Hirschsprung's disease is associated with certain inherited conditions, such as Down syndrome and other abnormalities present at birth, such as congenital heart disease. [mayoclinic.org]

A 45-year-old man with a past history of diabetes mellitus, coronary artery disease with two-vessel disease, and peripheral arterial occlusive disease with gangrene of the left big toe, status post amputation, presented to the emergency department. [ncbi.nlm.nih.gov]

Its mode of inheritance is assumed to be autosomal recessive; however, parental consanguinity was not present in either described case. [emedicine.medscape.com]

These webs are often present at birth. Often, the cause is unknown. Symptoms vary somewhat depending on whether the blockage develops slowly or occurs suddenly. Usually, the blockage and symptoms develop gradually over weeks or months. [merckmanuals.com]

An important finding is that surgery does not treat any anxiety or depression that is also present.11, 12 For those patients with recurrent or persistent abdominal pain, they are re-evaluated for possible re-narrowing of the celiac artery either due to [rarediseases.org]

• Fatigue

  Some of the symptoms are the same as those of gradually developing blockages: fatigue, an enlarged and tender liver, and abdominal pain in the upper abdomen. [merckmanuals.com]

  The characteristic symptoms include inability to maintain penile erection, fatigue of both lower limbs, intermittent bilateral claudication with ischemic pain, and absent or diminished femoral pulses along with pallor or coldness of both lower extremities [ncbi.nlm.nih.gov]

  […] include: Swollen belly Vomiting, including vomiting a green or brown substance Constipation or gas, which might make a newborn fussy Diarrhea In older children, signs and symptoms can include: Swollen belly Chronic constipation Gas Failure to thrive Fatigue [mayoclinic.org]

• Asymptomatic

  The possibilities of asymptomatic offspring or afflicted patients have not been excluded. [emedicine.medscape.com]

  In a study of 75 autopsies, the median arcuate ligament crossed the celiac artery origin entirely (33%) or partially (48%) in a majority of individuals, resulting in significant celiac artery compression.1 Since 13-50% of healthy asymptomatic patients [rarediseases.org]

• Inflammation

  Complete medical evaluation should include blood work (complete blood count, chemistry panel, liver function tests, amylase, lipase, inflammation markers (erythrocyte sedimentation rate, C-reactive protein), pre-albumin, thyroid function tests), upper [rarediseases.org]

• Congestive Heart Failure

  Causes of death are attributable to severe cachexia, anemia, congestive heart failure, embolism, shock, bronchopneumonia, and postoperative complications. One third of patients die from intractable nutritional deficiency. [emedicine.medscape.com]

• Vomiting

  Other signs and symptoms in newborns may include: Swollen belly Vomiting, including vomiting a green or brown substance Constipation or gas, which might make a newborn fussy Diarrhea In older children, signs and symptoms can include: Swollen belly Chronic [mayoclinic.org]

  He was a heavy smoker and complained of severe distension, vomiting, and diffuse abdominal pain for 4–5 days. [ncbi.nlm.nih.gov]

  Additional symptoms include vomiting and a yellow discoloration of the skin and whites of the eyes ( jaundice ). Severe liver failure is rare. [merckmanuals.com]

  […] the celiac artery by the median arcuate ligament is a poorly understood vascular compression syndrome involving the celiac artery and celiac nerve plexus that results in upper abdominal pain (frequently made worse with eating), weight loss, nausea and vomiting [rarediseases.org]

• Nausea

  Other symptoms include nausea and weight loss. [rarediseases.org]

  Some people have no symptoms, but others experience fatigue, abdominal pain, nausea, and jaundice. Fluid may accumulate in the abdomen, the spleen may enlarge, and sometimes severe bleeding occurs in the esophagus. [merckmanuals.com]

• Failure to Thrive

  […] to thrive Fatigue Causes It's not clear what causes Hirschsprung's disease. [mayoclinic.org]

• Heart Disease

  Hirschsprung's disease is associated with certain inherited conditions, such as Down syndrome and other abnormalities present at birth, such as congenital heart disease. [mayoclinic.org]

• Jaundice

  Additional symptoms include vomiting and a yellow discoloration of the skin and whites of the eyes ( jaundice ). Severe liver failure is rare. [merckmanuals.com]

Enterocolitis can be life-threatening and requires immediate treatment. [mayoclinic.org]

The longest-surviving patients were alive 15 and 17.5 years after successful surgical treatment. [emedicine.medscape.com]

Treatment of median arcuate ligament syndrome via traditional and robotic techniques. Hawaii J Med Public Health. 2013; 72: 279-81. 9. Joyce DD, Antiel RM, Oderich G, et al. [rarediseases.org]

Traditional surgical treatments for aortoiliac occlusive disease are aortoiliac endarterectomy (TEA) and aortobifemoral bypass (AFB). [ncbi.nlm.nih.gov]

Drugs (to dissolve or prevent blood clots) Procedures to improve blood flow Liver transplantation (in people with liver failure) Treatment depends on how rapidly the disorder developed and how severe it is. [merckmanuals.com]

The reported cases of infantile Cronkhite-Canada syndrome are scant (< 10). [15] Prognosis Cronkhite-Canada syndrome (CCS) is considered a relentlessly progressive disease with a variable course and poor prognosis depending mainly on control of protein [emedicine.medscape.com]

The developmental etiology and pathogenesis of Hirschsprung disease. Translational Research. 2013;162:1. [mayoclinic.org]

This raises the question of whether infantile Cronkhite-Canada syndrome may be a sporadic condition. [15, 16] Etiology The pathogenesis of Cronkhite-Canada syndrome (CCS) is unknown. [emedicine.medscape.com]

Epidemiology Frequency Cronkhite-Canada syndrome (CCS) has a worldwide distribution; over 500 cases have been reported. [21] The majority of these cases have been documented in Japan, including a large series of 180 patients. [22] Cronkhite-Canada syndrome [emedicine.medscape.com]

Canada as a new distinct clinical entity in two female patients with generalized gastrointestinal polyps, cutaneous pigmentation, alopecia, and onychodystrophy. [1] Pathophysiology The etiology of Cronkhite-Canada syndrome (CCS) is unknown. [emedicine.medscape.com]

Fluid accumulation in the abdomen : A low-salt (sodium) diet and diuretics can help prevent too much fluid from accumulating in the abdomen. Most people need to take anticoagulants indefinitely to prevent new blockages from developing. [merckmanuals.com]

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs [emedicine.medscape.com]