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Brucella


Presentation

  • Abstract The most common cardiovascular presentation of brucellosis (a zoonotic infection) in Iran is aortic valve endocarditis.[ncbi.nlm.nih.gov]
  • Abstract The involvement of the central nervous system (CNS) in brucellosis is rare and has a broad range of presentations. Subacute and chronic meningoencephalitis are described as the most common neurologic manifestations.[ncbi.nlm.nih.gov]
  • In the case presented here, we shared our experience in identification of Brucella directly from positive blood culture with mass spectrometry based method.[ncbi.nlm.nih.gov]
  • MATERIALS AND METHODS: Presented here are 5 cases of Brucella endocarditis, all managed uniformly.[ncbi.nlm.nih.gov]
  • We present the first case of Brucella infection of the thoracic vertebral arch with epidural abscess formation and discuss the clinical key points.[ncbi.nlm.nih.gov]
Turkish
  • Copyright 2017 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved.[ncbi.nlm.nih.gov]
  • It has been reported that the prevalence of seropositivity among the Turkish population varies from 3% to 14%. We present a case of brucellosis after pediatric liver transplantation.[ncbi.nlm.nih.gov]
Ascitic Fluid
  • Brucella was identified both in the ascitic fluid and blood; he was started on doxycycline plus rifampin with immediate clinical improvement. The antibiotic regimen was kept for 8 weeks.[ncbi.nlm.nih.gov]
Atrial Septal Defect
  • We report brucella endocarditis in an atrial septal defect (ASD) in a 55-year-old man who presented with fever and hemiplegia. Echocardiography showed a secundum ASD with large vegetations of 0.5 1 cm arising from the rim of the ASD.[ncbi.nlm.nih.gov]
Regurgitation
  • Echocardiography showed severe aortic regurgitation, moderate mitral regurgitation, severe left ventricular dysfunction and a mobile vegetation attached to the aortic valve.[ncbi.nlm.nih.gov]
  • Echocardiography confirmed aortic regurgitation with large vegetations on the aortic valve leaflets, and also showed mild left ventricular dilatation with systolic dysfunction.[ncbi.nlm.nih.gov]
Jaundice
  • We present the case of a 47-year-old Egyptian man, with hepatitis C cirrhosis, and a 2 week history of ascites, jaundice, encephalopathy, fever and pain on his right shoulder that started while travelling in the Middle East.[ncbi.nlm.nih.gov]
Diastolic Murmur
  • Cardiac auscultation revealed the presence of a diastolic murmur. Subsequently, a cardiac echocardiogram was done, which showed a large vegetation adherent to an anterior mitral leaflet. The blood culture was positive for Brucella species.[ncbi.nlm.nih.gov]
  • Clinical examination revealed hepatosplenomegaly and an early diastolic murmur in the aortic area.[ncbi.nlm.nih.gov]
Chest Pain
  • A 32-year-old Caucasian man with acute chest pain was examined at Sfax Hedi Chaker's Hospital. He had a night fever, although his cardiac examination was normal.[ncbi.nlm.nih.gov]
  • Abstract A previously healthy man, who had undergone coronary artery bypass 10 years earlier and had been diagnosed with brucellosis due to Brucella septicemia after Brucella arthritis, presented with chest pain and high fever.[ncbi.nlm.nih.gov]
Left Ventricular Dysfunction
  • Echocardiography showed severe aortic regurgitation, moderate mitral regurgitation, severe left ventricular dysfunction and a mobile vegetation attached to the aortic valve.[ncbi.nlm.nih.gov]
Ulcer
  • The patient was treated with doxycycline, rifampicin, and gentamicin, and underwent surgical repair of a penetrating aortic ulcer, with a good clinical recovery.[ncbi.nlm.nih.gov]
Testicular Pain
  • ., testicular pain, tenderness and scrotal swelling), a positive Rose Bengal test result, standard tube agglutination (STA) titer 1/160, and/or a positive blood culture.[ncbi.nlm.nih.gov]
Aphasia
  • Abstract A 55-year-old male presented with fever, stupor, aphasia, and left hemiparesis. A history of head trauma 3 months before was also reported.[ncbi.nlm.nih.gov]
Encephalopathy
  • We present the case of a 47-year-old Egyptian man, with hepatitis C cirrhosis, and a 2 week history of ascites, jaundice, encephalopathy, fever and pain on his right shoulder that started while travelling in the Middle East.[ncbi.nlm.nih.gov]
Stupor
  • Abstract A 55-year-old male presented with fever, stupor, aphasia, and left hemiparesis. A history of head trauma 3 months before was also reported.[ncbi.nlm.nih.gov]
Neurologic Manifestation
  • Subacute and chronic meningoencephalitis are described as the most common neurologic manifestations. We report a six-year-old boy with culture-proven neurobrucellosis who presented with an acute picture of meningoencephalitis.[ncbi.nlm.nih.gov]

Workup

Calcified Aortic Valve
  • His two-dimensional (2D) echocardiogram revealed a calcified aortic valve with mild aortic stenosis.[ncbi.nlm.nih.gov]
Legionella Pneumophila
  • KEYWORDS: Brucella; Legionella pneumophila; coinfection; fluorescent image analysis; intracellular pathogens; pathogenesis; phagosomes; reporter genes; type IV secretion system[ncbi.nlm.nih.gov]
  • Urine samples from 11 (3.85%) of 286 patients with severe pneumonia of unknown cause were positive for the Legionella pneumophila serogroup 1 antigen. We isolated Legionella strains from 7 patients.[doi.org]

Treatment

  • (34.21copies/μl) on 21st day after treatment depicting a significant reduction in DNA load over the course of treatment.[ncbi.nlm.nih.gov]
  • We present two cases for whom antibiotic treatments were initiated, and a follow-up surgery was planned for one of them. The surgery could not be done due to death of the patient, but the other patient fully recovered with antibiotic treatment only.[ncbi.nlm.nih.gov]
  • Resolution of the acute event was obtained without further surgical treatment. 18 months after endovascular treatment, the patient remains in good health.[ncbi.nlm.nih.gov]
  • In the absence of formal factual data, the surgical treatment is still discussed in the literature, especially since endovascular treatments have been in full expansion.[ncbi.nlm.nih.gov]
  • In uncomplicated patients, medical treatment is adequate for BEO.[ncbi.nlm.nih.gov]

Prognosis

  • We review the signs and symptoms, diagnostic approach, prognosis, and treatment of brucella arteritis.[ncbi.nlm.nih.gov]
  • The prognosis for patients with brucellar myopericarditis is usually favorable, as it was for the patient presented in this report.[revespcardiol.org]
  • The worst prognosis was observed for patients with panuveitis and posterior uveitis ( table 5 ). Table 5 Visual prognosis of uveitis. Table 5 Visual prognosis of uveitis.[academic.oup.com]
  • Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development . Front Cell Infect Microbiol 2 : 1 – 6 . 26.[asmscience.org]
  • […] optimization of treatment adherence, the monitoring for potential adverse effects, the importance of expert consultation in complicated disease, and the importance of a good relationship between patients and physicians, which is essential for a better prognosis[doi.org]

Etiology

  • MESSAGE: Brucellosis should be considered as an etiology of liver abscess in patients not responding to conventional antibiotics.[ncbi.nlm.nih.gov]
  • Among the six recognized species of the genus Brucella, Brucella melitensis is the main etiological agent involved in goat brucellosis and is also the most pathogenic for human.[ncbi.nlm.nih.gov]
  • We describe the magnitude and the etiological distribution changes in mainland China by genotyping data and emphasize its recent reemergence. We also provide the genetic diversity and molecular epidemiological characteristics of Brucella.[ncbi.nlm.nih.gov]
  • ., which would then require subsequent diagnostic tests to identify the etiologic agent.[dx.doi.org]
  • ., have been linked to a number of syndromes of as yet unknown etiology, which include fibromyalgia, CFS, and sarcoidosis ( 4 , 6 , 14 ), it will be of interest to investigate the potential role of Brucella sp. infection in such syndromes.[jcm.asm.org]

Epidemiology

  • The charts and map were processed by Excel 2013, and cluster analysis and epidemiological distribution was performed using BioNumerics (version 5.1).[ncbi.nlm.nih.gov]
  • CONCLUSIONS: The changing molecular epidemiology of brucellosis improve our understanding of apparent geographic expansion from the historically affected north of China to southern provinces in recent reemergence.[ncbi.nlm.nih.gov]
  • We describe the clinical and epidemiological aspects of a case of B. canis peritonitis.[ncbi.nlm.nih.gov]
  • Although these two disorders have some similar epidemiological features, we did not encounter any hydatid cyst cases superinfected with Brucella species (sp.) in a search of medical literature (Pubmed).[ncbi.nlm.nih.gov]
  • The three cases described came from areas of socio-economic deprivation and scarce epidemiological information where the healthcare personnel did not even consider such diagnosis.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test Brucella species are facultative intracellular Gram-negative staining bacilli capable of producing the disease "brucellosis"[mayomedicallaboratories.com]
  • Various trials have been performed with combinations omitting such a compound, often reporting adequate results; yet understanding the pathophysiology of the disease renders the inclusion of tetracyclines imperative.[doi.org]

Prevention

  • On February 10, 2012, the Maine Center for Disease Control and Prevention (Maine CDC) was notified of a positive Brucella culture from a harbor porpoise (Phocoena phocoena) found on the coast of southern Maine.[ncbi.nlm.nih.gov]
  • , Chinese Center for Disease Control and Prevention, Beijing, 102206, China.[ncbi.nlm.nih.gov]
  • We followed the US Centers for Disease Control and Prevention guidelines, but, of 14 staff members classified as high-risk exposure, none accepted post-exposure prophylaxis.[ncbi.nlm.nih.gov]
  • Our experience in rapid identification of Brucella from positive blood culture with MALDI-TOF SP could help preventing laboratory-acquired infection of Brucella.[ncbi.nlm.nih.gov]
  • The B. abortus vaccine strain 104 M is the only vaccine available in China for the prevention of brucellosis in humans. Although the B. abortus 104 M genome has been fully sequenced, the current genome annotations are not yet complete.[ncbi.nlm.nih.gov]

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