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Bumetanide


Presentation

  • In conjunction with our previous finding that tm 2 plays an important role in cation transport, the present observations implicate the fourth and seventh tm helices in anion transport.[ncbi.nlm.nih.gov]
  • Here we demonstrate that the gene encoding the bumetanide-sensitive cotransporter BSC2, one of the two major isoforms of Na-K-Cl cotransporters present in mammalian cells, can be differentially regulated by inflammatory cytokines and fluid mechanical[ncbi.nlm.nih.gov]
  • And all the experiments presented in this work were based on that BMTN inhibited the formation of [Fe-morin](3 ) ([FeR](3 )) complex by the reaction between Fe(3 ) and R, which led to severe quenching of room temperature phosphorescence (RTP) signal.[ncbi.nlm.nih.gov]
  • Abstract In the present study we used the Li clearance technique to evaluate the effects of submaximal bumetanide infusion on proximal and distal Na reabsorption in healthy volunteers with and without volume and Na replacement.[ncbi.nlm.nih.gov]
  • The aim of the present study was to investigate the oligomeric state of hNKCC2 to understand further its operational mechanism. To this end, hNKCC2 was heterologously expressed in Xenopus laevis oocytes.[ncbi.nlm.nih.gov]
Intravenous Administration
  • Abstract The effect of intravenous administration of the loop diuretics bumetanide, furosemide and ethacrynic acid on lithium (Li) clearance (CLi) and diluting segment reabsorption was studied in seven healthy water-loaded men.[ncbi.nlm.nih.gov]
  • OBJECTIVES: Account for the interindividual variability in the pharmacokinetics and pharmacodynamics of bumetanide after intravenous administration of single doses to critically ill infants.[ncbi.nlm.nih.gov]
  • Intravenous administration should be given over a period of 1 to 2 minutes. If the response to an initial dose is deemed insufficient, a second or third dose may be given at intervals of 2 to 3 hours, but should not exceed a daily dosage of 10 mg.[druglib.com]
Hypothermia
  • This study describes the first PK model of bumetanide in hypothermia-treated infants with seizures. 2015, The American College of Clinical Pharmacology. KEYWORDS: central nervous system; neonatology; population pharmacokinetics[ncbi.nlm.nih.gov]
Motor Symptoms
  • We report an improvement of PD motor symptoms in the 4 patients treated with bumetanide (5 mg/d for 2 months). Bumetanide also improved gait and freezing in 2 of these patients.[ncbi.nlm.nih.gov]

Treatment

  • However, strategies to select appropriate candidates for bumetanide treatment are lacking.[ncbi.nlm.nih.gov]
  • The combined treatment group received ABA training combined with oral bumetanide (0.5 mg twice a day). The single treatment group received ABA training only.[ncbi.nlm.nih.gov]
  • KEYWORDS: Autism spectrum disorders; GABA; bumetanide; emotion; fMRI; face perception; treatment[ncbi.nlm.nih.gov]
  • Only 14 (6.0%) patients ceased treatment because of adverse effects.[ncbi.nlm.nih.gov]
  • In turn, this concentration change makes the action of GABA more hyperpolarizing, which may be useful for treatment of neonatal seizures, which quite often are not responsive to traditional GABA-targeted treatment, such as barbiturates.[en.wikipedia.org]

Etiology

  • […] controlled, dose escalation study of BTN as add-on therapy to treat refractory seizures caused by HIE, focal or multi-focal stroke, intracranial hemorrhage, CNS infection, genetic syndrome, focal or diffuse brain malformation, idiopathic or presumed genetic etiology[clinicaltrials.gov]
  • Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 2009; 204 : 313–321. 16. Kemper TL, Bauman M. Neuropathology of infantile autism. J Neuropathol Exp Neurol 1998; 57 : 645–652. 17. Dossche DM.[dx.doi.org]
  • Hepatic coma or severe electrolyte depletion, until condition is improved or corrected. 4 Known hypersensitivity to bumetanide or any ingredient in the formulation. 4 Warnings/Precautions Warnings Fluid, Electrolyte, and Cardiovascular Effects Careful etiologic[drugs.com]

Pathophysiology

  • ., brain), as well as in the preservation of endothelial homeostasis in the face of fluctuating osmotic conditions that may accompany certain pathophysiological conditions (e.g., diabetes mellitus).[ncbi.nlm.nih.gov]
  • Bumetanide is increasingly being used for experimental treatment of brain disorders, including neonatal seizures, epilepsy, and autism, because the neuronal Na-K-Cl cotransporter NKCC1, which is inhibited by bumetanide, is implicated in the pathophysiology[ncbi.nlm.nih.gov]
  • Manager 2019 Oxford University Press Close Navbar Search Filter Mobile Microsite Search Term Close search filter search input Background: The presentation of Acute Heart Failure (AHF) patients is heterogeneous and may differ in underlying aetiology and pathophysiology[academic.oup.com]
  • J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. [ PubMed:10991988 ] VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology.[drugbank.ca]
  • Key words pathophysiology of renal failure, fluid overload and electrolyte imbalance in severe congestive heart failure (CHF) Introduction Renal failure is a consistent accompaniment of CHF. Renal failure progresses as CHF advances.[oatext.com]

Prevention

  • […] hepatic disease, hyperuricemia, hypomagnesemia, hypovolemia, neonates at risk for kernicterus Hypokalemia may occur; close medical supervision and dose evaluation required; may need potassium supplementation and/or use of potassium-sparing diuretics to prevent[reference.medscape.com]
  • Evaluating the safety of furosemide and bumetanide, which are often used to prevent bronchopulmonary dysplasia, in premature infants by analyzing previously collected clinical data.[pediatrictrials.org]
  • B alone significantly (P less than 0.05; N 7) reduced CI and increased total peripheral resistance; N prevented these effects of B. Neither drug altered BP consistently.[ncbi.nlm.nih.gov]
  • Bumetanide delayed the occurrence, and reduced the number of full motor seizures during kindling, and prevented the development of kindling-induced enhanced seizure susceptibility in a majority of animals.[ncbi.nlm.nih.gov]

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