Presentation
We present 2 cases of arthroscopic removal of a calcific deposition in the form of calcinosis circumscripta between the labrum and capsule of the hip joint. [ncbi.nlm.nih.gov]
Calcinosis cutis was diagnosed by FNA in a 20-yr-old male who presented with a solitary subcutaneous nodule near the ankle, on the lateral malleolus. [scinapse.io]
Case presentation: 33-year-old male presented to OPD with swelling over the right knee joint. Clinically the swelling was adhered to skin, bony hard, tender, and movements of right knee were painful. [docksci.com]
Top Abstract Introduction Case Presentation Discussion References [turkjpath.org]
Entire Body System
- Intravenous Administration
Calcinosis cutis:a complication of intravenous administration of calcium glucanate. J Cutan Pathol. 2006; 33 (2):60–2. [ PubMed ] [ Google Scholar ] 10. Palamaras I, Kyriakis K. [ncbi.nlm.nih.gov]
Calcinosis cutis: a complication of intravenous administration of calcium glucanate. J Cutan Pathol. 2006;33(2) :60-2. 10. Palamaras I, Kyriakis K. Calcium antagonists in dermatology: a review of the evidence and research-based studies. [docksci.com]
- Gangrene
It may progress to gangrene and conical atrophy of the terminal phalanges. The pathogenesis for the triad cannot be ascertained with certainty, as the etiology of each condition is still obscure. [pubs.rsna.org]
Vascular occlusion may result in gangrene. Ulceration may be complicated by bacterial infection. Conclusion Surgical excision is the mainstay of the treatment. [ncbi.nlm.nih.gov]
Musculoskeletal
- Myopathy
She denied having had any previous complaints compatible with myopathy. [scielo.br]
Eidelman et al. (11) hypothesized, that a loss of local inhibitors caused mineral deposition in inflammatory myopathies. [medicaljournals.se]
At age 10 yr, muscle biopsy showed an inflammatory myopathy. Serum creatine phosphokinase (CPK) level was approximately 12,600 U/L (normal, 30–220 U/L). [academic.oup.com]
- Osteophyte
The common clinical feature is rapid progression of joint destruction with marked resorption of bone and small or absent osteophytes (Fig. 13) [29]. [insightsimaging.springeropen.com]
Skin
- Calcinosis Cutis
Calcinosis cutis circumscripta is a very rare form of idiopathic calcinosis cutis arising in the second half of life. It typically involves the extremities and is associated with prior trauma and scleroderma. [journals.lww.com]
Keywords: Calcinosis cutis circumscripta, knee joint, rare What to Learn from this Article? Medical and surgical treatments are the options to cure calcinosis cutis. [ncbi.nlm.nih.gov]
- Insect Bite
In addition, trauma, insect bites, metabolic calcification (e.g. renal failure), and inherited disorders (e.g., pseudoxanthoma elasticum, Werner’s syndrome, and Ehlers-Danlos syndrome) may cause calcinosis circumscripta [ 5 ]. [ncbi.nlm.nih.gov]
In addition, trauma, insect bites, metabolic calcification (e.g. renal failure), and inherited disorders (e.g., pseudoxanthoma elasticum, Werner’s syndrome, and Ehlers-Danlos syndrome) may cause calcinosis circumscripta [5]. [docksci.com]
- Subcutaneous Mass
A 2.5-y-old, male common marmoset ( Callithrix jacchus jacchus ) developed a 2-cm, interscapular, subcutaneous mass with variably firm and cystic areas. [ingentaconnect.com]
Physical examination revealed a dome shape, hard consistency, non-movable, painless, subcutaneous mass with size 5x6 cm. [he01.tci-thaijo.org]
- Hyperkeratosis
[…] aestivalis) · Radiodermatitis · Erythema ab igne Pigmentation disorder hypopigmentation (Albinism, Vitiligo) · hyperpigmentation (Melasma, Freckle, Café au lait spot, Lentigo/Liver spot, Acanthosis nigricans, Acral acanthotic anomaly) Other skin keratosis/hyperkeratosis [wikidoc.org]
Psychiatrical
- Suggestibility
The cases serve to clarify the clinical and radiographic features of the condition and to discuss suggested treatment options. [ncbi.nlm.nih.gov]
The available evidence suggest that the lesion is commonly seen in negroes and coloured races. Scrotum is the commonest site of calcinosis cutis circumscripta in males while extremities are the site in females. [ijdvl.com]
Deep dermis and subcutaneous tissue showed thick collagen bundles with area of calcification suggestive of morphea (localised scleroderma) with changes of calcinosis circumscripta [Figure 5] a and b. [mjdrdypu.org]
Neurologic
- Confusion
The aim of this report is to make the hand surgeons aware about the unusual presentation of this rare condition, which can cause a diagnostic confusion. [ispub.com]
Clinically, it may be confused with a diagnosis of lupus panniculitis, and a biopsy is essential to confirm the diagnosis. It may be a source of pain and significant disability; no effective therapy is available at present. 1. [sajr.org.za]
There is confusion around terms like chondrocalcinosis and pseudogout, which needs clarification. [insightsimaging.springeropen.com]
Workup
Workup for collagen vascular disease was negative. Histopathology confirmed calcinosis cutis. [docksci.com]
Note chondrocalcinosis at the ulnocarpal joint space within the triangular fibrocartilage (arrowhead) Full size image The recommended radiographic workup for suspected CPPD arthropathy is: anteroposterior (AP) view of the knees; posteroanterior view of [insightsimaging.springeropen.com]
X-Ray
- Soft Tissue Calcification
Calcification in soft tissues. JAMA 1983;250:78–81. 2. Dalinka MK, Melchior EL. Soft tissue calcifications in systemic disease. Bull N Y Acad Med 1980;56:539–563. 3. Rothstein JL, Welt S. [ogscience.org]
If there is an associated underlying collagen vascular disease findings of soft tissue swelling and joint arthropathy may be present. all causes of soft tissue calcification References Promoted articles (advertising) [radiopaedia.org]
Soft tissue calcifications may be easily demonstrated on plain radiographs, but CT scan is more effective in demonstrating the location and extent of calcifications. [sajr.org.za]
Figure 2: (a and b)anteroposterior radiograph of pelvis and upper third of thighs showing extensive soft-tissue calcification involving the lateral aspect extending from mid ilium to mid-thigh. Visualized bones and joints appear normal. [mjdrdypu.org]
- Muscle Calcification
Calcific myonecrosis (benign calcified mass in leg muscles). Calcific tendonitis. Calcinosis circumscripta (calcium deposits in the skin and tissue of the hands and feet). [my.clevelandclinic.org]
Treatment
Especially in young patients, with a high activity level and without any symptoms of hip osteoarthritis, hip arthroscopy is the ideal treatment. [ncbi.nlm.nih.gov]
Prognosis
Thibierge-Weissenbach syndrome or as the CREST syndrome, because the manifestations usually consist of calcinosis cutis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia .Patients with this syndrome often have a better prognosis [dermaamin.com]
Outlook / Prognosis What is the outlook for someone with tumoral calcinosis? Most people with tumoral calcinosis enjoy full, active lives. It’s rare for the condition to cause serious health problems. [my.clevelandclinic.org]
The prognosis is usually bad. Calcinosis circumscripta has a benign course and occurs in middle-aged women. The deposits are small, nodular or streaky and affect the flexor tendon sheaths of hands and wrist. [ispub.com]
Etiology
The pathogenesis for the triad cannot be ascertained with certainty, as the etiology of each condition is still obscure. [pubs.rsna.org]
The etiology is unknown, and onset of the lesion is slow and insidious. It occurs in the periarticular area as a painful mass with surrounding erythema and edema. It is visible in x-rays as localized, scattered calcification. [ncbi.nlm.nih.gov]
It is classified into 4 major types according to etiology: dystrophic, metastatic, iatrogenic, and idiopathic. [ajnr.org]
FIDANZA, CARLO, MD * ; DAINESE, EMANUELE, MD † COMMUNICATIONS AND BRIEF REPORTS Abstract Author Information Authors Calcinosis cutis, a disease characterized by the presence of calcium deposits in the skin, is classified into four types according to etiology [journals.lww.com]
Epidemiology
Epidemiology Calcinosis cutis commonly occurs in patients with systemic sclerosis, especially the limited form (CREST). [statpearls.com]
Pathophysiology
The pathophysiology of calcinosis cutis remains unclear. The dystrophic form is the most common whereas the idiopathic one is the rarest. [ingentaconnect.com]
It is hoped that this will ultimately lead to new concepts of pathophysiology and treatment. [medicaljournals.se]
Patients with systemic lupus erythematosus can present with periarticular calcification in 33% of cases and soft tissue calcification in 17%. [2] Pathophysiology Dystrophic Calcification Dystrophic calcification is the most common type of calcinosis cutis [statpearls.com]
[…] subcutaneous fatty tissue septa, intramuscular septa, muscle fasciae, tenosinovitis or articular sinovitis. [4] Inflammatory stage of morphea reveal infiltration in the sucutaneous tissue with increase signal intensity on STIR sequences. [5] Depending on the pathophysiologic [mjdrdypu.org]
Prevention
Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]
It prevents the release of proinflammatory cytokines. It also reduces calcium turnover and resorption. Bisphosphonates show good response mainly in dermatomyositis and systemic sclerosis. Etidronate is used at 800 mg/d. [statpearls.com]
Diltiazem is thought to work by preventing the laying down of new calcium, but this cannot explain the additional re‐absorption of existing calcium. [academic.oup.com]
Prevention Can you prevent tumoral calcinosis? If you and your partner carry the mutated gene that causes tumoral calcinosis, you can speak to a genetic counselor about ways to lower your chances of passing the mutation to your children. [my.clevelandclinic.org]