Progressive hepatic and renal dysfunction along with respiratory decompensation ensued, and the patient died 48 days after initial presentation. [ncbi.nlm.nih.gov]

• Collapse

  If the victim has collapsed or is not breathing, call local emergency services at 911. Keep all appointments with your doctor. Do not let anyone else use your medication. [nlm.nih.gov]

  If the fluid is leaking, the hardness of the normal eye is compromised, leading to collapse and wilting of the cornea.[5] Clinical significance[edit] Glaucoma is a progressive optic neuropathy where retinal ganglion cells and their axons die causing a [en.wikipedia.org]

• Asymptomatic

  Ocular examination revealed the presence of asymptomatic dry eyes. He was managed conservatively with topical antibiotics, lubricants, and bandage contact lens application. [ncbi.nlm.nih.gov]

• Encephalopathy

  The clinical course was complicated by encephalopathy, fluid retention, and spontaneous bacterial peritonitis, prompting consideration for liver transplantation. With supportive measures, jaundice and fluid retention resolved over a 3-month period. [ncbi.nlm.nih.gov]

• Somnolence

  The acetaminophen/oxycodone group reported more somnolence and vomiting. Single doses of bromfenac provided analgesia at least equivalent to that of the acetaminophen/oxycodone combination, with a longer duration of action. [ncbi.nlm.nih.gov]

• Hepatic Necrosis

  A transjugular liver biopsy demonstrated submassive hepatic necrosis. The clinical course was complicated by encephalopathy, fluid retention, and spontaneous bacterial peritonitis, prompting consideration for liver transplantation. [ncbi.nlm.nih.gov]

• Lymphocytic Infiltrate

  Extensive confluent parenchymal necrosis that appeared to begin in the central zones and was accompanied by a predominantly lymphocytic infiltrate was noted in all the livers examined. [ncbi.nlm.nih.gov]

• Liver Biopsy

  A transjugular liver biopsy demonstrated submassive hepatic necrosis. The clinical course was complicated by encephalopathy, fluid retention, and spontaneous bacterial peritonitis, prompting consideration for liver transplantation. [ncbi.nlm.nih.gov]

After cataract surgery, patients were randomized to treatment with bromfenac, betamethasone or both agents. Twenty-five eyes were assigned to bromfenac, 23 to betamethasone and 24 to the combined treatment group. [ncbi.nlm.nih.gov]

No clinically significant treatment-related systemic adverse effects or changes in liver chemistries were observed. [dx.doi.org]

CONCLUSIONS: Although topical bromfenac during IVB therapy in eyes with ME secondary to BRVO did not affect the visual prognosis, it had the advantage of reducing the number of injections. TRIAL REGISTRATION NUMBER: UMIN 14929. [ncbi.nlm.nih.gov]

Toshikatsu Kaburaki 1）, Ayako Karakawa 1）, Kazuki Taoka 2）, Hiroshi Murata 1）, Muneyuki Takao 1）, Fumiyuki Araki 1）, Hidetoshi Kawashima 3）, Makoto Aihara 1） 1） Tokyo Univ, 2） Hematology and Oncology, Tokyo Univ, 3） Jichi Med Univ DPS2-2　Long-term prognosis [convention.jtbcom.co.jp]

However, it is very difficult to predict the prognosis of CSC, and in some cases, progressive visual loss may be seen.4,5 Although the exact pathophysiology of CSC has not been clearly elucidated, the primary abnormality leading to RPE disruption and [medcraveonline.com]

Bromfenac eye drops have been used as an acute postoperative anti-inflammatory treatment20, and our results suggest that they could also be effective against MCP-1-induced chronic inflammation by reducing the MCP-1 level, which might improve the prognosis [nature.com]

We conclude that prolonged use of bromfenac was the etiological agent in this case, and that this drug can cause severe hepatotoxicity resulting in liver failure. [ncbi.nlm.nih.gov]

Topical ocular delivery of NSAIDs. 2008 Jun 18437583 Off-label promotion, on-target sales. 2008 Oct 28 18959472 Comparison of ketorolac 0.4% and bromfenac 0.09% at trough dosing: aqueous drug absorption and prostaglandin E2 levels. 2008 Sep 18721711 Etiology [drugs.ncats.io]

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • macula/fovea • treatment outcomes of cataract surgery 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved [iovs.arvojournals.org]

Foster CS: The pathophysiology of ocular allergy: current thinking. Allergy 1995;50 (suppl 21):6–9. Uchio E, Miyakawa K, Ikezawa Z, Ohno S: Systemic and local immunological features of atopic dermatitis patients with ocular complications. [oadoi.org]

The pathophysiologic role of cyclo-oxygenases in the eye. J Ocul Pharmacol Ther. 2008;24(2):141–151) Google Scholar 17. Ruiz J, López M, Milà J et al (1993) QSAR and conformational analysis of the anti-inflammatory agent amfenac and analogues. [link.springer.com]

Although the exact pathophysiology of CSC has not been clearly elucidated, the primary abnormality leading to RPE disruption and leakage is thought to cause increase choroidal permeability. [medcraveonline.com]

Overall, published data suggest that bromfenac is safe and effective when used to prevent or treat CME. [ncbi.nlm.nih.gov]

Eissa and Amr El-Kannishy, Topical NSAIDs in Prevention of Postcataract Macular Edema, Frontiers in Ophthalmology and Ocular Imaging [Working Title], 10.5772/intechopen.82321, (2019). [dx.doi.org]