This case report presents a classic textbook presentation of ‘grape-like’ vaginal tissue loss. This classical presentation should alarm every doctor since a rapid diagnosis followed by treatment is necessary to prevent death. [ncbi.nlm.nih.gov]

We report a case of embryonal rhabdomyosarcoma (sarcoma botryoides) presenting as a cervical polyp in a 19-year-old female. [nebraska.pure.elsevier.com]

• Swelling

  […] most common; often arises in the head or neck region, or in relation to genitalia in childhood botryoid type - grapelike; occurs in female GU tract. alveolar type - often arises in the limbs pleomorphic type - classically in adults Presentation is as a swelling [gpnotebook.com]

  Cremin, Capetown and WHO) D The histology of a similar bladder, showing multiple calcified ova, marked mucosal swelling, and squamous metaplasia. AFIP 66-3065-54. ... ... Fig. 2.23 A-D. [isradiology.org]

  Extra oral examination showed facial asymmetry, and a diffuse, soft to firm, tender swelling in the posterior region of the mandible ( Figure 1 ). Figure 1: Swelling in left mandibular region. [omicsonline.org]

  Tumors around the eyes may cause bulging of the eye, problems with vision, swelling around the eye, or pain. Tumors in the ears, may cause pain, hearing loss, or swelling. [pennstatehershey.adam.com]

  A cyst is an abnormal lump, swelling, or sac that contains fluid, a part solid material, or a gas, and is covered with a membrane. A membrane is a thin layer of flexible tissue that covers something. [medfriendly.com]

• Surgical Procedure

  The indication for the surgical procedure is based on the clinical findings only and does not require histological confirmation. Primary total cystectomy is considered the treatment of choice. [karger.com]

  procedure like total abdominal hysterectomy in an endevour for better 5 year survival rate also thereby reducing the surgical morbidity. [jiom.com.np]

  They were treated with two-stage surgical procedure and chemotherapy. CONCLUSIONS: A combined modality approach to treating RMS using multidrug chemotherapy, radiotherapy, and surgery has markedly improved survival. [epathologies.com]

  In our case, we decided to treat the patient with neoadjuvant chemotherapy to down stage the tumor which played a role in ease the surgical procedure and minimize the surgical morbidity and complications. [academic.oup.com]

• Pelvic Mass

  Findings include vaginal bleeding and pelvic mass. May be observed protruding from the vagina. Morbidity is high. Treatment includes chemotherapy and surgical removal of the tumor. [visualdx.com]

  We report a case of an 18-month-old Saudi girl presented with history of abdo-pelvic mass, bleeding per vagina and a mass protruding through the introitus. [academic.oup.com]

  Ultrasonographic examination reveals left renal pelvic soft tissue mass around 3 Χ 4 cm [Figure 1], MRI confirms this finding and a tumor is confined to the left renal pelvis without evidence of abdominal lymphadenopathy [Figure 2] a and b. [urologyannals.com]

  This bleeding is postmenopausal in 48% of women with leiomyosarcomas. 19 Other symptoms and findings include vaginal discharge, pelvic pain, abdominal or pelvic masses, and vaginal prolapse. [glowm.com]

  Prostatic tumors can occur in relatively older children and usually present as large pelvic masses with or without urethral strangury and/or constipation. [jiaps.com]

• Constipation

  After four weeks, the patient was brought back with complaints of inability to pass urine and constipation for three days. On examination she was ill looking, dehydrated, febrile to touch (temp 38°C), pale but anicteric. [ijcasereportsandimages.com]

  • Perirectal tumors can cause constipation. • Paraspinal lesionscan cause nerve root abnormalities, such as paresthesia, hypesthesia, or paresis. Gross: • Expansile, rapidly growing soft tissue tumors with a fleshy, grey tan quality. [pedorthpath.com]

  Prostatic tumors can occur in relatively older children and usually present as large pelvic masses with or without urethral strangury and/or constipation. [jiaps.com]

• Osteoporosis

  Comprehensive health information about cancer, osteoporosis, high blood pressure and more. Comprehensive health information including health news updates and health resources. [web.archive.org]

• Fear

  At the same time we learnt primary recurrences in the pelvis has still to be feared of. There is 26% incidence of lymph node metastasis and pelvis is the most common site for primary recurrene. [jiom.com.np]

• Vaginal Bleeding

  Presentation[edit] For botryoid rhabdomyosarcoma of the vagina, the most common clinical finding is vaginal bleeding[2] but vaginal bleeding is not specific for sarcoma botryoides: other vaginal cancers are possible. [en.wikipedia.org]

  Presentation [ edit ] For botryoid rhabdomyosarcoma of the vagina, the most common clinical finding is vaginal bleeding [2] but vaginal bleeding is not specific for sarcoma botryoides: other vaginal cancers are possible. [wikivividly.com]

  Vaginal bleeding which is the most common presentation was reported in our case as well. [ncbi.nlm.nih.gov]

• Vaginal Discharge

  The mother states that her daughter has had intermittent white, foul-smelling vaginal discharge with occasional smearing of blood on her diaper. The mother also describes redness of the skin immediately surrounding the mass. [pedsinreview.aappublications.org]

  Keywords: young girl; vaginal growth; rhabdomyosarcoma; sarcomabytryoids. [jiom.com.np]

  Case Series Case 1: A four-year-old child was presented with a four-month history of serous vaginal discharge, three-month history of intermittent slight vaginal bleeding and two-month history of a mass protruding per vagina. [ijcasereportsandimages.com]

  In fact, in addition to VAC chemotherapy, a cone biopsy or a polypectomy are performed to establish a definitive diagnosis, to reduce tumor burden and to minimize the symptomatology of vaginal discomfort, bleeding and vaginal discharge. [jmedicalcasereports.biomedcentral.com]

Initial diagnostic workup includes an ultrasound of the pelvis, micturating cystourethrogram and a CECT or MRI of the abdomen. [jiaps.com]

[…] resonance imaging (MRI) Bone scanning Ultrasonography Echocardiography Biopsy Open or core needle biopsy: To obtain tissue sampling for diagnosis and molecular studies Bone marrow aspiration and biopsy: To assess for metastatic spread to bone marrow See Workup [emedicine.medscape.com]

Therapy has recently inclined towards conservative treatment. AB - Embryonal rhabdomyosarcoma (sarcoma botryoides) of the female genital tract is rare in the cervix. [nebraska.pure.elsevier.com]

Treatment - Sarcoma botryoides The list of treatments mentioned in various sources for Sarcoma botryoides includes the following list. [checkorphan.org]

A case report. ( 10202753 ) Vlahos NP...Veridiano NP 1999 38 Sarcoma botryoides of the female genital tract: long-term results of conservative treatment followed by pregnancy. [malacards.org]

[…] in the treatment of Embryonal RMS. [academic.oup.com]

Owing to the location, the type of tumour and the good response on chemotherapy, radical surgery or radiotherapy was omitted. 1 At the end of treatment MRI showed a small rest lesion. [ncbi.nlm.nih.gov]

It tends to occur in children and young women, and appears to have a better prognosis than sarcoma botryoides of the vagina and uterus. [nebraska.pure.elsevier.com]

The prognosis of sarcoma botryoides of the cervix is more satisfactory than other rhabdomyosarcomas of the genital system. [ncbi.nlm.nih.gov]

Hormonal milieu appears to play a role in their etiology. The criteria for distinguishing benign vaginal polyp from sarcoma botryoides and mixed mesodermal sarcoma are discussed. [scinapse.io]

Norris and Taylor suggested an etiologic relation between pelvic irradiation and uterine sarcomas. [glowm.com]

(Etiology) The exact cause and mechanism of formation of Embryonal Rhabdomyosarcoma of Vagina is unknown. [dovemed.com]

Etiology Rhabdomyosarcomas develop in the orbital soft tissues, rather than in the extraocular muscles, which supports the theory that the tissue of origin is pluripotential or undifferentiated mesenchyme cells. [eyewiki.aao.org]

This timely volume covers history, epidemiology, demographics, clinical diagnosis, pathology, imaging by echo, CT and MRI of both benign and malignant cardiac tumors, either primary or secondary. [books.google.it]

New multidrug chemotherapy regimens with or without radiation therapy are now used in combination with less radical surgery with good results, although outcome data are not yet available.[4] Epidemiology[edit] Sarcoma botryoides normally is found in children [en.wikipedia.org]

Epidemiology: • IFS accounts for 36%-80% of congenital cases and 36%-100% occurs in first year of life. • IFS is rare after 2 years of age. • There is slight male predominance. [pedorthpath.com]

Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol. 2009; 27 (20): 3391-7[ DOI ][ PubMed ] 13. [intjcancermanag.com]

New multidrug chemotherapy regimens with or without radiation therapy are now used in combination with less radical surgery with good results, although outcome data are not yet available. [4] Epidemiology [ edit ] Sarcoma botryoides normally is found [wikivividly.com]

Pathophysiology The tumor is believed to arise from primitive muscle cells, but tumors can occur anywhere in the body; however, a primary bone rhabdomyosarcoma has not been reported. [emedicine.medscape.com]

This case report describes the importance of early recognition of the typical clinical symptoms of sarcoma botryoides, since a rapid diagnosis followed by treatment is necessary to prevent death. [ncbi.nlm.nih.gov]

Abstract Copyright © 2016, Iranian Journal of Cancer Prevention. [intjcancermanag.com]