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J. 2005 ; 24 ( 5 Suppl ): S25-S34. (Link to PubMed) Forsyth,K., Tan,T., von Konig,C.H., Caro,J.J., Plotkin,S. [web.archive.org]

However, epidemiologically unrelated isolates were sometimes nearly undistinguishable. [research.pasteur.fr]

One of the important considerations in the design of a new vaccine is the pathophysiology of pertussis; identification of individual virulence factors and assessment of their roles in the disease will provide a sound basis for vaccine development, which [creative-diagnostics.com]

It causes inflammation and necrosis of the respiratory tract ciliated epithelium and it produces immunological and pathophysiological reactions. [diesse.it]

Useful For Suggests clinical disorders or settings where the test may be helpful Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical [mayomedicallaboratories.com]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Bordetella pertussis, the causative agent of whooping cough, is highly contagious and remains endemic in the United States despite [mayocliniclabs.com]

Epidemiology and prevention of vaccine preventable disease. (10th Ed., pp. #81-100). Atlanta, Georgia: Center for Disease - Centers for Disease Control (CDC) and Prevention; Department of Health and Human Services. [bioweb.uwlax.edu]

Acellular pertussis vaccination in baboons induces a Th2-skewed immune response and prevents pertussis-associated symptoms but does not prevent mucosal colonization or host-to-host transmission. [doi.org]

Prevention Pertussis is a vaccine-preventable infection. There are four combination vaccines used to prevent diphtheria, tetanus and pertussis: DTaP, Tdap, DT, and Td. [dentalcare.com]

(August 31, 2015) Centers for Disease Control and Prevention. Pertussis. Available online at http://www.cdc.gov/pertussis/. Accessed October 2015. (August 31, 2015) Centers for Disease Control and Prevention. Pertussis, Diagnosis Confirmation. [labtestsonline.org]

Centers for Disease Control and Prevention (2015). "Pertussis". In Atkinson, W.; Wolfe, S.; Hamborsky, J. (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases: The Pink Book (13th ed.). Public Health Foundation. [en.wikipedia.org]