A hamartoma is a benign tumor composed of various tissues, and one of its locations may be the breast. Patients can present with a painless, asymptomatic and well-demarcated palpable mass in a breast hamartoma. Imaging studies such as mammography, ultrasonography, and magnetic resonance imaging (MRI) show specific radiologic features, whereas a biopsy, either fine needle aspiration or core needle, may be sometimes necessary to confirm the diagnosis.
Defined as a well-established mass with a still incomplete etiology, hamartoma is a rare benign tumor that contains a mixture of different tissues (fibrous, adipose, glandular, and potentially other) in various proportions   . Numerous sites in the body may be the location of its development, including the breast, and between 4-8% of all benign breast lesions, are attributed to hamartomas . This benign tumor has been reported across different age groups after puberty  , but the majority of patients are women in their 30s and 40s    . The clinical presentation is characterized by the presence of a sharply defined, painless, and asymptomatic oval or round-shaped mass in the breast area that is freely palpable    . The nodular appearance of the mass is accompanied by its smooth surface and a soft consistency . However, studies show that up to 60% of breast hamartomas are not possible to palpate, and are thus interpreted as subclinical tumors . Hamartomas are most commonly found in the outer quadrants, and it is not uncommon for the diagnosis to be made incidentally during evaluation of other breast-related pathologies  . Additional symptoms are not present in the setting of hamartomas, which is one of the main clinical features of this tumor . Furthermore, breast hamartomas are mobile and not attached to the surrounding muscle or skin tissue, which might be an important clinical sign as well  .
Entire Body System
- Soft Tissue Mass
Presentation Large palpable soft tissue mass left breast. Patient Data Age: 45 years Gender: Female Loading images... [radiopaedia.org]
The macroscopic examination of the specimen revealed a huge and well encapsulated soft tissue mass measuring 39 x 32 x 21cm, three yellowish soft tissue masses measuring 17 x 9 x 6.5cm, 28.5 x 21 x 9cm, and 13 x 11 x 3cm; and a soft fibrofatty tissue [ispub.com]
Huge well-circumscribed, soft tissue masses of heterogeneous signal intensity were seen in both breasts on axial T1/T2-weighted magnetic resonance imaging (MRI) ( Figure 2D ). [jbd.or.kr]
Skeletal hemangiomatosis and lymphangiomatosis—also known as cystic angiomatoses and lymphangiectases of bone, respectively—are incidental findings that can be associated with pathologic fractures, soft tissue masses, or effusions. [emedicine.medscape.com]
- Axillary Mass
The excised left axillary mass was diagnosed as hamartoma arising from the accessory breast tissue ( Figure 4 ). [jbd.or.kr]
[…] hypoechoic, lobulated, ill-defined borders Irregular, partly ill-defined lesion with no microcalcification NR Core biopsy; myoid hamartoma Myoid hamartoma SMA +,Desmin +, S-100 - NR Borges da Silva et al., 2006 (22) 33, F Axillary mass 10 Compatible [ncbi.nlm.nih.gov]
- Breast Mass
CONCLUSION: PDVF imaging during breast sonography is an invaluable technique in the identification of breast hamartomas from other benign or malign breast masses. [ncbi.nlm.nih.gov]
(A) Right breast mass was 25×19 cm. (B) Left breast mass was 21×18 cm and axillary mass was 5.5×4.4 cm. Weight of each mass was 1,980 g on the right, 1,233 g on the left, and 36 g on the axilla. Figure 4. [jbd.or.kr]
Surgical excision of the right lower inner breast mass and right axillary lymph node was subsequently performed at our institution. View larger version (127K) Fig. 1A. —59-year-old woman with right-breast mass. [ajronline.org]
Presentation Palpable left breast mass. Patient Data Age: 35 Gender: Female Loading images... Lower outer quadrant left breast mass (partially behind the nipple), which demonstrates a thin capsule and contains fat and breast parenchyma. [radiopaedia.org]
- Motor Symptoms
Neurological symptoms ensue after several years, mainly due to nerve compression. Compression neuropathy leads to sensory and motor symptoms including pain, tenderness, diminished sensation, paresthesia, and weakness. [jmsh.ac.in]
She did not have any motor symptoms, hypoesthesia, or pain. There was no tenderness on palpation and no Tinel-like sign. Magnetic resonance imaging 2210-2612/$ - see front matter © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. [cyberleninka.org]
A detailed physical examination, together with a properly obtained patient history, is the first and perhaps most important step in order to make the diagnosis of a breast hamartoma. Adequate palpation of both breasts and the respective quadrants can result in detection of a mass, after which the use of various imaging studies might be employed. Various procedures have been mentioned, one of the more useful being mammography, the gold-standard procedure in the assessment of breast tissue  . A nonhomogeneous mass composed of adipose, fibrous and glandular tissue that is often enclosed by a thin capsule is the hallmark of a breast hamartoma on mammography, but the variability in the percentage of fat and glandular/connective tissue might pose a challenge to the physician   . For this reason, ultrasonography (US), but also MRI, might be used as adjunctive or even superior methods compared to mammography  . Main findings on the US are the absence of a retrotumor acoustic phenomenon, which is frequently found in malignant lesions  . On MRI, breast hamartomas are visualized as heterogeneous lesions with a sharp and clearly delineated capsule described as a hypointense rim . As mentioned previously, the distribution and dominance of different tissues may necessitate for a biopsy sample to be obtained, either by a core needle biopsy or a fine needle aspiration (FNAC), both valuable in the workup of this tumor   .
[…] and Treatment "John Paul II", Campobasso, Italy. 3 Department of Radiotherapy, Catholic University of the Sacred Heart-Foundation for Research and Treatment "John Paul II", Campobasso, Italy. [ncbi.nlm.nih.gov]
Sacred Heart-Foundation for Research and Treatment “John Paul II”, Campobasso, Italy Correspondence: [*] Corresponding author: Eleonora Cucci, Department of Radiology, Catholic University of the Sacred Heart-Foundation for Research and Treatment “John [content.iospress.com]
Due to the unique features of hamartomas, and of hamartomas in men, in particular, there is currently no standard treatment. [journals.lww.com]
Treatment of such pathology can be conservative. The second, more serious complication is malignant degeneration of the tissues of lipofibroma. In this case, treatment should be exclusively surgical. [rowland98.com]
Rarely invades lymph nodes and have a favorable prognosis. [quizlet.com]
Surgical excision is the treatment of choice, and the prognosis is generally good as recurrence rate is very less. [jiaomr.in]
They are treated, if at all, by surgical resection, with an excellent prognosis: generally, the only real danger is the inherent possibility of surgical complications. [en.wikipedia.org]
Liposarcomas: Prognosis and management. J Surg Oncol 1980;14:245-9. [ PUBMED ] [Figure 1], [Figure 2], [Figure 3], [Figure 4] [cancerjournal.net]
Defined as a well-established mass with a still incomplete etiology, hamartoma is a rare benign tumor that contains a mixture of different tissues (fibrous, adipose, glandular, and potentially other) in various proportions. [symptoma.com]
81:1) Arrigoni et al. first used the term hamartoma in 1971 (Surg Gynecol Obstet 1971;133:577) Also called fibroadenolipoma, adenolipoma Epidemiology Uncommon, ~5% of all benign breast masses Mean age 45 years Rare in teenagers (Breast J 2009;15:515) Etiology [pathologyoutlines.com]
Etiology Mutations in the PHOX2B gene are found in a significant number of patients with Haddad syndrome. The documents contained in this web site are presented for information purposes only. [orpha.net]
The exact etiology remains unclear, but currently, the most probable etiology of lipoma includes hereditary, fatty degeneration, hormonal basis, trauma, metaplasia of muscles, and lipoblastic embryonic cell nest origin. [ijdr.in]
The etiology of fibrolipoma is generally considered to be chronic mechanical irritation or inflammation that induces secondary fibrous changes in the lipoma. When fibrolipoma is found in the stomach, it is usually asymptomatic. [scielo.isciii.es]
A Birmingham (UK) group concluded that the establishment of a histopathology data pool facilitates epidemiological analysis . [symbiosisonlinepublishing.com]
The principal aim of Oncology Letters is to provide the prompt publication of original studies of high quality that pertain to clinical oncology, chemotherapy, oncogenes, carcinogenesis, metastasis, epidemiology and viral oncology in the form of original [ingentaconnect.com]
Epidemiology Approximately 5% of patients with pneumothorax will have concomitant hemothorax 6. [radiopaedia.org]
[…] lobular unit, adipose tissue and hyalinized stroma) Terminology Initially defined as mastoma (Beitr Pathol Anat 1928;81:1) Arrigoni et al. first used the term hamartoma in 1971 (Surg Gynecol Obstet 1971;133:577) Also called fibroadenolipoma, adenolipoma Epidemiology [pathologyoutlines.com]
Summary Epidemiology Birth incidence of Ondine syndrome is 1 in 200,000 live-births and Hirschsprung disease occurs concurrently in 16% of cases. [orpha.net]
Breast: 8 cases of hamartoma per 20,000 mammograms Kidney: renal hamartoma (angiomyolipoma) found in 40–80% of patients with tuberous sclerosis Etiology and Pathophysiology Functional disorder will depend on tissue of origin. [unboundmedicine.com]
Thus the pathophysiology of Becker's nevus remains unclear. [en.wikipedia.org]
Multiple osteochondromas have a relatively high (1-25%) incidence of malignant transformation.  There are many theories regarding the pathophysiology of epiphyseal osteochondromas. [emedicine.medscape.com]
They underlined the fact that most of the epiretinal membranes in the macula did not affect visual acuity and speculated that in NF 2, in response to pathophysiologic factors that cause proliferation of neural crest and other cells elsewhere in the nervous [ispub.com]
The author collated important benign lesions and based on peer-reviewed publications documented the relative risk of subsequent cancer to allow the patient and the clinician to institute preventative measures where possible. [books.google.com]
We presume that MRI can provide useful information to diagnose a hamartoma and prevent unnecessary biopsies in patients who do not have mammographically typical hamartoma appearance. [oatext.com]
Radiotherapy: preoperative for large fixed rectal tumour, Dukes B &C rectal T postoperatively to decrease recurrence. 32 Prevention: Chemoprevention: Secondary prevention: Aspirin. Calcium. Folic acid. Selective Cox.2 inhibitors. [slideplayer.com]
Mammary Hamartoma is difficult to prevent, because it is most likely caused by abnormal or fluctuating reproductive hormone levels. Since prevention is generally not possible, it is important to be aware of the risk factors of breast lumps. [dovemed.com]
Graduate student, at STES Sinhgad Dental College and Hospital, Pune, Maharashtra, India 2: Professor and head, at STES Sinhgad Dental College and Hospital, Pune, Maharashtra, India;, Email: [email protected] 3: Reader, Department of Pedodontics and Preventive [ingentaconnect.com]
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