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Bradykinesia


Presentation

  • On medication, sensory attenuation at movement onset was present.[ncbi.nlm.nih.gov]
  • This case illustrates an unusual clinical presentation of bilateral intracerebral haemorrhage with supranuclear ophthalmoplegia, bradykinesia and rigidity.[ncbi.nlm.nih.gov]
  • Abstract The aim of this paper is to describe and present the results of the automatic detection and assessment of bradykinesia in motor disease patients using wireless, wearable accelerometers.[ncbi.nlm.nih.gov]
  • The present study investigated which processes might be responsible for the observed slowness.[ncbi.nlm.nih.gov]
Dysmetria
  • (B) CDRS v the natural logarithm of the dysmetria score: scatter plot of the cerebellar disease rating scale (CDRS, table 2 ) v the dysmetria score (DS) in 12 patients with cerebellar dysfunction.[jnnp.bmj.com]
  • Kinesia scores (KS30, number of key taps in 30 seconds), akinesia times (AT30, mean dwell time on each key in milliseconds), incoordination scores (IS30, variance of travelling time between key presses) and dysmetria scores (DS30, accuracy of key presses[ncbi.nlm.nih.gov]
Delayed Speech and Language Development
  • DYSTONIA 16 Is also known as dyt16 early-onset dystonia parkinsonism Related symptoms: Intellectual disability Global developmental delay Pain Cognitive impairment Delayed speech and language development SOURCES: OMIM ORPHANET MESH MENDELIAN More info[mendelian.co]
Mental Deterioration
  • deterioration Dyskinesia Lewy bodies Ataxia Behavioral abnormality Seizures Spasticity Intellectual disability Abnormality of movement Rare Symptoms - Less than 30% cases Global developmental delay Abnormal caudate nucleus morphology Delayed speech and[mendelian.co]
Akathisia
  • […] include tremor of the limbs, bradykinesia (slowness of movement with loss of facial expression, absence of arm-swinging during walking, and a general muscular rigidity), dystonia (sudden sustained contraction of muscle groups, causing abnormal postures), akathisia[britannica.com]
Flaccid Paralysis
  • ., headache, nuchal rigidity),or acute flaccid paralysis (e.g., poliomyelitis-like syndrome or Guillain-Barré-like syndrome),3 or movement disorders (e.g., tremor, myoclonus), or Parkinsonism or Parkinsonian-like conditions (e.g., cogwheel rigidity, bradykinesia[glosbe.com]

Workup

  • ., sertraline, fluoxetine), meperidine Disorders that mimic Parkinsonism: Catatonia, depression, spasticity, hypothyroidism Workup It is important for the diagnosing physician to look for reversible or treatable causes of parkinsonism.[endoflifecare.tripod.com]
  • (For more information, see Parkinson-Plus Syndromes for detailed information regarding clinical clues, workup, differential diagnosis, and treatment of atypical parkinsonisms, including multiple system atrophy, progressive supranuclear palsy, parkinsonism-dementia[emedicine.medscape.com]
  • (For more information, see Parkinson-Plus Syndromes for detailed information regarding clinical clues, workup, differential diagnosis, and treatment of atypical parkinsonisms, including multiple system atrophy, progressive supranuclear palsy , parkinsonism-dementia[emedicine.medscape.com]

Treatment

  • In addition, they have not demonstrated a relationship between treatment-induced changes in synchronisation and changes in bradykinesia or rigidity on their own. To this end, we collected and analysed LFP and clinical data in 30 patients with PD.[ncbi.nlm.nih.gov]
  • In conclusion, impaired manual dexterity showing significantly diminished response to dopaminergic treatment suggests that dextrous deficits in PD are related to LKA rather than bradykinesia. (c) 2007 Movement Disorder Society.[ncbi.nlm.nih.gov]
  • A doctor or physical therapist is an excellent resource to develop an at-home treatment plan to manage symptoms. Crucially, a person should consult their doctor before making any changes to their treatment plan, even small ones.[medicalnewstoday.com]

Prognosis

  • Ünlü A, Brause R, Krakow K (2006) Handwriting analysis for diagnosis and prognosis of parkinson's disease. ISBMDA Lecture Notes in Computer Science 4345: 441–450. View Article Google Scholar 10.[journals.plos.org]
  • Although currently there is no cure for PD, the correct diagnosis is important not only for the treatment and prognosis, but also for clinical trials and epidemiological studies. However, practically misdiagnosis of PD is much common.[translationalneurodegeneration.biomedcentral.com]
  • Practice Parameter: diagnosis and prognosis of new onset Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2006 Apr 11. 66(7):968-75. [Medline].[medscape.com]
  • Patients with atypical parkinsonisms typically have a worse prognosis than those with Parkinson disease, and atypical parkinsonisms respond poorly to standard anti-Parkinson disease treatments.[emedicine.medscape.com]

Etiology

  • Etiology The causes of parkinsonism in children are different from those in adults, and thorough examination usually requires a careful search for metabolic as well as degenerative diseases.[endoflifecare.tripod.com]
  • Parkinson disease in twins: an etiologic study. JAMA. 1999 Jan 27. 281(4):341-6. [Medline]. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al.[medscape.com]
  • A paralyzed vocal fold suggests Parkinson-plus syndrome (PPS) as the etiology for the parkinsonism if other aspects of the diagnosis are present.[emedicine.medscape.com]

Epidemiology

  • DISCUSSION Epidemiological studies suggest that smokers are significantly less likely than nonsmokers to develop Parkinson's Disease ( Morens et al. 1995 ).[nature.com]
  • Epidemiology, pathophysiology and management". CNS Drugs. 27 (2): 97–112. doi : 10.1007/s40263-012-0012-3. ISSN 1179-1934.[en.wikipedia.org]
  • Although currently there is no cure for PD, the correct diagnosis is important not only for the treatment and prognosis, but also for clinical trials and epidemiological studies. However, practically misdiagnosis of PD is much common.[translationalneurodegeneration.biomedcentral.com]
  • Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur J Epidemiol. 2011 Jun. 26 Suppl 1:S1-58. [Medline]. Anderson P. More Evidence Links Pesticides, Solvents, With Parkinson's. Medscape Medical News. Available at .[medscape.com]
  • Mov Disord, 26, 1859–1863. [4] Camicioli R , Grossmann SJ , Spencer PS , Hudnell K , & Anger WK (2001) Discriminating mild parkinsonism: Methods for epidemiological research.[content.iospress.com]
Sex distribution
Age distribution

Pathophysiology

  • Department of Clinical Neurology, Oxford University, 6th Floor, West wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK. simon.little@balliol.ox.ac.uk Abstract Abnormal oscillatory activity in the basal ganglia is increasingly implicated in the pathophysiology[ncbi.nlm.nih.gov]
  • Abstract The aim of this paper is to summarise the main clinical and pathophysiological features of facial bradykinesia in Parkinson's disease (PD) and in atypical parkinsonism.[ncbi.nlm.nih.gov]
  • The kinematic assessment of the effects of selegiline on movement abnormalities in early PD provides a better understanding and interpretation of their pathophysiological mechanisms. Copyright 2016 Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
  • Descriptive models of pathophysiology that ignore the fine temporal resolution of neuronal spiking in favor of average neural activity cannot explain the mechanisms of DBS-induced symptom alleviation.[ncbi.nlm.nih.gov]
  • Pathophysiology of bradykinesia in Parkinson’s disease. Brain. 2001;124:2131–2146. Basal ganglia, Encyclopaedia Brittannica. Accessed online on 12/16/16 at . Gazewood JD, Richards DR, Clebak K. Parkinson disease: an update.[parkinsonsdisease.net]

Prevention

  • Noyce, Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, London, UK; E‐mail a.noyce@qmul.ac.uk Search for more papers[onlinelibrary.wiley.com]
  • Conclusions: Urinary problems in Parkinson’s patients are very frequent, which is why they must be monitored in order to improve their quality of life and prevent damage to the urinary tract, providing adequate and timely attention these problems can[mdsabstracts.org]
  • The effect of the attention appears to require constant vigilance to prevent reverting to more automatic control mechanisms. 2012 Mak [2] measured and compared the walking patterns of PD patients and controls using a treadmill.[en.wikiversity.org]
  • Prolonged intake of this medication can give rise to side effects like: Nausea Mood swings Uncontrolled movements Anxiety For this reason, Levodopa is often prescribed together with carbidopa, which prevents the former from getting dissociated before[primehealthchannel.com]
  • Use a cane, walker, or other kinds of walking sticks to prevent any kind of injuries that may occur due to falling.[healthylifemed.com]

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