We described an adult male presenting with well defined, purplish papules of varying size with verrucous to smooth surface distributed discretely over medial side of the left thigh, scrotum, and penile shaft. [cdriadvlkn.org]

It is related to HPV, and presents with gray-brown elevated papules or plaques. [ncbi.nlm.nih.gov]

• Asymptomatic

  A 34-month-old Haitian girl had a six-month history of asymptomatic vulvar papules. Histologic features and DNA probe studies were diagnostic of bowenoid papulosis. Resolution of the lesions was enhanced by cryotherapy. [ncbi.nlm.nih.gov]

  All the lesions were asymptomatic during most of the time. For the last few months one of the larger lesions of the scrotum started increasing in size and was associated with pain. There was also oozing from the lesion. [ijdvl.com]

• Pathologist

  Communication between the clinician and the pathologist is essential to avoid misdiagnosis. - Erythroplasia of Queyrat: squamous cell carcinoma-in situ (SCC-IS) of the glans penis. [dermatologyadvisor.com]

  Communication between the clinician and the pathologist is essential to avoid misdiagnosis. – Erythroplasia of Queyrat: squamous cell carcinoma-in situ (SCC-IS) of the glans penis. [psychiatryadvisor.com]

  Penile intraepithelial neoplasia (PeIN) is the standardized terminology for pathologic reporting, which may be integrated with clinical presentation for diagnosis of bowenoid papulosis (Eur Urol 2016;70:93) Bowenoid papulosis is no longer a term used by pathologists [pathologyoutlines.com]

  Neal, Vijaya Reddy, Stanley Robboy, Mona Saraiya, Steven Silverberg and Susan Spires, The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists [doi.org]

• Inflammation

  Risk factors The following risk factors may increase a man’s chance of developing PeIN: HPV infection inability to fully pull back (retract) the foreskin over the glans (called phimosis) poor genital hygiene long-term (chronic)irritation, inflammation [cancer.ca]

  Inguinal nodes may be enlarged due to inflammation and secondary infection. If cancer is suspected, biopsy is required; if possible, tissue under the lesion should be sampled. [merckmanuals.com]

  Inflammation, which starts as a phlegmon, quickly forms boundaries and an abscess develops in most cases. [science.gov]

  Jun Hyun Han, Recommended Managements for the Male Human Papillomavirus Infection, The Korean Journal of Urogenital Tract Infection and Inflammation, 9, 2, (79), (2014). Kruti P. [doi.org]

• Surgical Procedure

  This is usually destruction of the lesions via several medical and/or surgical procedures (see Genital warts: treatment). Regular checks are necessary after treatment to ensure the condition has completely resolved. [checkorphan.org]

  This is usually destruction of the lesions via several medical and/or surgical procedures (see Genital warts : treatment). Regular checks are necessary after treatment to ensure the condition has completely resolved. [dermnetnz.org]

  […] in 30 surgical procedures in dogs and cats was reviewed. [science.gov]

• Candidiasis

  The favored clinical diagnosis was candidiasis. Histologically, the biopsy specimen showed severe epithelial dysplasia. Three additional oral biopsies of different sites were performed and revealed similar histology. [ncbi.nlm.nih.gov]

  Two patients transplanted before routine prophylaxis with the use of nystatin developed esophageal candidiasis in the 1st 6 months after transplantation. [science.gov]

• Nausea

  Grade 3 to 4 events were neutropenia (n = 5), nausea (n = 2), chest pain (n = 2), deep vein thrombosis (n = 1), transaminitis (n = 1), and dehydration (n = 1). [science.gov]

• Vomiting

  Side effects included transient anorexia, vomiting and lethargy in some dogs, increased shedding of hair and gingival hyperplasia. [science.gov]

• Osteoporosis

  Herein we describe the case of a 14-month-old boy with multiple cutaneous nodules around small and large joints, papulous skin lesions, hyperpigmented plaques and nodules in the perianal region, flexion contractures and stiffness of joints and diffuse osteoporosis [science.gov]

• Papule

  Multiple linear bowenoid papulosis without surrounding papules. J Dermatol 2012; 39: 862-3. Kopf AW, Bart RS. Tumor conference No. 11: multiple bowenoid papules of the penis: a new entity? J Dermatol Surg Oncol 1977; 3: 265-9. [termedia.pl]

  It occurs on the genitalia of both sexes in sexually active young people as well-demarcated pigmented warty papules. Affects all races equally. The condition was originally described in 1977 by Kopf and Bart as papules on the penis. Bibliography A. [whonamedit.com]

  Clinical variants of BP such as papules coalescing to form plaques, lichenoid papules, macules, and leukoplakia-like lesions have been described. [1] In the present case, both genital and adjacent extragenital sites were involved. [cdriadvlkn.org]

  Skin biopsies were taken from the asymptomatic papule and from the edge of the ulcerated scrotal lesion. The papule showed near absence of maturation and moderate atypia of the squamous cells. Mitotic figures were seen above the basal layer. [ijdvl.com]

  We recently encountered a patient who presented with papules in the anal area. Human papillomavirus has been identified as the causative agent. [ncbi.nlm.nih.gov]

• Acne Vulgaris

  The... more Treating Acne With Topical Antibiotics: Current Obstacles and the Introduct.... ABSTRACT:Oral antibiotics are well established treatments for acne vulgaris but are ... more [jddonline.com]

  It is mainly indicated in the management of acne vulgaris and psoriasis. [ncbi.nlm.nih.gov]

• Pruritus

  The initial condition of Bowenoid papulosis and carcinoma in situ of the vulva was diagnosed on colposcopic biopsies performed to investigate chronic pruritus and superficial dyspareunia. [ncbi.nlm.nih.gov]

  Als Nebenwirkungen der lokalen Imiquimodtherapie traten während der Anwendung Pruritus, Brennen, Erytheme und Erosionen sowie anschließend diskrete Hypopigmentierungen der behandelten Areale auf. [thieme-connect.com]

  The main symptoms of pinworm infection include pruritus and bruxism. [science.gov]

• Withdrawn

  The stapler was then closed, fired and withdrawn. One patient complained of a perianal hematoma on the seventh postoperative day, requiring surgical excision. [science.gov]

• Hyperactivity

  The symptoms of abdominal pains, sleep disorders, loss of appetite, hyperactivity and occasional slimy stools appeared later. Proglottids on the underwear, in water while bathing and mobile proglottids passed with the stool were also observed. [science.gov]

• Genital Lesions

  The human papillomavirus causes a variety of genital lesions: condyloma acuminatum, bowenoid papulosis (carcinoma in situ), and squamous cell carcinoma. Only condylomata have been documented to be sexually transmitted. [ncbi.nlm.nih.gov]

  Discussion Bowenoid papulosis is clinically a benign appearing genital lesion showing histologic features of squamous cell carcinoma-in-situ. [ijdvl.com]

  In 1987 Lookingbill et al2 described one of the first reported cases of oral disease in a 33-year-old immunosuppressed man receiving prednisone therapy for systemic lupus erythematosus who had both mouth and genital lesions. [mdedge.com]

  These include common warts, flat pityriasis versicolor suh as lesions in epidermodysplasia verruciformis, oral and laryngeal papillomas, and various genital lesions. [4] Immune response appears to play a role in the development of BP. [cdriadvlkn.org]

• Pruritus Vulvae

  The main symptoms of pinworm infection include pruritus and bruxism. [science.gov]

The histologic workup of the resection specimen revealed patchy high-grade vulvar intraepithelial neoplasia Grade 3 (VIN 3) and 2 microscopic foci of superficially invasive squamous cell carcinoma. [science.gov]

The treatment for BP is conservative as it usually regresses spontaneously. [jddonline.com]

Imiquimod has proven effective in combating viral infections as well as UV-induced (pre) malignant lesions, and seems also effective in the treatment of BP.Because so far imiquimod treatment has not been related to the physical status of HPV, we present [clincancerres.aacrjournals.org]

(Topical treatment of BP of the penis with imiquimod 5% cream every other day for 8 weeks resulted in no recurrences 3 months after cessation of treatment.) Nakanishi, G, Yamasaki, O, Nagao, Y, Tanaka, T. [dermatologyadvisor.com]

Treatment - Bowenoid papulosis Because Bowenoid papulosis usually runs a benign course with many cases spontaneously regressing, treatment is often unnecessary. [checkorphan.org]

What is the treatment for bowenoid papulosis? Because bowenoid papulosis usually runs a benign course with many cases spontaneously regressing, treatment is often unnecessary. [dermnetnz.org]

Bowenoid papulosis may be a chronic dysplasia with a variable long-term prognosis linked to a cocarcinogenic factor. [ncbi.nlm.nih.gov]

Bowenoid papulosis may be a chronic dysplasia with a variable long-term prognosis linked to a cocarcinogenic factor. ( Arch Dermatol 1984;120:514-516) [jamanetwork.com]

It has poor prognosis due to invasion depth and increased risk of metastasis. We present the case of a 56-year-old man who developed an invasive penile squamous-cell carcinoma after a six-year history of Bowenoid papulosis. [rojced.com]

Prognosis - Bowenoid papulosis The condition usually resolves itself with time but they should be regularly checked due to the risk of malignancy. [checkorphan.org]

For these reasons the prognosis of someone with bowenoid papulosis is quite good. The elderly, HIV patients, and people who are otherwise immunosuppressed are at a higher risk for progression into malignancy. [contourderm.com]

The distinction between the two lesions is of importance as Bowen's disease represents a precancerous dermatosis and bowenoid papulosis a probably benign lesion of viral etiology. [unboundmedicine.com]

[…] penile intraepithelial neoplasia (males) or vulvar intraepithelial neoplasia (females) Epidemiology Preferentially affects sexually active young males (mean age 30 years) Sites Primarily penile shaft; may also be present in foreskin, glans or scrotum Etiology [pathologyoutlines.com]

Evidence supports an etiologic role of human papillomavirus (HPV), particularly type 16. HPV-16 is also associated with an increased risk for cervical intraepithelial neoplasia (CIN) and invasive carcinoma. [ncbi.nlm.nih.gov]

Recommend to your librarian Human papilloma virus (HPV) is known to be an etiologic agent for benign warts of the skin. [f1000.com]

[…] bowenoid papulosis progressing to Bowen's disease. [3] According to Wade there is a potential for bowenoid papulosis to become invasive squamous cell carcinoma and he advises complete removal of the lesion. [3] From the earlier description onwards the etiology [ijdvl.com]

The discovery of a possible oncogenic virus in BP and the epidemiologic behavior of carcinoma in situ and multicentric carcinomas suggest the need for a very careful follow-up evaluation of such lesions. [ncbi.nlm.nih.gov]

Terminology Type of penile intraepithelial neoplasia (males) or vulvar intraepithelial neoplasia (females) Epidemiology Preferentially affects sexually active young males (mean age 30 years) Sites Primarily penile shaft; may also be present in foreskin [pathologyoutlines.com]

Epidemiology Frequency Bowenoid papulosis lesions are related clinically to genital warts. They share the same age of onset in patients and are transmitted sexually. [emedicine.com]

Pathophysiology Bowenoid papulosis is an asymptomatic focal epidermal hyperplasia and dysplasia induced by HPV infection [1, 2] (most commonly by HPV 16). [emedicine.com]

[…] lesions include those that involve the mouth, face / neck (within beard distribution) and other areas of skin (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:466, Br J Dermatol 1999;140:761, Arch Dermatol 1989;125:655, Ann Dermatol 2014;26:381) Pathophysiology [pathologyoutlines.com]

Prevention - Bowenoid papulosis Not supplied. Diagnosis - Bowenoid papulosis Not supplied. Prognosis - Bowenoid papulosis The condition usually resolves itself with time but they should be regularly checked due to the risk of malignancy. [checkorphan.org]

Luckily there exists a vaccine – Gardasil – that both young boys and girls may receive which prevents infection from certain HPV strains that are most likely to lead to cancer. [contourderm.com]

In some milder cases the use of 5-Fluorouracil (a chemical that prevents cell division) in the form of a topical cream has been successful. [rarediseases.org]