Symptoma

Calcinosis

Calcinoses

We believe this is the first presentation in the literature of Mönckeberg medial calcinosis visualized in the infraorbital arteries. [ncbi.nlm.nih.gov]

It can progress to painful and disabling conditions, and can become infected, especially when skin ulceration is present. Objective: To present a case of calcinosis in the inguinal region and its surgical recovery. [rbcp.org.br]

  • Soft Tissue Swelling

    Calcinosis symptoms included painful deposits (88 %), soft tissue swelling (66 %), and recurrent infections (44 %) from these deposits. On DECT, calcinosis deposits had the same color and density as the bone and no MSU was found. [ncbi.nlm.nih.gov]

    If there is an associated underlying collagen vascular disease findings of soft tissue swelling and joint arthropathy may be present. Promoted articles (advertising) [radiopaedia.org]

  • Turkish

    Copyright 2016 Turkish Association of Orthopaedics and Traumatology. Production and hosting by Elsevier B.V. All rights reserved. [ncbi.nlm.nih.gov]

  • Hypoxemia

    If calcium deposits are extensive, a decreased diffusion, a restrictive functional pattern, and hypoxemia may be seen. Pulmonary fibrosis may occur in most severe cases, leading to respiratory insufficiency and even death. [revistanefrologia.com]

  • Intermittent Fever

    Two others experienced increased fatigue, inflammation-mediated anemia of chronic disease, and thrombocytosis; one also had intermittent fevers and a cutaneous inflammatory calcific reaction [ Ramnitz et al 2016 ]. [ncbi.nlm.nih.gov]

  • Hypopigmented Skin

    skin macules typically over arms & legs May have calcific tendinopathy Arterial calcification due to CD73 deficiency (OMIM 211800 ) NT5E AR Periarticular calcifications of large & small joints of lower extremities Symptomatic calcification of the large [ncbi.nlm.nih.gov]

  • Papular Rash

    rash Fibrodysplasia ossificans progressiva (OMIM 135100 ) ACVR1 AD Subcutaneous ossifications that can impair joint mobility Normal blood phosphorus Gradual replacement of muscle tissue & connective tissue by bone starting w/neck & shoulders & proceeding [ncbi.nlm.nih.gov]

  • Flexion Contracture

    However, their CT images showed better details of the calcinosis locations in the soft tissues as well as the bone destruction, especially if there was overlying bulky deposits or flexion contractures. [ncbi.nlm.nih.gov]

    On physical examination the patient appeared cachectic, with normal cardiac, pulmonary and abdominal examination, and characteristic sclerodermatous skin changes, including diffuse thickening, taut fingers with flexion contractures, the typical microstomia [ard.bmj.com]

  • Hand Deformity

    However, CT imaging was superior to plain radiographs in locating these deposits within the soft tissues and may be a useful tool to study SSc-calcinosis affecting the hands, particularly in the setting of progressive hand deformities. [ncbi.nlm.nih.gov]

A hormonal workup, including calcitonin, parathyroid hormone, and thyroid hormone levels, was also within normal limits. [karger.com]

Laboratory workup revealed normal blood counts, serum calcium, phosphorous, and alkaline phosphate levels. [jcnonweb.com]

Conclusion After clinical diagnosis of calcinosis cutis, a laboratory workup to rule out abnormalities of calcium and phosphorus metabolism, malignant processes, collagen vascular diseases, renal insufficiency, excessive milk ingestion, and vitamin D [hindawi.com]

  • Soft Tissue Calcification

    Figure 1 X‐ray of right elbow: soft‐tissue calcification throughout the elbow and forearm. Calcinosis universalis is soft‐tissue calcification presenting as a complication of JDM. It is often detected in childhood in 30% to 70% of patients. [journalofhospitalmedicine.com]

    Radiographically, idiopathic tumoral calcinosis demonstrates lobulated, cloudy soft-tissue calcifications near a joint (A). [jaocr.org]

    Soft tissue calcifications may be easily demonstrated on plain radiographs, but CT scan is more effective in demonstrating the location and extent of calcifications. [sajr.org.za]

    Click here to view Figure 2: Elbow X-ray: soft tissue calcification and vascular calcification. Click here to view Figure 3: a and b: Hands and knee X-ray showing vascular calcifications. [sjkdt.org]

    […] previous soft tissue calcification. [archivesofpathology.org]

  • Muscle Calcification

    Pathology: Calcinosis may affect the skin, subcutaneous layers including the fascia and muscle. Calcific lesions are rich in hydroxyapatite but may also contain calcium oxalate and uric acid in crystalline form. [rheumaknowledgy.com]

    Computed tomography (CT) scan showing calcifications in an adult with HFTC including shoulder and hip soft tissue calcifications (white arrows), aortic calcification (dashed arrow), papillary muscle calcification (black arrow), and submucosal gut calcifications [ncbi.nlm.nih.gov]

Experienced physicians are more likely to use non-immunosuppressive treatments. [ncbi.nlm.nih.gov]

Treatment and prognosis No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used with little consistent benefit. [radiopaedia.org]

EXPERT ANALYSIS FROM A SYMPOSIUM SPONSORED BY THE AMERICAN COLLEGE OF RHEUMATOLOGY CHICAGO – The prognosis for adults diagnosed with calcinosis remains grim, despite some excellent treatment responses reported in children for this often disabling and [mdedge.com]

Prognosis : Lesions tend to be chronic and less commonly are relapsing or remittent. Calciphylaxis has a significant mortality rate of 60% to 80%. BIBLIOGRAPHY Khafif RA, DeLima C, Silverberg A, et al. Calciphylaxis and systemic calcinosis. [rheumaknowledgy.com]

Prognosis The prognosis of CREST syndrome is relatively good with a long-lasting disease duration ( 10 years). However, pulmonary arterial hypertension may be a complication of the disease and may lead to a more severe prognosis. [orpha.net]

Surgical excision is the treatment of choice and has an excellent prognosis. This case series attempts to create an awareness of this rare pathology, which is often missed out on routine investigations and misdiagnosed. References 1. [ijdpdd.com]

It is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. [ajnr.org]

Abstract Calcinosis universalis is a rare and interesting condition of unknown etiology characterized by deposits of calcium in the skin and subcutaneous tissues. The diagnosis is easily made roentgenographically. [pubs.rsna.org]

PURPOSE OF REVIEW: This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). [ncbi.nlm.nih.gov]

This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). PubMed, Curr Opin Rheumatol, 2015 Nov;27(6):542–8. [sclero.org]

Smoller, Franco Rongioletti, 2010 4 The imaging of tropical diseases: with epidemiological, ... LaPorta GA et al: Tumoral calcinosis of the foot. [educalingo.com]

Summary Epidemiology The prevalence is estimated at about 1/12,500 adults. Women are predominantly affected (F/M sex ratio around 4:1). Clinical description The disease usually manifests at between 40 and 50 years of age. [orpha.net]

Epidemiologically, most ISC presentations occur in the third to fourth decade of life, following years of insidious onset without any systemic disorder of the calcium/phosphorus metabolism. 1 To the best of our knowledge, 10 cases of ISC have been reported [dovepress.com]

Pathophysiologically, MPC consists of calcium deposition in the epithelial and vascular basement membrane of alveoli, bronchial walls, and media layer of pulmonary arteries, resulting in a lymphoproliferative interstitial response and pulmonary fibrosis [revistanefrologia.com]

The pathophysiology of calcinosis cutis is not well understood, and there is a broad range of severity seen, from benign localized, small nodules to large, severely debilitating lesions (2). [clinicaltrials.gov]

PURPOSE OF REVIEW: This article reviews the most updated literature regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis (SSc). [ncbi.nlm.nih.gov]

(Also see Bone Resorption ) Calcinosis: pathophysiology and management. [sclero.org]

[…] pain and inflammation Diltiazem – A calcium channel blocker to prevent the influx of calcium into cells Corticosteroids – To reduce inflammation Bisphosphonates – To prevent osteoporosis and bone diseases Magnesium and Aluminum Containing Antacids – [medindia.net]

With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. [ncbi.nlm.nih.gov]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]

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