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Calcipotriene

Calcipotriol


Presentation

  • We present a pediatric case of EVHC associated with attention deficit hyperactivity disorder that partially responded to calcipotriene cream within 2 months.[ncbi.nlm.nih.gov]
  • We present a case of a 7-year-old boy with bilateral nevus comedonicus who experienced cosmetic improvement with topical tazarotene and calcipotriene cream.[ncbi.nlm.nih.gov]
  • Chronic plaque psoriasis (PP) is the most common clinical presentation.[ncbi.nlm.nih.gov]
  • Methods : A 75‐year old woman presented with pustules and hyperkeratotic erythematous papules, coalescing in plaques on the dorsal aspect of both great toes and on the perionychium of their nails.[dx.doi.org]
Asymptomatic
  • Eruptive vellus hair cysts (EVHCs) are characterized by asymptomatic, follicular, comedonelike papules usually located on the anterior chest and abdomen.[ncbi.nlm.nih.gov]
  • A 34-year-old Hispanic woman presented with an 18-month history of an intermittent, asymptomatic eruption that began on her left axilla after using a depilatory cream containing corn starch and thioglycolate (Figure 1A).[ncbi.nlm.nih.gov]
Axillary Lesion
  • After 2 weeks, she had complete resolution of the axillary lesions, but the abdominal lesions persisted. She has since had mild recurrences while using calcipotriene.[ncbi.nlm.nih.gov]
Reiter's Syndrome
  • OBJECTIVE: This article explores the possible use of topical calcipotriene ointment in the treatment of nail and intertriginous psoriasis, palmoplantar and pustular psoriasis, Reiter's syndrome, pityriasis rubra pilaris, and disorders of keratinization[ncbi.nlm.nih.gov]
Papule
  • Eruptive vellus hair cysts (EVHCs) are characterized by asymptomatic, follicular, comedonelike papules usually located on the anterior chest and abdomen.[ncbi.nlm.nih.gov]
  • Methods : A 75‐year old woman presented with pustules and hyperkeratotic erythematous papules, coalescing in plaques on the dorsal aspect of both great toes and on the perionychium of their nails.[oadoi.org]
  • Physical examination revealed multiple dark brown and black papules with a "stuck-on" appearance in both axillae and on the lower right abdomen.[ncbi.nlm.nih.gov]
  • Available from: Sir, Disseminated superficial actinic porokeratosis (DSAP) is a chronic disorder of keratinization characterized by numerous papules and plaques distributed on sun-exposed sites.[ijdvl.com]
Enlargement of the Wrists
  • An 8-year-old Nigerian boy with life-long skin findings consistent with lamellar ichthyosis had windswept deformity of the legs with rib beading and enlargement of the wrists and ankles.[ncbi.nlm.nih.gov]
Withdrawn
  • The Food and Drug Administration (FDA) is announcing its determination that DOVONEX (calcipotriene) Ointment, 0.005%, was not withdrawn from sale for reasons of safety or effectiveness.[federalregister.gov]
  • Forty-four subjects were prematurely withdrawn from the study due to adverse events, which were considered related to treatment in only 28.[ncbi.nlm.nih.gov]
  • RESULTS: Two (4.7%) subjects showed signs of adrenal suppression based on the ACTH stimulation test results at week 4; both were withdrawn from treatment and had normal serum cortisol 30-minute values at follow-up 4 weeks later.[ncbi.nlm.nih.gov]
  • Affected organisms Humans and other mammals Pathways Not Available Pharmacogenomic Effects/ADRs Not Available Drug Interactions All Drugs Approved Vet approved Nutraceutical Illicit Withdrawn Investigational Experimental Drug Interaction Unlock Additional[drugbank.ca]
Hyperactivity
  • We present a pediatric case of EVHC associated with attention deficit hyperactivity disorder that partially responded to calcipotriene cream within 2 months.[ncbi.nlm.nih.gov]
  • Besides the expected incidences of occasional skin itching, hyperactivity of rash spread, and over scaling of the plaques on afflicted areas, there is no known systemic effect associated with over usage of calcipotriene.[medicalook.com]

Treatment

  • ), scaling (week 4 of treatment and week 4 of the posttreatment phase, P or 0.05), erythema (week 4 of treatment and at the end of treatment, P or 0.05), and percentage of body surface area involvement (weeks 2 and 4 of treatment, P or 0.01).[ncbi.nlm.nih.gov]
  • Primary endpoint was the proportion of subjects in each treatment group who achieved treatment success after 8 weeks, analyzed on an intent-to-treat (ITT) basis.[ncbi.nlm.nih.gov]
  • By treatment end, treatment success was reported for 17 patients (55%) according to the IGA and 18 (58%) according to the PGA. Mean TSS improved from 6.9 at baseline to 2.9 at treatment end (59% improvement).[ncbi.nlm.nih.gov]
  • It consisted of a 2-week treatment phase, followed by a 4-week post-treatment observation phase. RESULTS: All 15 patients completed the treatment phase of the study.[ncbi.nlm.nih.gov]
  • Treatment-related adverse events were observed in 12 calcipotriene-treated subjects and 5 fluocinonide-treated subjects; all were considered minor. CONCLUSION: Calcipotriene was superior to fluocinonide in the treatment of plaque psoriasis.[ncbi.nlm.nih.gov]

Prognosis

  • Its poor prognosis is linked to its typically advanced clinical stage at diagnosis, rapid disease progression, and resistance to cytotoxic or targeted molecular therapies ( 2 ).[mcr.aacrjournals.org]

Etiology

  • Abstract Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. AA is chronic and relapsing, and no effective cure or preventive treatment has been established.[ncbi.nlm.nih.gov]
  • Calcipotriol, a vitamin D3 analog, acts not only to inhibit cell proliferation and enhance cell differentiation in the skin of patients with psoriasis, but also appears to have effects on immunologic markers that are thought to play a role in the etiology[ncbi.nlm.nih.gov]
  • Alopecia areata (AA) is an inflammatory hair loss of unknown etiology. A role of the immune system in the pathogenesis of this disease is supported by strong evidence.[doi.org]

Epidemiology

  • Patient Population: Prevalence and Epidemiology Knee // Shoulder & Elbow // Hip // Spine // Foot & Ankle // Hand & Wrist Fragility Fractures: Diagnosis and Treatment Shoulder & Elbow The Characteristics of Surgeons Performing Total Shoulder Arthroplasty[amjorthopedics.com]
  • METHODS: This BIM incorporated epidemiologic data, market uptake assumptions, and drug utilization costs, simulating the treatment mix for patients who are candidates for biologics before (Scenario #1) and after (Scenario #2) the introduction of C/BD[ncbi.nlm.nih.gov]
  • Clinico‐epidemiological parameters including severity of AA and SALT score were calculated at baseline and at 12 weeks. Hair regrowth was assessed monthly at 4, 8, 12 weeks. Serum vitamin D levels were measured at baseline.[doi.org]
  • […] developmental status None EU developmental status Phase III Clinical Trials US developmental status None Category Pharmacology An anhydrous calcipotriol (a synthetic derivative of calcitriol, a form of vitamin D) for administration as medicated nail lacquer, Epidemiology[sps.nhs.uk]
  • ABSTRACT:In the present single-center retrospective study, we investigated our data ... more Skin Cancer Epidemiology and Sun Protection Behaviors Among Native American....[jddonline.com]
Sex distribution
Age distribution

Pathophysiology

  • The pathophysiology of psoriasis involves a proliferation of keratinocytes. This cell proliferation can be suppressed by vitamin D, but the vitamin can also affect calcium metabolism (hypervitaminosis D causes hypercalcaemia).[nps.org.au]
  • Psoriasis is a common inflammatory skin disorder that appears to be induced by multifactorial pathophysiologic processes associated with immunologic dysregulation. 1 It can affect patients of any age, gender, and ethnicity, and it presents clinically[cutis.com]
  • Their mode of action, the pathophysiological rationale for the treatment of psoriasis, as well as their described adverse effects lead to the idea of combining calcipotriol and betamethasone as a promising treatment modality.[dovepress.com]

Prevention

  • AA is chronic and relapsing, and no effective cure or preventive treatment has been established. Vitamin D was recently reported to be important in cutaneous immune modulation as well as calcium regulation and bone metabolism.[ncbi.nlm.nih.gov]
  • Abstract The role of vitamin D3 in cancer prevention and its potential as an anticancer therapeutic agent have been researched and are well established.[ncbi.nlm.nih.gov]
  • Researching Advancements in Cancer Vaccines Cancer vaccines can be used either in the prevention or the treatment of cancer.[news-medical.net]
  • Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.[drugs.com]
  • Considering all of this, we hypothesized that topical application of calcipotriol could prevent hypertrophic scar formation by altering the biochemical properties of the epidermis.[jamanetwork.com]

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