By contrast, four patients in our study presented with unilateral, inguinal lymphadenitis. Another two patients presented with mediastinal lymphadenitis and prolonged fever. All patients had prompt and sustained response to therapy. [ncbi.nlm.nih.gov]

• Collapse

  Thus, collapse of a proton gradient across the cell membrane by the addition of CCCP should result in a marked increase in drug accumulation. Surprisingly, however, efflux of streptomycin was not inhibited by the addition of CCCP. [aac.asm.org]

• Abdominal Lymphadenopathy

  Ultrasonography demonstrated diffuse upper abdominal lymphadenopathy with ascites. [ncbi.nlm.nih.gov]

• Sore Throat

  We report a case of liver abscess due to B. pseudomallei in an immunocompetent 27-year-old male soldier admitted due to fever, sore throat and mild non-productive cough for 1 week. [ncbi.nlm.nih.gov]

• Abdominal Pain

  The patients demonstrated clinical improvement with decreasing abdominal pain and resolution of fever. [ncbi.nlm.nih.gov]

  After one month of maintenance antibiotic, the patient came back with abdominal pain and diarrhea. There was guarding over the abdomen and she was in septic shock. [sjkdt.org]

• Chronic Abdominal Pain

  She presented with prolonged fever and chronic abdominal pain. The early clinical diagnosis was carcinomatous mass with peritonitis. Diagnosis of melioidosis arose from the surgical finding and pus culture. [ncbi.nlm.nih.gov]

• Epigastric Tenderness

  Left flank pain, followed by right flank pain associated with epigastric tenderness developed. Sonography and computed tomography scan of the abdomen demonstrated liver abscess. [ncbi.nlm.nih.gov]

• Right Flank Pain

  Left flank pain, followed by right flank pain associated with epigastric tenderness developed. Sonography and computed tomography scan of the abdomen demonstrated liver abscess. [ncbi.nlm.nih.gov]

• Left Flank Pain

  Left flank pain, followed by right flank pain associated with epigastric tenderness developed. Sonography and computed tomography scan of the abdomen demonstrated liver abscess. [ncbi.nlm.nih.gov]

• Hepatomegaly

  A 10-month-old girl is described who presented with disseminated melioidosis with subcutaneous nodules, arthritis, hepatomegaly and a lung cavity, and developed a left medial rectus palsy. [ncbi.nlm.nih.gov]

  Flushing, cyanosis and a disseminated pustular eruption with regional lymphadenopathy, cellulitis or lymphangitis can be seen together with photophobia, lacrimation, cervical adenopathy, mild hepatomegaly and/or splenomegaly, tachycardia, generalised [web.archive.org]

• Joint Effusion

  We report a case of chronic left hip joint effusion in a known case of diabetes mellitus. Gram stain of computed tomography (CT)-guided aspirate from the joint revealed Gram-negative bacilli along with pus cells. [ncbi.nlm.nih.gov]

• Foot Ulcer

  Burkholderia pseudomallei was not isolated from 74 diabetic foot ulcer samples. [doi.org]

  Burkholderia pseudomallei was not isolated from 74 diabetic foot ulcer samples. Following careful local evaluation, focused use of selective media may be cost-effective. [ncbi.nlm.nih.gov]

• Subcutaneous Nodule

  A 10-month-old girl is described who presented with disseminated melioidosis with subcutaneous nodules, arthritis, hepatomegaly and a lung cavity, and developed a left medial rectus palsy. [ncbi.nlm.nih.gov]

• Flank Pain

  Left flank pain, followed by right flank pain associated with epigastric tenderness developed. Sonography and computed tomography scan of the abdomen demonstrated liver abscess. [ncbi.nlm.nih.gov]

• Vaginal Discharge

  She had odorless whitish vaginal discharge. The pelvic examination revealed excitation pain on the left side of her cervix. Transvaginal ultrasonography revealed a large left tubo-ovarian abscess size 9.4 4.8 cm located at anterior of the uterus. [ncbi.nlm.nih.gov]

• Headache

  A healthy 65-year-old female who had been treated with antipsychotic medication for neurotic depression for over 2 years presented with acute-onset fever, headache, lead-pipe rigidity of all limbs, and delirium. [ncbi.nlm.nih.gov]

  On the basis of a Dutch study, 95% of patients with meningitis displayed at least 2 of the following 4 symptoms: fever, headache, neck stiffness, and altered mental status. [12] In the Darwin Prospective Melioidosis Study, headache was prominent on admission [journals.lww.com]

  They develop respiratory distress, headaches, fever, diarrhea, pus-filled lesions on the skin, and abscesses throughout the body. Septicemia may be overwhelming, with a 90% fatality rate and death occurring within 24-48 hours. [emedicine.medscape.com]

  Signs and symptoms include fever, cough, chest pain, headache and anorexia. Risk factors include liver disease, diabetes, and thalassemia. [gii.co.jp]

• Penicillium

  Our findings confirm that MB bottles are necessary for isolating mycobacteria and likely improve the detection of certain fungi, such as H. capsulatum and Penicillium species. [doi.org]

Notably, this study revealed 184 bacterial genes and ORFs that were unique to in vivo ceftazidime treatment and thus provide candidate molecular markers for treatment response. [ncbi.nlm.nih.gov]

A high index of suspicion and diligent search helps in early diagnosis of these cases, thus helping in the initiation of appropriate treatment with a good prognosis. 1. White NJ. Melioidosis. Lancet 2003;361:1715-22. [ PUBMED ] 2. [ijpmonline.org]

[…] of B. pseudomallei in Peninsular Malaysia with strains obtained from other regions, especially other countries within Asia, and to investigate genotype diversity as a possible explanation for differences in disease presentation, treatment response, prognosis [slideheaven.com]

Prognosis: While 2036% of melioidosis cases have no evident predisposing risk factor, the vast majority of fatal cases have an identified risk factor, the most important of which are diabetes, alcoholism and chronic renal disease. 46% of cases were bacteraemic [web.archive.org]

A new γ-carbonic anhydrase (CA, EC 4.1.1.1) was cloned and characterized kinetically in the genome of the bacterial pathogen Burkholderia pseudomallei, the etiological agent of melioidosis, an endemic disease of tropical and sub-tropical regions of the [ncbi.nlm.nih.gov]

This study aims to determine the genetic diversity among the clinical isolates of B. pseudomaelli from India in order to establish a molecular epidemiology and elucidate the Southeast Asian association. [ncbi.nlm.nih.gov]

Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005 Apr;18(2):383–416. 2. Suputtamongkol Y, Chaowagul W, Chetc-hotisakd P, Lertpatanasuwun N, Intaran-ongpai S, Ruchutrakool T, et al. [jmscr.igmpublication.org]

Melioidosis: epidemiology, pathophysiology, and management. Clin. Microbiol. Rev. 18 : 383 -416. Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial susceptibility testing; 18th informational supplement. [doi.org]

Melioidosis: Epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005;18:383-416. 8. Li PK, Szeto CC, Piraino B, et al. Peritoneal dialysis-related infections recommendations: 2010 update. Perit Dial Int 2010;30:393-423. 9. [sjkdt.org]

Author information 1 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. 2 National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention [ncbi.nlm.nih.gov]