Characterize bortezomib pharmacokinetics/pharmacodynamics in relapsed myeloma patients after single and repeat intravenous administration at two doses. [ncbi.nlm.nih.gov]

Keith Stewart Original Article First Online: 20 March 2010 Abstract Purpose Characterize bortezomib pharmacokinetics/pharmacodynamics in relapsed myeloma patients after single and repeat intravenous administration at two doses. [doi.org]

"Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study". The Lancet Oncology. 12 (5): 431–40. doi : 10.1016/s1470-2045(11)70081-x. PMID 21507715. [en.wikipedia.org]

[see How Supplied/Storage and Handling] In clinical trials, local skin irritation was reported in 5% of patients, but extravasation of VELCADE was not associated with tissue damage. 2.7 Reconstitution/Preparation for Intravenous Administration Proper [globalrph.com]

KEYWORDS: Apoptosis; Blood cancer; Bortezomib; Cytotoxicity; Hyperthermia; Velcade [ncbi.nlm.nih.gov]

This report describes a 57-year-old patient with light chain (primary) amyloidosis receiving weekly subcutaneous bortezomib injections who presented with recurrent hypoxemia and interstitial pneumonitis. [ncbi.nlm.nih.gov]

M Beksac, R Haznedar, T Firatli-Tuglular, etal: Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: Results of a randomized trial from the Turkish Myeloma Study Group Eur J Haematol [doi.org]

Four patients who developed a bortezomib-induced peripheral neuropathy underwent electrophysiological testing, and 1 patient had a nerve biopsy. [ncbi.nlm.nih.gov]

Neuropathy Risk of severe (grade 3 or greater) new-onset peripheral neuropathy or exacerbation of preexisting peripheral neuropathy. 1 Occurs predominantly as peripheral sensory neuropathy, but severe peripheral motor neuropathy also reported. 1 Manifestations [drugs.com]

Peripheral neuropathy Severe sensory and motor peripheral neuropathy has been reported with bortezomib use. [pdr.net]

Posterior reversible encephalopathy syndrome (PRES) is a neuroradiological syndrome characterised by vasogenic oedema involving the postero-occipital cortical and subcortical white matter resulting in visual disturbances, seizures and altered mental status [ncbi.nlm.nih.gov]

We investigated in vitro BTZ sensitivity in a large panel of ALL cell lines that acted as a model system for refractory ALL, and found that Philadelphia chromosome-positive (Ph ) ALL, IKZF1 deletion, and biallelic loss of CDKN2A were associated with favorable [ncbi.nlm.nih.gov]

A liver biopsy showed light chain deposition in Disse spaces. [ncbi.nlm.nih.gov]