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Caffeine


Presentation

  • A 41-yr-old woman presented 3 h after ingesting approximately 50 g of caffeine.[ncbi.nlm.nih.gov]
Constipation
  • Some symptoms of caffeine withdrawal include headaches, irritability, nervousness, nausea, constipation and muscular tension.[uhs.umich.edu]
  • May Be Useful In Treatment Of: ALIMENTARY CANAL: Cancer, Constipation, Indigestion (dyspepsia), Ulcer (duodenal and peptic).[web.archive.org]
  • The high tannin content of tea, on the other hand, is apt to cause constipation." 17 When taken in very large doses, moreover, caffeine is a potent poison. "A fatal dose of caffeine given to an animal," Dr.[druglibrary.org]
  • Many patients with nOH also have autonomic failure resulting in constipation and anhidrosis, so these side effects may be salutary for some patients.[doi.org]
Persistent Vomiting
  • In the case 1 there was a severe intoxication (persistent vomiting, hypotension, tremor), and the concentration of caffeine in the blood was found to be 80.16 μg/mL.[ncbi.nlm.nih.gov]
Xerostomia
  • Morita, Relationship between xerostomia and gingival condition in young adults, Journal of Periodontal Research, 50, 1, (74-79), (2014). Matthew A. Tucker, Matthew S. Ganio, J. D. Adams, Lemuel A. Brown, Christian B. Ridings, Jenna M.[doi.org]
Bruxism
  • Marcin Berger, Monika Litko, Michał Ginszt, Hassan Alharby, Jacek Szkutnik, Piotr Majcher and Jolanta Szymańska, Use of common stimulants and awake bruxism – a survey study, Polish Journal of Public Health, 126, 3, (2016).[dx.doi.org]
Tachycardia
  • Atrial tachycardia time from a Holter recording was 44.2 minute/day before the caffeine load, compared with 215.2 minute/day during the caffeine load.[ncbi.nlm.nih.gov]
Palpitations
  • "If it's red-colored and it's sweet, kids might take three, four or five of them and go into an anxiety attack and palpitations," he said. "Kids get anxious when they take caffeine and it could put them over the top."[abcnews.go.com]
  • It used to be believed that premature cardiac contractions, which usually cause no symptoms or mild symptoms such as heart palpitations, ‘skipped’ beats or fluttering, were harmless.[nbcnews.com]
  • Of these energy drink users, 29 percent reported "weekly jolt and crash episodes," and 19 percent reported heart palpitations from drinking energy drinks.[sciencedaily.com]
  • Severe caffeine toxicity can lead to fits, an increased heart rate and an irregular heart beat or palpitations.[dailymail.co.uk]
  • Most tea drinkers, assuming they are not prone to heart palpitations or other medical problems diagnosed by their physician, can easily handle 200mg of caffeine in their diet per day.[web.archive.org]
Irregular Heart Rhythm
  • heart rhythms Have high blood pressure Take certain medicines or supplements, including stimulants, certain antibiotics, asthma medicines, and heart medicines.[nlm.nih.gov]
  • The report challenges a widely held belief that caffeinated drinks cause irregular heart rhythms that can lead to heart failure or dangerous heart rhythm disorders and is another vindication for coffee as a safe drink.[nbcnews.com]
  • heart rhythms Have high blood pressure Take certain medicines or supplements, including stimulants, certain antibiotics , asthma medicines, and heart medicines.[medlineplus.gov]
Orthostatic Hypotension
  • Neurogenic orthostatic hypotension. N Engl J Med 358(6):615–624 CrossRef PubMed Google Scholar 7. Low PA, Singer W (2008) Management of neurogenic orthostatic hypotension: an update.[doi.org]
  • hypotension, and for the short term treatment of apnea of prematurity in infants.[drugbank.ca]
  • Orthostatic hypotension treatment. Some people use caffeine-containing beverages such as coffee or tea to try to treat their asthma. Evidence to support this practice, however, is poor.[en.wikipedia.org]
Flushing
  • If you’ve had more than 250 mg of caffeine (two to three cups of brewed coffee) and experienced five or more of the following symptoms, says the guide, you’ve probably been caffeine-buzzed: restlessness, nervousness, excitement, insomnia, flushed face[newsfeed.time.com]
  • As a class of drugs, Methylated xanthines cause central nervous system (CNS) stimulation, diuresis (flushing of fluids through the body), cardiac (heart) muscle stimulation, & smooth muscle stimulation.[web.archive.org]
  • But hours later, he was flushed, lost his equilibrium and became nauseated. "He lay down on the couch, not asleep, but acting comatose and that night it really kicked in and he needed a bucket by the side of his bed," his wife said.[abcnews.go.com]
  • Water also naturally flushes caffeine from your body and keeps you hydrated. If you are a coffee drinker, gradually switch from regular coffee to decaf.[my.clevelandclinic.org]
Muscle Twitch
  • twitching, rambling flow of thought and speech, tachycardia or cardiac arrhythmia, periods of inexhaustibility or psychomotor agitation (unintentional motion, say, rapidly bouncing one leg).[newsfeed.time.com]
  • twitching, rambling flow of thought and speech, tachycardia or cardiac arrhythmia, periods of inexhaustibility, or psychomotor agitation.[draxe.com]
  • Common features of caffeine intoxication include nervousness (anxiety), restlessness, excitement, insomnia, rambling flow of thought and speech, gastrointestinal upset, tremors, tachycardia, diuresis, muscle twitching, periods of inexhaustibility, and[web.archive.org]
  • twitching, a rambling flow of thought and speech, irritability, irregular or rapid heart beat, and psychomotor agitation.[en.wikipedia.org]
  • Muscle twitching. 9. Rambling flow of thought and speech. 10. Tachycardia or cardiac arrhythmia. 11. Periods of inexhaustibility. 12. Psychomotor agitation. C. [doi.org]
Muscle Cramp
  • More toxic effects such as nausea, vomiting, muscle cramps, twitching and agitation may occur when a child consumes more than 4.5 mg of caffeine per pound of body weight.[dailymail.co.uk]
Anxiety Disorder
  • Caffeine toxicity remains a rarely reported condition, which may mimic anxiety disorders. Anxiety disorder patients do not consume toxic amounts of caffeine.[ncbi.nlm.nih.gov]
  • CrossRef Google Scholar Volume 19, Issue 1 February 1989, pp. 211-214 Synopsis Caffeine toxicity remains a rarely reported condition, which may mimic anxiety disorders. Anxiety disorder patients do not consume toxic amounts of caffeine.[doi.org]
Auditory Hallucination
  • An elderly patient with a history of chronic migraine was hospitalized with systolic hypertension and significant mental status changes, including increasing confusion, combative behavior, and remarkably detailed auditory hallucinations of several weeks[ncbi.nlm.nih.gov]
Urinary Incontinence
  • Lee, Green tea drinking is inversely associated with urinary incontinence in middle‐aged and older women, Neurourology and Urodynamics, 30, 7, (1262-1265), (2011). C.[doi.org]
  • Nevertheless, individuals with various conditions such as generalized anxiety disorder, panic disorder, primary insomnia, gastroesophageal reflux, pregnancy and urinary incontinence are often advised to reduce or eliminate regular caffeine use.[web.archive.org]
  • If you have urinary incontinence , you may experience a greater "urgency" to urinate after consuming a caffeinated beverage. You will need to monitor your reaction and tolerance to caffeine to determine how you are affected.[medicinenet.com]
  • Clinical signs of theobromine toxicity in canids usually manifest 8 hours after ingestion and can include: thirst, vomiting, diarrhea, urinary incontinence, nervousness, clonic muscle spasms, seizures and coma.[faqs.org]
Urinary Urgency
  • This may be due to voluntary restriction of intake for self-management of common conditions causing urinary urgency and urinary frequency including benign prostatic hyperplasia (BPH), overactive bladder, neurogenic bladder, stress incontinence or similar[doi.org]
Nocturia
  • Supine hypertension commonly leads to a pressure diuresis that occurs resulting in nocturia and blood volume depletion overnight. This nocturnal forced diuresis can be decreased by elevating the head of the bed.[doi.org]
Amenorrhea
  • METHODS: We conducted a prospective study including preterm infants (less than 34 weeks' amenorrhea) admitted to the intensive care and neonatal medicine department.[ncbi.nlm.nih.gov]
Headache
  • The increased volume was primarily contributed by patients of lower headache frequency (10-20 days/month) and with no psychological comorbidities.[ncbi.nlm.nih.gov]
  • In experimental studies, 50 percent of people experienced headache and 13 percent had clinically significant distress or functional impairment -- for example, severe headache and other symptoms incompatible with working.[hopkinsmedicine.org]
  • N Engl J Med 327:1109–1114 PubMed Google Scholar Sjaastad O, Bakketeig LS (2004) Caffeine-withdrawal headache: the Vaga study of headache epidemiology.[doi.org]
Insomnia
  • Caffeine intake and insomnia levels were measured using the Modified Caffeine Consumption Questionnaire and the Pittsburgh Insomnia Rating Scale (PIRS) in 130 clinically stable participants who were living with HIV, taking antiretroviral therapy, and[ncbi.nlm.nih.gov]
  • If you do eat or drink too much caffeine, it can cause health problems, such as Restlessness and shakiness Insomnia Headaches Dizziness Rapid or abnormal heart rhythm Dehydration Anxiety Dependency, so you need to take more of it to get the same results[nlm.nih.gov]
  • However, caffeine intake may also produce in people such negative effects as irritability, nervousness or anxiety, jitteriness, headaches, and insomnia.[britannica.com]
  • Some examples of the side effects of excessive caffeine intake include difficulty concentrating, insomnia, muscle tremors, fast heartbeat, jitteriness, heartburn, nervousness, stomach upset and irritability.[news-medical.net]
Seizure
  • Further research is required to elucidate the effect of these variables on seizure duration.[ncbi.nlm.nih.gov]
  • Vol. 5, Pg. 252, 1965. human TDLo intravenous 7mg/kg (7mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Acta Pharmacologica et Toxicologica.[chem.nlm.nih.gov]
Tremor
  • On the other hand, high doses can cause noticeable signs of mental confusion and error induction in intellectual tasks, anxiety, restlessness, muscle tremors, tachycardia, labyrinthine changes, and tinnitus.[ncbi.nlm.nih.gov]
  • Caffeine warning signs You may want to cut back on caffeine if you experience side effects such as: Headache Insomnia Nervousness Irritability Restlessness Stomach upset Fast heartbeat Muscle tremors[bbc.com]
Excitement
  • However, when used excessively or in vulnerable populations, caffeine can cause several unwanted side effects such as nervousness, sensory disturbances, insomnia, arrhythmia, excitability, inattentiveness, restlessness, mood changes, gastrointestinal[ncbi.nlm.nih.gov]
  • INHALATION CAUSES RAPID HEART RATE, EXCITEMENT, DIZZINESS, PAIN, COLLAPSE, HYPOTENSION, FEVER, SHORTNESS OF BREATHE. MAY CAUSE HEADACHE, INSOMNIA, NAUSEA, VOMITING, STOMACH PAIN, COLLAPSE AND CONVULSIONS...[chm.bris.ac.uk]
  • If you have a budding artist in your household, it’s time to dig out the crayons to take part in an exciting new project More Info My Voice A confidential and anonymous forum #MyVoice As a Canadian Armed Forces family member, you can participate in MyVoice[cg.cfpsa.ca]
  • If you’ve had more than 250 mg of caffeine (two to three cups of brewed coffee) and experienced five or more of the following symptoms, says the guide, you’ve probably been caffeine-buzzed: restlessness, nervousness, excitement, insomnia, flushed face[newsfeed.time.com]

Workup

Brain Edema
  • Only slight brain edema and congestion of other organs were observed, but no significant lesions were found in his organs. A yellowish granular substance was observed in the stomach, duodenum, and small intestine.[ncbi.nlm.nih.gov]

Treatment

  • Many combinations of caffeine concentration and duration produced comparable results; however, treatment with 3 g L 1 for 24 h was the most effective caffeine treatment on the basis of the number of seeds recovered, as well as the size and incidence of[doi.org]
  • Many combinations of caffeine concentration and duration produced comparable results; however, treatment with 3 g L 1 for 24 h was the most effective caffeine treatment on the basis of the number of seeds recovered, as well as the size and incidence of[ncbi.nlm.nih.gov]

Prognosis

  • DSRCT remains an aggressive malignancy, with a poor prognosis despite multi-modality treatments. In the published literature, there has been no patient who lived for three years or more without surgical excision.[ncbi.nlm.nih.gov]
  • Outcome at 5 years of age of children 23 to 27 weeks’ gestation: refining the prognosis. Pediatrics 2001;108:134–141.[doi.org]

Etiology

  • This pattern was present for both Alzheimer’s disease–related dementia and cerebrovascular disease etiologies, and persisted in analyses restricted to nonsmokers.[ajrccm.atsjournals.org]
  • The role of hormone use in PD etiology and its potential influence on the caffeine-PD relation should be further explored with larger sample sizes in the future.[doi.org]

Epidemiology

  • Almost all the congenital malformation epidemiology studies were negative.[ncbi.nlm.nih.gov]
  • Epidemiology 7, 250 – 255. 42. Fenster, L, Hubbard, AE, Swan, SH et al. ( 1997 ) Caffeinated beverages, decaffeinated coffee, and spontaneous abortion. Epidemiology 8, 515 – 523. 43.[doi.org]
  • Bracken Professor and Head Chronic Disease Epidemiology Department Yale University School of Medicine Marilyn E.[web.archive.org]
Sex distribution
Age distribution

Pathophysiology

  • Google Scholar Crossref Medline ISI Morelli, M, Carta, AR, Kachroo, A. ( 2010 ) Pathophysiological roles for purines: Adenosine, caffeine and urate. Progress in Brain Research 183: 183 – 208.[doi.org]
  • McDermott, Neuroimaging with magnetoencephalography: A dynamic view of brain pathophysiology, Translational Research, 10.1016/j.trsl.2016.01.007, 175, (17-36), (2016). Mohsin H.K. Roshan, Amos Tambo and Nikolai P.[dx.doi.org]

Prevention

  • The mechanism of action of caffeine on prevention of apnea and activation of breathing seems to be through central inhibition of adenosine receptors.[ncbi.nlm.nih.gov]
  • The prevention of dementia. Int J Geriatr Psychiatry 2009;24: 452–458. PubMed Google Scholar 10. de la Torre JC (2010). Alzheimer’s disease is incurable but preventable. J Alzheimers Dis 2010;20: 861–870. PubMed Google Scholar 11.[doi.org]

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