Progressive hepatic and renal dysfunction along with respiratory decompensation ensued, and the patient died 48 days after initial presentation. [ncbi.nlm.nih.gov]

These results suggest that Bromfenac 0.09% can improve safely the presentation of clinical signs on ocular inflammation. This abstract was presented at the 2019 ARVO Annual Meeting, held in Vancouver, Canada, April 28 - May 2, 2019. [iovs.arvojournals.org]

• Aspiration

  Samples of aqueous humor were aspirated through a paracentesis and analyzed by using high-performance liquid chromatography. [ncbi.nlm.nih.gov]

  The method of cataract extraction was the phacochop technique with bimanual irrigation and aspiration. All cataract surgeries wereperformed at one surgery center (SMA). The intraocular lens of choice was the AMO SI-40. [omicsonline.org]

  Psilas et al[ 17 ] compared indomethacin(1%), diclofenac (0.1%) and flurbiprofen (0.03%) with control group and measured pupil diameter at baseline, after capsulotomy, after expression of lens, after irrigation and aspiration of cortical remnants and [djo.org.in]

• Miosis

  RESULTS: Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p CONCLUSION: Adding preoperative and postoperative bromfenac 0.1% or ketorolac 0.45% to topical steroid can reduce intraoperative miosis, postoperative [ncbi.nlm.nih.gov]

  In one study done by Zanetti FR,[ 21 ] nepafenac 0.1% was found superior to placebo in the inhibition of intraoperative miosis. [djo.org.in]

  •Ophthalmic Activity: Following topical application to the eye, bromfenac inhibits miosis by inhibiting the biosynthesis of ocular prostaglandins. [pdr.net]

• Suggestibility

  CONCLUSION: These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC. Copyright (c) 2007 S. Karger AG, Basel. [ncbi.nlm.nih.gov]

  These results strongly suggest the utility of bromfenac ophthalmic solution 0.09% in treating inflammation of both the anterior and posterior ocular segments. [dx.doi.org]

• Amenorrhea

  Women considered capable of becoming pregnant include all females who have experienced menarche and who have not experienced menopause (as defined by amenorrhea for greater than 12 consecutive months) or have not undergone successful surgical sterilization [clinicaltrials.gov]

• Papilledema

  November 14, 2018 Last Update Posted: November 14, 2018 Last Verified: October 2018 Keywords provided by Melissa Toyos, Toyos Clinic: Retinal edema Cataract inflammation Additional relevant MeSH terms: Layout table for MeSH terms Inflammation Cataract Papilledema [clinicaltrials.gov]

  Cystoid macular edema and papilledema following cataract extraction: a fluorescein fundoscopic and angiographic study. Arch Ophthalmol. 1966;76(5):646–661. 3. Flach AJ. [dovepress.com]

• Gliosis

  Purpose: To study the effect of topical administration of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID), on retinal gliosis and levels of prostaglandin E2 (PGE2) after complete optic nerve crush (ONC). [ncbi.nlm.nih.gov]

  ONC causes hypertrophy of astrocytes and Müller cells (gliosis). [doi.org]

  "Topical Treatment With Bromfenac Reduces Retinal Gliosis and Inflammation After Optic Nerve Crush". Investigative Ophthalmology & Visual Science. 57 (14): 6098–6106. doi:10.1167/iovs.16-20425. [en.wikipedia.org]

After cataract surgery, patients were randomized to treatment with bromfenac, betamethasone or both agents. Twenty-five eyes were assigned to bromfenac, 23 to betamethasone and 24 to the combined treatment group. [ncbi.nlm.nih.gov]

No clinically significant treatment-related systemic adverse effects or changes in liver chemistries were observed. [oadoi.org]

CONCLUSIONS: Although topical bromfenac during IVB therapy in eyes with ME secondary to BRVO did not affect the visual prognosis, it had the advantage of reducing the number of injections. TRIAL REGISTRATION NUMBER: UMIN 14929. [ncbi.nlm.nih.gov]

Toshikatsu Kaburaki 1）, Ayako Karakawa 1）, Kazuki Taoka 2）, Hiroshi Murata 1）, Muneyuki Takao 1）, Fumiyuki Araki 1）, Hidetoshi Kawashima 3）, Makoto Aihara 1） 1） Tokyo Univ, 2） Hematology and Oncology, Tokyo Univ, 3） Jichi Med Univ DPS2-2　Long-term prognosis [convention.jtbcom.co.jp]

However, it is very difficult to predict the prognosis of CSC, and in some cases, progressive visual loss may be seen.4,5 Although the exact pathophysiology of CSC has not been clearly elucidated, the primary abnormality leading to RPE disruption and [medcraveonline.com]

Bromfenac eye drops have been used as an acute postoperative anti-inflammatory treatment20, and our results suggest that they could also be effective against MCP-1-induced chronic inflammation by reducing the MCP-1 level, which might improve the prognosis [nature.com]

We conclude that prolonged use of bromfenac was the etiological agent in this case, and that this drug can cause severe hepatotoxicity resulting in liver failure. [ncbi.nlm.nih.gov]

Topical ocular delivery of NSAIDs. 2008 Jun 18437583 Off-label promotion, on-target sales. 2008 Oct 28 18959472 Comparison of ketorolac 0.4% and bromfenac 0.09% at trough dosing: aqueous drug absorption and prostaglandin E2 levels. 2008 Sep 18721711 Etiology [drugs.ncats.io]

Keywords: clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials • macula/fovea • treatment outcomes of cataract surgery © 2006, The Association for Research in Vision and Ophthalmology, Inc., all rights [iovs.arvojournals.org]

Foster CS: The pathophysiology of ocular allergy: current thinking. Allergy 1995;50 (suppl 21):6–9. Uchio E, Miyakawa K, Ikezawa Z, Ohno S: Systemic and local immunological features of atopic dermatitis patients with ocular complications. [dx.doi.org]

The pathophysiologic role of cyclo-oxygenases in the eye. J Ocul Pharmacol Ther. 2008;24(2):141–151) Google Scholar 17. Ruiz J, López M, Milà J et al (1993) QSAR and conformational analysis of the anti-inflammatory agent amfenac and analogues. [link.springer.com]

Although the exact pathophysiology of CSC has not been clearly elucidated, the primary abnormality leading to RPE disruption and leakage is thought to cause increase choroidal permeability. [medcraveonline.com]

Overall, published data suggest that bromfenac is safe and effective when used to prevent or treat CME. [ncbi.nlm.nih.gov]

Eissa and Amr El-Kannishy, Topical NSAIDs in Prevention of Postcataract Macular Edema, Frontiers in Ophthalmology and Ocular Imaging [Working Title], 10.5772/intechopen.82321, (2019). [dx.doi.org]

ABOUT Bromsite ™ Defend against ocular pain and treat inflammation with the penetrating power of BromSite ™ formulated with the DuraSite ® delivery system 1 BromSite ™ is the first and only topical NSAID indicated to prevent ocular pain after cataract [bromsite.com]