We believe this is the first presentation in the literature of Mönckeberg medial calcinosis visualized in the infraorbital arteries. [ncbi.nlm.nih.gov]

It can progress to painful and disabling conditions, and can become infected, especially when skin ulceration is present. Objective: To present a case of calcinosis in the inguinal region and its surgical recovery. [rbcp.org.br]

The remaining four cases presented with multiple nodular swellings. [ijdpdd.com]

• Soft Tissue Swelling

  Calcinosis symptoms included painful deposits (88 %), soft tissue swelling (66 %), and recurrent infections (44 %) from these deposits. On DECT, calcinosis deposits had the same color and density as the bone and no MSU was found. [ncbi.nlm.nih.gov]

  If there is an associated underlying collagen vascular disease findings of soft tissue swelling and joint arthropathy may be present. Promoted articles (advertising) [radiopaedia.org]

• Hypoxemia

  If calcium deposits are extensive, a decreased diffusion, a restrictive functional pattern, and hypoxemia may be seen. Pulmonary fibrosis may occur in most severe cases, leading to respiratory insufficiency and even death. [revistanefrologia.com]

• Angiokeratoma

  Clinically, scrotal calcinosis may be confused with an epidermal inclusion cyst, steatocystoma, cutaneous horn (actinic keratosis) or other benign tumors, such as, lipoma, fibroma, angiokeratoma, and lymphangioma circumscriptum. [ijdpdd.com]

  A nodular lesion in the scrotum has several differential diagnoses which include steatocystoma multiforme, angiokeratoma, lipomata, fibromata, and lymphangioma circumscriptum [6]. [jmedicalcasereports.biomedcentral.com]

• Hand Deformity

  However, CT imaging was superior to plain radiographs in locating these deposits within the soft tissues and may be a useful tool to study SSc-calcinosis affecting the hands, particularly in the setting of progressive hand deformities. [ncbi.nlm.nih.gov]

• Social Isolation

  Discussion Scrotal Calcinosis is a benign, rare scrotal lesion with obscure etiology and pathogenesis mostly seen in adults and teenagers that causes embarrassment and social isolation. [17] The first described calcinosis of the scrotum was reported by [archintsurg.org]

• Urethral Discharge

  There was no urethral discharge, penile ulceration, or inguinal swelling. The patient noticed some of the papules disappeared after discharge of a whitish or chalk-like substance from them. [dovepress.com]

A hormonal workup, including calcitonin, parathyroid hormone, and thyroid hormone levels, was also within normal limits. [karger.com]

Laboratory workup revealed normal blood counts, serum calcium, phosphorous, and alkaline phosphate levels. [jcnonweb.com]

Conclusion After clinical diagnosis of calcinosis cutis, a laboratory workup to rule out abnormalities of calcium and phosphorus metabolism, malignant processes, collagen vascular diseases, renal insufficiency, excessive milk ingestion, and vitamin D [hindawi.com]

• Soft Tissue Calcification

  Figure 1 X‐ray of right elbow: soft‐tissue calcification throughout the elbow and forearm. Calcinosis universalis is soft‐tissue calcification presenting as a complication of JDM. It is often detected in childhood in 30% to 70% of patients. [journalofhospitalmedicine.com]

  Radiographically, idiopathic tumoral calcinosis demonstrates lobulated, cloudy soft-tissue calcifications near a joint (A). [jaocr.org]

  Soft tissue calcifications may be easily demonstrated on plain radiographs, but CT scan is more effective in demonstrating the location and extent of calcifications. [sajr.org.za]

  Click here to view Figure 2: Elbow X-ray: soft tissue calcification and vascular calcification. Click here to view Figure 3: a and b: Hands and knee X-ray showing vascular calcifications. [sjkdt.org]

  […] previous soft tissue calcification. [archivesofpathology.org]

• Muscle Calcification

  Pathology: Calcinosis may affect the skin, subcutaneous layers including the fascia and muscle. Calcific lesions are rich in hydroxyapatite but may also contain calcium oxalate and uric acid in crystalline form. [rheumaknowledgy.com]

  Computed tomography (CT) scan showing calcifications in an adult with HFTC including shoulder and hip soft tissue calcifications (white arrows), aortic calcification (dashed arrow), papillary muscle calcification (black arrow), and submucosal gut calcifications [ncbi.nlm.nih.gov]

• Granulomatous Tissue

  Stage 2 (intermediate lesions) contains a complex mixture of less prominent granulomatous tissue and acellular, quiescent fibrotic tissue. The calcium deposits tend to be more prominent. [archivesofpathology.org]

• Lymphocytic Infiltrate

  There was an occasional scalloped appearance, with some of the smaller fragments surrounded by multinucleated giant cells and a sparse lymphocytic infiltrate. [dovepress.com]

The best treatment for calcinosis cutis is still unclear, as no fully effective treatment is available. We attempted clinical drug treatment to stop or slow disease progression. [rbcp.org.br]

Systemic tetracycline in the treatment of non-infected corneal ulcers. Ann Opthalmol1985;17:742–4. ↵ Berk MA, Lorincz AL. The treatment of bullous phemphigoid with tetracycline and niacinamide. [ard.bmj.com]

Treatment *Primary focus is treatment of the causal condition *Goal of treatment is to relieve symptoms, but is of limited benefit *Lesions are only removed if circumstances require, as trauma can make the condition worse The best and most reliable treatment [ozarkderm.com]

Experienced physicians are more likely to use non-immunosuppressive treatments. [ncbi.nlm.nih.gov]

[…] of TC can be divided into surgical excision and medical treatment. [revistanefrologia.com]

Treatment and prognosis No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used with little consistent benefit. [radiopaedia.org]

Prognosis The prognosis of CREST syndrome is relatively good with a long-lasting disease duration (>10 years). However, pulmonary arterial hypertension may be a complication of the disease and may lead to a more severe prognosis. [orpha.net]

EXPERT ANALYSIS FROM A SYMPOSIUM SPONSORED BY THE AMERICAN COLLEGE OF RHEUMATOLOGY CHICAGO – The prognosis for adults diagnosed with calcinosis remains grim, despite some excellent treatment responses reported in children for this often disabling and [mdedge.com]

Prognosis : Lesions tend to be chronic and less commonly are relapsing or remittent. Calciphylaxis has a significant mortality rate of 60% to 80%. BIBLIOGRAPHY Khafif RA, DeLima C, Silverberg A, et al. Calciphylaxis and systemic calcinosis. [rheumaknowledgy.com]

Medicinos akademija Date: 2015 Note: Apginta: 2015-08-31 Autoriaus publikacijos disertacijos tema: p. 25-27 Keywords: Coronary artery disease;complications;Vascular calcification;genetics;Coronary thrombosis;genetics;Prognosis Abstract: Darbo tikslas [lsmuni.lt]

Several classifications based on the etiology, the location of brain calcifications and the clinical presentation have been proposed. [ncbi.nlm.nih.gov]

It is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. [ajnr.org]

Abstract Calcinosis universalis is a rare and interesting condition of unknown etiology characterized by deposits of calcium in the skin and subcutaneous tissues. The diagnosis is easily made roentgenographically. [pubs.rsna.org]

Etiology Although most cases are idiopathic there is an association with Raynaud syndrome, scleroderma or dermatomyositis in up to 40% of cases. Fine clustered calcifications are seen, usually around the finger and toe tips. [radiopaedia.org]

PURPOSE OF REVIEW: This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). [ncbi.nlm.nih.gov]

Summary Epidemiology The prevalence is estimated at about 1/12,500 adults. Women are predominantly affected (F/M sex ratio around 4:1). Clinical description The disease usually manifests at between 40 and 50 years of age. [orpha.net]

This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). PubMed, Curr Opin Rheumatol, 2015 Nov;27(6):542–8. [sclero.org]

Smoller, Franco Rongioletti, 2010 4 The imaging of tropical diseases: with epidemiological, ... LaPorta GA et al: Tumoral calcinosis of the foot. [educalingo.com]

Epidemiologically, most ISC presentations occur in the third to fourth decade of life, following years of insidious onset without any systemic disorder of the calcium/phosphorus metabolism. 1 To the best of our knowledge, 10 cases of ISC have been reported [dovepress.com]

Pathophysiologically, MPC consists of calcium deposition in the epithelial and vascular basement membrane of alveoli, bronchial walls, and media layer of pulmonary arteries, resulting in a lymphoproliferative interstitial response and pulmonary fibrosis [revistanefrologia.com]

The pathophysiology of calcinosis cutis is not well understood, and there is a broad range of severity seen, from benign localized, small nodules to large, severely debilitating lesions (2). [clinicaltrials.gov]

PURPOSE OF REVIEW: This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). [ncbi.nlm.nih.gov]

(Also see Bone Resorption ) Calcinosis: pathophysiology and management. [sclero.org]

[…] pain and inflammation Diltiazem – A calcium channel blocker to prevent the influx of calcium into cells Corticosteroids – To reduce inflammation Bisphosphonates – To prevent osteoporosis and bone diseases Magnesium and Aluminum Containing Antacids – [medindia.net]

A complete excision prevents recurrence. Psychological support is required in association with surgery because the lesions are benign and concern an intimate part of the body. [ncbi.nlm.nih.gov]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

Prevention Prevention or treatment of the underlying disease process, as well as prevention of trauma and factors associated with iatrogenic calcinosis, is optimal. Reiter N, El-Shabrawi L, Leinweber B, Berghold A, Aberer E. [emedicine.medscape.com]