We present a 20-year-old morphine-addicted man who presented with methadone-induced respiratory depression and responded safely and effectively to intravenous administration of buprenorphine. [ncbi.nlm.nih.gov]

• Intravenous Administration

  These deaths are generally related to misuse of HDB with intravenous administration and/or concomitant use of benzodiazepines, and they usually occur in patients on HDB substitution therapy for opioid dependence. [ncbi.nlm.nih.gov]

  Naloxone has poor bioavailability in the sublingual form; therefore, buprenorphine’s effect predominates. 15, 27 However, if buprenorphine-naloxone is taken inappropriately via subcutaneous, intramuscular, or intravenous administration, sufficient naloxone [cfp.ca]

• Burning Pain

  Three months later, he developed constant and burning pain within the entire right side of his body. He was diagnosed with central pain syndrome and treated with antiepileptics and tricyclic antidepressants. [ncbi.nlm.nih.gov]

• Limb Pain

  Phantom limb pain is a common consequence of limb amputation and is prevalent among the service members sustaining traumatic battlefield limb injuries during the conflicts in Iraq and Afghanistan. [ncbi.nlm.nih.gov]

• Urethral Discharge

  The patient was apyretic and presented a urethral discharge. His glans was blue without discoloration on digital pressure. [ncbi.nlm.nih.gov]

• Altered Mental Status

  In this case, a primary care patient on buprenorphine/naloxone maintenance therapy demonstrating altered mental status, hallucinations, falls, and rebound hypertension was found to be concomitantly abusing clonidine and amitryptyline, which share metabolic [ncbi.nlm.nih.gov]

• Encephalopathy

  We report a case of a young woman exhibiting dependence on codeine, originally prescribed for myalgic encephalopathy, after escalating use over a 10-year period. [ncbi.nlm.nih.gov]

PubMed was searched and literature was reviewed on the effectiveness, safety, and side effect profiles of abstinence-based treatment, buprenorphine-naloxone treatment, and methadone treatment. [ncbi.nlm.nih.gov]

Entry into buprenorphine treatment (PDF 225 KB) 3. Guidelines for maintenance treatment (PDF 400 KB) 4. Guidelines for the management of heroin withdrawal (PDF 327 KB) 5. Complications or adverse events with buprenorphine treatment (PDF 281 KB) 6. [nationaldrugstrategy.gov.au]

“As part of our ongoing work in supporting the treatment of those suffering from addiction to opioids, the FDA plans to issue guidance to expedite the development of new addiction treatment options. [fda.gov]

The Drug Addiction Treatment Act of 2000 (DATA 2000) expands the clinical context of medication-assisted opioid dependency treatment. [buprenorphine.samhsa.gov]

Regardless of etiology, sleep-disordered breathing and its consequences present unique challenges to the patient in recovery from an opioid use disorder and therefore warrants careful evaluation and management. [ncbi.nlm.nih.gov]

Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD)-10 and PHQ-2. In addition, information was gathered on participant demographics and treatment characteristics. [ncbi.nlm.nih.gov]

Levels of evidence Level I: At least one properly conducted randomized controlled trial, systematic review, or meta-analysis Level II: Other comparison trials, non-randomized, cohort, case-control, or epidemiologic studies, and preferably more than one [cfp.ca]

By evaluating the pharmacological characteristics of this substance, as well as the data previously published in the literature, we have attempted to explain the pathophysiological mechanisms of this particular mode of poisoning that can easily be fatal [ncbi.nlm.nih.gov]

The high affinity also prevents binding of other opioids, at commonly used clinical doses, to receptor sites - preventing their analgesic and likely minimum alveolar concentration (MAC) reducing benefits. [ncbi.nlm.nih.gov]

Severe withdrawal side effects can usually be prevented when a person is switched to buprenorphine and naloxone combination. It acts on the central nervous system (CNS) to help prevent the withdrawal side effects. [mayoclinic.org]