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Bordetella Pertussis

B Pertussis


Presentation

  • We report a 28-day-old female infant with pertussis presenting as severe acute bronchiolitis with cyanosis. On admission, the patient's symptoms were similar to those of acute bronchiolitis.[ncbi.nlm.nih.gov]
  • We present a very rare case of a patient with non-small-cell lung cancer and unilateral pleural effusion who presented BP infection. References [1] S. Mattoo, J.D.[archbronconeumol.org]
Fever
  • Tick-borne Rickettsia rickettsii Rocky Mountain spotted fever Rickettsia conorii Boutonneuse fever Rickettsia japonica Japanese spotted fever Rickettsia sibirica North Asian tick typhus Rickettsia australis Queensland tick typhus Rickettsia honei Flinders[en.wikipedia.org]
  • It is caused by Bordetella pertussis ... pneumophila (Legionellosis)- Pontiac Fever and Legionnaires’ Disease Mycoplasma pneumoniae Infection Pertussis ... to diagnose pertussis.[arupconsult.com]
  • A 60-year-old heterosexual man with AIDS was admitted to hospital with dyspnea, a severe paroxysmal non-productive cough of two months' duration, low-grade fever and exhaustion.[ncbi.nlm.nih.gov]
Malaise
  • The first stage, colonization, is an upper respiratory disease with fever, malaise and coughing, which increases in intensity over about a 10-day period.[textbookofbacteriology.net]
  • The first stage causes upper respiratory ailments with fever, malaise, and coughing. The second stage begins gradually with a prolonged and paroxysmal cough that ends with the characteristic gasp, or whoop.[web.mst.edu]
  • The first stage is the catarrhal phase with symptoms of mild respiratory infection including malaise, conjunctivitis, nasal discharge, sore throat, dry cough and mild fever. This progresses after one or two weeks to the paroxysmal coughing stage.[patient.info]
  • View/Print Table TABLE 1 Stages of Pertussis Infection Stage Duration(weeks) Symptoms Comment Catarrhal One to two Lacrimation, low-grade fever, malaise, mild conjunctival inflammation, rhinorrhea, late-phase nonproductive cough Insidious onset Gradually[aafp.org]
Low Fever
  • Symptomology is very similar to a traditional upper respiratory infection and includes mild coughing, low fever, and coryza. Individuals are most infectious during this stage.[pathwaymedicine.org]
  • The first stage, known as the catarrhal stage, mimics the common cold, and is classified by a runny nose, low fever, sneezing, and mild cough (4).[austincc.edu]
Rigor
  • Over 340 isolates were analyzed and analytical validation parameters, such as precision, reproducibility, and stability, were rigorously tested. Intra-plate and inter-plate variability measured at 9.8% and 11.5%, respectively.[ncbi.nlm.nih.gov]
Streptococcal Pharyngitis
  • A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect ... Kari Morandi - 2019-06-10 09:07 Pages[arupconsult.com]
Pertussis
  • (CDC) Bordetella pertussis Whooping cough ( pertussis ) is caused by the bacterium Bordetella pertussis. B. pertussis is a very small Gram-negative aerobic coccobacillus that appears singly or in pairs.[textbookofbacteriology.net]
  • Antibody Stain Bordetella pertussis by PCR 0065078 Polymerase Chain Reaction Bordetella pertussis/parapertussis by PCR 0065080 Polymerase Chain Reaction Bordetella pertussis Antibodies, IgG & IgM 0050801 Enzyme-Linked Immunosorbent Assay Bordetella pertussis[web.archive.org]
  • The previous statements that B. pertussis was a nonmotile organism were consistent with a stop codon located in the flagellar biosynthesis gene, flhA, discovered when the B. pertussis Tohama I genome was sequenced and analyzed by Parkhill et al. in 2003[ncbi.nlm.nih.gov]
Cough
  • Consider pertussis in patients with cough longer than 14 days.[web.archive.org]
  • CONCLUSIONS: B. pertussis is responsible for an important proportion of whooping cough in hospitalized children in Cajamarca.[ncbi.nlm.nih.gov]
  • A prolonged cough may be irritating and sometimes a disabling cough may go undiagnosed in adults for many months.[en.wikipedia.org]
  • To search the entire book, enter a term or phrase in the form below Custom Search Bordetella pertussis and Whooping Cough (page 1) (This chapter has 3 pages) Kenneth Todar, PhD Bordetella pertussis, the agent of pertussis or whooping cough.[textbookofbacteriology.net]
Paroxysmal Cough
  • After 7-10 day incubation, a prolonged course ensues,consisting of 3 overlapping stages Catarrhal Paroxysmal coughing Convalescent Partially immune persons and infants older than 6 months may not show all typical features Paroxysmal coughing may be absent[web.archive.org]
  • A baboon model for pertussis was recently developed that closely matches the clinical illness, including development of paroxysmal cough and demonstration of host-to-host transmission by aerosolized respiratory droplets.[doi.org]
  • Since paroxysmal cough is considered one of the main symptoms of pertussis, we retrospectively assessed the frequency of paroxysmal cough in ARI. Paroxysmal cough was reported by the parents or observed by the clinician.[bmcinfectdis.biomedcentral.com]
Common Cold
  • Initially, symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough. This is then followed by several weeks of severe coughing fits.[osmosis.org]
  • While common cold and flu viruses can cause ordinary coughs (which can often be relieved with humidifiers and cough syrups), B. pertussis bacteria causes “whooping cough,” a serious cough that can go on for over 6 weeks.[giantmicrobes.com]
  • Signs and Symptoms When symptoms first start, pertussis tends to look a lot like a common cold, causing a runny nose and perhaps a slight fever and mild cough. The severe coughing spells begin a week or so later.[intermountainhealthcare.org]
  • Pertussis is highly infectious and contagious Disease spread often not recognized due to mild symptoms in immunized persons Secondary spread common in families and schools Adult and teenage children with common cold symptoms are significant reservoirs[web.archive.org]
Persistent Cough
  • Besides the clinical diagnostics (long persisting cough with staccato cough attacks) the serological diagnostics is applied to determine the status of immunity (possibly after vaccination) and an acute infection.[mikrogen.de]
  • cough and in whom pertussis is suspected Children with consistent epidemiological and clinical features of disease A negative result does not rule out the presence of B. pertussis DNA in concentrations below detection level of assay A false positive[web.archive.org]
  • Pertussis, also known as whooping cough, is a respiratory infection that causes a persistent cough in all age groups from the newborn to the elderly.[ibl-international.com]
Choking
  • […] amusing gifts for anyone Each Plush doll is 5-to-7 inches and has an image of the real microbe it represents, as well as information about it. 69.95 21.90 19.95 79.00 69.00 69.00 29.95 15.95 18.95 11.95 Special offers and product promotions WARNING: CHOKING[amazon.com]
  • The child chokes, gasps and flails the extremities, with eyes bulging and watering and face reddened. There is frequently post-cough vomiting. The paroxysms may be severe enough to bring on cyanosis. This is called the paroxysmal stage.[patient.info]
  • You may have choking spells or may cough so hard that you vomit.DR.T.V.RAO MD 4 5.[slideshare.net]
  • Pertussis infection in infants may cause severe cough, choking, poor feeding, and apnea without paroxysmal cough Footnote 3, Footnote 7, Footnote 10.[canada.ca]
  • […] include symptoms such as: Frequent severe bouts of coughing, sometimes followed by vomiting Several rapid coughs followed by a whooping sound as the person inhales; affected adults may cough but not whoop, and infants may have trouble breathing and may choke[labtestsonline.org]
Gagging
  • They often have trouble breathing and coughing is frequently followed by vomiting or gagging. The name whooping cough comes from the noise of the cough that ends with a ‘whoop’ sound when the air is drawn back into the chest.[childrens.health.qld.gov.au]
Arthritis
  • Pneumonia Legionella pneumophila (Legionellosis)- Pontiac Fever and Legionnaires’ Disease Septic Arthritis ... Streptococcus pneumoniae bacteria cause a wide variety of infections, including pneumonia, bacteremia, otitis media (OM), ...[arupconsult.com]

Workup

  • However, whereas a genetic workup for complement regulator mutations was performed, no mutation was found in our patient.[ncbi.nlm.nih.gov]
  • Tamra Carlson - 2019-06-10 09:52 Disease Topic Infectious Encephalitis workup CSF analysis – critical for diagnosis unless contraindicated (Zunt, Infectious Diseases Society of ...[arupconsult.com]
Atelectasis
  • Autopsy studies of pertussis victims performed in the early 20th century revealed a diffuse bronchopneumonia with increased secretion of mucus, associated with airway plugging and atelectasis ( 1 ).[pnas.org]
Hyponatremia
  • Edema and mild hyponatremia were notable predominant symptoms of Bordetella pertussis infection. By exclusion of all other causes, the edema was probably due to inflammation and damage to the capillary wall caused by pertussis toxins.[ncbi.nlm.nih.gov]

Treatment

  • Here, we describe the disease course, diagnostic difficulties and treatment procedure. After 20 days of treatment based on the doctors’ experience (without an established diagnosis), the child was deemed healthy and discharged.[ncbi.nlm.nih.gov]
  • Treatment reduces contagious phase in 5 days and may negate PCR results. B. parapertussis is a related species that may also cause pertussis syndrome; illness usually milder.[web.archive.org]

Prognosis

  • […] vaccine against diphtheria, tetanus, and pertussis acellular pertussis vaccine 5 doses before school-age, completed by 4-6 years of age Tdap vaccine booster vaccine at 11-12 years of age should also be given to pregnant mothers and those around them Prognosis[medbullets.com]
  • Prognosis : Pertussis usually causes prolonged symptoms: often one to two weeks of cold-like symptoms, followed by several weeks to months of severe coughing. It may take a few more weeks of recovery with gradual clearing of symptoms.[thevaccinemom.com]
  • Prognosis [ 5 ] The most severe infections are usually in infants, with morbidity and mortality greatest in those aged less than 6 months.[patient.info]

Etiology

  • M. pneumoniae etiology was diagnosed by culture and RT-PCR. The evolution was fatal for all of the subjects.[ncbi.nlm.nih.gov]

Epidemiology

  • Microbiology Department, University Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, 08950, Spain. 3 CIBER of Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, 28029, Spain. 4 CIBER of Epidemiology and Public[ncbi.nlm.nih.gov]
  • Defining pertussis epidemiology: clinical, microbiologic and serologic perspectives. Pediatr Infect Dis J. 2005 ; 24 ( 5 Suppl ): S25-S34. (Link to PubMed) Forsyth,K., Tan,T., von Konig,C.H., Caro,J.J., Plotkin,S.[web.archive.org]
Sex distribution
Age distribution

Pathophysiology

  • One of the important considerations in the design of a new vaccine is the pathophysiology of pertussis; identification of individual virulence factors and assessment of their roles in the disease will provide a sound basis for vaccine development, which[creative-diagnostics.com]
  • It causes inflammation and necrosis of the respiratory tract ciliated epithelium and it produces immunological and pathophysiological reactions.[diesse.it]
  • Useful For Suggests clinical disorders or settings where the test may be helpful Diagnosis of recent infection with Bordetella pertussis in patients with or 2 weeks of symptoms consistent with whooping cough Clinical Information Discusses physiology, pathophysiology[mayomedicallaboratories.com]

Prevention

  • Acellular pertussis vaccination in baboons induces a Th2-skewed immune response and prevents pertussis-associated symptoms but does not prevent mucosal colonization or host-to-host transmission.[doi.org]
  • Centers for Disease Control and Prevention (2015). "Pertussis". In Atkinson, W.; Wolfe, S.; Hamborsky, J. (eds.). Epidemiology and Prevention of Vaccine-Preventable Diseases: The Pink Book (13th ed.). Public Health Foundation.[en.wikipedia.org]
  • The organism was detected with the BACTEC 9240 system after 6 days of incubation and was confirmed as B. pertussis by the Centers for Disease Control and Prevention.[ncbi.nlm.nih.gov]
  • (August 31, 2015) Centers for Disease Control and Prevention. Pertussis, Diagnosis Confirmation. Available online at . Accessed October 2015. (May 19, 2015) Centers for Disease Control and Prevention.[labtestsonline.org]

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