After treatment with ruxolitinib and bortezomib, RPMI-8226 and U266 presented 50% of cells in late apoptosis, reduction of anti-apoptotic genes expression and higher number of cells in SubG0 phase. [ncbi.nlm.nih.gov]

Our case presentation, we present a case of bortezomib-induced biopsy-proven AIN, which, to our knowledge, has not previously been reported. [doi.org]

• Intravenous Administration

  Characterize bortezomib pharmacokinetics/pharmacodynamics in relapsed myeloma patients after single and repeat intravenous administration at two doses. [ncbi.nlm.nih.gov]

  Keith Stewart Original Article First Online: 20 March 2010 Abstract Purpose Characterize bortezomib pharmacokinetics/pharmacodynamics in relapsed myeloma patients after single and repeat intravenous administration at two doses. [doi.org]

  [see How Supplied/Storage and Handling] In clinical trials, local skin irritation was reported in 5% of patients, but extravasation of VELCADE was not associated with tissue damage. 2.7 Reconstitution/Preparation for Intravenous Administration Proper [globalrph.com]

  "Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study". The Lancet. Oncology. 12 (5): 431–40. doi:10.1016/s1470-2045(11)70081-x. [en.wikipedia.org]

• Varicella-Zoster Virus Infection

  Infection Risk of reactivation of varicella zoster virus infection. 1 In phase 3 study, antiviral prophylaxis appeared to reduce risk of reactivation in patients receiving VMP regimen. 1 Consider antiviral prophylaxis in patients receiving bortezomib [drugs.com]

• Hyperthermia

  KEYWORDS: Apoptosis; Blood cancer; Bortezomib; Cytotoxicity; Hyperthermia; Velcade [ncbi.nlm.nih.gov]

• Hypoxemia

  This report describes a 57-year-old patient with light chain (primary) amyloidosis receiving weekly subcutaneous bortezomib injections who presented with recurrent hypoxemia and interstitial pneumonitis. [ncbi.nlm.nih.gov]

• Turkish

  M Beksac, R Haznedar, T Firatli-Tuglular, etal: Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: Results of a randomized trial from the Turkish Myeloma Study Group Eur J Haematol [doi.org]

• Peripheral Neuropathy

  Four patients who developed a bortezomib-induced peripheral neuropathy underwent electrophysiological testing, and 1 patient had a nerve biopsy. [ncbi.nlm.nih.gov]

  Neuropathy Risk of severe (grade 3 or greater) new-onset peripheral neuropathy or exacerbation of preexisting peripheral neuropathy. 1 Occurs predominantly as peripheral sensory neuropathy, but severe peripheral motor neuropathy also reported. 1 Manifestations [drugs.com]

  Peripheral neuropathy Severe sensory and motor peripheral neuropathy has been reported with bortezomib use. [pdr.net]

• Philadelphia Chromosome Positive

  We investigated in vitro BTZ sensitivity in a large panel of ALL cell lines that acted as a model system for refractory ALL, and found that Philadelphia chromosome-positive (Ph+) ALL, IKZF1 deletion, and biallelic loss of CDKN2A were associated with favorable [ncbi.nlm.nih.gov]

• Liver Biopsy

  A liver biopsy showed light chain deposition in Disse spaces. [ncbi.nlm.nih.gov]

We conclude that bortezomib could be an attractive escalating treatment option with a good side-effect profile for patients with treatment refractory CIDP. [ncbi.nlm.nih.gov]

Abstract Prognosis of childhood acute lymphoblastic leukemia (ALL) has been dramatically improved. However, prognosis of the cases refractory to primary therapy is still poor. [ncbi.nlm.nih.gov]

Surveillance, Epidemiology, and End Results Program. 2016. Available at http://seer.cancer.gov/statfacts/html/mulmy.html. Accessed December 13, 2016. 3. Multiple myeloma drug therapies. The MMRF. 2016. [amgen.com]

Universitätsmedizin Berlin, Berlin, Germany 2 Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany 3 Neurocure Clincal Research Center, Charite Universitätsmedizin Berlin, Berlin, Germany 4 Institute of Biometry and Clinical Epidemiology [bmjopen.bmj.com]

The eGFR was calculated according to the chronic kidney disease epidemiology collaboration formula. 11 Adherence to immunosuppressive medication was evaluated by self-assessment of all 19 patients alive. [journals.lww.com]

Another important issue is the risk of developing second primary malignancies because patients are living longer from time of diagnosis. 21 Population studies 22 – 25 and data from the National Cancer Institute's Surveillance, Epidemiology, and End Results [doi.org]

The study was investigated in accordance with the ethical principles stated in the most recent version of the Declaration of Helsinki or the applicable guidelines on epidemiological studies issued by the Ministry of Health, Labor and Welfare and the Ministry [bmccancer.biomedcentral.com]

The incidence of severe adverse effects in clinical trials was lower than 5%, and severe pulmonary complications were not described before the publication of a series of 4 cases. 1 The pathophysiological mechanism of bortezomib lung injury is not well [archbronconeumol.org]

Introduction In spite of a diversity of clinical manifestations, a number of autoimmune diseases are characterised by a common pathophysiology with the production of pathogenic autoantibodies leading to an autoimmune attack on various body sites such [bmjopen.bmj.com]

The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001 ;20: 4519 - 4527 15. Hideshima T, Chauhan D, Richardson P, et al. [nejm.org]

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment. J Hematol Oncol. 2017;10:67. https://doi.org/10.1186/s13045-017-0436-9. [jhoonline.biomedcentral.com]

The pathophysiology of POEMS syndrome is not well understood, but it may be related to changes in the levels of a cytokine or an overproduction of vascular endothelial growth factor (VEGF), probably secreted by clonal plasma cells. [medicalpolicies.amerigroup.com]

Taken together, these results suggest the possibility of developing novel antihypertensive drugs that prevent CYP11B2 expression. Copyright © 2017 Elsevier Inc. All rights reserved. [ncbi.nlm.nih.gov]

Highlights In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury. [eurekalert.org]

Bortezomib is approved for the treatment of multiple myeloma, a plasmacytoma, and has been shown to prevent and reverse antibody-mediated rejection in solid organ transplantation and in prevention of disease progression in lupus mouse models. [acrabstracts.org]