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Brucella Suis

Brucellosis


Presentation

  • […] or known to be present OIE Handistatus, 2005 Venezuela OIE Handistatus, 2005 Europe Andorra Disease not reported OIE Handistatus, 2005 Austria Reported present or known to be present OIE Handistatus, 2005 Belarus Disease never reported OIE Handistatus[cabi.org]
  • Evidence has been presented that the percentage of gamma delta T cells with Vgamma9Vdelta2 phenotype is dramatically increased in the peripheral blood of patients with acute brucellosis.[ncbi.nlm.nih.gov]
  • B. suis chvE is upstream of the putative sugar transporter-encoding genes gguA and gguB, also present in A. tumefaciens, but not adjacent to that of a LysR-type transcription regulator.[ncbi.nlm.nih.gov]
  • The present study provides evidence that Brucella infection inhibited spontaneously occurring apoptosis in human monocytes.[ncbi.nlm.nih.gov]
  • Furthermore, Brucella prevented the infected DCs from engaging in maturation processes and impaired their capacity to present antigen to naive T cells and to secrete interleukin-12 (IL-12).[ncbi.nlm.nih.gov]
Weakness
  • A low percentage of infected cells and few adhered and/or internalized bacteria following short-term infections could have resulted either from the fact that there were few sites of entry or the weak bacterial initial interactions with the host-cell membrane[ncbi.nlm.nih.gov]
  • Brucella LPS has weak endotoxic properties compared to other bacteria, allowing the organism to escape detection by Toll-like receptors of the innate immune system.[cabi.org]
Fishing
  • Fish and Wildlife Service.[itis.gov]
  • Med. 186 : 1769 Fish, P., E. Meuer, D. Pende, S. Rothenfusser, O. Viale, S. Kock, S. Ferrone, D. Fradelizi, G. Klein, L. Moretta, et al 1997 .[jimmunol.org]
Cape Verde
  • Verde Disease never reported OIE Handistatus, 2005 Central African Republic Disease not reported OIE Handistatus, 2005 Chad No information available OIE Handistatus, 2005 Congo Democratic Republic Disease not reported OIE Handistatus, 2005 Côte d'Ivoire[cabi.org]
Pertussis
  • Examples of systems playing a key role in the virulence of medically important pathogens are the Ptl, pertussis toxin liberation, the system of Bordetella pertussis ( 3 , 4 ), the cag pathogenicity island-encoded transporter of Helicobacter pylori ( 5[doi.org]
  • A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis . Molecular Microbiology, 33(6):1210-1220. OIE Handistatus, 2005.[cabi.org]
  • Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase.. Infect. Immun. 61 : 4064 Rogers, H. W., M. P. Callery, B. Deck, E. R. Unanue. 1996 . Listeria monocytogenes induces apoptosis of infected hepatocytes.. J.[jimmunol.org]
Pleural Effusion
  • From 13 patients in which chest radiography was performed, four (30%) had radiological abnormalities, including lobar pneumonia in two cases (one with pleural effusion) and interstitial involvement in other two.[ncbi.nlm.nih.gov]
Gagging
  • […] cac cgt tca ttc cct tca, RT-PCR 4; B5L, cat tat cct tcg cgt cta, RT-PCR 4, probe; FB4U, cga cat cat ccg cag tat, RT-PCR 5; B6L, ctt atg acg agt tgc gaa, RT-PCR 5; B5′U, att ctc agc ttc gca ttc, probe; B5U, acg aac gcc agc acg aat, RT-PCR 6; B8L, gtg gag[doi.org]
Ulcer
  • Here we present crystal structures of VirB8 of Brucella suis, the causative agent of brucellosis, and ComB10, a VirB10 homolog of Helicobacter pylori, the causative agent of gastric ulcers.[ncbi.nlm.nih.gov]
  • Nickel is essential for other important enzymatic reactions, among which ureolysis has become of major interest since a relationship between the highly ureolytic pathogen H. pylori and the human peptic ulceration has been found ( 28 ).[doi.org]
Excitement
  • About 50,000 individual events were excited with a 488-nm argon-ion laser, and emission light was detected through a 530-nm bandpass filter. Cell Quest software (Becton Dickinson) was used for the quantitation of fluorescence.[doi.org]
Vaginal Discharge
  • Many sows within this herd experienced abortions, while others exhibited vaginal discharge; three sows suffered posterior paralysis.[ncbi.nlm.nih.gov]

Workup

Bordetella Pertussis
  • A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis . Molecular Microbiology, 33(6):1210-1220. OIE Handistatus, 2005.[cabi.org]
  • Examples of systems playing a key role in the virulence of medically important pathogens are the Ptl, pertussis toxin liberation, the system of Bordetella pertussis ( 3 , 4 ), the cag pathogenicity island-encoded transporter of Helicobacter pylori ( 5[doi.org]
  • Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase.. Infect. Immun. 61 : 4064 Rogers, H. W., M. P. Callery, B. Deck, E. R. Unanue. 1996 . Listeria monocytogenes induces apoptosis of infected hepatocytes.. J.[jimmunol.org]
Bartonella Henselae
  • Genome sequencing projects also have identified type IV secretion systems in Rickettsia prowazekii and Bartonella henselae ; however, their roles in pathogenicity have not been investigated yet ( 9 , 10 ).[doi.org]
Trypanosoma Cruzi
  • Phagosome acidification has been shown to be essential for the virulence of Salmonella , Candida , Trypanosoma cruzi , and Coxiella ( 33 – 36 ).[doi.org]
Rickettsia Prowazekii
  • Genome sequencing projects also have identified type IV secretion systems in Rickettsia prowazekii and Bartonella henselae ; however, their roles in pathogenicity have not been investigated yet ( 9 , 10 ).[doi.org]
Legionella Pneumophila
  • pneumophila ( 6 , 7 ), and more recently the VirB system in Brucella ( 8 ).[doi.org]
Pleural Effusion
  • From 13 patients in which chest radiography was performed, four (30%) had radiological abnormalities, including lobar pneumonia in two cases (one with pleural effusion) and interstitial involvement in other two.[ncbi.nlm.nih.gov]

Treatment

  • The patient's fever persisted along with positive blood cultures despite specific antimicrobial treatment. Due to this adverse outcome, the patient was interrogated again and admitted having domestic swine.[ncbi.nlm.nih.gov]
  • Acidification of B. suis-containing phagosomes in the early phase of infection was abolished by treatment of host cells with 100 nM bafilomycin A(1), a specific inhibitor of vacuolar proton-ATPases.[ncbi.nlm.nih.gov]
  • Failure to correctly diagnose this zoonosis delays patient treatment and is dangerous, as in this case that could have been a laboratory-acquired disease. This type of infection is preventable if proper safety protocols are established and followed.[ncbi.nlm.nih.gov]
  • Brucella suis biovar 1 strain 1330 was isolated from a patient who worked in a waste treatment plant. Food borne transmission, contact with animals, and risk jobs were ruled out.[ncbi.nlm.nih.gov]
  • Before attempting treatment for other diseases, it is logical to test for brucellosis in herds in which sterility is a problem. Sterility in sows is more frequently temporary but may be permanent.[merckvetmanual.com]

Etiology

  • Abstract Brucella is a facultative intracellular pathogen of various mammals and the etiological agent of brucellosis.[ncbi.nlm.nih.gov]
  • Abstract Brucella suis has been recognized as the major etiological agent of human brucellosis in areas free from Brucella melitensis infection.[ncbi.nlm.nih.gov]
  • The gram-negative bacteria Brucella spp. are the etiologic agents of brucellosis, a disease that is encountered worldwide and is endemic in many underdeveloped countries.[doi.org]

Epidemiology

  • Epidemiological and clinical aspects of Brucella suis infection in 17 workers from a pork processing plant in Argentina occurring between January 2014 and July 2015 are presented.[ncbi.nlm.nih.gov]
  • Epidemiological data were obtained during medical follow-up visits. Seven human cases were identified between 2004 and 2016, all confirmed by the isolation of BSB2 in clinical specimens.[ncbi.nlm.nih.gov]
  • The aim of the study was to assess the epidemiological situation of porcine brucellosis primarily in Croatia and its relationship to genotypes present in other, mostly European countries.[ncbi.nlm.nih.gov]
  • Relevant epidemiological issues based on changes in the highly conserved genome of these bacteria will be valuable tools to describe outbreaks and disease status, along with risk factors that would otherwise be difficult to analyze.[digital.cic.gba.gob.ar]
Sex distribution
Age distribution

Prevention

  • Induction or prevention of host cell apoptosis appears to be a critical step for determining the infection outcome.[ncbi.nlm.nih.gov]
  • This type of infection is preventable if proper safety protocols are established and followed.[ncbi.nlm.nih.gov]
  • Timely identification of Brucella is essential for providing proper treatment to the patient and for advising safe handling of laboratory cultures in biological safety cabinets to prevent laboratory-acquired infection.[ncbi.nlm.nih.gov]
  • Author information 1 US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA. samuel.yingst@amedd.army.mil Abstract The US Centers for Disease Control and Prevention lists Brucella as a potential bioterrorism[ncbi.nlm.nih.gov]
  • Furthermore, Brucella prevented the infected DCs from engaging in maturation processes and impaired their capacity to present antigen to naive T cells and to secrete interleukin-12 (IL-12).[ncbi.nlm.nih.gov]

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