Review of the case histories of these patients revealed some atypical clinical features and variability in clinical presentation. [ncbi.nlm.nih.gov]

• Periodontitis

  (human diarrheal disease, swine dysentery), and oral treponemes associated with periodontal disease ( 5 – 8 ). The periplasmic flagella of spirochetes have been characterized in detail. [doi.org]

• Hepatosplenomegaly

  Physical examination revealed hepatosplenomegaly, and laboratory studies showed anemia, thrombocytopenia, increased aspartate transaminase level, and microscopic hematuria. [ncbi.nlm.nih.gov]

• Dry Eyes

  However, he had never complained of Raynaud's phenomenon of the fingers, dry mouth, or dry eyes. At this first visit to our hospital, he complained of erythematous cutaneous sclerosis with swelling of the dorsum of the neck. [ncbi.nlm.nih.gov]

• Flexion Contracture

  A 49-year-old man presented a progressive swelling and induration of the skin resulting in flexion contracture. He had a history of two tick bites at the age of 17 and 47 years. [ncbi.nlm.nih.gov]

• Hyperkeratosis

  Determination of the causative agent of erythema-like skin lesions in case of nonspecific superficial perivascular dermatitis was supported by histological examination and led to the latter diagnosis of Hyperkeratosis lenticularis perstans (Flegel disease [ncbi.nlm.nih.gov]

• Subcutaneous Nodule

  It presented clinically as a solitary subcutaneous nodule. Histopathologically, the lesion resembled subcutaneous panniculitis-like T-cell lymphoma by manifesting atypically appearing lymphocytes with cytotoxic phenotype. [ncbi.nlm.nih.gov]

• Microscopic Hematuria

  Physical examination revealed hepatosplenomegaly, and laboratory studies showed anemia, thrombocytopenia, increased aspartate transaminase level, and microscopic hematuria. [ncbi.nlm.nih.gov]

• Catatonia

  Abstract We report a 19-year-old patient who presented with an acute encephalopathy manifested by catatonia. We isolated Borrelia burgdorferi from the CSF and demonstrated intrathecal production of IgG antibodies against B burgdorferi. [ncbi.nlm.nih.gov]

• Mental Deterioration

  The cerebellar ataxia and subsequent mental deterioration are unusual clinical features of Lyme neuroborreliosis. [ncbi.nlm.nih.gov]

• Cerebellar Sign

  A 36-year-old Japanese woman presented with progressive cerebellar signs and mental deterioration of subacute course after her return from the USA. Her serum antibody to spirochete Borrelia burgdorferi was significantly elevated. [ncbi.nlm.nih.gov]

Extensive ophthalmic and systemic workup, including serologic testing and imaging techniques. [ncbi.nlm.nih.gov]

• Pericardial Effusion

  Pericardial effusion associated with Lyme disease has not been described as yet. This article demonstrates a case of a female patient, 54 years of age, with Borrelia burgdorferi infection and associated pericardial effusion. [ncbi.nlm.nih.gov]

• Gliosis

  The dentate nucleus and inferior olivary nucleus showed the most advanced lesions with profound fibrillary gliosis. [ncbi.nlm.nih.gov]

Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. [email protected] 2 Collaborative Innovation Center for Diagnosis and Treatment [ncbi.nlm.nih.gov]

[…] and Chronic Lyme Disease The long-term prognosis for individuals who are treated appropriately with antimicrobials for Lyme disease, regardless of the stage of the illness, is excellent. [pedsinreview.aappublications.org]

What should you tell the family about the patient’s prognosis? Most patients recover fully within 3-4 weeks after appropriate treatment. [infectiousdiseaseadvisor.com]

Lyme Disease Treatment and Prognosis Centers for Disease Control and Prevention [On-line information]. Available online at . Accessed March 2009. Mayo Clinic Staff (2008 May 2). Lyme disease. MayoClinic.com [On-line information]. [labtestsonline.it]

Abstract Despite considerable achievements in the study of localized scleroderma, the etiology of the disease has not been investigated completely. [ncbi.nlm.nih.gov]

* Lyme Disease/microbiology Male Multilocus Sequence Typing Netherlands/epidemiology Phylogeny RNA, Ribosomal, 23S/genetics RNA, Ribosomal, 5S/genetics Substances DNA, Intergenic RNA, Ribosomal, 23S RNA, Ribosomal, 5S [ncbi.nlm.nih.gov]

Microbiology and pathophysiology Radolf, JD, Caimano, MJ, Stevenson, B, Hu, LT. "Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes". Nat Rev Microbiol. vol. 10. 2012. pp. 87-99. [infectiousdiseaseadvisor.com]

The pathophysiology of this syndrome is not well understood, although proposed to be an autoimmune based process [ 17 ], the role of ongoing bacterial infection in the process remains under investigation [ 18, 19 ]. [bmcinfectdis.biomedcentral.com]

The discovery of some causative infections in MALT lymphomas has allowed significant progress in understanding the pathophysiology of this malignancy. [doi.org]

Author information 1 State Key Laboratory of Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. [email protected] [ncbi.nlm.nih.gov]

Aug 1;34:12C.5.1-31 Centers for Disease Control and Prevention: Lyme Disease [thenativeantigencompany.com]