We present a case of calciphylaxis leading to lower gastrointestinal (GI) bleeding and rectal ulceration of the GI mucosa. [ncbi.nlm.nih.gov]

• Regurgitation

  We present the case of a 74-year-old woman with chronic kidney disease stage III who developed calciphylaxis leading to mitral valve calcification, chordae tendineae rupture and acute mitral regurgitation. [ncbi.nlm.nih.gov]

  Clinical signs of the heart-failure state included both pleural and pericardial effusions, secondary mitral regurgitation due to cardiac dilation, and atrial fibrillation. [bmcnephrol.biomedcentral.com]

• Diplopia

  A 45-year-old man presented with 2-day history of left upper blepharoptosis, periorbital pain, left-sided headache, binocular diplopia, and left V2 numbness. [ncbi.nlm.nih.gov]

• Blepharoptosis

  A 45-year-old man presented with 2-day history of left upper blepharoptosis, periorbital pain, left-sided headache, binocular diplopia, and left V2 numbness. [ncbi.nlm.nih.gov]

• Lacrimation

  Fundus exam and brain magnetic resonance imaging (MRI) showed normality of optic nerves, chiasma, retrochiasmatic area, ocular muscles, eyeballs, lacrimal glands, periorbital fat, cavernous sinuses, and occipital cortex. [ncbi.nlm.nih.gov]

• Eczema

  […] acanthoma），Pilar tumor；Malignant proliferating trichilemmal cyst/tumor，Proliferating tricholemmal cystic squamous cell carcinoma 増殖性外毛根鞘（性）嚢腫（増殖性外毛根鞘嚢腫性棘細胞腫）；悪性増殖性外毛根鞘（性）嚢腫，増殖性外毛根鞘嚢腫性有棘細胞癌 144．P rurigo chronica multiforme 多形慢性痒疹 145．P rurigo nodularis，Eczema [mall-md.seikyou.ne.jp]

  […] acanthoma），Pilar tumor；Malignant proliferating trichilemmal cyst/tumor，Proliferating tricholemmal cystic squamous cell carcinoma 増殖性外毛根鞘（性）嚢腫（増殖性外毛根鞘嚢腫性棘細胞腫）；悪性増殖性外毛根鞘（性）嚢腫，増殖性外毛根鞘嚢腫性有棘細胞癌 144．Prurigo chronica multiforme 多形慢性痒疹 145．Prurigo nodularis，Eczema [nankodo.co.jp]

• Bitemporal Headache

  Two months later, the patient reported new-onset intermittent bitemporal headache and bilateral swollen, tender temporal arteries. Temporal artery biopsy revealed features consistent with calciphylaxis. [ncbi.nlm.nih.gov]

• Kidney Failure

  Urgent Kidney Transplantation as Successful Treatment of Calciphylaxis in Three Patients with End-Stage Kidney Failure. [abstract]. [atcmeetingabstracts.com]

  It is predominantly seen in patients with chronic kidney failure treated with dialysis (uremic calciphylaxis) but is also described in patients with earlier stages of chronic kidney disease and with normal kidney function. [ncbi.nlm.nih.gov]

  Diabetes and hypertension are major causes of kidney failure, although Huber notes that many kidney failure patients are not obese. [news-medical.net]

• Incontinence

  Over the course of 2 months, his wound worsened in the setting of continued urinary incontinence, and before planned diversion with a suprapubic catheter, he progressed to gangrene and sepsis. [ncbi.nlm.nih.gov]

• Urinary Incontinence

  Over the course of 2 months, his wound worsened in the setting of continued urinary incontinence, and before planned diversion with a suprapubic catheter, he progressed to gangrene and sepsis. [ncbi.nlm.nih.gov]

• Rectal Ulcer

  We present a case of calciphylaxis leading to lower gastrointestinal (GI) bleeding and rectal ulceration of the GI mucosa. [ncbi.nlm.nih.gov]

Most of the current treatments for non-uraemic calciphylaxis are derived from uraemic calciphylaxis treatment protocols. [ncbi.nlm.nih.gov]

Patients with skin involvement over the trunk or proximal extremities have a poorer prognosis. [jasn.asnjournals.org]

Prognosis - Calciphylaxis Unfortunately, response to treatment is not guaranteed. [checkorphan.org]

It is most often seen in patients with renal failure among many other occasionally reported etiologies. [ncbi.nlm.nih.gov]

Although most calciphylaxis patients have abnormalities of the calcium:phosphate axis or elevated levels of parathyroid hormone, these abnormalities do not appear to be fundamental to the pathophysiology of the disorder, and the etiology of calciphylaxis [jasn.asnjournals.org]

Department, Guy's and St Thomas' Hospitals, London, UK. 5 Division of Nephrology, Ambroise Paré University Hospital, APHP, University of Paris Ouest-Versailles-St-Quentin-en-Yvelines (UVSQ), Boulogne-Billancourt, Paris INSERM U1018, Research Centre in Epidemiology [ncbi.nlm.nih.gov]

As high as 85% mortality from secondary infections leading to sepsis Synonym(s): calcific uremic arteriolopathy; uremic gangrene syndrome; calcifying panniculitis Epidemiology Incidence 3.5 new cases/1,000 patient-years among patient with ESRD on chronic [unboundmedicine.com]

These theories remain speculative. [8, 11] Epidemiology Frequency Calciphylaxis is an uncommon condition that affects 1-4% of the population with ESRD. [18, 19] A concern exists that the incidence has increased during the last decade because of a number [emedicine.com]

The lack of understanding of the pathophysiology of the disease results in treatments that are equally unsatisfactory. [jasn.asnjournals.org]

Calcific uremic arteriolopathy: pathophysiology, reactive oxygen species and therapeutic approaches. Oxid Med Cell Longev. 2010;3(2):109-21. 3. Brandenburg VM, Cozzolino M, Ketteler M. Calciphylaxis: a still unmet challenge. [woundeducators.com]

As the pathogenesis of calciphylaxis is better understood, targeted therapies aimed at disease prevention and reversal will follow. [ncbi.nlm.nih.gov]

Calciphylaxis Prevention This is an incurable and fatal condition, which means preventing the occurrence of the disorder is very important for individuals at risk of developing these lesions. [hxbenefit.com]

Early recognition and treatment are vital to prevent unnecessary suffering and increase patient’s quality of life. [o-wm.com]