Diagnosis and management of this potentially lethal condition present significant challenges, as was shown in several cases Dr. Hirsch presented at a meeting sponsored by the American Diabetes Association. [mdedge.com]

At present, BDF lists 18 known causes of brittleness. Unlike type 1 diabetes, brittleness leads to a highly disruptive daily life for those who suffer from this rare disease. [change.org]

Diabetes mellitus constitutes a major health disease and its clinical presentation and progression may vary considerably. [molab.es]

Unstable and Brittle Diabetes: Past and Present 2. An Overview of Brittle Diabetes 3. The Syndrome of Recurrent Diabetic Ketoacidosis 4. Insulin Resistance in Diabetes 5. [bookdepository.com]

NOTOC A *Acanthosis nigricans A brown to black, poorly defined, velvety hyperpigmentation of the skin, usually present in the posterior and lateral folds of the neck, the axilla, groin,… … Wikipedia Glossary of diabetes — See also: Diabetes (disambiguation [medizin.deacademic.com]

• Fatigue

  Symptoms of high blood sugar include: Fatigue Blurry vision Excessive thirst Increased hunger Increased urination Fruity breath Nausea and vomiting Symptoms of low blood sugar include: Confusion Lack of energy, fatigue, tiredness Dizziness Headache Sweating [verywellhealth.com]

  […] chills Irritability Confusion Fast heart rate Dizziness Nausea Blurred vision Weakness Headache Seizures Unconsciousness When your blood sugar shoots up above 200 mg/dl, your symptoms will likely include: Frequent urination Extreme thirst Blurred vision Fatigue [webmd.com]

  Fatigue (feeling weak, tired). Frequent urination (peeing). Headache. Skin infections and slow-healing cuts. Thirst or hunger. [my.clevelandclinic.org]

  […] shaking rapid or irregular heart rate dizziness and weakness confusion seizures fainting coma The symptoms of hyperglycemia may include: frequent urge to urinate excessive thirst intense, unusual hunger headaches blurred vision unexplained weight loss fatigue [medicalnewstoday.com]

  -- Constant fatigue. -- Difficult paying attention or confusion. When blood sugar levels aren't normalized with insulin, it can lead to serious complications such as cardiac arrest -- when the heart stops -- or kidney failure and death. [news.yahoo.com]

• Weight Loss

  A further concern to keep in mind with a patient such as this is that between one-third and one-half of all teenage girls with type 1 diabetes will withhold insulin at some time for weight loss. [mdedge.com]

  loss fatigue irritability Brittle diabetes involves frequent and severe fluctuations of blood glucose and episodes of hyper- and hypoglycemia that may require hospitalization. [medicalnewstoday.com]

• Osteoporosis

  A diagnostic work-up determined that she had underlying celiac disease, with an important clue being the osteoporosis. “When you see osteoporosis in a young person you have to think about calcium absorption,” he said. [mdedge.com]

• Headache

  […] will likely include: Frequent urination Extreme thirst Blurred vision Fatigue Headache If you don’t treat high blood sugar, it can turn into a more serious condition called ketoacidosis. [webmd.com]

  Headache. Skin infections and slow-healing cuts. Thirst or hunger. Untreated hyperglycemia can lead to diabetes-related ketoacidosis (DKA), a complication of diabetes, which can cause: Confusion. Dehydration. Fast heart rate. Fruity-smelling breath. [my.clevelandclinic.org]

  Symptoms of very low blood sugar levels include: dizziness weakness irritability extreme hunger trembling hands double vision severe headaches trouble sleeping Symptoms of high blood glucose levels can include: weakness increased thirst and urination [healthline.com]

  […] hypoglycemia can include: hunger tiredness sweating shaking rapid or irregular heart rate dizziness and weakness confusion seizures fainting coma The symptoms of hyperglycemia may include: frequent urge to urinate excessive thirst intense, unusual hunger headaches [medicalnewstoday.com]

  Symptoms of high blood sugar include: Fatigue Blurry vision Excessive thirst Increased hunger Increased urination Fruity breath Nausea and vomiting Symptoms of low blood sugar include: Confusion Lack of energy, fatigue, tiredness Dizziness Headache Sweating [verywellhealth.com]

If psychological issues are behind brittleness, treatment with medication or counseling may help iron out things. [diabetesforecast.org]

Treatment may involve exploring the cause of your stress and trying a variety of methods to lessen it. Psychotherapy, in particular, has proven to be effective in the long-term treatment of diabetes. [verywellhealth.com]

Special equipment or treatment of another underlying condition may be able to help. [my.clevelandclinic.org]

That makes sense, because insulin is the main treatment for this common disease. But it isn’t a cure. [statnews.com]

BT1D defies all modes of standard treatment applied to stable T1D patients. 2. Blood glucose levels are unstable, uncontrollable and unpredictable not “harder to control”. 3. [bdtype1.com]

ETIOLOGY • Psychological[most comon] • Nonphysiologic matching of meals,exercise and insulin • Poor adherence /compliance to treatment • Chronic infections • Chronic medical illness • Endocrinopathies • -Recurrent Ketoacidosis ✦ 1]Acromegaly 4 5. • -Recurrent [de.slideshare.net]

Working with your doctor, you can learn to manage — or prevent — brittle diabetes. [healthline.com]

Prevention How can I prevent brittle diabetes? It’s not always possible to prevent brittle diabetes, depending on the underlying cause. Monitoring your blood glucose regularly and closely following your healthcare provider’s instructions can help. [my.clevelandclinic.org]

38 Johnson CN...Adams DB 24308511 2014 50 Results of open and robot-assisted pancreatectomies with autologous islet transplantations: treating chronic pancreatitis and preventing surgically induced diabetes. 38 Gruessner RW...Rilo H 25131087 2014 [malacards.org]

New developments enable controlled delivery to balance concurrent blood sugar levels, reacting to prevent hypoglycaemia and to limit glucose rises. NHS restrictions limit pump availability and selection. [londondiabetes.com]

Fortunately, treatment advances allowing continuous glucose monitoring and more responsive delivery of insulin have greatly improved the ability to control blood sugar and have helped prevent complications and deaths from Type 1 diabetes. [ Read: Differences [news.yahoo.com]