Dermatomyositis sine myositis presenting with calcinosis universalis SIR, Dermatomyositis can initially present without muscle involvement. [deepdyve.com]

It is classified into four types according to etiology, namely as dystrophic if calcium and phosphorus levels are normal and tissue damage is present, as idiopathic if calcium and phosphorus levels are normal and no tissue damage is present, or as metastatic [karger.com]

The authors present the case of a 25 year-old female diagnosed with dermatomyositis who developed calcinosis universalis after stopping therapy. [ncbi.nlm.nih.gov]

The purpose of this paper is to present a case of a rare condition and a treatment which yielded satisfactory results. The case was observed at frequent intervals for a period of four years. [jamanetwork.com]

Lupus erythematosus: uncommon presentations. Clin Dermatol 2005;23:470-479. 6. Wollina U, Hein G. Lupus erythematosus: uncommon presentations. Clin Dermatol 2005;23:470-479. Fig. 4. [sajr.org.za]

• Weight Gain

  Concurrent with resolution of the calcinosis was an improved sense of well-being and a 16.5-kg weight gain. Range of motion improved in all joints, except internal rotation of his hips. [academic.oup.com]

• Respiratory Distress

  The patient denied any history of fever, joint pains, weakness or pain in the muscles around shoulder and hip, pain or bluish discolouration of extremities, chest pain or respiratory distress. There was no family history of a similar illness. [ijdvl.com]

• Pleural Effusion

  Her chest radiograph showed a right pleural effusion with cardiomegaly (Fig. 1), and radiographs of the hips and hands demonstrated widespread calcifications in the soft tissue and no evidence of arthropathy (Figs 2a and b). [sajr.org.za]

• Gagging

  Akkari; Gilberto Waisberg; Clóris Kessler; Tabata de Alcantara; Patrícia L Delai Related Documents : 8206076 - Vulvar intraepithelial neoplasia of low grade: a challenging diagnosis. 8367356 - Acute urinary retention in children. 9533356 - Psychogenic gagging [biomedsearch.com]

• Cardiomegaly

  Her chest radiograph showed a right pleural effusion with cardiomegaly (Fig. 1), and radiographs of the hips and hands demonstrated widespread calcifications in the soft tissue and no evidence of arthropathy (Figs 2a and b). [sajr.org.za]

• Oral Ulcers

  There was no facial erythema, oral ulceration, finger tip ulceration or scars, nail fold capillaries, sclerodactyly and telangiectasia. Raynaud's phenomena could not be elicited. [ijdvl.com]

• Myopathy

  She denied having had any previous complaints compatible with myopathy. [scielo.br]

  Chester V Oddis, Idiopathic inflammatory myopathy: management and prognosis, Rheumatic Disease Clinics of North America, 28, 4, (979), (2002). Ann M. [doi.org]

  Inflammatory myopathies: Part 1. Ann Neurol. 1985;17:215-27. [ pubmed/open access ] [ crossref ] 5. Mastaglia FL, Ojeda VJ. Inflammatory myopathies: Part 2. Ann Neurol. 1985;17:317-23. [ pubmed/open access ] [ crossref ] 6. Miller FW. [jped.com.br]

  At age 10 yr, muscle biopsy showed an inflammatory myopathy. Serum creatine phosphokinase (CPK) level was approximately 12,600 U/L (normal, 30–220 U/L). [academic.oup.com]

  Introduction Juvenile dermatomyositis (JDM) is a rare disease but it is the most common inflammatory myopathy in children. It is an autoimmune vasculopathy which primarily affects skin and proximal striated muscles. [scirp.org]

• Hip Pain

  The patient denied any history of fever, joint pains, weakness or pain in the muscles around shoulder and hip, pain or bluish discolouration of extremities, chest pain or respiratory distress. There was no family history of a similar illness. [ijdvl.com]

• Morning Stiffness

  Her current complaints were polyarthritis involving the small joints of her hands,elbows and knees with associated morning stiffness. On examination, she appeared chronically affected. [sajr.org.za]

• Leg Pain

  Our review of his medical records revealed that he presented to a local medical facility at age 9 yr following a 1-month history of progressive weakness and leg pains. At age 10 yr, muscle biopsy showed an inflammatory myopathy. [academic.oup.com]

• Shuffling Gait

  He walked with a shuffling gait secondary to limited range of motion at his hips and knees. Figure 1. Patient, age 18 yr, before probenecid therapy showing arm contractures caused by ectopic calcifications. Figure 1. [academic.oup.com]

• Soft Tissue Calcification

  No cause could be found for the soft tissue calcification. The co-existence of the two diseases is probably incidental. [ncbi.nlm.nih.gov]

  Soft tissue calcifications may be easily demonstrated on plain radiographs, but CT scan is more effective in demonstrating the location and extent of calcifications. [sajr.org.za]

  Abstract Soft tissue calcification is sometimes found in scleroderma and dermatomyositis, however, to our knowledge, only 29 cases of systemic lupus erythematosus (SLE) were reported to have soft tissue calcification. [jstage.jst.go.jp]

  Soft tissue calcification, with special reference to its occurrence in “collagen disease”. Ann. int. Med. 36, 1050. PubMed Google Scholar Copyright information Dr. K C Chaudhuri Foundation 1968 Authors and Affiliations A. S. Sethi 1 S. C. [link.springer.com]

• Right Pleural Effusion

  Her chest radiograph showed a right pleural effusion with cardiomegaly (Fig. 1), and radiographs of the hips and hands demonstrated widespread calcifications in the soft tissue and no evidence of arthropathy (Figs 2a and b). [sajr.org.za]

• TmP/GFR Decreased

  Intact PTH levels became measurable in the normal range, and urinary tubular reabsorption of phosphate (TRP) and TmP/GFR decreased. [academic.oup.com]

• Staphylococcus Aureus

  A 5 2.5 cm left gluteus abscess was identified over MRI and Methicillin-resistant Staphylococcus aureus was isolated, and treated with vancomycin and surgical drainage. [casereports.bmj.com]

  A 5 2.5 cm left gluteus abscess was identified over MRI and Methicillin-resistant Staphylococcus aureus was isolated, and treated with vancomycin and surgical drainage. [docksci.com]

• Pleural Effusion

  Her chest radiograph showed a right pleural effusion with cardiomegaly (Fig. 1), and radiographs of the hips and hands demonstrated widespread calcifications in the soft tissue and no evidence of arthropathy (Figs 2a and b). [sajr.org.za]

Different treatments have been used in an attempt to clear calcinosis lesions and prevent its recurrence but none has been clearly effective. [ncbi.nlm.nih.gov]

The treatment and possible mechanisms of this complication are discussed. [pennstate.pure.elsevier.com]

Medical and surgical treatment are options to cure calcinosis cutis. Medical treatment using bisphosphonate. A better understanding of the process of calcinosis cutis will lead to therapies to improve patient morbidity. [ijpeonline.biomedcentral.com]

There is no specific treatment, but the use of calcium chelates (EDTA), biphosphonates (disodium etidronate) and steroids are mentioned. [biomedsearch.com]

Treatment and prognosis No established therapy is recognized, but calcium chelates (EDTA) bisphosphonates, and steroids have been used with little consistent benefit. [radiopaedia.org]

The prognosis however is generally poor. References 1. Black MM, Gawkrodyer DJ, Seymour CA, Weismann K. Metabolic and nutritional disorders. In: Champion RH, Burton JL, Ebling FJG, eds. Oxford: Blackwell Scientific Publication, 1993:2295-381. 2. [ijdvl.com]

Chester V Oddis, Idiopathic inflammatory myopathy: management and prognosis, Rheumatic Disease Clinics of North America, 28, 4, (979), (2002). Ann M. [doi.org]

In general, dysphagia portends a poor prognosis. Vascular involvement in DM usually presents as small vessel vasculitis. 1,8 Treatment Treatment of DM. DM usually responds well to treatment with systemic steroids. [woundsresearch.com]

Abstract Calcinosis universalis is a rare and interesting condition of unknown etiology characterized by deposits of calcium in the skin and subcutaneous tissues. The diagnosis is easily made roentgenographically. [pubs.rsna.org]

Since then, the syndrome has been the subject of a great deal of discussion and controversy as to the etiology, the pathology and the therapy concerned. [jamanetwork.com]

The etiology is not known. [nejm.org]

2:1, and which has an incidence of 3.2/1,000,000 children and adolescents/year in the United States. 7 Despite its rarity, it is the fourth most frequent disease at tertiary pediatric rheumatology services, and there are no Brazilian studies of its epidemiology [jped.com.br]

Little is known about the pathophysiology of calcinosis and there is no universally recognized treatment. Intravenous pamidronate significantly reduced the calcinosis. Early recognition and aggressive treatment of calcinosis is highlighted. [content.iospress.com]

[…] scleroderma CREST syndrome, lupus erythematosus, overlap syndromes or dermatomyosistis. 1 Likewise the rarely described calcinosis cutis universalis is mostly associated with collagenoses but even other diseases like graft-versus-host can be rare causes. 2 Pathophysiologically [academic.oup.com]

Associate Professor, Department of Pathology, Division of Dermatopathology, Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil Mailing address ABSTRACT Calcinosis cutis is an uncommon disease of unclear pathophysiology that is often [scielo.br]

Different treatments have been used in an attempt to clear calcinosis lesions and prevent its recurrence but none has been clearly effective. [ncbi.nlm.nih.gov]

Succinct, targeted coverage of normal childhood growth and development, as well as the diagnosis, management, and prevention of common pediatric diseases and disorders, make this an ideal medical reference book for students, pediatric residents, nurse [books.google.com]

Although the existing lesions showed slow improvement, systemic pamidronate therapy was effective in preventing the occurrence of new lesions. Surgical excision proved to be an effective and successful treatment. [karger.com]

However, diffuse, rock-hard enlargements of both shoulders extended anteriorly and posteriorly into the pectoral and infrascapular areas that completely prevented adduction of his arms. [academic.oup.com]

Your skin Holds body fluids in, preventing dehydration Keeps harmful microbes out, preventing infections Helps you feel things like heat, cold, and pain Keeps your body temperature even Makes vitamin D when the sun shines on it Anything that irritates [icdlist.com]