Review of the case histories of these patients revealed some atypical clinical features and variability in clinical presentation. [ncbi.nlm.nih.gov]

• Hepatosplenomegaly

  Physical examination revealed hepatosplenomegaly, and laboratory studies showed anemia, thrombocytopenia, increased aspartate transaminase level, and microscopic hematuria. [ncbi.nlm.nih.gov]

• Periodontitis

  (human diarrheal disease, swine dysentery), and oral treponemes associated with periodontal disease ( 5 – 8 ). The periplasmic flagella of spirochetes have been characterized in detail. [doi.org]

• Flexion Contracture

  A 49-year-old man presented a progressive swelling and induration of the skin resulting in flexion contracture. He had a history of two tick bites at the age of 17 and 47 years. [ncbi.nlm.nih.gov]

• Hyperkeratosis

  Determination of the causative agent of erythema-like skin lesions in case of nonspecific superficial perivascular dermatitis was supported by histological examination and led to the latter diagnosis of Hyperkeratosis lenticularis perstans (Flegel disease [ncbi.nlm.nih.gov]

• Subcutaneous Nodule

  It presented clinically as a solitary subcutaneous nodule. Histopathologically, the lesion resembled subcutaneous panniculitis-like T-cell lymphoma by manifesting atypically appearing lymphocytes with cytotoxic phenotype. [ncbi.nlm.nih.gov]

• Microscopic Hematuria

  Physical examination revealed hepatosplenomegaly, and laboratory studies showed anemia, thrombocytopenia, increased aspartate transaminase level, and microscopic hematuria. [ncbi.nlm.nih.gov]

• Catatonia

  Abstract We report a 19-year-old patient who presented with an acute encephalopathy manifested by catatonia. We isolated Borrelia burgdorferi from the CSF and demonstrated intrathecal production of IgG antibodies against B burgdorferi. [ncbi.nlm.nih.gov]

• Mental Deterioration

  The cerebellar ataxia and subsequent mental deterioration are unusual clinical features of Lyme neuroborreliosis. [ncbi.nlm.nih.gov]

• Cerebellar Sign

  A 36-year-old Japanese woman presented with progressive cerebellar signs and mental deterioration of subacute course after her return from the USA. Her serum antibody to spirochete Borrelia burgdorferi was significantly elevated. [ncbi.nlm.nih.gov]

Extensive ophthalmic and systemic workup, including serologic testing and imaging techniques. [ncbi.nlm.nih.gov]

• Gliosis

  The dentate nucleus and inferior olivary nucleus showed the most advanced lesions with profound fibrillary gliosis. [ncbi.nlm.nih.gov]

An early diagnosis and a prompt establishment of an adequate antibiotic treatment is needed for a successful recovery. [ncbi.nlm.nih.gov]

[…] and Chronic Lyme Disease The long-term prognosis for individuals who are treated appropriately with antimicrobials for Lyme disease, regardless of the stage of the illness, is excellent. [pedsinreview.aappublications.org]

Lyme Disease Treatment and Prognosis Centers for Disease Control and Prevention [On-line information]. Available online at http://www.cdc.gov/ncidod/dvbid/lyme/ld_humandisease_treatment.htm. Accessed March 2009. Mayo Clinic Staff (2008 May 2). [labtestsonline.it]

What should you tell the family about the patient’s prognosis? Most patients recover fully within 3-4 weeks after appropriate treatment. [infectiousdiseaseadvisor.com]

Abstract Despite considerable achievements in the study of localized scleroderma, the etiology of the disease has not been investigated completely. [ncbi.nlm.nih.gov]

* Lyme Disease/microbiology Male Multilocus Sequence Typing Netherlands/epidemiology Phylogeny RNA, Ribosomal, 23S/genetics RNA, Ribosomal, 5S/genetics Substances DNA, Intergenic RNA, Ribosomal, 23S RNA, Ribosomal, 5S [ncbi.nlm.nih.gov]

Microbiology and pathophysiology Radolf, JD, Caimano, MJ, Stevenson, B, Hu, LT. "Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes". Nat Rev Microbiol. vol. 10. 2012. pp. 87-99. [infectiousdiseaseadvisor.com]

Gibson GJ: Diaphragmatic paresis: pathophysiology, clinical features, and investigation. Thorax. 1989; 44 (11): 960–70. PubMed Abstract | Publisher Full Text | Free Full Text 6. [f1000research.com]

The pathophysiology of this syndrome is not well understood, although proposed to be an autoimmune based process [ 17 ], the role of ongoing bacterial infection in the process remains under investigation [ 18, 19 ]. [bmcinfectdis.biomedcentral.com]

Author information 1 State Key Laboratory of Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. [email protected] [ncbi.nlm.nih.gov]

Aug 1;34:12C.5.1-31 Centers for Disease Control and Prevention: Lyme Disease [thenativeantigencompany.com]

Jeannine Petersen, microbiologist at the Centers for Disease Control and Prevention. [cdc.gov]

Steps to prevent Lyme disease include using insect repellent, removing ticks promptly, applying pesticides, and reducing tick habitat. The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well. [microbiologyinpictures.com]