Presentation
Seventy-seven (13%) individuals showed lymphedema of the leg that occasionally presented severe elephantiasis. No hydrocele or genital lymphedema were observed. [ncbi.nlm.nih.gov]
Our presentation revealed that adult female worm and microfilaria may even be present at rare sites such as submandibular region. [jcytol.org]
Individuals with Brugia Timori Infection commonly present with no symptoms. [dovemed.com]
Entire Body System
- Lymphedema
Seventy-seven (13%) individuals showed lymphedema of the leg that occasionally presented severe elephantiasis. No hydrocele or genital lymphedema were observed. [ncbi.nlm.nih.gov]
Also, the sheath of B. timori does not stain pink with Giemsa stain as is observed with B. malayi and W. bancrofti. [ 4 ] Brugia timori filariasis Like other human filariasis infections, Brugia timori filariasis causes acute fever and chronic lymphedema [dictionnaire.sensagent.leparisien.fr]
Also, the sheath of B. timori does not stain pink with Giemsa stain as is observed with B. malayi and W. bancrofti. [4] Brugia timori filariasis Like other human filariasis infections, Brugia timori filariasis causes acute fever and chronic lymphedema [ipfs.io]
This obstruction results in lymphedema of the legs, arms, breasts, and/or genitalia. Male genital involvement such as hydrocele is very common in W. bancrofti infection but uncommon in Brugia species infection. [clinicalgate.com]
Also, the sheath of B. timori does not stain pink with Giemsa stain as is observed with B. malayi and W. bancrofti.[4] Brugia Timori Filariasis Like other human filariasis infections, Brugia timori filariasis causes acute fever and chronic lymphedema. [wikidoc.org]
- Swelling
Additional steps may be taken to lessen the effects of swelling. [dovemed.com]
When lymphatic filariasis develops into chronic conditions, it leads to lymphoedema (tissue swelling) or elephantiasis (skin/tissue thickening) of limbs and hydrocele (scrotal swelling). [cdc.gov.tw]
FNAC from the swelling yielded purulent material along with a creamy white thread. [jcytol.org]
Treatment consists of: 1) medicine to kill circulating larvae and adult worms, 2) soap and water and skin care to prevent secondary infections, and 3) elevation, exercises, and, in some cases, pressure bandages to reduce swelling. [web.archive.org]
Keywords: Brugia malayi, GLIDE Docking, Glucosidase inhibitors, Homology Modeling, Lymphatic Filariasis, Trehalose-6 Phosphate Phosphatase, Filariasis, Tropical diseases, Thread like parasitic round worms, Parasitic Diseases, Disfiguring swelling of the [eurekaselect.com]
- Pain
Lymphatic filariasis, commonly known as elephantiasis, is a painful and profoundly disfiguring disease. In communities where filariasis is transmitted, all ages are affected. [who.int]
Location of egg, larvae and adult Ovoviviparous: microfilariae in blood, turns into larvae in mosquitoes, infectious larvae goes into lymphatic ducts and become adults Caused by adults Inflammatory response around lymph vessels Painful lymphatics, chills [quizlet.com]
[…] mainly in filariasis; the legs and groin area; Malayan fever, headache, and filariasis backache may also be seen Dirofilaria Dirofilariasis Typically asymptomatic; immitis occasionally localized vasculitis and pulmonary infarcts are found producing chest pain [medical-dictionary.thefreedictionary.com]
Inflammatory filariasis is associated with periodic erythema, warmth, pain, and swelling that mimic cellulitis (associated with peripheral eosinophilia). [antiinfectivemeds.com]
Boils and carbuncles are generally inflamed, painful lumps. Compared with acne, boils are generally more painful, inflamed, and reddened around the border. Diagnosis Skin abscesses, boils, and related conditions are diagnosed by visual inspection. [brighterdayfoods.com]
- Disability
Lymphatic filariasis (LF) is a disabling, mosquito-borne disease of humans caused by the parasitic filarial nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori. [medical-dictionary.thefreedictionary.com]
The infection affects the normal flow of lymph leading to abnormal enlargement of body parts, severe pain, permanent disability, and social stigma. [unboundmedicine.com]
While the infection may be acquired during childhood its visible manifestations may occur later in life, causing temporary or permanent disability. [who.int]
- Weakness
There was one instance of a child having an initial “weak positive” result by ICT that, upon repeat testing, was found to be negative. [journals.plos.org]
This included weak IgG4 reactivities demonstrated by L. loa - and O. volvulus -infected patients tested with Ov- Bm R1 and Ll- Bm R1 (or Bm R1). [filariajournal.biomedcentral.com]
However, due to methodological weakness of this research, further evidence is needed to confirm these results. Avoid if allergic or hypersensitive to bitter orange or any members of the Rutaceae family. [brighterdayfoods.com]
Immune System
- Splenomegaly
A chronic syndrome called “tropical pulmonary eosinophilia” has been associated with W. bancrofti and B. malayi infections, involving eosinophilic pulmonary infiltrate, peripheral hypereosinophilia, wheezing, chest pain, splenomegaly, and bloody sputum [cdc.gov]
Discoveries of endosymbiont rickettsia-like bacterium, Wolbachia in filar… Publisher Full Text (DOI) Filarial huge splenomegaly dramatically regressed by anti-filarial medication: A rare clinical scenario. [unboundmedicine.com]
Respiratoric
- Aspiration
In the present case, the patient had a solitary swelling from which purulent exudates and fragment of adult worm was aspirated. [jcytol.org]
To… Publisher Full Text (DOI) Rare association of microfilaria with poorly differentiated mucin-secreting metastatic carcinoma in liver aspirate cytology. [unboundmedicine.com]
Skin
- Skin Rash
rash, stomach discomfort, stomach ulcers, and vomiting. [brighterdayfoods.com]
Neurologic
- Neglect
A review of neglected tropical diseases: filariasis. Asian Pac J Trop Med. 2011;4:581–6. CrossRef CAS PubMed Google Scholar David HL, Edeson JF. Filariasis in Portuguese timor, with observations on a new microfilaria found in man. [link.springer.com]
African Journal of Health Sciences 13(1-2): 69-79, 2007 The 6th Meeting of the Global Alliance to Eliminate Lymphatic Filariasis: A half-time review of lymphatic filariasis elimination and its integration with the control of other neglected tropical diseases [eurekamag.com]
In UCSF's Center for Parasitic Diseases, lead compounds that are approved as safe and can be repurposed to treat neglected diseases are of particular interest. [awol.lstmed.ac.uk]
What is Lymphatic Filariasis Lymphatic filariasis is a disfiguring and debilitating neglected tropical diseases caused by filarial parasitic nematodes. Wuchereria bancrofti, Brugia malayi and Brugia timori infect over 100 million people worldwide. [ctegd.uga.edu]
Lymphatic filariasis (LF) is a neglected tropical disease caused by the parasitic nematodes Brugia malayi, Brugia timori, and Wucheria bancrofti and has been targeted by the World Health Organization for eradication by 2020. [jordandward.com]
- Irritability
Use cautiously with gastrointestinal irritation or peptic ulcer disease due to anecdotal reports of gastrointestinal irritation. [brighterdayfoods.com]
Workup
Microbiology
- Brugia Malayi
Médard Athlétisme Bruges, Belgium Bruges, Belgium Bruges, Belgium Brugge Brugge Brugge Brügge Brügge Brügge Brugge, Belgium Brugge, Belgium Brugge, Belgium Brugges Brugges Brugges brugh Brugia Brugia filariasis Brugia malayi Brugia Malayi Microfilarial [medical-dictionary.thefreedictionary.com]
Abstract The microfilaria of Brugia timori was compared with microfilariae of Indonesian strains of periodic and subperiodic Brugia malayi using alcohol-fixed (stained) and formalin-fixed (unstained) preparations. [pubmed.ncbi.nlm.nih.gov]
The microfilariae of Brugia timori are longer and morphologically distinct from those of Brugia malayi and Wuchereria bancrofti, with a cephalic space length-to-width ratio of about 3:1. [dictionnaire.sensagent.leparisien.fr]
[…] microfilariae of Brugia timori are longer and morphologically distinct from those of Brugia malayi and Wuchereria bancrofti, with a cephalic space length-to-width ratio of about 3:1. [ipfs.io]
- Dirofilaria Immitis
Cited by 13 articles Seasonal distribution and environmental parameters associated with Brugia pahangi and Dirofilaria immitis in naturally infected dogs in Bangkok and vicinity, Thailand. [pubmed.ncbi.nlm.nih.gov]
immitis larva Magnification 400× Scientific classification Kingdom: Animalia Phylum: Nematoda Class: Chromadorea Order: Rhabditida Suborder: Spirurida Superfamilies 10, but see text Spirurida is an order of spirurian nematodes. [en.wikipedia.org]
Similar studies have been performed on the filarial nematode Dirofilaria immitis, or dog heartworm, and its Wolbachia endosymbiont, wDi [30, 54]. [journals.plos.org]
Other Pathologies
- Tissue Nematode
The filarial nematodes are a group of arthropod‑borne worms that reside in the subcutaneous tissues, deep connective tissues, lymphatic system, or body cavities of humans. [med-chem.com]
Treatment
Re-infection with A. lumbricoides may return six months after treatment to almost 90% of the pre-treatment prevalence and worm density may drop to about 75% [ 35 ]. [filariajournal.com]
One year after treatment 69 subjects (72%) were mf-negative and the overall geometric mean mf density reduced to 3 mf/mL (0-2456 mf/mL). The reduction of mf was more pronounced 1 year after treatment compared with 6 months after treatment. [ncbi.nlm.nih.gov]
[…] and DEC–Alb treatments (P = 0.527). [onlinelibrary.wiley.com]
Prognosis
(Outcomes/Resolutions) The prognosis for Brugia Timori Infection is generally quite good, as those with early to mild infection may be asymptomatic Treatment with DEC has proved to be effective in eliminating the infection It is currently not possible [dovemed.com]
Etiology
The etiological diagnosis is mainly based on detection and visualization of the microfilarias, in blood or skin. [medicineonline.es]
(Etiology) Brugia Timori Infection is caused by the parasitic roundworm Brugia timori. [dovemed.com]
Epidemiology
Abstract The epidemiological and clinical features of Brugia timori filariasis in a newly established village, Karakuak, West Flores, is described. [ncbi.nlm.nih.gov]
Epidemiological and clinical features of Brugia timori in a newly established village, Karakuak, West Flores, Indonesia. Am. J. Trop. Med. Hyg. 1978; 27: 910-915 Partono F et al. [cell.com]
The epidemiology and treatment of infection due to Brugia malayi. Bull World Health Organ. 1962;27(4–5):529–41. Google Scholar Okon OE, Iboh CI, Opara KN. Bancroftian filariasis among the Mbembe people in Cross River State, Nigeria. [link.springer.com]
Abstract Abstract The epidemiological and clinical features of Brugia timori filariasis in a newly established village, Karakuak, West Flores, is described. [ajtmh.org]
While classical cases of filariasis are common and hence dealt at epidemiologic scales, uncommon infections are largely neglected and reported rarely. [tropicalparasitology.org]
Prevention
How can lymphatic filariasis be prevented? There is no vaccine for filariasis. [web.archive.org]
For individuals with this condition, proper care of the limb must be taken to prevent infection. Additional steps may be taken to lessen the effects of swelling. [dovemed.com]
Epidemiology Currently, 856 million people in 52 countries worldwide remain threatened by lymphatic filariasis and require preventive chemotherapy to stop the spread of this parasitic infection. [cdc.gov.tw]
Tea tree oil : Tea tree oil is purported to have antiseptic properties, and has been used traditionally to prevent and treat infections. [brighterdayfoods.com]
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