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Bordetella Pertussis

B Pertussis


Presentation

  • Abstract A 20 mo old male child, born at 31 weeks, presented to an out-of-hours General Practitioner (GP) with a 7 d history of cough and fever. There was history of post-tussive vomiting.[ncbi.nlm.nih.gov]
  • While children that present with pertussis have a characteristic whooping cough, adults can simply have a persistent, nonspecific cough and remain undiagnosed.[ncbi.nlm.nih.gov]
  • We describe a 64 year-old male with classic signs and symptoms of pertussis and documented Bordetella pertussis infection that were overlooked because he presented with a chief complaint of cough and fear of falling asleep.[ncbi.nlm.nih.gov]
  • We present a very rare case of a patient with non-small-cell lung cancer and unilateral pleural effusion who presented BP infection. References [1] S. Mattoo, J.D.[archbronconeumol.org]
  • METHODS: Culture confirmed cases presenting to tertiary paediatric hospitals in three Australian states between 2008 and 2012 were classified as severe if they required a hospital stay greater than seven days, were admitted to intensive care, or if death[ncbi.nlm.nih.gov]
Fever
  • Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders[en.wikipedia.org]
  • Abstract A 60-year-old heterosexual man with AIDS was admitted to hospital with dyspnea, a severe paroxysmal non-productive cough of two months' duration, low-grade fever and exhaustion.[ncbi.nlm.nih.gov]
  • Abstract A 20 mo old male child, born at 31 weeks, presented to an out-of-hours General Practitioner (GP) with a 7 d history of cough and fever. There was history of post-tussive vomiting.[ncbi.nlm.nih.gov]
  • Abstract A 37-year-old Japanese woman, who was not vaccinated against Bordetella pertussis, developed a nocturnal fever with persistent dry cough for more than 2 weeks. A chest radiograph showed poorly-defined nodular opacities in the left lung.[ncbi.nlm.nih.gov]
  • We present a 63 years old man with multiple myeloma who was admitted to the medical department with cough, hoarseness and fever.[ncbi.nlm.nih.gov]
Malaise
  • The first stage, colonization, is an upper respiratory disease with fever, malaise and coughing, which increases in intensity over about a 10-day period.[textbookofbacteriology.net]
  • The first stage causes upper respiratory ailments with fever, malaise, and coughing. The second stage begins gradually with a prolonged and paroxysmal cough that ends with the characteristic gasp, or whoop.[web.mst.edu]
  • The first stage is the catarrhal phase with symptoms of mild respiratory infection including malaise, conjunctivitis, nasal discharge, sore throat, dry cough and mild fever. This progresses after one or two weeks to the paroxysmal coughing stage.[patient.info]
Low Fever
  • Symptomology is very similar to a traditional upper respiratory infection and includes mild coughing, low fever, and coryza. Individuals are most infectious during this stage.[pathwaymedicine.org]
  • The first stage, known as the catarrhal stage, mimics the common cold, and is classified by a runny nose, low fever, sneezing, and mild cough (4).[austincc.edu]
Pertussis
  • Antibody Stain Bordetella pertussis by PCR 0065078 Polymerase Chain Reaction Bordetella pertussis/parapertussis by PCR 0065080 Polymerase Chain Reaction Bordetella pertussis Antibodies, IgG & IgM 0050801 Enzyme-Linked Immunosorbent Assay Bordetella pertussis[web.archive.org]
  • (CDC) Bordetella pertussis Whooping cough ( pertussis ) is caused by the bacterium Bordetella pertussis . B. pertussis is a very small Gram-negative aerobic coccobacillus that appears singly or in pairs.[textbookofbacteriology.net]
  • Abstract Pertussis is an acute respiratory infectious disease caused by the bacterium Bordetella pertussis. Although pertussis vaccination was introduced in the 1960s, pertussis is still an endemic disease in China.[ncbi.nlm.nih.gov]
Cough
  • Despite the high prevalence of coughs for many years, what causes them remains unknown.[ncbi.nlm.nih.gov]
  • Search results Disease Topic Bordetella pertussis- Whooping Cough topic for more information Bordetella pertussis Antibody, IgG by ELISA with Reflex to Immunoblot 2001768 ...[arupconsult.com]
  • The presence of whooping cough (LR , 2.1) and posttussive vomiting (LR , 1.7) somewhat increased the likelihood of BP, whereas the absence of paroxysmal cough (LR-, 0.58) and the absence of sputum (LR-, 0.63) decreased it.[ncbi.nlm.nih.gov]
  • CONCLUSIONS: B. pertussis is responsible for an important proportion of whooping cough in hospitalized children in Cajamarca.[ncbi.nlm.nih.gov]
  • Consider pertussis in patients with cough longer than 14 days.[web.archive.org]
Paroxysmal Cough
  • After 7-10 day incubation, a prolonged course ensues,consisting of 3 overlapping stages Catarrhal Paroxysmal coughing Convalescent Partially immune persons and infants older than 6 months may not show all typical features Paroxysmal coughing may be absent[web.archive.org]
  • The presence of whooping cough (LR , 2.1) and posttussive vomiting (LR , 1.7) somewhat increased the likelihood of BP, whereas the absence of paroxysmal cough (LR-, 0.58) and the absence of sputum (LR-, 0.63) decreased it.[ncbi.nlm.nih.gov]
  • Since paroxysmal cough is considered one of the main symptoms of pertussis, we retrospectively assessed the frequency of paroxysmal cough in ARI. Paroxysmal cough was reported by the parents or observed by the clinician.[bmcinfectdis.biomedcentral.com]
Common Cold
  • While common cold and flu viruses can cause ordinary coughs (which can often be relieved with humidifiers and cough syrups), B. pertussis bacteria causes “whooping cough,” a serious cough that can go on for over 6 weeks.[giantmicrobes.com]
  • Signs and Symptoms When symptoms first start, pertussis tends to look a lot like a common cold, causing a runny nose and perhaps a slight fever and mild cough. The severe coughing spells begin a week or so later.[intermountainhealthcare.org]
  • Pertussis is highly infectious and contagious Disease spread often not recognized due to mild symptoms in immunized persons Secondary spread common in families and schools Adult and teenage children with common cold symptoms are significant reservoirs[web.archive.org]
Persistent Cough
  • Besides the clinical diagnostics (long persisting cough with staccato cough attacks) the serological diagnostics is applied to determine the status of immunity (possibly after vaccination) and an acute infection.[mikrogen.de]
  • Pertussis, also known as whooping cough, is a respiratory infection that causes a persistent cough in all age groups from the newborn to the elderly.[ibl-international.com]
Choking
  • […] amusing gifts for anyone Each Plush doll is 5-to-7 inches and has an image of the real microbe it represents, as well as information about it. 69.95 21.90 19.95 79.00 69.00 69.00 29.95 15.95 18.95 11.95 Special offers and product promotions WARNING: CHOKING[amazon.com]
  • The child chokes, gasps and flails the extremities, with eyes bulging and watering and face reddened. There is frequently post-cough vomiting. The paroxysms may be severe enough to bring on cyanosis. This is called the paroxysmal stage.[patient.info]
  • […] include symptoms such as: Frequent severe bouts of coughing, sometimes followed by vomiting Several rapid coughs followed by a whooping sound as the person inhales; affected adults may cough but not whoop, and infants may have trouble breathing and may choke[labtestsonline.org]
Gagging
  • They often have trouble breathing and coughing is frequently followed by vomiting or gagging. The name whooping cough comes from the noise of the cough that ends with a ‘whoop’ sound when the air is drawn back into the chest.[childrens.health.qld.gov.au]
Hematuria
  • Diagnostic work-up of unexplained hematuria and proteinuria during the illness revealed low serum complement component 3 (C3) levels. During follow-up, C3 levels remained low (400-600 mg/L).[ncbi.nlm.nih.gov]

Workup

  • However, whereas a genetic workup for complement regulator mutations was performed, no mutation was found in our patient.[ncbi.nlm.nih.gov]
  • Kari Morandi - 2018-09-17 11:32 Disease Topic Infectious Encephalitis workup CSF analysis – critical for diagnosis unless contraindicated (Zunt, Infectious Diseases Society of ...[arupconsult.com]
Hyponatremia
  • Edema and mild hyponatremia were notable predominant symptoms of Bordetella pertussis infection. By exclusion of all other causes, the edema was probably due to inflammation and damage to the capillary wall caused by pertussis toxins.[ncbi.nlm.nih.gov]

Treatment

  • Here, we describe the disease course, diagnostic difficulties and treatment procedure. After 20 days of treatment based on the doctors’ experience (without an established diagnosis), the child was deemed healthy and discharged.[ncbi.nlm.nih.gov]
  • Treatment reduces contagious phase in 5 days and may negate PCR results. B. parapertussis is a related species that may also cause pertussis syndrome; illness usually milder.[web.archive.org]
  • Macrolide antibiotics, such as azithromycin, are the currently recommended treatment for pertussis.[ncbi.nlm.nih.gov]
  • The infection was detected and the 2 patients had good outcomes following azithromycin treatment.[ncbi.nlm.nih.gov]

Prognosis

  • […] vaccine against diphtheria, tetanus, and pertussis acellular pertussis vaccine 5 doses before school-age, completed by 4-6 years of age Tdap vaccine booster vaccine at 11-12 years of age should also be given to pregnant mothers and those around them Prognosis[medbullets.com]
  • Prognosis : Pertussis usually causes prolonged symptoms: often one to two weeks of cold-like symptoms, followed by several weeks to months of severe coughing. It may take a few more weeks of recovery with gradual clearing of symptoms.[thevaccinemom.com]
  • Prognosis [ 5 ] The most severe infections are usually in infants, with morbidity and mortality greatest in those aged less than 6 months.[patient.info]

Etiology

  • M. pneumoniae etiology was diagnosed by culture and RT-PCR. The evolution was fatal for all of the subjects.[ncbi.nlm.nih.gov]
  • B. pertussis is a strict human pathogen of recent evolutionary origin and is the primary etiologic agent of whooping cough.[ncbi.nlm.nih.gov]
  • Bordetella pertussis is the etiological agent of pertussis and produces various virulence factors, including pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN), most of which are positively regulated by the BvgAS two-component sensory[ncbi.nlm.nih.gov]
  • Bordetella pertussis, the etiological agent of whooping cough, still causes outbreaks.[ncbi.nlm.nih.gov]
  • We conclude by assessing the evidence for causation against the Bradford Hill criteria, and advocate for further investigation into the potential role of BP in the etiology of AD. Copyright 2016 The Author(s). Published by Elsevier GmbH..[ncbi.nlm.nih.gov]

Epidemiology

  • Microbiology Department, University Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, 08950, Spain. 3 CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. 4 CIBER of Epidemiology and Public[ncbi.nlm.nih.gov]
  • This review discusses recent findings in B. pertussis epidemiology and evolution in the light of pertussis resurgence, and highlights the important role for genomics-based studies in monitoring B. pertussis adaptation.[ncbi.nlm.nih.gov]
  • Building on these observations with supporting epidemiologic and biologic evidence, we propose that, contrary to conventional wisdom that subclinical pertussis infections are innocuous to hosts, B. pertussis colonization is an important cause of multiple[ncbi.nlm.nih.gov]
  • In this study, we report the result of antimicrobial susceptibility testing performed for the suspected erythromycin-resistant isolate, as well as for an additional 27 B. pertussis clinical isolates that represented almost all epidemiologically unrelated[ncbi.nlm.nih.gov]
  • CONCLUSION: The use of RT-PCR permits improved detection and diagnosis of pertussis and a better understanding of the epidemiology of sources of infection. The complications and mortality rate of pertussis continue to be high.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Useful For Suggests clinical disorders or settings where the test may be helpful Diagnosis of recent infection with Bordetella pertussis in patients with or 2 weeks of symptoms consistent with whooping cough Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Preferred diagnostic test for the detection of Bordetella pertussis or Bordetella parapertussis Clinical Information Discusses physiology, pathophysiology, and general clinical[mayomedicallaboratories.com]

Prevention

  • The organism was detected with the BACTEC 9240 system after 6 days of incubation and was confirmed as B. pertussis by the Centers for Disease Control and Prevention.[ncbi.nlm.nih.gov]
  • B. pertussis immunization may not prevent infection but can reduce the severity. B. pertussis was detected in sputum from the adult by direct-fluorescent antibody staining and was grown on Regan-Lowe medium.[ncbi.nlm.nih.gov]
  • Prevention Pertussis is a vaccine-preventable infection. There are four combination vaccines used to prevent diphtheria, tetanus and pertussis: DTaP, Tdap, DT, and Td.[dentalcare.com]
  • B. pertussis should be suspected in infants hospitalized for acute respiratory symptoms for early treatment and prevent complications.[ncbi.nlm.nih.gov]
  • (August 31, 2015) Centers for Disease Control and Prevention. Pertussis, Diagnosis Confirmation. Available online at . Accessed October 2015. (May 19, 2015) Centers for Disease Control and Prevention.[labtestsonline.org]

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